Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZO10Y)

• Drug Name: Testosterone undecanoate Drug Info
• Synonyms: Restandol (TN)

Indication

Disease Entry	ICD 11	Status	REF
Hypogonadism	5A61.0	Approved	[1]

• Cross-matching ID:
  PubChem CID: 65157
  ChEBI ID: CHEBI:135741
  CAS Number: CAS 5949-44-0
  TTD Drug ID: DMZO10Y
  INTEDE Drug ID: DR1566

Molecule-Related Drug Atlas

Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[9]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[10]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[11]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[12]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[13]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[14]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[15]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[16]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[17]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[12]

Drug(s) Metabolized By Cytochrome P450 3A7 (CYP3A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[18]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[12]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[12]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[12]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[19]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[20]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[12]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[12]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[12]
Metronidazole	DMTIVEN	Abscess		Approved	[21]

Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[22]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[6]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[6]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[19]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[23]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[24]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[25]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[6]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[26]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[27]

Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[3]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[28]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[29]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[19]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[30]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[19]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[31]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[32]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[33]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]

Drug(s) Metabolized By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[35]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[19]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[36]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[5]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[37]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[38]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[39]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[40]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[41]

Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[42]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[3]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[43]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[44]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[19]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[45]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[47]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[27]

Drug(s) Affected By Prostaglandin E synthase (PTGES)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[48]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[54]
Mestranol	DMG3F94	Contraception	QA21	Approved	[48]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[55]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[56]

Drug(s) Affected By Calcineurin B homologous protein 2 (CHP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[57]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[60]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[62]

Drug(s) Affected By Ribonuclease H1 (RNASEH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[56]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[65]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[66]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[67]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[67]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[49]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]

Drug(s) Affected By Hyaluronan mediated motility receptor (HMMR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[70]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[70]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[73]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]

Drug(s) Affected By Inactive peptidyl-prolyl cis-trans isomerase FKBP6 (FKBP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[76]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[77]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[78]

Drug(s) Affected By Immunoglobulin superfamily member 6 (IGSF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[79]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[80]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[81]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[82]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[83]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[84]

Drug(s) Affected By Serine/threonine-protein kinase Chk2 (CHEK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[85]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[86]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[87]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[88]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[89]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[90]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[73]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[91]

Drug(s) Affected By C-X-C motif chemokine 10 (CXCL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[92]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[93]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[94]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[95]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[96]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[97]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]

Drug(s) Affected By Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[99]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[100]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[103]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Pyruvic acid	DM7Q41G	Malnutrition	5B50-5B71	Approved	[104]
Topiramate	DM82Z30	Alcohol dependence	6C40.2	Approved	[105]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[105]
ABIRATERONE	DM8V75C	Prostate cancer	2C82.0	Approved	[106]

Drug(s) Affected By Inhibin alpha chain (INHA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[108]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[81]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[109]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[110]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[76]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[111]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[111]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[111]

Drug(s) Affected By Homeobox protein Hox-C6 (HOXC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[113]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[114]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[115]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[116]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[117]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[118]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[119]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[120]

Drug(s) Affected By Serglycin (SRGN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[121]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[119]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[56]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[123]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[65]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[124]

Drug(s) Affected By Gamma-interferon-inducible lysosomal thiol reductase (IFI30)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[83]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[125]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[124]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[127]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[128]

Drug(s) Affected By 15-hydroxyprostaglandin dehydrogenase (HPGD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[79]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[73]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[131]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[131]

Drug(s) Affected By Protein kinase C alpha type (PRKCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[133]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[134]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[136]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[137]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[138]

Drug(s) Affected By Insulin-like growth factor-binding protein 3 (IGFBP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[83]
Selenium	DM25CGV	N. A.	N. A.	Approved	[139]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[140]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[141]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[143]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[145]

Drug(s) Affected By Galactoside alpha-(1,2)-fucosyltransferase 1 (FUT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[147]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[148]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[149]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[124]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[128]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[150]

