Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMV2X1B)

• Drug Name: Farnesol Drug Info
• Synonyms: farnesol; 4602-84-0; Farnesyl alcohol; 3,7,11-trimethyldodeca-2,6,10-trien-1-ol; Spectrum_001282; 2,6,10-Dodecatrien-1-ol, 3,7,11-trimethyl-, (2Z,6Z)-; ACMC-20aplp; ACMC-209ukw; SpecPlus_000549; AC1L1FOK; Spectrum3_001070; Spectrum2_001397; Spectrum4_001221; KBioSS_001762; KBioGR_001682; 2,6,10-Dodecatrien-1-ol, 3,7,11-trimethyl-, (2E,6Z)-; DivK1c_006645; SPBio_001414; GTPL3215; DTXSID3032389; KBio2_006898; KBio1_001589; KBio3_001880; KBio2_004330; CTK1B4647; CTK1D5922; KBio2_001762; CTK0H6624; CTK0E6577; MolPort-006-116-336

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 445070
  ChEBI ID: CHEMBL25308
  CAS Number: CAS 4602-84-0
  TTD Drug ID: DMV2X1B

Molecule-Related Drug Atlas

Drug(s) Targeting Monoamine oxidase type B (MAO-B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selegiline Hydrochloride	DM3VR1L	Parkinson disease	8A00.0	Approved	[7]
Phenelzine	DMHIDUE	Depression	6A70-6A7Z	Approved	[8]
Tranylcypromine	DMGB5RE	Major depressive disorder	6A70.3	Approved	[9]
Selegiline	DM6034S	Major depressive disorder	6A70.3	Approved	[10]
Safinamide mesylate	DM0J2ZT	Parkinson disease	8A00.0	Approved	[11]
Rasagiline	DM3WKQ4	Parkinson disease	8A00.0	Approved	[12]
Sulphadoxine	DMZI2UF	Malaria	1F40-1F45	Approved	[13]
Pargyline	DMM0HR1	Hypertension	BA00-BA04	Approved	[14]
Indeloxazine	DMWO3N6	Dementia	6D80-6D86	Approved	[15]
Budipine	DMODHQI	Migraine	8A80	Approved	[16]

Drug(s) Affected By Long-chain fatty acid transport protein 2 (SLC27A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[17]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[18]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[21]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[22]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[23]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[24]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[25]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[26]

Drug(s) Affected By Hepatic triacylglycerol lipase (LIPC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[19]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[27]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[22]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[31]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[34]

Drug(s) Affected By Short-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[35]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[36]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[34]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[37]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[35]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[38]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[39]
CITCO	DM0N634	Discovery agent	N.A.	Investigative	[3]

Drug(s) Affected By Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[19]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[24]
Haloperidol	DM96SE0	Delirium		Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[42]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[43]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[45]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[44]

Drug(s) Affected By Phosphoenolpyruvate carboxykinase, cytosolic (PCK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[46]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[18]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[19]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[27]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[47]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[49]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[50]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]

Drug(s) Affected By Trifunctional enzyme subunit alpha, mitochondrial (HADHA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[35]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[18]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[42]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[53]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[54]
Bortezomib	DMNO38U	Leukemia		Approved	[55]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[35]

Drug(s) Affected By Protein farnesyltransferase subunit beta (CHURC1-FNTB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[57]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[45]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[58]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[59]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[60]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[61]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[19]

Drug(s) Affected By Apolipoprotein C-IV (APOC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[62]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[64]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[65]
Fenretinide	DMRD5SP	Macular degeneration	9B78.3	Phase 3	[66]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[38]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[67]
GW7647	DM9RD0C	Discovery agent	N.A.	Investigative	[3]

Drug(s) Affected By Trifunctional enzyme subunit beta, mitochondrial (HADHB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[42]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[40]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[40]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[43]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[53]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[68]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[59]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[69]

Drug(s) Affected By Protoheme IX farnesyltransferase, mitochondrial (COX10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[24]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[71]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[72]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[59]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[57]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[73]

Drug(s) Affected By Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[18]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[22]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[74]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[42]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[77]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[71]

Drug(s) Affected By Nuclear receptor subfamily 0 group B member 2 (NR0B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[78]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[79]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[17]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[81]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[79]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[82]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[83]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[19]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[79]

Drug(s) Affected By All trans-polyprenyl-diphosphate synthase PDSS1 (PDSS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[85]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[85]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[87]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[89]

