Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6E50A)

• Drug Name: PMID27336223-Compound-5 Drug Info
• Cross-matching ID:
  PubChem CID: 2126
  ChEBI ID: CHEBI:64210
  CAS Number: CAS 102121-60-8
  TTD Drug ID: DM6E50A

Molecule-Related Drug Atlas

Drug(s) Targeting Retinoic acid receptor alpha (RARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[6]
IRX-5183	DMCED9U	Solid tumour/cancer	2A00-2F9Z	Phase 1	[7]
SY-1425	DMH8UF0	Acute myeloid leukaemia	2A60	Phase 1	[8]
PMID27336223-Compound-4	DMJFSOM	N. A.	N. A.	Patented	[1]
LG100268	DM41RK2	Acquired immune deficiency syndrome	1C62.3	Discontinued in Phase 1	[9]
CD666	DMC8X9Y	Discovery agent	N.A.	Investigative	[10]
AGN193109	DMC0YOE	Discovery agent	N.A.	Investigative	[11]
AGN193836	DMEB93D	Discovery agent	N.A.	Investigative	[12]
BMS614	DMZWNO9	Discovery agent	N.A.	Investigative	[13]
Ro-40-0655	DM8PYAN	Colorectal cancer	2B91.Z	Investigative	[14]

Drug(s) Affected By Cytochrome P450 26A1 (CYP26A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[15]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[16]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[15]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Dolutegravir	DMCZGRE	Human immunodeficiency virus infection	1C62	Approved	[20]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[15]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[21]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[22]

Drug(s) Affected By Choriogonadotropin subunit beta 3 (CGB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[24]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[27]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[28]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[29]
Bezafibrate	DMZDCS0	Hypercholesterolaemia	5C80.0	Approved	[30]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[31]

Drug(s) Affected By Aromatase (CYP19A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[32]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[33]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[34]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[35]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[34]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[37]
Bifonazole	DM3KN7V	Fungal infection	1F29-1F2F	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[34]

Drug(s) Affected By Golgin subfamily A member 8A (GOLGA8A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[43]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[44]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[46]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[47]

Drug(s) Affected By CMRF35-like molecule 7 (CD300LB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]

Drug(s) Affected By Regulatory factor X-associated protein (RFXAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[54]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[29]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[55]

Drug(s) Affected By Agrin (AGRN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[57]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[57]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[59]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[60]

Drug(s) Affected By Phospholipid phosphatase 3 (PLPP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[61]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 12 (TNFSF12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[66]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[68]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[69]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[70]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[71]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[72]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[73]

Drug(s) Affected By F-box-like/WD repeat-containing protein TBL1X (TBL1X)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[75]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[69]
Bortezomib	DMNO38U	Leukemia		Approved	[77]

Drug(s) Affected By Leukocyte immunoglobulin-like receptor subfamily A member 1 (LILRA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]

Drug(s) Affected By Short-chain dehydrogenase/reductase 3 (DHRS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[78]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[80]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]

Drug(s) Affected By Rho-related BTB domain-containing protein 3 (RHOBTB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[83]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]

Drug(s) Affected By Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPSS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[87]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[88]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[89]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 6 (MAP3K6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[91]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[92]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[93]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[94]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[95]

Drug(s) Affected By BAG family molecular chaperone regulator 2 (BAG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[97]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[68]

Drug(s) Affected By Adenosine deaminase (ADA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[99]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[69]
Corticotropin	DMP9TWZ	Cushing disease	5A70	Approved	[100]

Drug(s) Affected By Fibronectin (FN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[101]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[103]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[104]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[106]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[107]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[66]

Drug(s) Affected By T-cell surface glycoprotein CD1a (CD1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[90]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[108]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[110]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]
24(S), 25-epoxycholesterol	DMW2KI5	Discovery agent	N.A.	Investigative	[108]

Drug(s) Affected By Beta-glucuronidase (GUSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[50]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[112]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[47]

Drug(s) Affected By Retinol-binding protein 1 (RBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[113]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[115]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[54]

Drug(s) Affected By Tumor-associated calcium signal transducer 2 (TACSTD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[117]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[117]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[64]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]

Drug(s) Affected By Peroxisomal coenzyme A diphosphatase NUDT7 (NUDT7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[69]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[54]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[91]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]

Drug(s) Affected By Interleukin-1 receptor type 1 (IL1R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[122]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[122]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]

