Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTV4L0)

Drug Name
Myricetin Drug Info
Synonyms
myricetin; 529-44-2; Cannabiscetin; Myricetol; Myricitin; 3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one; 3,3',4',5,5',7-Hexahydroxyflavone; 3,5,7,3',4',5'-Hexahydroxyflavone; UNII-76XC01FTOJ; NSC 407290; CCRIS 5838; 4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-; 3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one; 3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)chromen-4-one; EINECS 208-463-2; NSC407290; CHEMBL164; NSC-407290; BRN 0332331; 76XC01FTOJ
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
5281672
ChEBI ID
CHEMBL164
CAS Number
CAS 529-44-2
TTD Drug ID
DMTV4L0
VARIDT Drug ID
DR00676

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting PI3-kinase gamma (PIK3CG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BAY 80-6946 DMLOS5R Follicular lymphoma 2A80 Approved [9]
IPI-145 DMWA24P Follicular lymphoma 2A80 Approved [10]
Buparlisib DM1WEHC Breast cancer 2C60-2C65 Phase 3 [11]
Enzastaurin DM5H0R9 Diffuse large B-cell lymphoma 2A81 Phase 3 [12]
Rigosertib DMOSTXF Myelodysplastic syndrome 2A37 Phase 3 [13]
GDC-0032 DMT4QHD Breast cancer 2C60-2C65 Phase 3 [12]
PQR309 DMMCYZ8 Squamous head and neck cell carcinom 2D60.0 Phase 2 [14]
SAR245409 DMQM7IL Solid tumour/cancer 2A00-2F9Z Phase 2 [15]
XL147 DMML7BE Solid tumour/cancer 2A00-2F9Z Phase 2 [15]
SF1126 DML10K3 Head and neck cancer 2D42 Phase 2 [16]
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Drug(s) Affected By Poly(ADP-ribose) glycohydrolase (PARG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [17]
Quercetin DM3NC4M Obesity 5B81 Approved [18]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [19]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [20]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [22]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [23]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [24]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [25]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [26]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [27]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [28]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [29]
Gefitinib DM15F0X Colon adenocarcinoma Approved [30]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [31]
Selenium DM25CGV N. A. N. A. Approved [32]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [33]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [34]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [35]
Methotrexate DM2TEOL Anterior urethra cancer Approved [36]
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Drug(s) Affected By Catenin beta-1 (CTNNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [37]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [38]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [39]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [42]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [43]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [44]
Testosterone DM7HUNW Hot flushes GA30 Approved [45]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [46]
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Drug(s) Affected By Egl nine homolog 1 (EGLN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [3]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [47]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [48]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [49]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [51]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [22]
Ethanol DMDRQZU Chronic pain MG30 Approved [52]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [48]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [24]
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Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [53]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [54]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [55]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [56]
Capsaicin DMGMF6V Back pain ME84.Z Approved [57]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [58]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [59]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [58]
Desipramine DMT2FDC Attention deficit hyperactivity disorder 6A05.Z Approved [54]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [60]
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Drug(s) Affected By Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PIK3C2B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [61]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [19]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [62]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [20]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [64]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [24]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [65]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [66]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [67]
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Drug(s) Affected By Tumor protein p73 (TP73)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [68]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [69]
Etretinate DM2CZFA Keratosis ED56 Approved [70]
Quercetin DM3NC4M Obesity 5B81 Approved [71]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [72]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [73]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [74]
Menthol DMG2KW7 Back pain ME84.Z Approved [75]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [76]
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [70]
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Drug(s) Affected By E3 ubiquitin-protein ligase listerin (LTN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [77]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [78]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [78]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [51]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [78]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [78]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [23]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [78]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [80]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [81]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [82]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [83]
Cepharanthine DM9Y5JB N. A. N. A. Approved [84]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [85]
Clozapine DMFC71L Schizophrenia 6A20 Approved [86]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [87]
Trifluoperazine DMKBYWI Anxiety Approved [88]
Olanzapine DMPFN6Y Bipolar depression Approved [86]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [89]
Gefitinib DM15F0X Colon adenocarcinoma Approved [90]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [91]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [92]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [93]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [94]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [93]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [95]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [96]
Methotrexate DM2TEOL Anterior urethra cancer Approved [97]
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Drug(s) Affected By Cytochrome c oxidase subunit 5B, mitochondrial (COX5B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [19]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [98]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [22]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [23]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [101]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [102]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [103]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [104]
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Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [40]
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [105]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [106]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [107]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [108]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [109]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [108]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [47]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [110]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [111]
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Drug(s) Affected By Tyrosine-protein kinase JAK1 (JAK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [17]
Quercetin DM3NC4M Obesity 5B81 Approved [112]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [113]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [99]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [114]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Tofacitinib DMBS370 Rheumatoid arthritis FA20 Approved [115]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Clozapine DMFC71L Schizophrenia 6A20 Approved [116]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [117]
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Drug(s) Affected By Cofilin-1 (CFL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [109]
Etretinate DM2CZFA Keratosis ED56 Approved [118]
Quercetin DM3NC4M Obesity 5B81 Approved [119]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [19]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [120]
Haloperidol DM96SE0 Delirium Approved [107]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [121]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [22]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [122]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [123]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [124]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [125]
Gefitinib DM15F0X Colon adenocarcinoma Approved [126]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [127]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [128]
Etretinate DM2CZFA Keratosis ED56 Approved [70]
Prednisone DM2HG4X Acute asthma CA23 Approved [129]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [94]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [130]
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Drug(s) Affected By Cyclin-dependent kinase 4 inhibitor C (CDKN2C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [89]
Quercetin DM3NC4M Obesity 5B81 Approved [112]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [131]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [132]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [133]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [134]
Testosterone DM7HUNW Hot flushes GA30 Approved [135]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [135]
Leflunomide DMR8ONJ Arthritis FA20 Approved [136]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [20]
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Drug(s) Affected By Rho GDP-dissociation inhibitor 2 (ARHGDIB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [36]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [137]
Quercetin DM3NC4M Obesity 5B81 Approved [112]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [137]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [99]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [111]
Leflunomide DMR8ONJ Arthritis FA20 Approved [136]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [139]
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Drug(s) Affected By Cytochrome c (CYCS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [140]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [141]
Gefitinib DM15F0X Colon adenocarcinoma Approved [90]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [142]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [143]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [144]
Methotrexate DM2TEOL Anterior urethra cancer Approved [36]
Quercetin DM3NC4M Obesity 5B81 Approved [112]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [145]
Pefloxacin DM49IGF Gonococcal urethritis 1A70.0Y Approved [146]
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Drug(s) Affected By Quinone oxidoreductase PIG3 (TP53I3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [92]
Methotrexate DM2TEOL Anterior urethra cancer Approved [147]
Quercetin DM3NC4M Obesity 5B81 Approved [5]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Amifostine DM5FL14 Mucositis CA00 Approved [149]
Testosterone DM7HUNW Hot flushes GA30 Approved [150]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [151]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [78]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [78]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
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Drug(s) Affected By Tumor protein 63 (TP63)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [69]
Quercetin DM3NC4M Obesity 5B81 Approved [5]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [152]
Panobinostat DM58WKG Chronic graft versus host disease Approved [153]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [154]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [155]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [156]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [24]
Topotecan DMP6G8T Central nervous system neoplasm Approved [157]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [65]
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Drug(s) Affected By Serine/threonine-protein kinase 38-like (STK38L)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [158]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [19]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [111]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [159]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [24]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [65]
Arsenic DMTL2Y1 N. A. N. A. Approved [160]
Urethane DM7NSI0 N. A. N. A. Phase 4 [161]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [158]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
PI3-kinase gamma (PIK3CG) TTHBTOP PK3CG_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Gene/Protein Processing [2]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Gene/Protein Processing [3]
Cofilin-1 (CFL1) OTT6D5MH COF1_HUMAN Gene/Protein Processing [4]
Cyclin-dependent kinase 4 inhibitor C (CDKN2C) OTCLOV90 CDN2C_HUMAN Gene/Protein Processing [5]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [6]
Cytochrome c (CYCS) OTBFALJD CYC_HUMAN Protein Interaction/Cellular Processes [7]
Cytochrome c oxidase subunit 5B, mitochondrial (COX5B) OTDP94F3 COX5B_HUMAN Gene/Protein Processing [4]
Cytochrome P450 2C19 (CYP2C19) OTFMJYYE CP2CJ_HUMAN Gene/Protein Processing [8]
E3 ubiquitin-protein ligase listerin (LTN1) OTIW2HTX LTN1_HUMAN Gene/Protein Processing [4]
Egl nine homolog 1 (EGLN1) OT5QODDK EGLN1_HUMAN Gene/Protein Processing [3]

