Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMPFN6Y)

• Drug Name: Olanzapine Drug Info
• Synonyms: Lanzac; Midax; Olansek; Olanzapina; Olanzapinum; Symbyax; Zalasta; Zydis; Zyprexa; Eli Lilly brand of olanzapine; Lilly brand of olanzapine; Zyprexa Intramuscular; Zyprexa Velotab; Zyprexa Zydis; LY 170053; ALKS-7921; KS-1090; LY-170052; LY-170053; Olanzapine (OLA); Olanzapine [USAN:INN]; Olzapin (TN); Rexapin (TN); Zalasta (TN); Zolafren (TN); Zydis (TN); Zyprexa (TN); Olanzapine (JAN/USAN/INN); 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno(2,3-b)(1,5)benzodiazepine; 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine; 2-methyl-4-(4-methyl-1-piperazinyl)-10 H-thieno[2,3-b ] [1,5]benzodiazepine; 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine; 2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[2,3-b][1,5]benzodiazepine; 2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[3,2-c][1,5]benzodiazepine

Indication

Disease Entry	ICD 11	Status	REF
Bipolar depression		Approved	[1]
Major depressive disorder	6A70.3	Approved	[1]
Schizoaffective disorder	6A21	Approved	[1]
Schizophrenia	6A20	Approved	[2]

• Therapeutic Class: Antipsychotic Agents
• Cross-matching ID:
  PubChem CID: 135398745
  ChEBI ID: CHEBI:7735
  CAS Number: CAS 132539-06-1
  TTD Drug ID: DMPFN6Y
  VARIDT Drug ID: DR00462
  INTEDE Drug ID: DR1186
  ACDINA Drug ID: D00484

Molecule-Related Drug Atlas

Drug(s) Targeting Dopamine D2 receptor (D2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[12]
Haloperidol	DM96SE0	Delirium		Approved	[13]
Perphenazine	DMA4MRX	Schizophrenia	6A20	Approved	[14]
Perazine	DM2AOTZ	Psychotic disorder	6A20-6A25	Approved	[15]
Domperidone	DMBDPY0	Gastrointestinal disease	DE2Z	Approved	[16]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[17]
Quetiapine	DM1N62C	Anorexia nervosa cachexia	6B80	Approved	[18]
Pimozide	DMW83TP	Schizophrenia	6A20	Approved	[19]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[20]
Iloperidone	DM6AUFY	Schizophrenia	6A20	Approved	[21]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[22]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[23]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[24]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[25]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[24]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[26]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[24]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[27]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[28]

Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[29]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[30]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[31]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[32]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[33]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[34]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[35]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[36]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[37]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[38]

Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[39]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[40]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[41]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[42]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[43]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[44]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[45]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[46]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[47]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[48]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[49]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[50]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[51]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[52]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[53]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[54]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[55]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[56]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[57]
Levetiracetam	DMTGDN8	Epilepsy	8A60-8A68	Approved	[52]

Drug(s) Affected By D(2) dopamine receptor (DRD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Droperidol	DM0DXA8	Nausea	MD90	Approved	[58]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[58]
Zuclopenthixol	DMKYD5N	Schizophrenia	6A20	Approved	[58]
Meglitinides	DM1OFHN	Type-2 diabetes	5A11	Approved	[59]
Sulpiride	DMF54ZG	Schizophrenia	6A20	Approved	[60]
Risperidone	DMN6DXL	Bipolar I disorder		Approved	[61]
Methamphetamine	DMPM4SK	Anxiety		Approved	[62]
Bromocriptine	DMVE3TK	Acromegaly	5A60.0	Approved	[63]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[64]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[65]

Drug(s) Affected By Lathosterol oxidase (SC5D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[67]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[70]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[7]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[71]
Haloperidol	DM96SE0	Delirium		Approved	[7]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]

Drug(s) Affected By Low-density lipoprotein receptor (LDLR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[74]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[75]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[74]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[76]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[70]

Drug(s) Affected By 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[81]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[77]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[82]
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[58]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[75]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[83]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[67]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]

Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[85]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[86]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[87]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[87]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[88]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[87]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]

Drug(s) Affected By Long-chain fatty acid transport protein 2 (SLC27A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[93]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[70]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[94]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[95]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[96]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[97]

Drug(s) Affected By Bile salt export pump (ABCB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[98]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[99]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[99]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[100]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[98]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[99]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[101]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[98]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[102]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[98]

