Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMC9O43)

Drug Name
Sevoflurane Drug Info
Synonyms
Sevofluran; Sevoflurano; Sevofluranum; Sevofrane; Sevorane; Sojourn; Ultane; Fluoromethyl hexafluoroisopropyl ether; Bax 3084; F0691; MR6S4; MR_6S4; PC4681; Sevoflurano [INN-Spanish]; Sevofluranum [INN-Latin]; Ultane (TN); Sevoflurane (JAN/USAN/INN); Sevoflurane [USAN:INN:BAN:JAN]; Fluoromethyl 1,1,1,3,3,3-Hexafluoroisopropyl Ether; Fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether; Fluoromethyl-2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether; 1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane
Indication
Disease Entry ICD 11 Status REF
Anaesthesia 9A78.6 Approved [1]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 3 [2]
Therapeutic Class
Anesthetics
Cross-matching ID
PubChem CID
5206
ChEBI ID
CHEBI:9130
CAS Number
CAS 28523-86-6
TTD Drug ID
DMC9O43
VARIDT Drug ID
DR00465
INTEDE Drug ID
DR1478

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Glutamate receptor AMPA (GRIA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Halothane DM80OZ5 Anaesthesia 9A78.6 Approved [14]
E-2007 DMJDYNQ Diabetic neuropathy 8C0Z Approved [15]
Zopiclone DMPI6Z0 Insomnia 7A00-7A0Z Approved [16]
Enflurane DM0YJSB Anaesthesia 9A78.6 Approved [17]
Isoflurane DMY6T31 Anaesthesia 9A78.6 Approved [18]
Bromazepam DMY9TCW Anxiety disorder 6B00-6B0Z Approved [19]
Artemisinin SP DMFETDK Malaria 1F40-1F45 Approved [20]
Dihydroergotoxine DM5D6WZ Alzheimer disease 8A20 Approved [21]
Barbiturate DMJIA6T Anaesthesia 9A78.6 Approved [22]
Fospropofol disodium DMKLJRD Monitored anaesthesia care N.A. Approved [23]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [24]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [25]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [26]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [27]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [28]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [29]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [30]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [31]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [25]
Verapamil DMA7PEW Angina pectoris BA40 Approved [32]
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Drug(s) Metabolized By Cytochrome P450 2A6 (CYP2A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [33]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [7]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [34]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [28]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [7]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [35]
Metronidazole DMTIVEN Abscess Approved [36]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [37]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [38]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [7]
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Drug(s) Metabolized By Cytochrome P450 2E1 (CYP2E1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Folic Acid DMEMBJC Colorectal carcinoma Approved [39]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [40]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [34]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [41]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [42]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [43]
Verapamil DMA7PEW Angina pectoris BA40 Approved [7]
Estrone DM5T6US Acne vulgaris ED80 Approved [44]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [5]
Ethanol DMDRQZU Chronic pain MG30 Approved [45]
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Drug(s) Metabolized By Cytochrome P450 2B6 (CYP2B6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [46]
Verapamil DMA7PEW Angina pectoris BA40 Approved [7]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [47]
Estrone DM5T6US Acne vulgaris ED80 Approved [48]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [49]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [50]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [51]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [52]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [53]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [54]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [55]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [56]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [57]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [58]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [59]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [60]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [61]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [62]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [63]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [64]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aprepitant DM053KT Depression 6A70-6A7Z Approved [63]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [65]
Verapamil DMA7PEW Angina pectoris BA40 Approved [66]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [67]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [68]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [69]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [70]
Meloxicam DM2AR7L Arthritis FA20 Approved [71]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [72]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [73]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [74]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [75]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [76]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [77]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [65]
Verapamil DMA7PEW Angina pectoris BA40 Approved [66]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [78]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [79]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [80]
Flucytosine DM13VTW Cryptococcal meningitis Approved [81]
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Drug(s) Affected By Glycine receptor subunit alpha-1 (GLRA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [82]
Leflunomide DMR8ONJ Arthritis FA20 Approved [83]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [84]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [86]
Glycine DMIOZ29 Allergic rhinitis CA08.0 Approved [87]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [82]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [88]
acetaldehyde DMJFKG4 Discovery agent N.A. Investigative [89]
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Drug(s) Affected By Glutamate dehydrogenase 1, mitochondrial (GLUD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [90]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [91]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [92]
Testosterone DM7HUNW Hot flushes GA30 Approved [93]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [93]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [94]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [11]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [95]
Capsaicin DMGMF6V Back pain ME84.Z Approved [96]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [97]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [98]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [99]
Gefitinib DM15F0X Colon adenocarcinoma Approved [100]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [101]
Selenium DM25CGV N. A. N. A. Approved [102]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [103]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [104]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [105]
Methotrexate DM2TEOL Anterior urethra cancer Approved [106]
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Drug(s) Affected By GTPase HRas (HRAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [107]
Selenium DM25CGV N. A. N. A. Approved [108]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [109]
Quercetin DM3NC4M Obesity 5B81 Approved [110]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [111]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [112]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [113]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [114]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [115]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
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Drug(s) Affected By GTPase KRas (KRAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [116]
Quercetin DM3NC4M Obesity 5B81 Approved [117]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [118]
Tiazofurin DM5JWV9 Solid tumour/cancer 2A00-2F9Z Approved [119]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [120]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [121]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [114]