Drug(s) Affected By Apolipoprotein A-V (APOA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[17]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[17]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[29]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[37]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[38]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[56]

Drug(s) Affected By Acetyl-coenzyme A thioesterase (ACOT12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[34]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]
OLEIC ACID	DM54O1Z	Discovery agent	N.A.	Investigative	[3]
GW7647	DM9RD0C	Discovery agent	N.A.	Investigative	[3]

Drug(s) Affected By Bile acid receptor (NR1H4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[17]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[90]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[93]
Nisoldipine	DM7ISKJ	Hypertension	BA00-BA04	Approved	[90]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[91]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]

Drug(s) Affected By Peroxisomal acyl-coenzyme A oxidase 2 (ACOX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[19]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[27]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[22]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[85]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[85]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]

Drug(s) Affected By Perilipin-2 (PLIN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[96]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[97]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[22]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[98]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[26]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[99]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[42]

Drug(s) Affected By Phosphatidate phosphatase LPIN3 (LPIN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[101]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[34]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[59]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[38]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[39]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[102]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[102]

Drug(s) Affected By Acetyl-CoA acetyltransferase, cytosolic (ACAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[22]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[42]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[104]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[106]

Drug(s) Affected By Stromelysin-1 (MMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[107]
Fluvastatin	DM4MDJY	Arteriosclerosis	BD40	Approved	[107]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[107]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[107]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[108]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[109]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[110]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[111]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[113]

Drug(s) Affected By C-C motif chemokine 4 (CCL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[114]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[116]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[117]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[118]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[119]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[120]

Drug(s) Affected By Fatty acid-binding protein, adipocyte (FABP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[121]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[122]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[97]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[123]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[121]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[124]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[125]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[126]

Drug(s) Affected By Serpin B3 (SERPINB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[130]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[5]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[129]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[38]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[5]

Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[132]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[133]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[134]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[135]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[133]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[133]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[136]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[137]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[135]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[133]

Drug(s) Affected By Pro-interleukin-16 (IL16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[138]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[140]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[141]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[5]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[142]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[143]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[144]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[145]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[146]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[147]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[148]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[149]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[150]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[151]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[152]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[150]

Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[153]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[155]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[158]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[159]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[160]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[161]

Drug(s) Affected By DnaJ homolog subfamily B member 4 (DNAJB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[162]
Selenium	DM25CGV	N. A.	N. A.	Approved	[35]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[19]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[114]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[163]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[164]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[165]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[166]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[167]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[162]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[168]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[169]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[170]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[171]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[172]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[173]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[174]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[175]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[176]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[177]

Drug(s) Affected By Aldo-keto reductase family 1 member B10 (AKR1B10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[17]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[19]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[53]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[178]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[179]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[180]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[182]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[183]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[184]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[185]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[186]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[187]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[188]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[189]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[170]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[190]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[191]

Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[59]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[133]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[134]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[192]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[192]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[133]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[133]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[193]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[194]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Monoamine oxidase type B (MAO-B)	TTGP7BY	AOFB_HUMAN	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Acetyl-CoA acetyltransferase, cytosolic (ACAT2)	OTZ092ZJ	THIC_HUMAN	Gene/Protein Processing	[3]
Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)	OTJC60Q7	THIL_HUMAN	Gene/Protein Processing	[3]
Acetyl-coenzyme A thioesterase (ACOT12)	OTN4RQK8	ACO12_HUMAN	Gene/Protein Processing	[3]
Aldo-keto reductase family 1 member B10 (AKR1B10)	OTOA4HTH	AK1BA_HUMAN	Biotransformations	[4]
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Gene/Protein Processing	[5]
Aldo-keto reductase family 1 member C3 (AKR1C3)	OTU2SXBA	AK1C3_HUMAN	Biotransformations	[4]
All trans-polyprenyl-diphosphate synthase PDSS1 (PDSS1)	OTXGVHAB	DPS1_HUMAN	Gene/Protein Processing	[3]
Apolipoprotein A-V (APOA5)	OTEVKLVA	APOA5_HUMAN	Gene/Protein Processing	[3]
Apolipoprotein C-IV (APOC4)	OTE8ZUXY	APOC4_HUMAN	Gene/Protein Processing	[3]
Bcl-2 homologous antagonist/killer (BAK1)	OTDP6ILW	BAK_HUMAN	Gene/Protein Processing	[6]

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