Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMEYLH9)

Drug Name
Ribavirin Drug Info
Synonyms
ribavirin; 36791-04-5; Tribavirin; Rebetol; Virazole; Ribavirine; Copegus; Vilona; Ribamide; Ribasphere; Ribamidil; Viramid; Ribamidyl; Ribavirinum; Ribavirina; Rebetron; Varazid; RTCA; Ribavirin Capsules; Ribavirinum [INN-Latin]; Ribavirine [INN-French]; Ribavirina [INN-Spanish]; ICN-1229; Rebretron; Virazid; Ribav; 1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide; DRG-0028; 1-beta-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide; UNII-49717AWG6K; Ribavirin (Copegus); Copegus; Cotronak; RBV; RTC; Ravanex; Ribacine; Ribovirin; Viramide; Virazide; R 9644; SCH 18908; C-Virin; Copegus (TN); Drug: Ribavirin; KS-1104; R-964; RG-964; Rebetol (TN); Ribasphere (TN); Ribavirin [USAN:INN]; Vilona (TN); Virazole (Ribavirin) Inhalation Solution; Virazole (TN); AA-504/07617051; Ro 20-9963/000; Ro-20-9963; Ribavirin (JAN/USP/INN); 1-beta-D-Ribofuranosyl-1,2,4-triazolo-3-carboxamide; 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide; 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1,2,4-triazole-3-carboxamide; 1-beta-D-ribofuranosyl-1-H-1,2,4-triazole-3-carboxamide; RBI034 (2-5A antisense compound) + Ribavirin
Indication
Disease Entry ICD 11 Status REF
Hepatitis C virus infection 1E51.1 Approved [1]
Respiratory syncytial virus infection 1C80 Approved [2]
Coronavirus Disease 2019 (COVID-19) 1D6Y Investigative [3]
Middle East Respiratory Syndrome (MERS) 1D64 Investigative [4]
Severe acute respiratory syndrome (SARS) 1D65 Investigative [5]
Therapeutic Class
Antiviral Agents
Cross-matching ID
PubChem CID
37542
ChEBI ID
CHEBI:63580
CAS Number
CAS 36791-04-5
TTD Drug ID
DMEYLH9
VARIDT Drug ID
DR00176
INTEDE Drug ID
DR1413
ACDINA Drug ID
D00589

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [22]
Merimepodib DM0HS92 Breast cancer 2C60-2C65 Approved [23]
Tiazofurin DM5JWV9 Solid tumour/cancer 2A00-2F9Z Approved [24]
Mizoribine DMW6F0S Transplant rejection NE84 Approved [23]
Viramidine DMJFNR9 Hepatitis C virus infection 1E51.1 Phase 3 [25]
VX-944 DME321B Solid tumour/cancer 2A00-2F9Z Phase 2 [26]
VX-148 DML32R8 Psoriasis vulgaris EA90 Patented [27]
PMID28074661-Compound-US20100022547C81 DMM9E1U N. A. N. A. Patented [26]
PMID28074661-Compound-US20120264760C80 DM75QVW N. A. N. A. Patented [26]
Carbamide derivative 9 DMY06VC N. A. N. A. Patented [26]
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Drug(s) Targeting HUMAN inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Merimepodib DM0HS92 Breast cancer 2C60-2C65 Approved [28]
Drug(s) Targeting MERS-CoV RNA-directed RNA polymerase (RdRp)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [29]
Galidesivir DMG9C4I Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 1 Trial [5]
PMID31244113-compound-2c DMZJWON Middle East Respiratory Syndrome (MERS) 1D64 Preclinical [30]
PMID26048809-compound2 DMFNS7U Middle East Respiratory Syndrome (MERS) 1D64 Preclinical [5]
Amarylline DML9W2V Middle East Respiratory Syndrome (MERS) 1D64 Investigative [31]
Drug(s) Targeting SARS-CoV RNA-directed RNA polymerase (RdRp)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [29]
Galidesivir DMG9C4I Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 1 Trial [5]
PMID31244113-compound-2c DMZJWON Middle East Respiratory Syndrome (MERS) 1D64 Preclinical [30]
Drug(s) Transported By Peptide transporter 1 (SLC15A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [32]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [33]
Ampicillin DMHWE7P Acute epiglottitis Approved [34]
Losartan DM72JXH Diabetic kidney disease GB61.Z Approved [35]
Enalapril DMNFUZR Congestive heart failure BD10 Approved [36]
Cefazolin DMPDYFR Bacteremia 1A73 Approved [37]
Ceftriaxone DMCEW64 Acute gonococcal cervicitis Approved [38]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [33]
Cefadroxil DMMC345 Bacterial infection 1A00-1C4Z Approved [35]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [35]
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Drug(s) Transported By Concentrative nucleoside transporter 2 (SLC28A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [39]
Entecavir DM7VTQO Hepatitis B virus infection 1E51.0 Approved [40]
Uridine DMQTREB Depression 6A70-6A7Z Approved [41]
Didanosine DMI2QPE Human immunodeficiency virus infection 1C62 Approved [42]
Drug(s) Transported By Concentrative Na(+)-nucleoside cotransporter 3 (SLC28A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [43]
Entecavir DM7VTQO Hepatitis B virus infection 1E51.0 Approved [40]
Clofarabine DMCVJ86 Acute lymphoblastic leukaemia 2A85 Approved [44]
Thioguanine DM7NKEV Acute lymphocytic leukaemia 2B33.3 Approved [43]
Drug(s) Transported By Equilibrative nucleoside transporter 1 (SLC29A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [45]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [39]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [46]
Entecavir DM7VTQO Hepatitis B virus infection 1E51.0 Approved [40]
Clofarabine DMCVJ86 Acute lymphoblastic leukaemia 2A85 Approved [44]
Trifluridine DMG2YBD Herpetic keratitis 1F00.10 Approved [47]
Adenosine DMM2NSK Paroxysmal supraventricular tachycardia BC81.Z Approved [48]
Tecadenoson DM9T6MS Atrial fibrillation BC81.3 Discontinued in Phase 3 [49]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [302]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [303]
Adenosine DMM2NSK Paroxysmal supraventricular tachycardia BC81.Z Approved [304]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [209]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [294]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [305]
Testosterone DM7HUNW Hot flushes GA30 Approved [306]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [306]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [51]
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Drug(s) Metabolized By Cytosolic 5'-nucleotidase II (NT5C2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Inosine DMY65AR N. A. N. A. Investigative [12]
Drug(s) Affected By Protein arginine N-methyltransferase 5 (PRMT5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [50]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [54]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [55]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [56]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [57]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [58]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [59]
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Drug(s) Affected By Protein arginine N-methyltransferase 3 (PRMT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [50]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [54]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [56]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [60]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [61]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [59]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [50]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [62]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [63]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [64]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [65]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [66]
