Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUYNEI)

Drug Name
Amoxicillin Drug Info
Synonyms
AMPC; Actimoxi; Amoclen; Amolin; Amopen; Amopenixin; Amoxi; Amoxibiotic; Amoxicaps; Amoxicilina; Amoxicillanyl; Amoxicilline; Amoxicillinum; Amoxiden; Amoxil; Amoxivet; Amoxycillin; Anemolin; Aspenil; Biomox; Bristamox; Cemoxin; Clamoxyl; Delacillin; DisperMox; Efpenix; Flemoxin; Hiconcil; Histocillin; Hydroxyampicillin; Ibiamox; Imacillin; Lamoxy; Larotid; Moxacin; Moxal; Moxatag; Ospamox; Pamoxicillin; Piramox; Polymox; Robamox; Sumox; Tolodina; Trimox; Unicillin; Utimox; Vetramox; Wymox; AMOXICILLIN CRYSTALLINE; AMOXICILLIN PEDIATRIC; Amoxicillin anhydrous; Amoxicilline [INN]; Amoxycillin Trihydrate; Metafarma capsules; Metifarma capsules; Sawamox PM; BLP 1410; AMK (TN); Actimoxi (TN); Alphamox (TN); Amoksibos (TN); Amoksiklav (TN); Amoxi-Mast; Amoxibiotic (TN); Amoxicilina (TN); Amoxicilina [INN-Spanish]; Amoxicillin (INN); Amoxicillin (TN); Amoxicillin (anhydrous); Amoxicilline [INN-French]; Amoxicillinum [INN-Latin]; Amoxiclav (TN); Amoxidal (TN); Amoxil (TN); Amoxin (TN); Apo-Amoxi; Augmentin (TN); BL-P 1410; BRL-2333; Bactox (TN); Betalaktam (TN); Cilamox (TN); Clamoxyl (TN); Curam (TN); D-Amoxicillin; Dedoxil (TN); Dispermox (TN); Duomox (TN); Enhancin (TN); Geramox (TN); Gimalxina (TN); Hiconcil (TN); Isimoxin (TN); Klavox (TN); Lamoxy (TN); Moxatag (TN); Moxilen (TN); Moxypen (TN); Moxyvit (TN); Nobactam (TN); Novamoxin (TN); Ospamox (TN); P-Hydroxyampicillin; Pamoxicillin (TN); Panamox (TN); Panklav (TN); Polymox (TN); Ro 10-8756; Samthongcillin (TN); Sandoz (TN); Senox (TN); Sinacilin (TN); Tolodina (TN); Trimox (TN); Wymox (TN); Yucla (TN); Zerrsox (TN); Zimox (TN); Apo-Amoxi (TN); Alpha-Amino-p-hydroxybenzylpenicillin; D-2-Amino-2-(4-hydroxyphenyl)acetamidopenicillanic acid; D-(-)-alpha-Amino-p-hydroxybenzylpenicillin; (-)-6-(2-Amino-2-(P-hydroxyphenyl)acetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo-(3.2.0)heptane-2-carboxylic acid; (2S,5R,6R)-6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (2S,5R,6R)-6-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(2-amino-2-(p-hydroxyphenyl)acetamido)-3,3-dimethyl-7-oxo-, D-(8CI); 6-(D-(-)-alpha-Amino-p-hydroxyphenylacetamido)penicillanic acid; 6-(D-(-)-p-Hydroxy-alpha-aminobenzyl)penicillin; 6-(p-Hydroxy-alpha-aminophenylacetamido)penicillanic acid; 6beta-[(2R)-2-amino-2-(4-hydroxyphenyl)acetamido]-2,2-dimethylpenam-3alpha-carbonyl; 6beta-[(2R)-2-amino-2-(4-hydroxyphenyl)acetamido]-2,2-dimethylpenam-3alpha-carboxylic acid
Indication
Disease Entry ICD 11 Status REF
Acute otitis media AB00 Approved [1]
Bacterial infection 1A00-1C4Z Approved [2]
Staphylococcus aureus infection Approved [1]
Streptococcal pneumonia Approved [1]
Urinary tract infection GC08 Approved [1]
Pneumonia due to Klebsiella pneumoniae CA40.03 Investigative [1]
Sinusitis CA0A.Z Investigative [1]
Therapeutic Class
Antibiotics
Cross-matching ID
PubChem CID
33613
ChEBI ID
CHEMBL1082
CAS Number
CAS 26787-78-0
TTD Drug ID
DMUYNEI
VARIDT Drug ID
DR00190
INTEDE Drug ID
DR0104
ACDINA Drug ID
D00035

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Bacterial Cell membrane (Bact CM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Teicoplanin DMAQ2LK Bacterial infection 1A00-1C4Z Approved [32]
Delamanid DMXE76K Multi-drug resistant tuberculosis MG52.00 Approved [33]
Diphtheria-tetanus vaccine DM0FSIM Clostridium infection 1A04 Approved [34]
D2A21 DMYJ2QB Burn and burn infection ND90-NE2Z Phase 3 [35]
DPK-060 DM059CZ Atopic dermatitis EA80 Phase 2 [36]
Brilacidin DMXI9BP Acute bacterial skin infection 1C41 Phase 2 [37]