Drug(s) Affected By Ceruloplasmin (CP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[103]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[106]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[97]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[107]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[108]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[78]

Drug(s) Affected By Prothrombin (F2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[109]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[91]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[112]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[113]
Phytonadione	DM8HDOL	Bleeding disorder	GA20-GA21	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[72]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[115]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[116]

Drug(s) Affected By Complement factor B (CFB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[118]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[79]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[121]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]
Danazol	DML8KTN	Menorrhagia	GA20.50	Approved	[123]

Drug(s) Affected By Alpha-1-antichymotrypsin (SERPINA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[124]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[125]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[126]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[124]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[124]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[127]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[128]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[124]

Drug(s) Affected By Alpha-2-macroglobulin (A2M)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[129]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[130]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[131]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[70]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[132]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Aminocaproic Acid	DMFGND4	Bleeding disorder	GA20-GA21	Approved	[130]

Drug(s) Affected By Complement C3 (C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[133]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[91]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[127]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[70]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[135]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[136]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[127]

Drug(s) Affected By Complement C5 (C5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[137]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[138]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[108]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[139]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[140]

Drug(s) Affected By Kininogen-1 (KNG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[72]
Mepyramine	DMB4SFH	Allergic rhinitis	CA08.0	Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[141]
Perindopril	DMOPZDT	Hypertension	BA00-BA04	Approved	[142]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[139]
Indomethacin	DMSC4A7	Bursitis		Approved	[141]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]

Drug(s) Affected By Prolactin (PRL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[144]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[145]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[146]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[147]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[91]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[148]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[149]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[150]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[151]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[152]

Drug(s) Affected By Insulin (INS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[153]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[91]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[154]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[155]
Fructose	DM43AN2	Vomiting	MD90	Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[157]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[158]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[159]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[160]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]

Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[58]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[162]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[163]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[164]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[167]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[168]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[169]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[170]

Drug(s) Affected By Apolipoprotein A-I (APOA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[171]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[172]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[68]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[173]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[174]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[175]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[178]

Drug(s) Affected By Complement component C9 (C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[100]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[180]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[181]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[182]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[183]

Drug(s) Affected By Beta-2-glycoprotein 1 (APOH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[139]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[184]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[185]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[187]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[188]

Drug(s) Affected By Fibronectin (FN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[189]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[190]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[191]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[192]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[193]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[70]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[194]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[195]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[196]

Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[197]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[58]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[198]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[199]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[200]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[83]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[201]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[109]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[203]

Drug(s) Affected By Vitamin D-binding protein (GC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[204]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[132]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[72]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[205]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[206]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[207]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[208]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[209]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[210]

Drug(s) Affected By Hemopexin (HPX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[139]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[211]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[212]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[213]

Drug(s) Affected By Apolipoprotein B-100 (APOB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[214]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[214]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[215]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[214]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[216]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[214]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[217]

Drug(s) Affected By Histidine-rich glycoprotein (HRG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[137]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[132]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[218]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[219]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[220]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[72]

Drug(s) Affected By Alpha-1B-glycoprotein (A1BG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[221]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[222]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[139]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[223]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[224]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[225]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[226]

Drug(s) Affected By Sex hormone-binding globulin (SHBG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[227]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Fructose	DM43AN2	Vomiting	MD90	Approved	[228]
Oxcarbazepine	DM5PU6O	Epilepsy	8A60-8A68	Approved	[229]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[230]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[231]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[221]
Dienestrol	DMBSXI0	Atrophic vaginitis	GA30.2	Approved	[230]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[230]
Masoprocol	DMMVNZ0	Prostate cancer	2C82.0	Approved	[230]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[232]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[91]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[233]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[234]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[235]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[236]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[237]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[238]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[239]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[240]

Drug(s) Affected By Plasma protease C1 inhibitor (SERPING1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[70]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[241]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]
Danazol	DML8KTN	Menorrhagia	GA20.50	Approved	[123]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[139]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[180]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[242]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[243]

Drug(s) Affected By Apolipoprotein A-IV (APOA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Fructose	DM43AN2	Vomiting	MD90	Approved	[244]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[79]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[139]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[184]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[188]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[245]

Drug(s) Affected By Fatty acid-binding protein, liver (FABP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[124]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[126]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[124]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[91]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[124]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[246]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[247]

