Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMEYLH9)

• Drug Name: Ribavirin Drug Info
• Synonyms: ribavirin; 36791-04-5; Tribavirin; Rebetol; Virazole; Ribavirine; Copegus; Vilona; Ribamide; Ribasphere; Ribamidil; Viramid; Ribamidyl; Ribavirinum; Ribavirina; Rebetron; Varazid; RTCA; Ribavirin Capsules; Ribavirinum [INN-Latin]; Ribavirine [INN-French]; Ribavirina [INN-Spanish]; ICN-1229; Rebretron; Virazid; Ribav; 1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide; DRG-0028; 1-beta-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide; UNII-49717AWG6K; Ribavirin (Copegus); Copegus; Cotronak; RBV; RTC; Ravanex; Ribacine; Ribovirin; Viramide; Virazide; R 9644; SCH 18908; C-Virin; Copegus (TN); Drug: Ribavirin; KS-1104; R-964; RG-964; Rebetol (TN); Ribasphere (TN); Ribavirin [USAN:INN]; Vilona (TN); Virazole (Ribavirin) Inhalation Solution; Virazole (TN); AA-504/07617051; Ro 20-9963/000; Ro-20-9963; Ribavirin (JAN/USP/INN); 1-beta-D-Ribofuranosyl-1,2,4-triazolo-3-carboxamide; 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide; 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1,2,4-triazole-3-carboxamide; 1-beta-D-ribofuranosyl-1-H-1,2,4-triazole-3-carboxamide; RBI034 (2-5A antisense compound) + Ribavirin

Indication

Disease Entry	ICD 11	Status	REF
Hepatitis C virus infection	1E51.1	Approved	[1]
Respiratory syncytial virus infection	1C80	Approved	[2]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Investigative	[3]
Middle East Respiratory Syndrome (MERS)	1D64	Investigative	[4]
Severe acute respiratory syndrome (SARS)	1D65	Investigative	[5]

• Therapeutic Class: Antiviral Agents
• Cross-matching ID:
  PubChem CID: 37542
  ChEBI ID: CHEMBL63580
  CAS Number: CAS 36791-04-5
  TTD Drug ID: DMEYLH9
  VARIDT Drug ID: DR00176
  INTEDE Drug ID: DR1413
  ACDINA Drug ID: D00589

Molecule-Related Drug Atlas

Drug(s) Targeting Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[19]
Merimepodib	DM0HS92	Breast cancer	2C60-2C65	Approved	[20]
Tiazofurin	DM5JWV9	Solid tumour/cancer	2A00-2F9Z	Approved	[21]
Mizoribine	DMW6F0S	Transplant rejection	NE84	Approved	[20]
Viramidine	DMJFNR9	Hepatitis C virus infection	1E51.1	Phase 3	[22]
VX-944	DME321B	Solid tumour/cancer	2A00-2F9Z	Phase 2	[23]
VX-148	DML32R8	Psoriasis vulgaris	EA90	Patented	[24]
PMID28074661-Compound-US20100022547C81	DMM9E1U	N. A.	N. A.	Patented	[23]
PMID28074661-Compound-US20120264760C80	DM75QVW	N. A.	N. A.	Patented	[23]
Carbamide derivative 9	DMY06VC	N. A.	N. A.	Patented	[23]

Drug(s) Targeting HUMAN inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Merimepodib	DM0HS92	Breast cancer	2C60-2C65	Approved	[25]

Drug(s) Targeting MERS-CoV RNA-directed RNA polymerase (RdRp)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[26]
Galidesivir	DMG9C4I	Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 1 Trial	[5]
PMID31244113-compound-2c	DMZJWON	Middle East Respiratory Syndrome (MERS)	1D64	Preclinical	[27]
PMID26048809-compound2	DMFNS7U	Middle East Respiratory Syndrome (MERS)	1D64	Preclinical	[5]
Amarylline	DML9W2V	Middle East Respiratory Syndrome (MERS)	1D64	Investigative	[28]

Drug(s) Targeting SARS-CoV RNA-directed RNA polymerase (RdRp)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[26]
Galidesivir	DMG9C4I	Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 1 Trial	[5]
PMID31244113-compound-2c	DMZJWON	Middle East Respiratory Syndrome (MERS)	1D64	Preclinical	[27]

Drug(s) Transported By Peptide transporter 1 (SLC15A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[29]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[30]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[31]
Losartan	DM72JXH	Diabetic kidney disease	GB61.Z	Approved	[32]
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[33]
Cefazolin	DMPDYFR	Bacteremia	1A73	Approved	[34]
Ceftriaxone	DMCEW64	Acute gonococcal cervicitis		Approved	[35]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[30]
Cefadroxil	DMMC345	Bacterial infection	1A00-1C4Z	Approved	[32]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[32]

Drug(s) Transported By Concentrative nucleoside transporter 2 (SLC28A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[36]
Entecavir	DM7VTQO	Hepatitis B virus infection	1E51.0	Approved	[37]
Uridine	DMQTREB	Depression	6A70-6A7Z	Approved	[38]
Didanosine	DMI2QPE	Human immunodeficiency virus infection	1C62	Approved	[39]

Drug(s) Transported By Concentrative Na(+)-nucleoside cotransporter 3 (SLC28A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Entecavir	DM7VTQO	Hepatitis B virus infection	1E51.0	Approved	[37]
Clofarabine	DMCVJ86	Acute lymphoblastic leukaemia	2A85	Approved	[41]
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[40]

