Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMFCIH)

Drug Name
Clotrimazole Drug Info
Synonyms
Canesten; Canestene; Canestine; Canifug; Chlotrimazole; Cimitidine; Clomatin; Clotrimaderm; Clotrimazol; Clotrimazolum; Clotrimeizol; Cutistad; Empecid; Esparol; FemCare; Gynix; Kanesten; Klotrimazole; Lotrimax; Lotrimin; Monobaycuten; Mycelax; Mycelex; Mycofug; Mycosporin; Mykosporin; Nalbix; Pedisafe; Rimazole; Stiemazol; Tibatin; Trimysten; Canesten Cream; Canesten Solution; Clotrimazole Schering Brand; Desamix F; Fem Care; Gyne lotrimin; Lotrimin AF Cream; Lotrimin AF Lotion; Lotrimin AF Solution; Lotrimin Af; Lotrimin Cream; Lotrimin Lotion; Lotrimin Solution; Mycelex Cream; Mycelex G; Mycelex OTC; Mycelex Solution; Mycelex Troches; Mycelex Twin Pack; Myclo Cream; Myclo Solution; Myclo Spray Solution; Schering Brand of Clotrimazole; B 5097; Bay b 9057; Bayer Brand 1 of Clotrimazole; Bayer Brand 2 of Clotrimazole; C 6019; FB 5097; FB b 5097; Mycelex 7; Trivagizole 3; Bay-B 5097; Candid Vaginal (TN); Candinil (TN); Canesten (TN); Canesten 1-Day Therapy; Canesten 3-Day Therapy; Canesten 6-Day Therapy; Clobrate VT (TN); Clotrimazol [INN-Spanish]; Clotrimazolum [INN-Latin]; DRG-0072; Gino-Lotremine; Gyne-Lotrimin; Gyne-Lotrimin 3; Gyne-Lotrimin 3 Combination Pack; Gyne-Lotrimin Combination Pack; Lotrimin (TN); Lotrimin AF Jock-Itch Cream; Mono-baycuten; Mycelex (TN); Mycelex-7; Mycelex-7 Combination Pack; Mycelex-G; Mycelex: MycosporinRimazole; Myclo-Gyne; Neo-Zol Cream; Pan-Fungex; Cancap-VT (TN); Candid - V Gel (TN); Canesten 1-Day Cream Combi-Pak; Canesten Combi-Pak 1-Day Therapy; Canesten Combi-Pak 3-Day Therapy; Clotrimazole (JP15/USP/INN); Clotrimazole [USAN:INN:BAN:JAN]; (Chlorotrityl)imidazole; 1-(o-Chlorotrityl)imidazole
Indication
Disease Entry ICD 11 Status REF
Cutaneous candidiasis 1F23.14 Approved [1]
Fungal infection 1F29-1F2F Approved [2]
Mycoses 1F2Z Approved [1]
Oral candidiasis 1F23.0 Approved [1]
Tinea corporis 1F28.Y Approved [1]
Tinea cruris 1F28.3 Approved [1]
Tinea versicolor 1F2D.0 Approved [1]
Tinea pedis 1F28.2 Investigative [1]
Therapeutic Class
Antifungal Agents
Cross-matching ID
PubChem CID
2812
ChEBI ID
CHEMBL104
CAS Number
CAS 23593-75-1
TTD Drug ID
DMMFCIH
VARIDT Drug ID
DR00574
INTEDE Drug ID
DR0362
ACDINA Drug ID
D00959

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting C-X-C chemokine receptor type 2 (CXCR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [14]
Reparixin DMVBA7I Pancreatic islet transplantation failure NE84 Phase 3 [14]
SCH-527123 DMPUAOE Chronic obstructive pulmonary disease CA22 Phase 2 [15]
SB-265610 DM8TKG5 Asthma CA23 Phase 2 [16]
AZD-5069 DM3JSFK Asthma CA23 Phase 2 [17]
PS-938285 DMHZIFJ Chronic obstructive pulmonary disease CA22 Phase 2 [18]
GSK1325756 DMA6RBF Chronic obstructive pulmonary disease CA22 Phase 2 [19]
SB-656933 DMCY785 Chronic obstructive pulmonary disease CA22 Phase 2 [20]
RIST4721 DMA3DKO Hidradenitis suppurativa ED92.0 Phase 2 [21]
SX-682 DMHMG6X Melanoma 2C30 Phase 1 [22]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [23]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [24]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [25]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [26]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [27]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [28]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [29]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [30]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [24]
Verapamil DMA7PEW Angina pectoris BA40 Approved [31]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [32]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [33]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [34]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [35]
Cepharanthine DM9Y5JB N. A. N. A. Approved [36]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [37]
Clozapine DMFC71L Schizophrenia 6A20 Approved [38]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [39]
Trifluoperazine DMKBYWI Anxiety Approved [40]
Olanzapine DMPFN6Y Bipolar depression Approved [38]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [41]
Vidarabine DM0N85H Hepatosplenic T-cell lymphoma Approved [41]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [42]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [43]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [44]
Etidronic acid DM1XHYJ Bone Paget disease Approved [41]
Tiaprofenic acid DM23D7J Osteoarthritis FA00-FA05 Approved [41]
Bromperidol DM24XYQ Schizophrenia 6A20 Approved [41]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [45]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [46]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [45]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [48]
Artemether DM48QOT Malaria 1F40-1F45 Approved [49]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [50]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [51]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [52]
Estrone DM5T6US Acne vulgaris ED80 Approved [53]
Leflunomide DMR8ONJ Arthritis FA20 Approved [54]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [55]
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Drug(s) Affected By Bile salt export pump (ABCB11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [56]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [9]
Glipizide DMZA5PQ Diabetic complication 5A2Y Approved [9]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [57]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [56]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [9]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [58]
Gefitinib DM15F0X Colon adenocarcinoma Approved [56]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [59]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [56]
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Drug(s) Affected By ATP-binding cassette sub-family C member 3 (ABCC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [60]
Methotrexate DM2TEOL Anterior urethra cancer Approved [61]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [62]
Calcipotriol DM03CP7 Psoriasis EA90 Approved [63]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [64]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [65]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Prednisone DM2HG4X Acute asthma CA23 Approved [67]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [68]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [69]
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Drug(s) Affected By Intermediate conductance calcium-activated potassium channel protein 4 (KCNN4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [70]
Chlorzoxazone DMCYVDT Acute pain MG31 Approved [71]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [72]
Charybdotoxin DMKN345 Scorpion envenoming syndrome 8D43 Approved [73]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [74]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [66]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [75]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [76]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [77]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [78]
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Drug(s) Affected By Adenylate cyclase type 9 (ADCY9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [79]
Leflunomide DMR8ONJ Arthritis FA20 Approved [80]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [55]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [81]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [82]
Miconazole DMPMYE8 Cutaneous candidiasis 1F23.14 Approved [5]
