Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6E50A)

• Drug Name: PMID27336223-Compound-5 Drug Info
• Cross-matching ID:
  PubChem CID: 2126
  ChEBI ID: CHEMBL69367
  CAS Number: CAS 102121-60-8
  TTD Drug ID: DM6E50A

Molecule-Related Drug Atlas

Drug(s) Targeting Retinoic acid receptor alpha (RARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[4]
IRX-5183	DMCED9U	Solid tumour/cancer	2A00-2F9Z	Phase 1	[5]
SY-1425	DMH8UF0	Acute myeloid leukaemia	2A60	Phase 1	[6]
PMID27336223-Compound-4	DMJFSOM	N. A.	N. A.	Patented	[1]
LG100268	DM41RK2	Acquired immune deficiency syndrome	1C62.3	Discontinued in Phase 1	[7]
CD666	DMC8X9Y	Discovery agent	N.A.	Investigative	[8]
AGN193109	DMC0YOE	Discovery agent	N.A.	Investigative	[9]
AGN193836	DMEB93D	Discovery agent	N.A.	Investigative	[10]
BMS614	DMZWNO9	Discovery agent	N.A.	Investigative	[11]
Ro-40-0655	DM8PYAN	Colorectal cancer	2B91.Z	Investigative	[12]

Drug(s) Affected By Choriogonadotropin subunit beta 3 (CGB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[13]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[14]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[17]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[18]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[17]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[19]
Bezafibrate	DMZDCS0	Hypercholesterolaemia	5C80.0	Approved	[20]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[21]

Drug(s) Affected By Golgin subfamily A member 8A (GOLGA8A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[13]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[23]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[25]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[26]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[27]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[28]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[29]

Drug(s) Affected By CMRF35-like molecule 7 (CD300LB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]

Drug(s) Affected By Regulatory factor X-associated protein (RFXAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[36]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[19]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[37]

Drug(s) Affected By Agrin (AGRN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[39]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[39]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[41]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[42]

Drug(s) Affected By Phospholipid phosphatase 3 (PLPP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[32]
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[43]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[45]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[47]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 12 (TNFSF12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[48]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[50]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[51]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[52]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[53]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[54]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[55]

Drug(s) Affected By Leukocyte immunoglobulin-like receptor subfamily A member 1 (LILRA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]

Drug(s) Affected By Rho-related BTB domain-containing protein 3 (RHOBTB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[45]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[47]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[58]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]

Drug(s) Affected By Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPSS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[23]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[62]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[63]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[64]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 6 (MAP3K6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[67]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[68]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[69]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[70]

Drug(s) Affected By BAG family molecular chaperone regulator 2 (BAG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[50]

Drug(s) Affected By Retinol-binding protein 1 (RBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[73]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[75]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[76]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[36]

Drug(s) Affected By Peroxisomal coenzyme A diphosphatase NUDT7 (NUDT7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[51]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[36]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]

Drug(s) Affected By Antigen-presenting glycoprotein CD1d (CD1D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[83]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[26]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[85]

Drug(s) Affected By Protein-glutamine gamma-glutamyltransferase 2 (TGM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[86]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[88]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[91]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]

Drug(s) Affected By Collagen alpha-3(V) chain (COL5A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[19]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[27]
Alendronate	DMY2KX9	Bone Paget disease		Approved	[93]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[68]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[57]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[94]

Drug(s) Affected By Rap1 GTPase-activating protein 1 (RAP1GAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[96]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[23]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[57]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[97]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[98]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[99]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[36]

Drug(s) Affected By Nuclear receptor-interacting protein 1 (NRIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Teniposide	DMLW57T	Acute lymphoblastic leukaemia	2A85	Approved	[103]

Drug(s) Affected By Thrombospondin-3 (THBS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[104]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[105]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[51]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[42]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[106]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[85]

Drug(s) Affected By PDZ and LIM domain protein 4 (PDLIM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[109]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[51]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[110]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[27]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[68]

Drug(s) Affected By Histone H2B type 1-D (H2BC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[104]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[22]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[45]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[111]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]

Drug(s) Affected By Ras-related protein Rab-15 (RAB15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[51]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[113]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[27]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[114]

Drug(s) Affected By Oxidized low-density lipoprotein receptor 1 (OLR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[86]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[115]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[41]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[86]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[86]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[116]

