Details of Disease

General Information of Disease (ID: DISLD1RL)

• Disease Name: Encephalitis
• Synonyms: brain inflammation
• Definition: An acute inflammatory process affecting the brain parenchyma. Causes include viral infections and less frequently bacterial infections, toxins, and immune-mediated processes.
• Disease Hierarchy:
  DISB3X5A: Nervous system inflammation
  DISBV50J: Acute disease
  DISWD40R: Disease
  DIS6ZC3X: Brain disease
  DISLD1RL: Encephalitis
• Disease Identifiers:
  MONDO ID: MONDO_0019956
  MESH ID: D004660
  UMLS CUI: C0014038
  MedGen ID: 4027
  Orphanet ID: 97275
  SNOMED CT ID: 45170000

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 33 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CCR2	TTFZYTO	Limited	Biomarker	[1]
GRIA2	TTWM461	Limited	Biomarker	[2]
GRIN1	TTLD29N	Limited	Biomarker	[3]
GRM2	TTXJ47W	Limited	Biomarker	[2]
KNG1	TTDJ4MY	Disputed	Biomarker	[4]
CXCL10	TTQOVYA	moderate	Biomarker	[5]
EEF2K	TT1QFLA	moderate	Biomarker	[6]
PAOX	TTNQ760	moderate	Altered Expression	[7]
ABCB1	TT3OT40	Strong	Biomarker	[8]
APP	TTE4KHA	Strong	Altered Expression	[9]
CD46	TTMS7DF	Strong	Biomarker	[10]
CXCL11	TTWG0RE	Strong	Biomarker	[11]
CXCL13	TT0NIZ1	Strong	Biomarker	[12]
FCER2	TTCH6MU	Strong	Biomarker	[13]
GAD1	TTKGEP3	Strong	Biomarker	[14]
GFAP	TTI6FFX	Strong	Altered Expression	[15]
GRM5	TTHS256	Strong	Biomarker	[16]
GSTO1	TTWO3SH	Strong	Biomarker	[17]
IL17F	TT2B6PS	Strong	Biomarker	[18]
IL1RN	TT6GSR3	Strong	Biomarker	[19]
LAMC2	TTNS7H3	Strong	Biomarker	[20]
MBP	TT2RY5P	Strong	Biomarker	[21]
MOG	TTQAFX5	Strong	Biomarker	[22]
NFKBIA	TTSHAEB	Strong	Biomarker	[23]
NLRP1	TTQX29T	Strong	Biomarker	[24]
PSMD10	TT2H4LN	Strong	Biomarker	[17]
TCIRG1	TTVRN05	Strong	Genetic Variation	[25]
TPP2	TTQ7R2V	Strong	Genetic Variation	[26]
TSPO	TTPTXIN	Strong	Biomarker	[27]
BTK	TTGM6VW	Definitive	Genetic Variation	[28]
IRF3	TTYR7OH	Definitive	Biomarker	[29]
STAT1	TTN7R6K	Definitive	Biomarker	[30]
TLR3	TTD24Y0	Definitive	Biomarker	[31]

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
ABCD1	DTKM9DZ	Definitive	Biomarker	[32]

This Disease Is Related to 3 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
AOC2	DE8DP90	moderate	Biomarker	[33]
PRODH	DEVJIHS	moderate	Genetic Variation	[34]
SMOX	DEOH5V3	moderate	Altered Expression	[7]