LTX-109 DMXEQ0R Bacterial infection 1A00-1C4Z Phase 2 [38]
Friulimicin DMUI8F3 Bacterial infection 1A00-1C4Z Phase 1 [39]
IDR-1018 DM1RNT7 Bacterial infection 1A00-1C4Z Phase 1 [40]
Lotilibcin DMDLTCU Bacterial infection 1A00-1C4Z Phase 1 [41]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [42]
Methotrexate DM2TEOL Anterior urethra cancer Approved [43]
Folic Acid DMEMBJC Colorectal carcinoma Approved [44]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [43]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [43]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [45]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [43]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [46]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [47]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [48]
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Drug(s) Transported By Peptide transporter 1 (SLC15A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [49]
Ampicillin DMHWE7P Acute epiglottitis Approved [50]
Losartan DM72JXH Diabetic kidney disease GB61.Z Approved [51]
Enalapril DMNFUZR Congestive heart failure BD10 Approved [52]
Cefazolin DMPDYFR Bacteremia 1A73 Approved [53]
Ceftriaxone DMCEW64 Acute gonococcal cervicitis Approved [54]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [49]
Cefadroxil DMMC345 Bacterial infection 1A00-1C4Z Approved [51]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [51]
Valsartan DMREUQ6 Chronic heart failure BD1Z Approved [51]
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Drug(s) Transported By Peptide transporter 2 (SLC15A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ampicillin DMHWE7P Acute epiglottitis Approved [55]
Enalapril DMNFUZR Congestive heart failure BD10 Approved [56]
Entecavir DM7VTQO Hepatitis B virus infection 1E51.0 Approved [57]
Cefadroxil DMMC345 Bacterial infection 1A00-1C4Z Approved [58]
Cephalexin DMD5JU8 Acute otitis media AB00 Approved [55]
Valaciclovir DMHKS94 Genital herpes 1A94 Approved [59]
Cefaclor DMJXDGC Bacterial infection 1A00-1C4Z Approved [4]
Aminolevulinic acid hci DMS4BLQ Acne vulgaris ED80 Approved [60]
Spirapril DM5XLTY Hypertension BA00-BA04 Approved [61]
Cefixime DMY60I8 Acute gonococcal cervicitis Approved [55]
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Drug(s) Transported By Organic anion transporter 1 (SLC22A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [62]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [63]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [64]
Aciclovir DMYLOVR Genital herpes 1A94 Approved [64]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [64]
Cefazolin DMPDYFR Bacteremia 1A73 Approved [65]
Olmesartan medoxomil DMWBHRY High blood pressure BA00 Approved [66]
Zalcitabine DMH7MUV Human immunodeficiency virus infection 1C62 Approved [67]
FLUORESCEIN DMQTFAO Ocular disease 1F00.1Z Approved [68]
Tenofovir DM1IS6U Chronic hepatitis B virus infection Approved [69]
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Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [70]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [71]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [72]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [73]
Verapamil DMA7PEW Angina pectoris BA40 Approved [74]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [75]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [76]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [77]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [78]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [73]