Gefitinib DM15F0X Colon adenocarcinoma Approved [67]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [68]
Selenium DM25CGV N. A. N. A. Approved [69]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [70]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [71]
Methotrexate DM2TEOL Anterior urethra cancer Approved [72]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [73]
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Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [74]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [75]
Fructose DM43AN2 Vomiting MD90 Approved [16]
Ketoprofen DMRKXPT Bursitis Approved [16]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [76]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [77]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [78]
Gefitinib DM15F0X Colon adenocarcinoma Approved [79]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [80]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [81]
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Drug(s) Affected By Interferon gamma (IFNG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [82]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [83]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [84]
Methotrexate DM2TEOL Anterior urethra cancer Approved [72]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [85]
Quercetin DM3NC4M Obesity 5B81 Approved [86]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [87]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [88]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [89]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [90]
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Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [91]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [92]
Gefitinib DM15F0X Colon adenocarcinoma Approved [93]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [94]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [94]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [96]
Selenium DM25CGV N. A. N. A. Approved [97]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [98]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [99]
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Drug(s) Affected By Erythropoietin (EPO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [100]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [101]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [54]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [102]
Fenoterol DMIP3ZV Asthma CA23 Approved [103]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [104]
Enalapril DMNFUZR Congestive heart failure BD10 Approved [105]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [106]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [57]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [107]
Methotrexate DM2TEOL Anterior urethra cancer Approved [72]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [108]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [109]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [110]
Paclitaxel DMLB81S Breast carcinoma Approved [111]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [112]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [113]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [114]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [115]
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Drug(s) Affected By Interleukin-4 (IL4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [116]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [117]
Tolnaftate DM28MU7 Dermatophytosis 1F28.2 Approved [118]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [119]
Prednisone DM2HG4X Acute asthma CA23 Approved [120]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [84]
Methotrexate DM2TEOL Anterior urethra cancer Approved [72]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [85]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [121]
Quercetin DM3NC4M Obesity 5B81 Approved [86]
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Drug(s) Affected By Interleukin-5 (IL5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [83]
Tolnaftate DM28MU7 Dermatophytosis 1F28.2 Approved [118]
Prednisone DM2HG4X Acute asthma CA23 Approved [122]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [123]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [124]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [125]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [126]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [128]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [129]
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Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [130]
Dicloxacillin DM8EU0Z Bacterial infection 1A00-1C4Z Approved [130]
Ergonovine DM0VEC1 Postpartum haemorrhage JA43 Approved [16]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [131]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [132]
Mizolastine DM1FDN8 Allergic rhinitis CA08.0 Approved [133]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [134]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [99]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [135]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [136]
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Drug(s) Affected By Eukaryotic translation initiation factor 4E (EIF4E)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [137]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [138]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [139]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [140]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [141]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [56]
Momelotinib DMF98Q0 Myelofibrosis 2A20.2 Approved [142]
Flurbiprofen DMGN4BY Osteoarthritis FA00-FA05 Approved [141]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [57]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [143]
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Drug(s) Affected By Proliferating cell nuclear antigen (PCNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [144]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [66]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [145]
Selenium DM25CGV N. A. N. A. Approved [69]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [146]
Meloxicam DM2AR7L Arthritis FA20 Approved [147]
Methotrexate DM2TEOL Anterior urethra cancer Approved [148]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [149]
Epinephrine DM3KJBC Acute asthma CA23 Approved [150]
Quercetin DM3NC4M Obesity 5B81 Approved [151]
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Drug(s) Affected By Myosin-6 (MYH6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [152]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [153]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [154]