Drug(s) Affected By Zinc-alpha-2-glycoprotein (AZGP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[152]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[153]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[154]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[155]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[153]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[156]

Drug(s) Affected By Ciliary neurotrophic factor (CNTF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[158]
Nitrous oxide	DMTHWBI	Anxiety disorder	6B00-6B0Z	Approved	[157]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[159]

Drug(s) Affected By Olfactory receptor 10J1 (OR10J1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[160]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]

Drug(s) Affected By Protein EVI2B (EVI2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[126]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[162]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[163]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[164]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[165]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[119]

Drug(s) Affected By Thrombopoietin (THPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[124]
Methamphetamine	DMPM4SK	Anxiety		Approved	[167]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[168]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[169]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[116]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[170]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[76]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[171]

Drug(s) Affected By T-lymphocyte activation antigen CD86 (CD86)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[172]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[92]
Kanamycin	DM2DMPO	Bacteremia	1A73	Approved	[173]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[174]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[173]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[175]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[173]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]

Drug(s) Affected By CCN family member 3 (CCN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[178]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[56]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[65]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[179]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[180]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[177]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[181]

Drug(s) Affected By Granzyme K (GZMK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[182]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[183]
CHOLINE	DM5D9YK	Insomnia	7A00-7A0Z	Investigative	[184]

Drug(s) Affected By Insulin-like 3 (INSL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[185]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[124]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[81]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[185]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[186]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[187]
BADGE	DMCK5DG	Discovery agent	N.A.	Investigative	[188]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[190]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[137]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[191]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[192]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[66]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[110]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[115]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[76]

Drug(s) Affected By Growth/differentiation factor 10 (GDF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[193]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[194]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[179]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[116]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[60]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[195]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[196]

Drug(s) Affected By C-C motif chemokine 18 (CCL18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[178]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[119]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[197]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]

Drug(s) Affected By Ras-related protein Rab-1A (RAB1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[198]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[137]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[124]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[200]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[201]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[198]

Drug(s) Affected By Cdc42 effector protein 1 (CDC42EP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[202]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[190]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[55]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[127]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[169]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[203]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[116]

Drug(s) Affected By AMP deaminase 3 (AMPD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[152]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[124]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[200]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[110]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[171]

Drug(s) Affected By Desmoglein-1 (DSG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[204]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[205]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[206]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[114]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[116]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[207]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]

Drug(s) Affected By Pappalysin-1 (PAPPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[89]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[152]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[113]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[208]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[56]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[193]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[209]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[168]

Drug(s) Affected By Transformer-2 protein homolog alpha (TRA2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[210]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[175]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[158]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[190]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[211]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]

Drug(s) Affected By Deoxyribonuclease gamma (DNASE1L3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[190]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[119]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[54]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[124]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[212]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[76]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[171]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]

Drug(s) Affected By Transcription factor Dp-2 (TFDP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[198]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[213]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[214]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[54]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[65]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[215]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[216]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[160]

Drug(s) Affected By Inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[217]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[127]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[169]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]

Drug(s) Affected By Protein GREB1 (GREB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[218]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[219]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[220]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[190]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[219]
Nandrolone	DMFWKG1	Osteoporosis	FB83.0	Approved	[221]
Mestranol	DMG3F94	Contraception	QA21	Approved	[219]

Drug(s) Affected By Novel acetylcholine receptor chaperone (TMEM35A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[113]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[137]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[117]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[222]

Drug(s) Affected By Probable E3 ubiquitin-protein ligase HERC4 (HERC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[137]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[223]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[224]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[56]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[110]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[225]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[76]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[78]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[226]

Drug(s) Affected By ADP-ribosylation factor-like protein 9 (ARL9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[113]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[227]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[227]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[116]