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Drug(s) Metabolized By Beta-lactamase (blaB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ticarcillin DM4ME02 Aspiration pneumonia Approved [19]
Cefotaxime DMEB837 Bacteremia 1A73 Approved [17]
Ticarcillin DM4ME02 Aspiration pneumonia Approved [19]
Benzylpenicillin DMS9503 Actinomycosis Phase 3 [11]
Ticarcillin DM4ME02 Aspiration pneumonia Approved [19]
Ticarcillin DM4ME02 Aspiration pneumonia Approved [19]
Ticarcillin DM4ME02 Aspiration pneumonia Approved [19]
Cefotaxime DMEB837 Bacteremia 1A73 Approved [20]
Ampicillin DMHWE7P Acute epiglottitis Approved [79]
Piperacillin DMTBKF3 Acute gonococcal cervicitis Approved [79]
Cefalotin DMVYSLE Bacteremia 1A73 Approved [79]
Benzylpenicillin DMS9503 Actinomycosis Phase 3 [79]
Cephaloridine DM4Y95F Gram-positive bacterial infection 1B74-1G40 Withdrawn from market [79]
Imipenem DMI9FBP Bacteremia 1A73 Approved [80]
Cefazolin DMPDYFR Bacteremia 1A73 Approved [81]
Avibactam DM1AEH4 N. A. N. A. Approved [82] , [83]
Cefotaxime DMEB837 Bacteremia 1A73 Approved [81] , [82]
Cefoxitin DMY8NC4 Acute gonococcal cervicitis Approved [81]
Cefazolin DMPDYFR Bacteremia 1A73 Approved [14]
Meropenem DM62UHC Bacterial infection 1A00-1C4Z Approved [14]
Cefalotin DMVYSLE Bacteremia 1A73 Approved [84]
Benzylpenicillin DMS9503 Actinomycosis Phase 3 [11]
Cefotaxime DMEB837 Bacteremia 1A73 Approved [21]
Cefoxitin DMY8NC4 Acute gonococcal cervicitis Approved [21]
Cefotaxime DMEB837 Bacteremia 1A73 Approved [21]
Cefoxitin DMY8NC4 Acute gonococcal cervicitis Approved [21]
Cefotaxime DMEB837 Bacteremia 1A73 Approved [21]
Cefoxitin DMY8NC4 Acute gonococcal cervicitis Approved [21]
Cefotaxime DMEB837 Bacteremia 1A73 Approved [21] , [85]
Cefoxitin DMY8NC4 Acute gonococcal cervicitis Approved [21]
Cefotaxime DMEB837 Bacteremia 1A73 Approved [21]
Cefoxitin DMY8NC4 Acute gonococcal cervicitis Approved [21]
Ampicillin DMHWE7P Acute epiglottitis Approved [86]
Ticarcillin DM4ME02 Aspiration pneumonia Approved [18]
Benzylpenicillin DMS9503 Actinomycosis Phase 3 [11]
Ampicillin DMHWE7P Acute epiglottitis Approved [86]
Benzylpenicillin DMS9503 Actinomycosis Phase 3 [87]
⏷ Show the Full List of 37 Drug(s)
Drug(s) Metabolized By N-acylhomoserine lactone acylase (lacA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ampicillin DMHWE7P Acute epiglottitis Approved [13]
Cefadroxil DMMC345 Bacterial infection 1A00-1C4Z Approved [13]
Cephalexin DMD5JU8 Acute otitis media AB00 Approved [13]
Carbenicillin DMLEDNK Infection of the upper and lower urinary tract GC08 Approved [13]
Benzylpenicillin DMS9503 Actinomycosis Phase 3 [13]
Drug(s) Metabolized By New delhi metallo-beta-lactamase NDM-1 (blaNDM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meropenem DM62UHC Bacterial infection 1A00-1C4Z Approved [9]
Drug(s) Affected By HLA class II histocompatibility antigen, DQ beta 1 chain (HLA-DQB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [88]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [29]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [89]
Allopurinol DMLPAOB Gout FA25 Approved [90]
Ticlopidine DMO946V Acute coronary syndrome BA41 Approved [91]
Selenium DM25CGV N. A. N. A. Approved [92]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [29]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [93]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [94]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [29]
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Drug(s) Affected By Aldo-keto reductase family 1 member B10 (AKR1B10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [31]