Drug(s) Affected By Protein C-ets-2 (ETS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[75]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[123]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[124]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]

Drug(s) Affected By Antigen-presenting glycoprotein CD1d (CD1D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[125]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[127]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[128]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[44]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[112]

Drug(s) Affected By Plasma membrane calcium-transporting ATPase 1 (ATP2B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[129]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[80]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[130]

Drug(s) Affected By Protein-glutamine gamma-glutamyltransferase 2 (TGM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[131]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[132]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[80]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[135]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]

Drug(s) Affected By Collagen alpha-3(V) chain (COL5A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[29]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Alendronate	DMY2KX9	Bone Paget disease		Approved	[137]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[93]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[138]

Drug(s) Affected By Integrin alpha-E (ITGAE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[54]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[139]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[140]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[141]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[142]

Drug(s) Affected By Rap1 GTPase-activating protein 1 (RAP1GAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[143]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[144]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[145]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[146]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[54]

Drug(s) Affected By Nuclear receptor-interacting protein 1 (NRIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[147]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Teniposide	DMLW57T	Acute lymphoblastic leukaemia	2A85	Approved	[149]

Drug(s) Affected By Thrombospondin-3 (THBS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[151]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[69]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[60]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[152]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[153]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[112]

Drug(s) Affected By PDZ and LIM domain protein 4 (PDLIM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[155]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[69]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[156]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[79]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[93]

Drug(s) Affected By Histone H2B type 1-D (H2BC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[157]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[80]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[158]

Drug(s) Affected By Ras-related protein Rab-15 (RAB15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[69]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[159]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[160]

Drug(s) Affected By Oxidized low-density lipoprotein receptor 1 (OLR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[131]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[131]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[64]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[161]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[59]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[131]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[131]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[162]

Drug(s) Affected By Amyloid beta precursor like protein 2 (APLP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[164]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[50]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[165]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[110]

Drug(s) Affected By Myotonin-protein kinase (DMPK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[110]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[95]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[166]

Drug(s) Affected By Dystrophia myotonica WD repeat-containing protein (DMWD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[167]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[95]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[168]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]

Drug(s) Affected By Alpha-(1,3)-fucosyltransferase 7 (FUT7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[169]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]

Drug(s) Affected By P-selectin glycoprotein ligand 1 (SELPLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[97]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[29]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[128]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[95]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[168]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[166]

Drug(s) Affected By H2.0-like homeobox protein (HLX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[29]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[93]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[23]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[46]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]

Drug(s) Affected By Uncharacterized protein KIAA0040 (KIAA0040)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[158]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[170]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[29]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[128]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[171]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]

Drug(s) Affected By Serum paraoxonase/arylesterase 2 (PON2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[172]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[54]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[128]

Drug(s) Affected By Nicotinate-nucleotide pyrophosphorylase (QPRT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[174]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[54]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[128]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[152]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[175]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[176]

Drug(s) Affected By Calcitonin gene-related peptide type 1 receptor (CALCRL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[128]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[46]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[46]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[177]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]

Drug(s) Affected By Zinc finger protein SNAI3 (SNAI3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[80]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[29]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[178]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[179]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]
Nitrobenzanthrone	DMN6L70	N. A.	N. A.	Investigative	[180]

Drug(s) Affected By Pleckstrin homology-like domain family A member 2 (PHLDA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[181]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]

Drug(s) Affected By Late cornified envelope-like proline-rich protein 1 (LELP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[22]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[110]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[182]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[183]

Drug(s) Affected By Protein sel-1 homolog 3 (SEL1L3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[184]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[69]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[60]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[185]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]

Drug(s) Affected By Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[187]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[128]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[188]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[168]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[189]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[190]

Drug(s) Affected By Myogenesis-regulating glycosidase (MYORG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[191]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[166]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[98]

Drug(s) Affected By Uncharacterized protein C16orf46 (C16ORF46)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[192]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[71]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[95]
cordycepin	DM72Y01	Discovery agent	N.A.	Investigative	[193]

Drug(s) Affected By Phospholipase B-like 1 (PLBD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[50]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[194]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[79]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[168]

Drug(s) Affected By Low-density lipoprotein receptor-related protein 11 (LRP11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[69]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[54]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[87]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[112]

Drug(s) Affected By Sodium-independent sulfate anion transporter (SLC26A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[195]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[196]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Bortezomib	DMNO38U	Leukemia		Approved	[77]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[54]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[139]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[197]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]