References

1 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2 Structure-activity relationship and mechanism of flavonoids on the inhibitory activity of P-glycoprotein (P-gp)-mediated transport of rhodamine123 and daunorubicin in P-gp overexpressed human mouth epidermal carcinoma (KB/MDR) cells. Food Chem Toxicol. 2021 Sep;155:112381. doi: 10.1016/j.fct.2021.112381. Epub 2021 Jul 1.
3 Involvement of SIRT1 in hypoxic down-regulation of c-Myc and beta-catenin and hypoxic preconditioning effect of polyphenols. Toxicol Appl Pharmacol. 2012 Mar 1;259(2):210-8.
4 Potential role of nucleoside diphosphate kinase in myricetin-induced selective apoptosis in colon cancer HCT-15?cells. Food Chem Toxicol. 2018 Jun;116(Pt B):315-322. doi: 10.1016/j.fct.2018.04.053. Epub 2018 Apr 24.
5 Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2/M arrest and inducing apoptosis. Food Chem Toxicol. 2008 Jun;46(6):2042-53. doi: 10.1016/j.fct.2008.01.049. Epub 2008 Feb 7.
6 Cytotoxicity of flavones and flavonols to a human esophageal squamous cell carcinoma cell line (KYSE-510) by induction of G2/M arrest and apoptosis. Toxicol In Vitro. 2009 Aug;23(5):797-807. doi: 10.1016/j.tiv.2009.04.007. Epub 2009 May 3.
7 Mitochondrial-dependent, reactive oxygen species-independent apoptosis by myricetin: roles of protein kinase C, cytochrome c, and caspase cascade. Biochem Pharmacol. 2005 Mar 15;69(6):913-27. doi: 10.1016/j.bcp.2004.12.005.
8 Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. Toxicol Lett. 2018 Sep 15;294:27-36.
9 BAY 80-6946 is a highly selective intravenous PI3K inhibitor with potent p110 and p110 activities in tumor cell lines and xenograft models.Mol Cancer Ther.2013 Nov;12(11):2319-30.
10 PI3K-delta and PI3K-gamma inhibition by IPI-145 abrogates immune responses and suppresses activity in autoimmune and inflammatory disease models. Chem Biol. 2013 Nov 21;20(11):1364-74.
11 Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev Drug Discov. 2009 Aug;8(8):627-44.
12 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
13 Phase I study of oral rigosertib (ON 01910.Na), a dual inhibitor of the PI3K and Plk1 pathways, in adult patients with advanced solid malignancies. Clin Cancer Res. 2014 Mar 15;20(6):1656-65.
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