Quercetin DM3NC4M Obesity 5B81 Approved [96]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [97]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [98]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [28]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [99]
Reserpine DM6VM38 Hypertension BA00-BA04 Approved [100]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [101]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [102]
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Drug(s) Affected By Sulfiredoxin-1 (SRXN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [103]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [104]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [105]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [106]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [28]
Ethacrynic acid DM60QMR Edema MG29 Approved [107]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [108]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [109]
Leflunomide DMR8ONJ Arthritis FA20 Approved [110]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [109]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [111]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [112]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [113]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [114]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [115]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [116]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [117]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [118]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [119]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [117]
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Drug(s) Affected By Organic solute transporter subunit alpha (SLC51A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [104]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [31]
Methotrexate DM2TEOL Anterior urethra cancer Approved [120]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [121]
Quercetin DM3NC4M Obesity 5B81 Approved [96]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [122]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [124]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [121]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [125]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bacterial Cell membrane (Bact CM) TTXT4D5 NOUNIPROTAC Modulator [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Peptide transporter 2 (SLC15A2) DT8QKNP S15A2_HUMAN Substrate [4]
Peptide transporter 1 (SLC15A1) DT9G7XN S15A1_HUMAN Substrate [4]
Organic anion transporter 1 (SLC22A6) DTQ23VB S22A6_HUMAN Substrate [5]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [6]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Substrate [7]
Metallo-beta-lactamase (blaM) DEK9VG2 BLAN1_KLEPN Substrate [8]
Beta-lactamase (blaB) DEW193R BLA1_KLEPN Substrate [8]
New delhi metallo-beta-lactamase NDM-1 (blaNDM) DEBGCYQ A0A345N7K5_SALET Substrate [9]
Beta-lactamase (blaB) DE7IH52 AMPC_CITFR Substrate [10]
Metallo-beta-lactamase (blaM) DEPCQ12 Q68K11_ALCXX Substrate [8]
Beta-lactamase (blaB) DEV0KWQ Q8KT52_9BACT Substrate [10] , [11]
Beta-lactamase (blaB) DEACNTL Q2F4C6_SHISO Substrate [12]
N-acylhomoserine lactone acylase (lacA) DEIU0XN A0A0A1VBK6_9BURK Substrate [13]
Beta-lactamase (blaB) DET9I1W BLAC_BACUN Substrate [14]
Beta-lactamase (blaB) DENJ2SQ BLAB_BACFG Substrate [14]
Beta-lactamase (blaB) DED0TBR A0A414M273_9BACE Substrate [15]
Beta-lactamase (blaB) DEX8KJO A6NX15_9FIRM Substrate [16]
Beta-lactamase (blaB) DEAYSTX C0W968_9FIRM Substrate [17]
Beta-lactamase (blaB) DERGEVU C3WC84_FUSMR Substrate [18] , [19]
Beta-lactamase (blaB) DEQMISO F9Z530_ODOSD Substrate [18] , [19]