Drug(s) Affected By Cerebellar degeneration-related protein 2-like (CDR2L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[128]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[95]

Drug(s) Affected By SLIT and NTRK-like protein 4 (SLITRK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[152]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[46]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[166]

Drug(s) Affected By Glycerol-3-phosphate dehydrogenase 1-like protein (GPD1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[60]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[54]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[29]

Drug(s) Affected By Sesquipedalian-1 (PHETA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[192]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[128]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[95]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[166]

Drug(s) Affected By Refilin-B (RFLNB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[80]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[198]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[60]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[29]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]

Drug(s) Affected By Uncharacterized protein FAM241A (FAM241A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[144]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[69]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[60]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[199]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[54]

Drug(s) Affected By RalBP1-associated Eps domain-containing protein 2 (REPS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[199]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[127]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[93]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[94]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[95]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[199]

Drug(s) Affected By CMRF35-like molecule 1 (CD300LF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[168]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[200]

Drug(s) Affected By Serine-rich single-pass membrane protein 1 (SSMEM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[139]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]

Drug(s) Affected By Interactor protein for cytohesin exchange factors 1 (IPCEF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[93]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[177]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[168]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[166]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[177]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[201]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[98]

Drug(s) Affected By Cortactin-binding protein 2 (CTTNBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[202]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[29]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[203]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[191]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[166]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[204]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[91]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[112]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[205]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[46]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[206]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]

Drug(s) Affected By Kinesin-like protein KIFC2 (KIFC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[46]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]

Drug(s) Affected By Metalloendopeptidase OMA1, mitochondrial (OMA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[54]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[91]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[87]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[92]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[112]

Drug(s) Affected By PDZ and LIM domain protein 2 (PDLIM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[80]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[80]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[22]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[128]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[56]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[168]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]

Drug(s) Affected By PML-RARA-regulated adapter molecule 1 (PRAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[207]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[208]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[209]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[168]

Drug(s) Affected By Growth/differentiation factor 15 (GDF15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[210]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[211]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[212]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[213]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[214]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[117]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[117]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[215]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[216]

Drug(s) Affected By TBC1 domain family member 2A (TBC1D2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[80]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[80]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[54]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[29]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[217]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[218]

Drug(s) Affected By Dendritic cell-specific transmembrane protein (DCSTAMP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[127]
Methamphetamine	DMPM4SK	Anxiety		Approved	[219]
ANW-32821	DMMJOZD	N. A.	N. A.	Phase 2	[220]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[191]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[221]

Drug(s) Affected By Homeodomain-interacting protein kinase 2 (HIPK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[136]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[80]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[69]

Drug(s) Affected By Tensin-1 (TNS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[54]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[29]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[139]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[87]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[44]

Drug(s) Affected By Interleukin-1 receptor accessory protein (IL1RAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[222]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[97]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Febuxostat	DMDEXQ0	Hyperuricaemia	5C55.Y	Approved	[223]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[224]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[54]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[29]

Drug(s) Affected By Nuclear receptor-interacting protein 3 (NRIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[43]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[69]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[54]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[225]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[226]

Drug(s) Affected By Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC (MAN1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[184]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[128]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[112]

Drug(s) Affected By 1-acyl-sn-glycerol-3-phosphate acyltransferase delta (AGPAT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[60]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[54]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[221]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[60]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[183]

Drug(s) Affected By Ras-related protein Rab-20 (RAB20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[228]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[115]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[54]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[87]

Drug(s) Affected By Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C (MGAT4C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[91]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[93]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[73]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[98]

Drug(s) Affected By DnaJ homolog subfamily C member 5B (DNAJC5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[71]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[98]

Drug(s) Affected By CMRF35-like molecule 8 (CD300A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[196]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[229]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[93]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[23]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[168]

Drug(s) Affected By Meteorin (METRN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[230]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[54]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[29]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[166]

Drug(s) Affected By Adherens junction-associated protein 1 (AJAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Methamphetamine	DMPM4SK	Anxiety		Approved	[231]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[79]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[182]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]

Drug(s) Affected By Paladin (PALD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[29]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[152]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[232]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[233]

Drug(s) Affected By Protein NDRG2 (NDRG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[60]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[54]

Drug(s) Affected By Phosphatidylinositide phosphatase SAC2 (INPP5F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[207]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[234]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[29]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[152]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[234]