Drug(s) Affected By Amyloid beta precursor like protein 2 (APLP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[117]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[118]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[32]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]

Drug(s) Affected By Myotonin-protein kinase (DMPK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[22]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[27]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[70]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[121]

Drug(s) Affected By Dystrophia myotonica WD repeat-containing protein (DMWD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[122]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[70]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[123]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]

Drug(s) Affected By Alpha-(1,3)-fucosyltransferase 7 (FUT7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[124]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]

Drug(s) Affected By H2.0-like homeobox protein (HLX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[13]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[23]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[19]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[27]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[68]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[13]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[28]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]

Drug(s) Affected By Uncharacterized protein KIAA0040 (KIAA0040)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[126]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[19]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[127]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[27]

Drug(s) Affected By Nicotinate-nucleotide pyrophosphorylase (QPRT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[128]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[36]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[106]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[129]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[130]

Drug(s) Affected By Zinc finger protein SNAI3 (SNAI3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[19]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[131]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[132]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
Nitrobenzanthrone	DMN6L70	N. A.	N. A.	Investigative	[133]

Drug(s) Affected By Pleckstrin homology-like domain family A member 2 (PHLDA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[22]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[134]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[45]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]

Drug(s) Affected By Late cornified envelope-like proline-rich protein 1 (LELP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[135]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[120]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[136]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[137]

Drug(s) Affected By Protein sel-1 homolog 3 (SEL1L3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[47]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[51]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[42]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[139]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]

Drug(s) Affected By Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[141]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[142]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[123]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[143]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[144]

Drug(s) Affected By Myogenesis-regulating glycosidase (MYORG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[145]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[121]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[146]

Drug(s) Affected By Uncharacterized protein C16orf46 (C16ORF46)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[146]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[147]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[53]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[70]
cordycepin	DM72Y01	Discovery agent	N.A.	Investigative	[148]

Drug(s) Affected By Phospholipase B-like 1 (PLBD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[32]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[27]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[149]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[57]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[123]

Drug(s) Affected By Low-density lipoprotein receptor-related protein 11 (LRP11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[51]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[36]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[62]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[27]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[85]

Drug(s) Affected By Sodium-independent sulfate anion transporter (SLC26A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[151]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Bortezomib	DMNO38U	Leukemia		Approved	[152]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[36]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[153]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[154]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[27]

Drug(s) Affected By Cerebellar degeneration-related protein 2-like (CDR2L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[22]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[155]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[23]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[27]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[70]

Drug(s) Affected By SLIT and NTRK-like protein 4 (SLITRK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[97]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[106]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[27]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[28]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[57]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[121]

Drug(s) Affected By Glycerol-3-phosphate dehydrogenase 1-like protein (GPD1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[42]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[36]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[19]

Drug(s) Affected By Sesquipedalian-1 (PHETA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[147]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[70]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[121]

Drug(s) Affected By Refilin-B (RFLNB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[156]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[42]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[19]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[27]

Drug(s) Affected By Uncharacterized protein FAM241A (FAM241A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[96]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[51]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[42]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[157]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[36]

Drug(s) Affected By CMRF35-like molecule 1 (CD300LF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[123]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[158]

Drug(s) Affected By Serine-rich single-pass membrane protein 1 (SSMEM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[153]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]

Drug(s) Affected By Interactor protein for cytohesin exchange factors 1 (IPCEF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[68]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[159]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[123]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[121]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[159]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[160]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[146]

Drug(s) Affected By Cortactin-binding protein 2 (CTTNBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[161]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[23]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[19]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[162]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[145]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[121]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[163]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[85]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[165]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[28]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[166]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]

Drug(s) Affected By Kinesin-like protein KIFC2 (KIFC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[22]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[27]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[28]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]

Drug(s) Affected By Metalloendopeptidase OMA1, mitochondrial (OMA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[22]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[36]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[62]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[67]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[85]

Drug(s) Affected By PDZ and LIM domain protein 2 (PDLIM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[135]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[38]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[123]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]

Drug(s) Affected By PML-RARA-regulated adapter molecule 1 (PRAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[169]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[123]

Drug(s) Affected By TBC1 domain family member 2A (TBC1D2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[89]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[33]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[36]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[19]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[170]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[171]