Drug(s) Transported By Equilibrative nucleoside transporter 1 (SLC29A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[42]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[36]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[43]
Entecavir	DM7VTQO	Hepatitis B virus infection	1E51.0	Approved	[37]
Clofarabine	DMCVJ86	Acute lymphoblastic leukaemia	2A85	Approved	[41]
Trifluridine	DMG2YBD	Herpetic keratitis	1F00.10	Approved	[44]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[45]
Tecadenoson	DM9T6MS	Atrial fibrillation	BC81.3	Discontinued in Phase 3	[46]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[134]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[135]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[136]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[132]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[137]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[89]

Drug(s) Metabolized By Cytosolic 5'-nucleotidase II (NT5C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Inosine	DMY65AR	N. A.	N. A.	Investigative	[12]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[47]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[48]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[49]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[50]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[53]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[54]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[55]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[56]

Drug(s) Affected By Eukaryotic translation initiation factor 4E (EIF4E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[58]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[59]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[60]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[61]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[62]
Momelotinib	DMF98Q0	Myelofibrosis	2A20.2	Approved	[63]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[61]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[64]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[65]

Drug(s) Affected By Myosin-6 (MYH6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[66]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[68]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[69]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[70]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[71]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[70]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[72]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[70]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[74]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[75]
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[77]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[79]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[80]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[83]

Drug(s) Affected By Sodium-dependent serotonin transporter (SLC6A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[84]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[85]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[86]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[87]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[88]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[89]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[90]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Mepyramine	DMB4SFH	Allergic rhinitis	CA08.0	Approved	[92]

Drug(s) Affected By Alpha-actinin-2 (ACTN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[64]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[97]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[100]

Drug(s) Affected By Transcription factor GATA-4 (GATA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[71]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[105]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[106]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[107]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[107]

Drug(s) Affected By Troponin T, cardiac muscle (TNNT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[68]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[69]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[64]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[106]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Tacrolimus	DMZ7XNQ	Graft-versus-host disease	4B24	Approved	[108]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[109]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[110]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[111]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[112]
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[113]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[89]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[116]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]

Drug(s) Affected By Protein arginine N-methyltransferase 2 (PRMT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[118]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[122]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[64]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[123]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[124]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[125]

Drug(s) Affected By Insulin gene enhancer protein ISL-1 (ISL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[126]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[106]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[102]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[94]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[73]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[100]

Drug(s) Affected By Protein arginine N-methyltransferase 6 (PRMT6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[64]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[128]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[106]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[124]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[129]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[125]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[130]

Drug(s) Affected By Protein arginine N-methyltransferase 8 (PRMT8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[68]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[106]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[125]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[131]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]

Drug(s) Affected By Equilibrative nucleoside transporter 3 (SLC29A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[132]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[68]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[64]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[133]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[124]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[15]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[15]

Drug(s) Affected By Inosine triphosphate pyrophosphatase (ITPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[62]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[123]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[141]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[142]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[17]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[129]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1)	TTL7C8Q	IMDH1_HUMAN	Inhibitor	[6]
HUMAN inosine-5'-monophosphate dehydrogenase 1 (IMPDH1)	TT3GRLK	IMDH1_HUMAN	Inhibitor	[3]
HUMAN inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)	TTTU6X1	IMDH2_HUMAN	Inhibitor	[3]
MERS-CoV RNA-directed RNA polymerase (RdRp)	TTOA6YT	R1AB_CVEMC (4378-5310)	Inhibitor	[5]
SARS-CoV RNA-directed RNA polymerase (RdRp)	TTKXI53	R1AB_CVHSA (4370-5301)	Inhibitor	[5]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Equilibrative nucleoside transporter 1 (SLC29A1)	DTXD1TQ	S29A1_HUMAN	Substrate	[7]
Concentrative nucleoside transporter 2 (SLC28A2)	DT82KPY	S28A2_HUMAN	Substrate	[8]
Concentrative Na(+)-nucleoside cotransporter 3 (SLC28A3)	DT4YL5R	S28A3_HUMAN	Substrate	[9]
Peptide transporter 1 (SLC15A1)	DT9G7XN	S15A1_HUMAN	Substrate	[10]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Purine nucleoside phosphorylase (PNP)	DE2WSAL	PNPH_HUMAN	Substrate	[11]
Cytosolic 5'-nucleotidase II (NT5C2)	DE1DOKJ	5NTC_HUMAN	Substrate	[12]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Alpha-actinin-2 (ACTN2)	OT9FOLD7	ACTN2_HUMAN	Gene/Protein Processing	[13]
Equilibrative nucleoside transporter 1 (SLC29A1)	OTLOOZZS	S29A1_HUMAN	Regulation of Drug Effects	[14]
Equilibrative nucleoside transporter 3 (SLC29A3)	OTGLX8XU	S29A3_HUMAN	Regulation of Drug Effects	[15]
Eukaryotic translation initiation factor 4E (EIF4E)	OTDAWNLA	IF4E_HUMAN	Gene/Protein Processing	[16]
Histone H2AX (H2AX)	OT18UX57	H2AX_HUMAN	Gene/Protein Processing	[13]
Inosine triphosphate pyrophosphatase (ITPA)	OTQ47WVR	ITPA_HUMAN	Drug Response	[17]
Insulin gene enhancer protein ISL-1 (ISL1)	OTVNVKAX	ISL1_HUMAN	Gene/Protein Processing	[13]
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Gene/Protein Processing	[18]
Myosin-6 (MYH6)	OT3YNCH1	MYH6_HUMAN	Gene/Protein Processing	[13]
Protein arginine N-methyltransferase 2 (PRMT2)	OT63JZCI	ANM2_HUMAN	Gene/Protein Processing	[16]

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