Testosterone enanthate DMB6871 N. A. N. A. Approved [122]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [123]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [95]
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Drug(s) Affected By Progonadoliberin-1 (GNRH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [124]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [125]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [126]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [8]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [127]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [128]
ACYLINE DM9GRTK Prostate cancer 2C82.0 Phase 2 [129]
3R14S-OCHRATOXIN A DM2KEW6 Discovery agent N.A. Investigative [130]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [131]
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Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [132]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [133]
Gefitinib DM15F0X Colon adenocarcinoma Approved [134]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [135]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [136]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [135]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [137]
Selenium DM25CGV N. A. N. A. Approved [138]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [139]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [140]
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Drug(s) Affected By Fibronectin (FN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [141]
Methotrexate DM2TEOL Anterior urethra cancer Approved [106]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Aripiprazole DM3NUMH Bipolar I disorder Approved [143]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [145]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [118]
Ethacrynic acid DM60QMR Edema MG29 Approved [146]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [147]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [148]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
Methotrexate DM2TEOL Anterior urethra cancer Approved [106]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [150]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [151]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [57]
Paclitaxel DMLB81S Breast carcinoma Approved [152]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [153]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [64]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [154]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [155]
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Drug(s) Affected By Insulin-like growth factor I (IGF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dantrolene DM1D8XY Hyperthermia MG26 Approved [156]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [157]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [158]
Quercetin DM3NC4M Obesity 5B81 Approved [159]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [160]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [160]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [161]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [162]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [163]
Testosterone DM7HUNW Hot flushes GA30 Approved [164]
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Drug(s) Affected By Amyloid-beta precursor protein (APP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [70]
Selenium DM25CGV N. A. N. A. Approved [108]
Methotrexate DM2TEOL Anterior urethra cancer Approved [106]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [165]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [167]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [168]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [169]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [161]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [170]
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Drug(s) Affected By Integrin beta-3 (ITGB3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [171]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [172]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [173]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [174]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [175]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [176]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [177]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [178]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [179]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [180]
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Drug(s) Affected By Hepatocyte growth factor receptor (MET)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cabozantinib DMIYDT4 Medullary thyroid gland carcinoma Approved [181]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [182]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [135]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [135]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [135]
Methotrexate DM2TEOL Anterior urethra cancer Approved [183]
Quercetin DM3NC4M Obesity 5B81 Approved [90]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [135]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [184]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [183]
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Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [185]
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [186]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [187]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [188]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [189]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [190]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [189]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [192]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [161]
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Drug(s) Affected By Cadherin-1 (CDH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [67]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [193]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [194]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [195]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [196]
Quercetin DM3NC4M Obesity 5B81 Approved [90]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [197]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [198]
Panobinostat DM58WKG Chronic graft versus host disease Approved [199]
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Drug(s) Affected By Proto-oncogene tyrosine-protein kinase Src (SRC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bosutinib DMTI8YE Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [200]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [201]
Methotrexate DM2TEOL Anterior urethra cancer Approved [106]
Quercetin DM3NC4M Obesity 5B81 Approved [202]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [161]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [203]
Plicamycin DM7C8YV Hypercalcaemia 5B91.0 Approved [204]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [8]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [95]
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Drug(s) Affected By Hepatocyte growth factor (HGF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [70]
Quercetin DM3NC4M Obesity 5B81 Approved [205]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [206]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [207]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [207]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [101]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [208]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [209]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [210]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [211]
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Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [212]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [213]
Gefitinib DM15F0X Colon adenocarcinoma Approved [214]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [157]
Selenium DM25CGV N. A. N. A. Approved [215]
Pentosan Polysulfate DM2HRKE Interstitial cystitis GC00.3 Approved [216]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [217]
Methotrexate DM2TEOL Anterior urethra cancer Approved [218]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [219]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [220]