Folic Acid DMEMBJC Colorectal carcinoma Approved [155]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [156]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [157]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [156]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [158]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [156]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [159]
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Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [160]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [161]
Selenium DM25CGV N. A. N. A. Approved [50]
Etretinate DM2CZFA Keratosis ED56 Approved [162]
Methotrexate DM2TEOL Anterior urethra cancer Approved [163]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [164]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [165]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [166]
Quercetin DM3NC4M Obesity 5B81 Approved [167]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [168]
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Drug(s) Affected By Cyclin-A2 (CCNA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [169]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [170]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [66]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [171]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [172]
Methotrexate DM2TEOL Anterior urethra cancer Approved [173]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [149]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [174]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Fluoxetine DM3PD2C Bipolar depression Approved [175]
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Drug(s) Affected By Interleukin-10 (IL10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [134]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [83]
Methotrexate DM2TEOL Anterior urethra cancer Approved [176]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [177]
Quercetin DM3NC4M Obesity 5B81 Approved [178]
Bisoprolol DM3UZ95 Hypertension BA00-BA04 Approved [179]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [87]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [180]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [90]
Paroxetine DM5PVQE Anxiety disorder 6B00-6B0Z Approved [181]
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Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [182]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [183]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [184]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [185]
Gefitinib DM15F0X Colon adenocarcinoma Approved [186]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [187]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [188]
Selenium DM25CGV N. A. N. A. Approved [50]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [189]
Methotrexate DM2TEOL Anterior urethra cancer Approved [148]
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Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [144]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [190]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [191]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [172]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Fluoxetine DM3PD2C Bipolar depression Approved [175]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [192]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [193]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [194]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [195]
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Drug(s) Affected By Sodium-dependent serotonin transporter (SLC6A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paroxetine DM5PVQE Anxiety disorder 6B00-6B0Z Approved [196]
Fluoxetine DM3PD2C Bipolar depression Approved [197]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [198]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [199]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [200]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Aripiprazole DM3NUMH Bipolar I disorder Approved [201]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [199]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [202]
Mepyramine DMB4SFH Allergic rhinitis CA08.0 Approved [203]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [204]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [205]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [113]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [184]
Gefitinib DM15F0X Colon adenocarcinoma Approved [206]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [207]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [208]
Selenium DM25CGV N. A. N. A. Approved [50]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [146]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [70]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Alpha-actinin-2 (ACTN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [209]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [210]
Heroin diacetylmorphine DMDBWHY Neurological disorder 6B60 Approved [211]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [57]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [212]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [213]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [59]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [159]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [62]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [63]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [214]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [215]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [216]
Gefitinib DM15F0X Colon adenocarcinoma Approved [217]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [218]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [199]
Quercetin DM3NC4M Obesity 5B81 Approved [219]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [220]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [221]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [199]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [222]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [223]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [224]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [110]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [225]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [226]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [227]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [228]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [229]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [230]
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Drug(s) Affected By Transcription factor GATA-4 (GATA4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [231]
Panobinostat DM58WKG Chronic graft versus host disease Approved [232]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [233]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [234]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [157]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [235]