Drug(s) Affected By Complement factor H (CFH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[248]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[72]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[249]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[250]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[205]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[79]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[242]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[251]

Drug(s) Affected By Complement C4-A (C4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[108]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[252]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[253]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[210]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[254]

Drug(s) Affected By Clusterin (CLU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[255]
Selenium	DM25CGV	N. A.	N. A.	Approved	[248]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[255]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[256]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[257]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[95]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[71]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[255]

Drug(s) Affected By Muscarinic acetylcholine receptor M1 (CHRM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pirenzepine	DMP6M1N	Peptic ulcer	DA61	Approved	[258]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[58]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[259]
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[260]
Atropine	DMEN6X7	Organophosphate poisoning	NE6Z	Approved	[261]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[262]
Gallamine Triethiodide	DMPO0MS	Stabilize muscle contraction	FB3Z	Approved	[263]
Carbachol	DMX9K8F	Glaucoma/ocular hypertension	9C61	Approved	[260]
Methylscopolamine	DM5VWOB	Peptic ulcer	DA61	Approved	[264]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[265]

Drug(s) Affected By Complement component C6 (C6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[252]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[182]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 4 (SLC2A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[266]
Fructose	DM43AN2	Vomiting	MD90	Approved	[267]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[268]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[269]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[270]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[270]
Haloperidol	DM96SE0	Delirium		Approved	[271]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[272]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[273]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[274]

Drug(s) Affected By Inter-alpha-trypsin inhibitor heavy chain H2 (ITIH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[275]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[139]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[276]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[209]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[182]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[277]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[278]

Drug(s) Affected By Brain-derived neurotrophic factor (BDNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[279]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[133]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[280]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Bupivacaine	DM4PRFC	Anaesthesia	9A78.6	Approved	[281]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[282]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[241]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[283]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]

Drug(s) Affected By 5-hydroxytryptamine receptor 2A (HTR2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[58]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[64]
Paliperidone	DM7NPJS	Psychotic disorder	6A20-6A25	Approved	[284]
Haloperidol	DM96SE0	Delirium		Approved	[284]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[285]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[188]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[243]
Ketanserin	DMVLMW6	Hypertension	BA00-BA04	Approved	[286]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[287]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[288]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[289]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[290]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[291]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[292]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[293]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[294]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[295]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[296]

Drug(s) Affected By Histamine H1 receptor (HRH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Desloratadine	DM56YN7	Allergic rhinitis	CA08.0	Approved	[297]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[297]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[58]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[298]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[91]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[299]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[9]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[222]

Drug(s) Affected By Leptin (LEP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[300]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[125]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[301]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[302]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[303]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[300]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[300]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[304]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[305]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[306]

Drug(s) Affected By Pituitary adenylate cyclase-activating polypeptide type I receptor (ADCYAP1R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[256]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[241]
Haloperidol	DM96SE0	Delirium		Approved	[307]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[308]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[256]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[308]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[256]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[309]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[86]

Drug(s) Affected By Afamin (AFM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[79]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[72]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[310]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[311]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[312]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[313]
Selenium	DM25CGV	N. A.	N. A.	Approved	[248]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[314]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[315]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[316]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[317]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[318]

Drug(s) Affected By 5-hydroxytryptamine receptor 6 (HTR6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[9]
Methamphetamine	DMPM4SK	Anxiety		Approved	[319]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[182]
LYSERGIC ACID DIETHYLAMIDE	DMACMLO	Addictive disorder	6C50-6C5Z	Withdrawn from market	[320]
SB 258585	DM2QJKZ	Discovery agent	N.A.	Investigative	[321]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[322]

Drug(s) Affected By Potassium voltage-gated channel subfamily H member 2 (KCNH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metoclopramide	DMFA5MY	Nausea	MD90	Approved	[323]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[324]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[325]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[326]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[326]
Disopyramide	DM5SYZP	Long QT syndrome	BC65.0	Approved	[327]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[328]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[329]
Dofetilide	DMPN1TW	Sinus rhythm disorder	BC9Y	Approved	[330]
Flecainide	DMSQDLE	Tachyarrhythmias	BC71	Approved	[326]

Drug(s) Affected By Bcl-2-interacting killer (BIK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[331]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[332]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[333]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[334]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[335]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[272]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[221]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[336]

Drug(s) Affected By Inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[337]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[182]