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Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-2 (ATF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [98]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [221]
Methotrexate DM2TEOL Anterior urethra cancer Approved [222]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [223]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [224]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [94]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [225]
Bortezomib DMNO38U Leukemia Approved [226]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [227]
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Drug(s) Affected By Sphingomyelin phosphodiesterase (SMPD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [126]
Quercetin DM3NC4M Obesity 5B81 Approved [185]
Fluoxetine DM3PD2C Bipolar depression Approved [228]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [229]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [230]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [94]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [127]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [95]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [231]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [227]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [232]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [233]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [234]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [79]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [235]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [236]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [237]
Gefitinib DM15F0X Colon adenocarcinoma Approved [238]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [239]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [240]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [241]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [233]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [242]
Paclitaxel DMLB81S Breast carcinoma Approved [243]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [244]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [232]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [77]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [132]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [79]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [235]
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Drug(s) Affected By Ephrin type-B receptor 2 (EPHB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [91]
Panobinostat DM58WKG Chronic graft versus host disease Approved [199]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [8]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [127]
Bortezomib DMNO38U Leukemia Approved [226]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [245]
Arsenic DMTL2Y1 N. A. N. A. Approved [246]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [178]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [199]
Urethane DM7NSI0 N. A. N. A. Phase 4 [247]
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Drug(s) Affected By Macrosialin (CD68)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [132]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [190]
Methotrexate DM2TEOL Anterior urethra cancer Approved [248]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [91]
Testosterone DM7HUNW Hot flushes GA30 Approved [93]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [93]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [94]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [8]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [249]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [250]
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Drug(s) Affected By Merlin (NF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [70]
Selenium DM25CGV N. A. N. A. Approved [108]
Methotrexate DM2TEOL Anterior urethra cancer Approved [222]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [251]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [95]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [252]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [227]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [177]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [126]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [253]
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Drug(s) Affected By Pigment epithelium-derived factor (SERPINF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [108]
Quercetin DM3NC4M Obesity 5B81 Approved [90]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [254]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Panobinostat DM58WKG Chronic graft versus host disease Approved [199]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [230]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [94]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [11]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [255]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [256]
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Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [257]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [258]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [259]
Gefitinib DM15F0X Colon adenocarcinoma Approved [260]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [261]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [103]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [262]
Quercetin DM3NC4M Obesity 5B81 Approved [263]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [112]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [264]
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Drug(s) Affected By Cell surface glycoprotein MUC18 (MCAM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [265]
Haloperidol DM96SE0 Delirium Approved [188]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [266]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [95]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [267]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [231]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [252]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [227]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [177]
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Drug(s) Affected By Collagenase 3 (MMP13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [268]
Clindamycin DM15HL8 Acne vulgaris ED80 Approved [269]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [268]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [270]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [271]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [272]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [273]
Doxycycline DM7ICNU Acne vulgaris ED80 Approved [269]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [274]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [275]
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Drug(s) Affected By Proliferation marker protein Ki-67 (MKI67)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [276]
Methotrexate DM2TEOL Anterior urethra cancer Approved [277]
Quercetin DM3NC4M Obesity 5B81 Approved [278]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [279]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [280]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [281]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [282]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [283]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [163]
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Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [108]
Methotrexate DM2TEOL Anterior urethra cancer Approved [222]
Quercetin DM3NC4M Obesity 5B81 Approved [90]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [111]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [91]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [112]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [94]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [95]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [284]
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Drug(s) Affected By Stromal cell-derived factor 1 (CXCL12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [67]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [285]
Methotrexate DM2TEOL Anterior urethra cancer Approved [106]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [286]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [118]
Panobinostat DM58WKG Chronic graft versus host disease Approved [199]
Estrone DM5T6US Acne vulgaris ED80 Approved [285]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [287]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [266]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [11]