Beta-lactamase (blaB) DEHFJ4G Q8KT51_9BACT Substrate [18] , [19]
Beta-lactamase (blaB) DEHPJRC Q8KT60_9BACT Substrate [18] , [19]
Beta-lactamase (blaB) DEITMS0 Q9XBM2_ACIFE Substrate [20]
Beta-lactamase (blaB) DE5HV8P A0A4Q5I6I2_9BACE Substrate [14]
Beta-lactamase (blaB) DE47ARF B5WXV2_9BACT Substrate [21]
Beta-lactamase (blaB) DEG2PK9 B5WXV3_BACOV Substrate [14]
Beta-lactamase (blaB) DEWHJ7A B5WXV7_BACT4 Substrate [14]
Beta-lactamase (blaB) DEU1RXB BLAC_BACVU Substrate [14] , [22]
Beta-lactamase (blaB) DETDS7E A0A2S0LB67_9FLAO Substrate [10]
Beta-lactamase (blaB) DE37FJH C6JIU1_FUSVA Substrate [18]
Beta-lactamase (blaB) DEC7JEF A0A1S1G219_9NEIS Substrate [10]
Beta-lactamase (blaB) DEP7MN1 Q9X4S7_PREIN Substrate [23]
Beta-lactamase (blaB) DEAILCM A0A246EJV2_9BACT Substrate [23] , [10]
Beta-lactamase (blaB) DET4XFN Q8KT59_9BACT Substrate [10]
Beta-lactamase (blaB) DEE8742 O32372_CAPOC Substrate [24]
Beta-lactamase (blaB) DEY09SU C9MN73_9BACT Substrate [10]
Beta-lactamase (blaB) DEQLVCA C9LD75_9BACT Substrate [23]
Beta-lactamase (blaB) DE2IL34 C2M7J0_CAPGI Substrate [24]
Beta-lactamase (blaB) DE1NJIW B6VMJ3_PHOAA Substrate [25] , [26]
Beta-lactamase (blaB) DEDIMN9 A0A413GBG0_9BACE Substrate [14]
Beta-lactamase (blaB) DEJ8X2W A0A412YFL9_9BACE Substrate [14]
Beta-lactamase (blaB) DEFEVNH A0A381DV31_9FLAO Substrate [24]
Beta-lactamase (blaB) DEAPGXV A0A347B2J2_9BACT Substrate [10]
Beta-lactamase (blaB) DE0PDVC A0A2A3N1K0_CAPSP Substrate [24]
Beta-lactamase (blaB) DEQL32N A0A250F962_9FLAO Substrate [24]
Beta-lactamase (blaB) DE9HF0I A0A120A1C6_BACSE Substrate [14]
Beta-lactamase (blaB) DESHI6O A0A108T9G3_9BACE Substrate [14]
Beta-lactamase (blaB) DEZS3N4 A0A069QS91_PRELO Substrate [10]
Beta-lactamase (blaB) DE5NSUX A0A095XPV0_9FIRM Substrate [10]
Beta-lactamase (blaB) DEQ1CTE A0A2T4TNV5_9BACT Substrate [27]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Aldo-keto reductase family 1 member B10 (AKR1B10) OTOA4HTH AK1BA_HUMAN Gene/Protein Processing [28]
HLA class II histocompatibility antigen, DQ beta 1 chain (HLA-DQB1) OTVVI3UI DQB1_HUMAN Gene/Protein Processing [29]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [30]
Organic solute transporter subunit alpha (SLC51A) OTDJRZ0P OSTA_HUMAN Gene/Protein Processing [31]
Sulfiredoxin-1 (SRXN1) OTYDBO4L SRXN1_HUMAN Gene/Protein Processing [28]

References

1 Amoxicillin FDA Label
2 Emerging therapies for the treatment and prevention of otitis media. Expert Opin Emerg Drugs. 2006 May;11(2):251-64.
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4 Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters. Drug Metab Dispos. 2006 Apr;34(4):547-55.
5 The anti-influenza drug oseltamivir exhibits low potential to induce pharmacokinetic drug interactions via renal secretion-correlation of in vivo and in vitro studies. Drug Metab Dispos. 2002 Jan;30(1):13-9.
6 Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
7 High-dose rabeprazole/amoxicillin therapy as the second-line regimen after failure to eradicate H. pylori by triple therapy with the usual doses of a proton pump inhibitor, clarithromycin and amoxicillin. Hepatogastroenterology. 2003 Nov-Dec;50(54):2274-8.
8 Interspecies dissemination of a mobilizable plasmid harboring blaIMP-19 and the possibility of horizontal gene transfer in a single patient. Antimicrob Agents Chemother. 2016 Aug 22;60(9):5412-9.
9 Genomic characterization of an extensively-drug resistance Salmonella enterica serotype Indiana strain harboring bla NDM-1 gene isolated from a chicken carcass in China. Microbiol Res. 2017 Nov;204:48-54.
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