Drug(s) Affected By Long-chain fatty acid transport protein 5 (SLC27A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[338]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[139]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[339]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[72]

Drug(s) Affected By D(3) dopamine receptor (DRD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[340]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[341]
Risperidone	DMN6DXL	Bipolar I disorder		Approved	[342]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[343]
Methamphetamine	DMPM4SK	Anxiety		Approved	[344]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[345]
Droperidol	DM0DXA8	Nausea	MD90	Approved	[58]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[58]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[58]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[58]

Drug(s) Affected By 5-hydroxytryptamine receptor 1A (HTR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trazodone	DMK1GBJ	Depression	6A70-6A7Z	Approved	[346]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[346]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[347]
Methamphetamine	DMPM4SK	Anxiety		Approved	[348]
Perospirone	DMVHJLX	Psychotic disorder	6A20-6A25	Approved	[8]
Etoperidone	DMR7U8F	N. A.	N. A.	Phase 4	[346]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[349]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[182]
DU 125530	DM63UA9	Mood disorder	6A60-6E23	Discontinued in Phase 2	[350]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[349]

Drug(s) Affected By 5-hydroxytryptamine receptor 2C (HTR2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[351]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[351]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[351]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Nortriptyline	DM4KDYJ	Depression	6A70-6A7Z	Approved	[352]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[270]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[283]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[353]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[354]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[238]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[355]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[356]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[357]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[358]
Selenium	DM25CGV	N. A.	N. A.	Approved	[248]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[83]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[359]

Drug(s) Affected By Aquaporin-4 (AQP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[360]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[299]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[361]
Guanfacine extended release	DMB1CZ8	Attention deficit hyperactivity disorder	6A05.Z	Approved	[360]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ammonia	DMOEVK6	Coronary artery disease	BA80	Approved	[362]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[210]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[363]

Drug(s) Affected By D(4) dopamine receptor (DRD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[364]
Haloperidol	DM96SE0	Delirium		Approved	[365]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[222]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Methamphetamine	DMPM4SK	Anxiety		Approved	[366]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[367]
Droperidol	DM0DXA8	Nausea	MD90	Approved	[58]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[58]

Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[368]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[369]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[370]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[371]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[372]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[372]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[297]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[373]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[374]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[375]

Drug(s) Affected By Methylenetetrahydrofolate reductase (MTHFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[376]
Benazepril	DMH1M9B	Hypertension	BA00-BA04	Approved	[377]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[378]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[379]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[270]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[270]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[197]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[380]

Drug(s) Affected By Synaptosomal-associated protein 25 (SNAP25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[381]
Selenium	DM25CGV	N. A.	N. A.	Approved	[248]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[256]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[382]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[383]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[108]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[121]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine D2 receptor (D2R)	TTEX248	DRD2_HUMAN	Agonist	[3]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[4]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 2D6 (CYP2D6) Main DME	DECB0K3	CP2D6_HUMAN	Substrate	[5]
Cytochrome P450 1A2 (CYP1A2) Main DME	DEJGDUW	CP1A2_HUMAN	Substrate	[6]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)	OTRT3F3U	HMDH_HUMAN	Gene/Protein Processing	[7]
5-hydroxytryptamine receptor 1A (HTR1A)	OT38K9MK	5HT1A_HUMAN	Drug Response	[8]
5-hydroxytryptamine receptor 2A (HTR2A)	OTWXJX0M	5HT2A_HUMAN	Protein Interaction/Cellular Processes	[9]
5-hydroxytryptamine receptor 2C (HTR2C)	OT6H8DE0	5HT2C_HUMAN	Drug Response	[10]
5-hydroxytryptamine receptor 6 (HTR6)	OT8GTDDY	5HT6R_HUMAN	Protein Interaction/Cellular Processes	[9]
Afamin (AFM)	OTPOR8IO	AFAM_HUMAN	Post-Translational Modifications	[11]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Post-Translational Modifications	[11]
Alpha-1-antichymotrypsin (SERPINA3)	OT9BP2S0	AACT_HUMAN	Post-Translational Modifications	[11]
Alpha-1B-glycoprotein (A1BG)	OTFVUGNQ	A1BG_HUMAN	Post-Translational Modifications	[11]
Alpha-2-macroglobulin (A2M)	OTFTX90K	A2MG_HUMAN	Post-Translational Modifications	[11]

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