Drug(s) Affected By Lysophospholipase D GDPD3 (GDPD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[228]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[229]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[228]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[230]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[230]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[228]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[57]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[73]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Haloperidol	DM96SE0	Delirium		Approved	[230]

Drug(s) Affected By Monocarboxylate transporter 9 (SLC16A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[113]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[191]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[55]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[56]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[127]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[114]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[115]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[225]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[231]

Drug(s) Affected By Alpha-protein kinase 2 (ALPK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[73]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[190]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[119]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[232]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[153]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[208]

Drug(s) Affected By Immunoglobulin superfamily member 1 (IGSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[233]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[137]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[124]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[234]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[110]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[171]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[156]

Drug(s) Affected By Collagen alpha-1(XXII) chain (COL22A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[235]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[110]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[171]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[116]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[171]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[83]

Drug(s) Affected By Leukocyte immunoglobulin-like receptor subfamily B member 1 (LILRB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[206]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]

Drug(s) Affected By Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (LINGO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[152]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[55]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[127]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[114]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[110]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[236]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[225]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[237]

Drug(s) Affected By F-box/LRR-repeat protein 20 (FBXL20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[189]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[227]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[216]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[200]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[114]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[110]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[171]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[76]

Drug(s) Affected By Fc receptor-like protein 5 (FCRL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[199]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]

Drug(s) Affected By Heat shock protein beta-9 (HSPB9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[178]

Drug(s) Affected By Katanin p60 ATPase-containing subunit A-like 1 (KATNAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[83]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[178]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Bortezomib	DMNO38U	Leukemia		Approved	[223]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[124]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[216]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[81]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]

Drug(s) Affected By Oxysterol-binding protein-related protein 10 (OSBPL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[233]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[56]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[193]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[238]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[124]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[227]

Drug(s) Affected By Protein maestro (MRO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[169]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[116]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[237]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[239]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[120]

Drug(s) Affected By Apoptosis facilitator Bcl-2-like protein 14 (BCL2L14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[178]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[240]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[241]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[210]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[54]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[171]
Fenretinide	DMRD5SP	Macular degeneration	9B78.3	Phase 3	[242]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]

Drug(s) Affected By Kelch-like protein 4 (KLHL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[243]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[127]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[110]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[225]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[116]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[49]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[244]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[117]

Drug(s) Affected By Chondrolectin (CHODL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[192]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[245]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[60]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[60]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[83]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[121]

Drug(s) Affected By Reticulon-4 (RTN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[190]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[113]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[137]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[124]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[169]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[110]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[225]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[76]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[246]

Drug(s) Affected By Olfactomedin-like protein 3 (OLFML3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[152]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[191]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[247]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[248]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[215]

Drug(s) Affected By Kelch-like protein 11 (KLHL11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[190]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[124]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[203]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[76]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[117]
RESORCINOL	DMM37C0	Discovery agent	N.A.	Investigative	[249]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[250]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF216 (RNF216)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[56]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[206]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[110]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[251]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[117]

Drug(s) Affected By Docking protein 5 (DOK5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[152]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[60]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[117]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[222]

Drug(s) Affected By Rho GTPase-activating protein 23 (ARHGAP23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[216]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[206]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[169]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[252]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[251]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[253]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[117]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[202]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[83]

Drug(s) Affected By Signal recognition particle subunit SRP68 (SRP68)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[137]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[124]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[254]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[202]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[255]

Drug(s) Affected By Kallikrein-13 (KLK13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[256]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[84]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[62]

Drug(s) Affected By Hippocalcin-like protein 4 (HPCAL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[257]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[137]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[208]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[258]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[116]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[171]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[83]

Drug(s) Affected By Syntaxin-binding protein 5-like (STXBP5L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[171]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[202]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform (PPP2R2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[259]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[260]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[261]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[262]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[67]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[171]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[261]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[76]

Drug(s) Affected By Sodium- and chloride-dependent glycine transporter 2 (SLC6A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[175]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]