Drug(s) Affected By Dendritic cell-specific transmembrane protein (DCSTAMP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[83]
Methamphetamine	DMPM4SK	Anxiety		Approved	[172]
ANW-32821	DMMJOZD	N. A.	N. A.	Phase 2	[173]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[145]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[174]

Drug(s) Affected By Tensin-1 (TNS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[22]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[36]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[19]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[153]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[62]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[26]

Drug(s) Affected By Nuclear receptor-interacting protein 3 (NRIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[25]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[97]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[51]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[36]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[176]

Drug(s) Affected By Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC (MAN1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[138]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[27]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[85]

Drug(s) Affected By 1-acyl-sn-glycerol-3-phosphate acyltransferase delta (AGPAT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[177]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[42]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[36]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[27]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[174]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[42]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[137]

Drug(s) Affected By Ras-related protein Rab-20 (RAB20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[65]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[178]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[75]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[36]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[62]

Drug(s) Affected By Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C (MGAT4C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[68]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[55]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[146]

Drug(s) Affected By DnaJ homolog subfamily C member 5B (DNAJC5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[53]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[146]

Drug(s) Affected By Meteorin (METRN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[36]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[19]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[57]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[121]

Drug(s) Affected By Adherens junction-associated protein 1 (AJAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Methamphetamine	DMPM4SK	Anxiety		Approved	[180]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[136]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[57]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]

Drug(s) Affected By Paladin (PALD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[19]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[106]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[181]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[182]

Drug(s) Affected By Protein NDRG2 (NDRG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[47]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[42]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[76]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[36]

Drug(s) Affected By Phosphatidylinositide phosphatase SAC2 (INPP5F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[183]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[19]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[106]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[27]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[183]

Drug(s) Affected By Transducin beta-like protein 2 (TBL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[36]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[106]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[184]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]

Drug(s) Affected By Transmembrane protein 14A (TMEM14A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[22]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[51]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[36]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]

Drug(s) Affected By Interferon gamma receptor 1 (IFNGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[185]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[32]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[186]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[92]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[187]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[188]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[189]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[86]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[190]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[191]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[192]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[193]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[194]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[195]
Fructose	DM43AN2	Vomiting	MD90	Approved	[196]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[197]

Drug(s) Affected By 2'-5'-oligoadenylate synthase 2 (OAS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[3]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[47]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[199]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[51]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[200]
Amantadine	DMS3YE9	Influenza A virus infection	1E30	Approved	[201]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[202]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[203]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[204]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[205]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[207]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[208]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[209]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[210]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[211]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[212]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[213]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[86]
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[214]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[215]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[216]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[22]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[217]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[218]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[219]

Drug(s) Affected By Occludin (OCLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[220]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[221]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[222]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[223]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[155]
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[224]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[225]

Drug(s) Affected By Bile acid receptor (NR1H4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[226]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[227]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[228]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[229]
Nisoldipine	DM7ISKJ	Hypertension	BA00-BA04	Approved	[226]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[227]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[230]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Retinoic acid receptor alpha (RARA)	TTW38KT	RARA_HUMAN	Agonist	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (AGPAT4)	OT5CTQKO	PLCD_HUMAN	Gene/Protein Processing	[2]
2'-5'-oligoadenylate synthase 2 (OAS2)	OT64CCTM	OAS2_HUMAN	Gene/Protein Processing	[3]
Adherens junction-associated protein 1 (AJAP1)	OTAAW121	AJAP1_HUMAN	Gene/Protein Processing	[2]
Agrin (AGRN)	OTWJENAZ	AGRIN_HUMAN	Gene/Protein Processing	[2]
Alpha-(1,3)-fucosyltransferase 7 (FUT7)	OTJF6BSN	FUT7_HUMAN	Gene/Protein Processing	[2]
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C (MGAT4C)	OTQ2R629	MGT4C_HUMAN	Gene/Protein Processing	[2]
Amyloid beta precursor like protein 2 (APLP2)	OTTFE53M	APLP2_HUMAN	Gene/Protein Processing	[2]
Antigen-presenting glycoprotein CD1d (CD1D)	OT3ROU4J	CD1D_HUMAN	Gene/Protein Processing	[2]
BAG family molecular chaperone regulator 2 (BAG2)	OTI6LD27	BAG2_HUMAN	Gene/Protein Processing	[2]
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPSS2)	OTDLEXPN	PAPS2_HUMAN	Gene/Protein Processing	[2]

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