Arsenic DMTL2Y1 N. A. N. A. Approved [83]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [84]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [85]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [86]
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Drug(s) Affected By Protein c-Fos (FOS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [87]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [88]
Verapamil DMA7PEW Angina pectoris BA40 Approved [89]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [90]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [89]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [65]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [91]
Methotrexate DM2TEOL Anterior urethra cancer Approved [92]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [93]
Quercetin DM3NC4M Obesity 5B81 Approved [94]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [95]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [90]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [65]
Gefitinib DM15F0X Colon adenocarcinoma Approved [96]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [79]
Selenium DM25CGV N. A. N. A. Approved [97]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [98]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [99]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [100]
Methotrexate DM2TEOL Anterior urethra cancer Approved [101]
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Drug(s) Affected By ATP-dependent 6-phosphofructokinase, muscle type (PFKM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [7]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [102]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [103]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [104]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [75]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [105]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [106]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [107]
Bardoxolone methyl DMODA2X Mixed connective tissue disease 4A43.3 Phase 3 [108]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [109]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [110]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [111]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [112]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [113]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [114]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [115]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [116]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [117]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [118]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [116]
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Drug(s) Affected By Glial fibrillary acidic protein (GFAP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Penicillin V DMKVOYF Acute otitis media AB00 Approved [119]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [119]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [120]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [121]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [122]
Testosterone DM7HUNW Hot flushes GA30 Approved [123]
Haloperidol DM96SE0 Delirium Approved [124]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [102]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [103]
Ethanol DMDRQZU Chronic pain MG30 Approved [125]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [126]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [88]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [127]
Gefitinib DM15F0X Colon adenocarcinoma Approved [128]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [129]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [130]
Etretinate DM2CZFA Keratosis ED56 Approved [131]
Prednisone DM2HG4X Acute asthma CA23 Approved [132]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [133]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [134]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [135]
Gefitinib DM15F0X Colon adenocarcinoma Approved [136]
Prednisone DM2HG4X Acute asthma CA23 Approved [132]
Methotrexate DM2TEOL Anterior urethra cancer Approved [137]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [138]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [139]
Quercetin DM3NC4M Obesity 5B81 Approved [140]
Fluoxetine DM3PD2C Bipolar depression Approved [141]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [143]
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Drug(s) Affected By Heat shock factor protein 1 (HSF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [144]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [145]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [145]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [146]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [147]
Ceftazidime DM41GRA Bacteremia 1A73 Approved [145]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Chlorpheniramine DM5URA2 Allergic rhinitis CA08.0 Approved [145]
Ethacrynic acid DM60QMR Edema MG29 Approved [145]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [145]
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Drug(s) Affected By Eukaryotic translation initiation factor 2A (EIF2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [149]
Quercetin DM3NC4M Obesity 5B81 Approved [150]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [152]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [153]
Cerulenin DM6N4PR Weight loss MG43.5 Approved [154]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [155]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [156]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [55]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [102]
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Drug(s) Affected By DnaJ homolog subfamily B member 4 (DNAJB4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [157]
Selenium DM25CGV N. A. N. A. Approved [158]
Quercetin DM3NC4M Obesity 5B81 Approved [159]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [160]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [161]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [162]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [79]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [11]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [163]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [157]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
C-X-C chemokine receptor type 2 (CXCR2) TT30C9G CXCR2_HUMAN Modulator [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Adenylate cyclase type 9 (ADCY9) OT1IZT5K ADCY9_HUMAN Gene/Protein Processing [5]
ATP-binding cassette sub-family C member 3 (ABCC3) OTC3IJV4 MRP3_HUMAN Gene/Protein Processing [6]
ATP-dependent 6-phosphofructokinase, muscle type (PFKM) OT1QY9JM PFKAM_HUMAN Gene/Protein Processing [7]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Gene/Protein Processing [8]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Gene/Protein Processing [9]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [10]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Gene/Protein Processing [10]
DnaJ homolog subfamily B member 4 (DNAJB4) OTUD01BK DNJB4_HUMAN Gene/Protein Processing [11]
Eukaryotic translation initiation factor 2A (EIF2A) OTWXELQP EIF2A_HUMAN Post-Translational Modifications [12]
Glial fibrillary acidic protein (GFAP) OTQ01ZAS GFAP_HUMAN Gene/Protein Processing [13]

References

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3 Mode of action of clotrimazole: implications for therapy. Am J Obstet Gynecol. 1985 Aug 1;152(7 Pt 2):939-44.