Drug(s) Affected By Nuclear protein AMMECR1 (AMMECR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[149]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[127]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[206]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[200]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[114]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[263]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[110]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[252]

Drug(s) Affected By Atrial natriuretic peptide-converting enzyme (CORIN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[121]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[264]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[264]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[206]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[169]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[265]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[264]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[116]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[237]

Molecular Interaction Atlas of This Drug

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Substrate	[2]
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Substrate	[3]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Substrate	[4]
Cytochrome P450 2B6 (CYP2B6)	DEPKLMQ	CP2B6_HUMAN	Substrate	[5]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Substrate	[6]
Cytochrome P450 3A7 (CYP3A7)	DERD86B	CP3A7_HUMAN	Substrate	[7]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
15-hydroxyprostaglandin dehydrogenase (HPGD)	OTYZI6JB	PGDH_HUMAN	Gene/Protein Processing	[8]
ADP-ribosylation factor-like protein 9 (ARL9)	OTCP868V	ARL9_HUMAN	Gene/Protein Processing	[8]
Alpha-protein kinase 2 (ALPK2)	OTWZZDQ9	ALPK2_HUMAN	Gene/Protein Processing	[8]
AMP deaminase 3 (AMPD3)	OT5SP1KJ	AMPD3_HUMAN	Gene/Protein Processing	[8]
Apoptosis facilitator Bcl-2-like protein 14 (BCL2L14)	OT87E7HW	B2L14_HUMAN	Gene/Protein Processing	[8]
Atrial natriuretic peptide-converting enzyme (CORIN)	OT4SK7DK	CORIN_HUMAN	Gene/Protein Processing	[8]
C-C motif chemokine 18 (CCL18)	OT7JYSK9	CCL18_HUMAN	Gene/Protein Processing	[8]
C-X-C motif chemokine 10 (CXCL10)	OTTLQ6S0	CXL10_HUMAN	Gene/Protein Processing	[8]
Calcineurin B homologous protein 2 (CHP2)	OT4UMKUR	CHP2_HUMAN	Gene/Protein Processing	[8]
CCN family member 3 (CCN3)	OTOW5YL4	CCN3_HUMAN	Gene/Protein Processing	[8]

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] Human cytochrome p450 induction and inhibition potential of clevidipine and its primary metabolite h152/81. Drug Metab Dispos. 2006 May;34(5):734-7.
• [3] Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes. Arch Biochem Biophys. 1997 Oct 1;346(1):161-9.
• [4] In vitro metabolism of midazolam, triazolam, nifedipine, and testosterone by human liver microsomes and recombinant cytochromes p450: role of cyp3a4 and cyp3a5. Drug Metab Dispos. 2003 Jul;31(7):938-44.
• [5] Insights into CYP2B6-mediated drug-drug interactions. Acta Pharm Sin B. 2016 Sep;6(5):413-425.
• [6] Role of cytochrome P450 2C8 in drug metabolism and interactions. Pharmacol Rev. 2016 Jan;68(1):168-241.
• [7] Steroid hydroxylation by human fetal CYP3A7 and human NADPH-cytochrome P450 reductase coexpressed in insect cells using baculovirus. Res Commun Mol Pathol Pharmacol. 1998 Apr;100(1):15-28.
• [8] Levonorgestrel enhances spermatogenesis suppression by testosterone with greater alteration in testicular gene expression in men. Biol Reprod. 2009 Mar;80(3):484-92.
• [9] Drug related genetic polymorphisms affecting adverse reactions to methotrexate, vinblastine, doxorubicin and cisplatin in patients with urothelial cancer. J Urol. 2008 Dec;180(6):2389-95.
• [10] Human prostate CYP3A5: identification of a unique 5'-untranslated sequence and characterization of purified recombinant protein. Biochem Biophys Res Commun. 1999 Jul 14;260(3):676-81.
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