Arsenic DMTL2Y1 N. A. N. A. Approved [236]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [59]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [237]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [237]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Troponin T, cardiac muscle (TNNT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [209]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [154]
Folic Acid DMEMBJC Colorectal carcinoma Approved [155]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [57]
Arsenic DMTL2Y1 N. A. N. A. Approved [236]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [59]
Tacrolimus DMZ7XNQ Graft-versus-host disease 4B24 Approved [238]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [239]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [159]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [240]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [241]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [242]
Selenium DM25CGV N. A. N. A. Approved [50]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [243]
Methotrexate DM2TEOL Anterior urethra cancer Approved [244]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [245]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [137]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [246]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [247]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein arginine N-methyltransferase 2 (PRMT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [50]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [248]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [249]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [54]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [55]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [250]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [57]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [251]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [61]
Berberine DMC5Q8X N. A. N. A. Phase 4 [252]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-2 (IL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sirolimus DMGW1ID Advanced cancer 2A00-2F9Z Approved [16]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [117]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [253]
Methotrexate DM2TEOL Anterior urethra cancer Approved [254]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [255]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [124]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [126]
Fentanyl DM8WAHT Analgesia MB40.8 Approved [256]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [257]
Folic Acid DMEMBJC Colorectal carcinoma Approved [258]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin gene enhancer protein ISL-1 (ISL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [209]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [54]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [55]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [259]
Arsenic DMTL2Y1 N. A. N. A. Approved [236]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [232]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [210]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [159]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [62]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [63]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [260]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [261]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [137]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [262]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [263]
Testosterone DM7HUNW Hot flushes GA30 Approved [264]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [140]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [54]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [265]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [56]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone-arginine methyltransferase CARM1 (CARM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [266]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [267]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [154]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [56]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [213]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [268]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [59]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [269]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [270]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein arginine N-methyltransferase 6 (PRMT6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [54]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [55]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [57]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [271]
Arsenic DMTL2Y1 N. A. N. A. Approved [236]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [61]
Urethane DM7NSI0 N. A. N. A. Phase 4 [272]
Berberine DMC5Q8X N. A. N. A. Phase 4 [252]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [273]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein arginine N-methyltransferase 1 (PRMT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [50]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [274]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [137]
Dapsone DM4LT8A Acne vulgaris ED80 Approved [275]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [153]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [276]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [54]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [154]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [56]
Benzatropine DMF7EXL Parkinsonian disorder Approved [277]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein arginine N-methyltransferase 8 (PRMT8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [154]
Arsenic DMTL2Y1 N. A. N. A. Approved [236]
Berberine DMC5Q8X N. A. N. A. Phase 4 [252]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [278]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [62]
Drug(s) Affected By Protein arginine N-methyltransferase 7 (PRMT7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [54]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [57]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [59]
Berberine DMC5Q8X N. A. N. A. Phase 4 [252]
(L-)-S-adenosyl-L-homocysteine DMDUN83 Discovery agent N.A. Investigative [15]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Epidermal growth factor receptor (EGFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [279]
Gefitinib DM15F0X Colon adenocarcinoma Approved [186]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [280]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [281]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [282]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [283]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [65]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [145]
Selenium DM25CGV N. A. N. A. Approved [284]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [285]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hepatocyte growth factor (HGF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [286]