4 Tacrolimus interaction with clotrimazole: a concise case report and literature review. P T. 2010 Oct;35(10):568-9.
5 Direct stimulation of adenylyl cyclase 9 by the fungicide imidazole miconazole. Naunyn Schmiedebergs Arch Pharmacol. 2019 Apr;392(4):497-504. doi: 10.1007/s00210-018-01610-1. Epub 2019 Jan 3.
6 Activation of p38 Mitogen-Activated Protein Kinase by Clotrimazole Induces Multidrug Resistance-Associated Protein 3 Activation through a Novel Transcriptional Element. J Pharmacol Exp Ther. 2016 Oct;359(1):102-9. doi: 10.1124/jpet.115.231589. Epub 2016 Aug 9.
7 Combination of imatinib and clotrimazole enhances cell growth inhibition in T47D breast cancer cells. Chem Biol Interact. 2015 May 25;233:147-56. doi: 10.1016/j.cbi.2015.03.028. Epub 2015 Apr 8.
8 Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells. Mol Pharmacol. 1996 Feb;49(2):311-8.
9 Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11). Toxicol Sci. 2013 Dec;136(2):328-43.
10 Clotrimazole induces a late G1 cell cycle arrest and sensitizes glioblastoma cells to radiation in vitro. Anticancer Drugs. 2010 Oct;21(9):841-9. doi: 10.1097/CAD.0b013e32833e8022.
11 An in vitro skin sensitization assay termed EpiSensA for broad sets of chemicals including lipophilic chemicals and pre/pro-haptens. Toxicol In Vitro. 2017 Apr;40:11-25. doi: 10.1016/j.tiv.2016.12.005. Epub 2016 Dec 10.
12 Androgen signaling promotes translation of TMEFF2 in prostate cancer cells via phosphorylation of the subunit of the translation initiation factor 2. PLoS One. 2013;8(2):e55257. doi: 10.1371/journal.pone.0055257. Epub 2013 Feb 6.
13 Effects of clotrimazole on the growth, morphological characteristics, and cisplatin sensitivity of human glioblastoma cells in vitro. J Neurosurg. 1999 May;90(5):918-27. doi: 10.3171/jns.1999.90.5.0918.
14 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31.
15 CXCR2 Antagonist MK-7123.A Phase 2 Proof-of-Concept Trial for Chronic Obstructive Pulmonary Disease.Am J Respir Crit Care Med.2015 May 1;191(9):1001-11.
16 Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91.
17 Pharmacological characterization of AZD5069, a slowly reversible CXC chemokine receptor 2 antagonist. J Pharmacol Exp Ther. 2015 May;353(2):340-50.
18 CenterWatch. Drugs in Clinical Trials Database. CenterWatch. 2008.
19 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
20 Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
21 A Randomized, Double-Blind, Placebo-Controlled, Phase 2a Study to Evaluate the Efficacy and Safety of RIST4721 in Subjects with Palmoplantar Pustulosis. Dermatol Ther (Heidelb). 2021 Dec;11(6):2179-2193.
22 Inhibition of MDSC Trafficking with SX-682, a CXCR1/2 Inhibitor, Enhances NK-Cell Immunotherapy in Head and Neck Cancer Models. Clin Cancer Res. 2020 Mar 15;26(6):1420-1431.
23 Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines. Cancer. 2007 Mar 1;109(5):957-65.
24 Contribution of human hepatic cytochrome P450 isoforms to regioselective hydroxylation of steroid hormones. Xenobiotica. 1998 Jun;28(6):539-47.
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