Drug(s) Affected By Transducin beta-like protein 2 (TBL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[54]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[152]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[235]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[49]

Drug(s) Affected By Transmembrane protein 14A (TMEM14A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[2]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[69]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[54]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[128]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[236]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[237]
Fructose	DM43AN2	Vomiting	MD90	Approved	[238]
Ketoprofen	DMRKXPT	Bursitis		Approved	[238]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[239]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[240]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[241]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[242]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[243]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[244]

Drug(s) Affected By Steryl-sulfatase (STS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[61]
Tazarotene	DM8SMD1	Acne vulgaris	ED80	Approved	[245]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[228]
Danazol	DML8KTN	Menorrhagia	GA20.50	Approved	[246]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[245]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[61]

Drug(s) Affected By Androgen receptor (AR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[247]
Nilutamide	DMFN07X	Prostate cancer	2C82.0	Approved	[247]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[247]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[248]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[249]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[250]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[251]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[5]
Selenium	DM25CGV	N. A.	N. A.	Approved	[252]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[253]

Drug(s) Affected By Interferon regulatory factor 1 (IRF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[75]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[76]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[255]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]

Drug(s) Affected By Interferon gamma receptor 1 (IFNGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[136]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[256]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[257]

Drug(s) Affected By Retinoic acid receptor RXR-alpha (RXRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[258]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Selenium	DM25CGV	N. A.	N. A.	Approved	[259]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[260]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[261]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[262]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[263]
Acitretin	DM8BKU9	Psoriasis vulgaris	EA90	Approved	[264]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[265]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[131]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[211]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[266]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[267]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[268]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[269]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[270]
Fructose	DM43AN2	Vomiting	MD90	Approved	[271]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[131]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[272]

Drug(s) Affected By ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[273]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[274]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[4]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[275]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[276]
Bortezomib	DMNO38U	Leukemia		Approved	[77]
Omacetaxine mepesuccinate	DMPU2WX	Adult acute monocytic leukemia		Approved	[274]
Novobiocin	DMRFWGK	Bacterial infection	1A00-1C4Z	Approved	[277]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[29]

Drug(s) Affected By 2'-5'-oligoadenylate synthase 2 (OAS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[3]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[278]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[65]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[279]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[69]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[280]
Amantadine	DMS3YE9	Influenza A virus infection	1E30	Approved	[281]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[128]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[282]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[283]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[284]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[285]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[286]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[287]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[288]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[289]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[290]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[291]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[292]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[293]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[131]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[294]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[295]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[296]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[297]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[298]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[78]

Drug(s) Affected By Occludin (OCLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[299]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[300]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[301]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[302]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[303]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[304]

Drug(s) Affected By Galactose mutarotase (GALM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[97]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[54]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[29]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[50]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[87]

Drug(s) Affected By Bile acid receptor (NR1H4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[143]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[5]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[305]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[306]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[307]
Nisoldipine	DM7ISKJ	Hypertension	BA00-BA04	Approved	[5]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[305]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[308]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Retinoic acid receptor alpha (RARA)	TTW38KT	RARA_HUMAN	Agonist	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (AGPAT4)	OT5CTQKO	PLCD_HUMAN	Gene/Protein Processing	[2]
2'-5'-oligoadenylate synthase 2 (OAS2)	OT64CCTM	OAS2_HUMAN	Gene/Protein Processing	[3]
Adenosine deaminase (ADA)	OTOX2872	ADA_HUMAN	Gene/Protein Processing	[2]
Adherens junction-associated protein 1 (AJAP1)	OTAAW121	AJAP1_HUMAN	Gene/Protein Processing	[2]
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38)	OTG0TTX7	CD38_HUMAN	Gene/Protein Processing	[4]
Agrin (AGRN)	OTWJENAZ	AGRIN_HUMAN	Gene/Protein Processing	[2]
Alpha-(1,3)-fucosyltransferase 7 (FUT7)	OTJF6BSN	FUT7_HUMAN	Gene/Protein Processing	[2]
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C (MGAT4C)	OTQ2R629	MGT4C_HUMAN	Gene/Protein Processing	[2]
Amyloid beta precursor like protein 2 (APLP2)	OTTFE53M	APLP2_HUMAN	Gene/Protein Processing	[2]
Androgen receptor (AR)	OTUBKAZZ	ANDR_HUMAN	Gene/Protein Processing	[5]

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