Quercetin DM3NC4M Obesity 5B81 Approved [287]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [288]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [289]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [289]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [68]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [290]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [291]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [292]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [293]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Equilibrative nucleoside transporter 3 (SLC29A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [209]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [294]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [54]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [154]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [57]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [295]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [61]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [18]
Zalcitabine DMH7MUV Human immunodeficiency virus infection 1C62 Approved [18]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Haptoglobin (HP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [296]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [297]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [81]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [298]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [299]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [276]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [300]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [301]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interferon lambda-3 (IFNL3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [154]
Peginterferon alfa-2a DMJI3BA Chronic hepatitis B virus infection Approved [307]
Peginterferon alfa-2b DMAP58Y Hepatitis C virus infection 1E51.1 Approved [307]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [62]
Drug(s) Affected By Inosine triphosphate pyrophosphatase (ITPA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [308]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [210]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [56]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [251]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [59]
Methotrexate DM2TEOL Anterior urethra cancer Approved [310]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [311]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [312]
Urethane DM7NSI0 N. A. N. A. Phase 4 [272]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) TTL7C8Q IMDH1_HUMAN Inhibitor [6]
HUMAN inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) TT3GRLK IMDH1_HUMAN Inhibitor [3]
HUMAN inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) TTTU6X1 IMDH2_HUMAN Inhibitor [3]
MERS-CoV RNA-directed RNA polymerase (RdRp) TTOA6YT R1AB_CVEMC (4378-5310) Inhibitor [5]
SARS-CoV RNA-directed RNA polymerase (RdRp) TTKXI53 R1AB_CVHSA (4370-5301) Inhibitor [5]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Equilibrative nucleoside transporter 1 (SLC29A1) DTXD1TQ S29A1_HUMAN Substrate [7]
Concentrative nucleoside transporter 2 (SLC28A2) DT82KPY S28A2_HUMAN Substrate [8]
Concentrative Na(+)-nucleoside cotransporter 3 (SLC28A3) DT4YL5R S28A3_HUMAN Substrate [9]
Peptide transporter 1 (SLC15A1) DT9G7XN S15A1_HUMAN Substrate [10]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Purine nucleoside phosphorylase (PNP) DE2WSAL PNPH_HUMAN Substrate [11]
Cytosolic 5'-nucleotidase II (NT5C2) DE1DOKJ 5NTC_HUMAN Substrate [12]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Alpha-actinin-2 (ACTN2) OT9FOLD7 ACTN2_HUMAN Gene/Protein Processing [13]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [14]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [13]
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Gene/Protein Processing [15]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Drug Response [16]
Equilibrative nucleoside transporter 1 (SLC29A1) OTLOOZZS S29A1_HUMAN Regulation of Drug Effects [17]
Equilibrative nucleoside transporter 3 (SLC29A3) OTGLX8XU S29A3_HUMAN Regulation of Drug Effects [18]
Erythropoietin (EPO) OTZ90CN4 EPO_HUMAN Gene/Protein Processing [19]
Eukaryotic translation initiation factor 4E (EIF4E) OTDAWNLA IF4E_HUMAN Gene/Protein Processing [20]
Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1) OTHBQVD5 4EBP1_HUMAN Post-Translational Modifications [21]

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 Ribavirin FDA Label
3 Proteomics of SARS-CoV-2-infected Host Cells Reveals Therapy Targets. Nature. 2020 May 14. doi: 10.1038/s41586-020-2332-7.
4 SARS and MERS: recent insights into emerging coronaviruses. Nat Rev Microbiol. 2016 Aug;14(8):523-34.
5 Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47.
6 Treating HCV with ribavirin analogues and ribavirin-like molecules. J Antimicrob Chemother. 2006 Jan;57(1):8-13.
7 Effects of dipyridamole coadministration on the pharmacokinetics of ribavirin in healthy volunteers. Drug Metab Pharmacokinet. 2013;28(5):406-10.
8 Identification and functional analysis of variants in the human concentrative nucleoside transporter 2, hCNT2 (SLC28A2) in Chinese, Malays and Indians. Pharmacogenet Genomics. 2007 Sep;17(9):783-6.
9 Kinetic study of anti-viral ribavirin uptake mediated by hCNT3 and hENT1 in Xenopus laevis oocytes. Biophys Chem. 2010 Mar;147(1-2):59-65.
10 Transport of levovirin prodrugs in the human intestinal Caco-2 cell line. J Pharm Sci. 2006 Jun;95(6):1318-25.
11 Functional analysis of purine nucleoside phosphorylase as a key enzyme in ribavirin metabolism. Drug Metab Pharmacokinet. 2014;29(2):211-4.
12 Phosphorylation of ribavirin and viramidine by adenosine kinase and cytosolic 5'-nucleotidase II: Implications for ribavirin metabolism in erythrocytes. Antimicrob Agents Chemother. 2005 Jun;49(6):2164-71.
13 Inhibition of cardiomyocyte differentiation of human induced pluripotent stem cells by Ribavirin: Implication for its cardiac developmental toxicity. Toxicology. 2020 Apr 15;435:152422. doi: 10.1016/j.tox.2020.152422. Epub 2020 Feb 26.
14 Ribavirin and alpha interferon enhance death receptor-mediated apoptosis and caspase activation in human hepatoma cells. Antimicrob Agents Chemother. 2003 Jun;47(6):1912-21. doi: 10.1128/AAC.47.6.1912-1921.2003.
15 Ribavirin inhibits colorectal cancer growth by downregulating PRMT5 expression and H3R8me2s and H4R3me2s accumulation. Toxicol Appl Pharmacol. 2021 Mar 15;415:115450. doi: 10.1016/j.taap.2021.115450. Epub 2021 Feb 9.
16 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
17 Characterization of ribavirin uptake systems in human hepatocytes. J Hepatol. 2010 Apr;52(4):486-92.
18 Facilitated mitochondrial import of antiviral and anticancer nucleoside drugs by human equilibrative nucleoside transporter-3. Am J Physiol Gastrointest Liver Physiol. 2009 Apr;296(4):G910-22. doi: 10.1152/ajpgi.90672.2008. Epub 2009 Jan 22.
19 Normal erythropoietin response in chronic hepatitis C patients with ribavirin-induced anaemia. Antivir Ther. 2003 Feb;8(1):57-63.
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