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Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [126]
Methotrexate DM2TEOL Anterior urethra cancer Approved [288]
Quercetin DM3NC4M Obesity 5B81 Approved [90]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [111]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [289]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [273]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [274]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [94]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [127]
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Drug(s) Affected By Caspase-7 (CASP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [212]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [98]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [290]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [291]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [292]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [292]
Methotrexate DM2TEOL Anterior urethra cancer Approved [293]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [294]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [295]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [296]
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Drug(s) Affected By Beta-secretase 1 (BACE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [297]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [298]
Quercetin DM3NC4M Obesity 5B81 Approved [299]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [91]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [300]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [163]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [301]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [94]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [127]
TRIENTINE DMD2WPG Inborn error of metabolism 5C50-5C59 Approved [302]
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Drug(s) Affected By C-X-C chemokine receptor type 4 (CXCR4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [67]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [126]
Methotrexate DM2TEOL Anterior urethra cancer Approved [183]
Quercetin DM3NC4M Obesity 5B81 Approved [185]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [303]
Carfilzomib DM48K0X Multiple myeloma 2A83 Approved [304]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [183]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [305]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [306]
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Drug(s) Affected By Protein SET (SET)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [91]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [161]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [307]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [115]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [8]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [127]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [95]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [225]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [308]
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [309]
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Drug(s) Affected By RNA-binding protein EWS (EWSR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [126]
Selenium DM25CGV N. A. N. A. Approved [108]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [310]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [8]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [311]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [95]
Benzatropine DMF7EXL Parkinsonian disorder Approved [188]
Romidepsin DMT5GNL Cutaneous T-cell lymphoma 2B01 Approved [312]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [313]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [314]
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Drug(s) Affected By Urokinase plasminogen activator surface receptor (PLAUR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [285]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [315]
Quercetin DM3NC4M Obesity 5B81 Approved [316]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [317]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [101]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [318]
Testosterone DM7HUNW Hot flushes GA30 Approved [93]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [274]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [93]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
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Drug(s) Affected By Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A (MGAT5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [222]
Quercetin DM3NC4M Obesity 5B81 Approved [185]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [319]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [8]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [127]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [227]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [178]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [124]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [314]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [320]
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Drug(s) Affected By Metastasis-associated protein MTA1 (MTA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [213]
Quercetin DM3NC4M Obesity 5B81 Approved [90]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [229]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [321]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [95]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [256]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [322]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [227]
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Drug(s) Affected By Sequestosome-1 (SQSTM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [258]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [259]
Gefitinib DM15F0X Colon adenocarcinoma Approved [323]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [324]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [325]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [326]
Methotrexate DM2TEOL Anterior urethra cancer Approved [293]
Quercetin DM3NC4M Obesity 5B81 Approved [90]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [327]
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Drug(s) Affected By Integrin alpha-7 (ITGA7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [70]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [328]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [94]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [329]
Arsenic DMTL2Y1 N. A. N. A. Approved [330]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [331]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [314]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [332]
Seocalcitol DMKL9QO Rickets 5B57 Phase 3 [275]
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Drug(s) Affected By Interleukin-18 (IL18)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [132]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [70]
Methotrexate DM2TEOL Anterior urethra cancer Approved [106]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [333]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [334]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [335]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [266]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [8]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [336]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [127]
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Drug(s) Affected By Metastasis-suppressor KiSS-1 (KISS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [261]
Methotrexate DM2TEOL Anterior urethra cancer Approved [106]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [91]
Testosterone DM7HUNW Hot flushes GA30 Approved [337]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [338]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [178]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [339]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [88]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [340]
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Drug(s) Affected By Mothers against decapentaplegic homolog 2 (SMAD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [324]
Quercetin DM3NC4M Obesity 5B81 Approved [341]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [229]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [342]
Panobinostat DM58WKG Chronic graft versus host disease Approved [199]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [343]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [8]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [95]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [344]
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Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [345]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [346]
Prednisone DM2HG4X Acute asthma CA23 Approved [347]
Triamterene DM2HU9I Congestive heart failure BD10 Approved [347]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [348]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [349]
Epinephrine DM3KJBC Acute asthma CA23 Approved [350]
Quercetin DM3NC4M Obesity 5B81 Approved [185]
Fluoxetine DM3PD2C Bipolar depression Approved [351]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [352]
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Drug(s) Affected By KiSS-1 receptor (KISS1R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [353]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [289]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [94]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [338]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [353]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [332]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [199]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [88]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [131]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By FXYD domain-containing ion transport regulator 5 (FXYD5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [90]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [254]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [91]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [94]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [199]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [254]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [227]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [354]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [354]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [178]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 5 (MAP3K5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [108]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [111]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [355]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [289]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [356]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [357]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [127]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [231]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [358]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [359]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Oxidoreductase HTATIP2 (HTATIP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [126]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [91]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [101]
Testosterone DM7HUNW Hot flushes GA30 Approved [337]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [360]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [360]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [8]
Testosterone enanthate DMB6871 N. A. N. A. Approved [122]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [127]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [95]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [259]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [261]
Methotrexate DM2TEOL Anterior urethra cancer Approved [293]
Quercetin DM3NC4M Obesity 5B81 Approved [90]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [361]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [362]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [363]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [364]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [365]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [264]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Autophagy protein 5 (ATG5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [260]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [361]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [364]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [365]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [366]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [367]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [368]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [115]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [311]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [95]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pinin (PNN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [229]
Leflunomide DMR8ONJ Arthritis FA20 Approved [83]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [8]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [255]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [95]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [231]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [227]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [126]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [313]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [369]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Programmed cell death 1 ligand 1 (CD274)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [370]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [91]
Panobinostat DM58WKG Chronic graft versus host disease Approved [371]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [326]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [283]
Testosterone DM7HUNW Hot flushes GA30 Approved [93]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [328]
Leflunomide DMR8ONJ Arthritis FA20 Approved [83]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [372]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heparanase (HPSE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [185]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [289]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [8]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [373]
Folic Acid DMEMBJC Colorectal carcinoma Approved [374]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [231]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [375]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [177]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [376]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [377]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitochondrial pyruvate carrier 1 (MPC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [90]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [91]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [118]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [115]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [11]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [127]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [329]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [378]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [227]
Arsenic DMTL2Y1 N. A. N. A. Approved [246]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Glutamate receptor AMPA (GRIA) TTAN6JD NOUNIPROTAC Antagonist [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [4]
Cytochrome P450 2E1 (CYP2E1) DEVDYN7 CP2E1_HUMAN Substrate [5]
Cytochrome P450 2A6 (CYP2A6) DEJVYAZ CP2A6_HUMAN Substrate [6]
Cytochrome P450 2B6 (CYP2B6) DEPKLMQ CP2B6_HUMAN Substrate [7]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A (MGAT5) OTU4DD4G MGT5A_HUMAN Gene/Protein Processing [8]
Amyloid-beta precursor protein (APP) OTKFD7R4 A4_HUMAN Gene/Protein Processing [9]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [10]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [10]
Autophagy protein 5 (ATG5) OT4T5SMS ATG5_HUMAN Gene/Protein Processing [10]
Beta-secretase 1 (BACE1) OTCA7B6A BACE1_HUMAN Gene/Protein Processing [9]
C-X-C chemokine receptor type 4 (CXCR4) OTUFSBX2 CXCR4_HUMAN Gene/Protein Processing [11]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Gene/Protein Processing [8]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [12]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Gene/Protein Processing [13]

References

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88 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
89 Does acetaldehyde mediate ethanol action in the central nervous system?. Alcohol Clin Exp Res. 2001 Nov;25(11):1570-5.
90 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
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