This Disease Is Related to 57 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CCL8	OTCTWYN8	Limited	Altered Expression	[35]
CPT2	OTIN6G20	Limited	Genetic Variation	[36]
DPYSL5	OT6F9T6F	Limited	Genetic Variation	[37]
OAS2	OT64CCTM	Limited	Genetic Variation	[38]
PELI1	OTMLBCLC	Limited	Biomarker	[39]
CHI3L1	OT2Z7VJH	Disputed	Biomarker	[40]
DHX58	OT19BYB1	Disputed	Biomarker	[41]
PRKRA	OTUTVZZU	Disputed	Biomarker	[41]
RBBP6	OTTVG4HU	Disputed	Biomarker	[41]
AGA	OTNWT1WB	moderate	Biomarker	[42]
ALKBH3	OTS1CD9Z	moderate	Genetic Variation	[43]
AMPH	OTWPGWZX	moderate	Biomarker	[44]
ANXA13	OTM33P73	moderate	Biomarker	[45]
CDSN	OTQW4HV6	moderate	Biomarker	[46]
CTNND2	OTYKE30Y	moderate	Biomarker	[47]
DBR1	OTLTWLTE	moderate	Biomarker	[48]
ELF4	OT167PR5	moderate	Biomarker	[49]
GMFB	OTR1JN1D	moderate	Altered Expression	[50]
GRK1	OT7MPSG7	moderate	Biomarker	[51]
HLA-DRB4	OTNXIHQU	moderate	Biomarker	[52]
KCTD16	OTGSOX3C	moderate	Biomarker	[53]
NRTN	OT4PAKUY	moderate	Altered Expression	[7]
OGA	OT7ZBWT1	moderate	Biomarker	[54]
PSPN	OT54LLZJ	moderate	Altered Expression	[7]
RANBP2	OTFG5CVF	moderate	Genetic Variation	[55]
RTN1	OTCX1SMK	moderate	Biomarker	[56]
SAMHD1	OTBCIBC7	moderate	Biomarker	[57]
SNCB	OTELSEK6	moderate	Biomarker	[58]
TINAGL1	OTZZO56M	moderate	Altered Expression	[59]
TJP1	OTBDCUPK	moderate	Biomarker	[17]
TLK2	OTZ09CG8	moderate	Biomarker	[6]
AQP4	OTA9MYD5	Strong	Biomarker	[60]
ATP6V0A1	OT1IK0KA	Strong	Genetic Variation	[25]
ATP6V0A2	OTJBDX0Y	Strong	Genetic Variation	[25]
ATP6V0A4	OT149Z7Q	Strong	Genetic Variation	[25]
BCAP31	OTKSACR4	Strong	Biomarker	[17]
CABIN1	OT4G5CIK	Strong	Biomarker	[61]
DNALI1	OTTB3L8N	Strong	Biomarker	[17]
ENO2	OTRODL0T	Strong	Biomarker	[62]
GABBR1	OTU5A52J	Strong	Biomarker	[63]
GOSR1	OTX8TMVU	Strong	Biomarker	[17]
IGLON5	OTB94PY2	Strong	Biomarker	[64]
ITIH4	OT460OO1	Strong	Biomarker	[65]
KLHL2	OT1NG8V7	Strong	Biomarker	[66]
LGI1	OTPS77HO	Strong	Biomarker	[67]
NEFL	OTQESJV4	Strong	Altered Expression	[68]
NGB	OTW0SIUY	Strong	Biomarker	[69]
ORM2	OTRJGZP8	Strong	Biomarker	[70]
RAB32	OTTR4H7S	Strong	Biomarker	[71]
RELA	OTUJP9CN	Strong	Altered Expression	[72]
SARS1	OTFKXQ1O	Strong	Biomarker	[73]
SARS2	OTU4T99W	Strong	Biomarker	[73]
SMOC1	OTJG2JQY	Strong	Altered Expression	[74]
SYF2	OTY2ZW1H	Strong	Biomarker	[75]
TMED5	OT70W1J8	Strong	Biomarker	[17]
APOD	OTT77XW8	Definitive	Biomarker	[76]
CNTNAP2	OT48T2ZP	Definitive	Biomarker	[77]

References

• [1] CCR2 Plays a Protective Role in Rocio Virus-Induced Encephalitis by Promoting Macrophage Infiltration Into the Brain.J Infect Dis. 2019 May 24;219(12):2015-2025. doi: 10.1093/infdis/jiz029.
• [2] Anti--amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor GluR2 encephalitis in a myasthenia gravis patient with complete thymectomy: a case report.BMC Neurol. 2019 Jun 13;19(1):126. doi: 10.1186/s12883-019-1358-7.
• [3] Immunopathological characterization of ovarian teratomas associated with anti-N-methyl-D-aspartate receptor encephalitis.Acta Neuropathol Commun. 2019 Mar 11;7(1):38. doi: 10.1186/s40478-019-0693-7.
• [4] Kininogen Level in the Cerebrospinal Fluid May Be a Potential Biomarker for Predicting Epileptogenesis.Front Neurol. 2019 Jan 31;10:37. doi: 10.3389/fneur.2019.00037. eCollection 2019.
• [5] Etiology is the key determinant of neuroinflammation in epilepsy: Elevation of cerebrospinal fluid cytokines and chemokines in febrile infection-related epilepsy syndrome and febrile status epilepticus.Epilepsia. 2019 Aug;60(8):1678-1688. doi: 10.1111/epi.16275. Epub 2019 Jul 8.
• [6] Chemoproteomic Discovery of a Ritanserin-Targeted Kinase Network Mediating Apoptotic Cell Death of Lung Tumor Cells.Mol Pharmacol. 2018 Nov;94(5):1246-1255. doi: 10.1124/mol.118.113001. Epub 2018 Aug 29.
• [7] Analysis of neurotrophic and antioxidant factors related to midbrain dopamine neuronal loss and brain inflammation in the cerebrospinal fluid of the elderly.Exp Gerontol. 2018 Sep;110:54-60. doi: 10.1016/j.exger.2018.05.009. Epub 2018 May 19.
• [8] Downregulation of mdr1a expression in the brain and liver during CNS inflammation alters the in vivo disposition of digoxin.Br J Pharmacol. 2003 May;139(1):35-48. doi: 10.1038/sj.bjp.0705227.
• [9] EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid- oligomers and plaques.Nat Commun. 2015 Dec 8;6:8997. doi: 10.1038/ncomms9997.
• [10] Productive measles virus brain infection and apoptosis in CD46 transgenic mice.J Virol. 2000 Feb;74(3):1373-82. doi: 10.1128/jvi.74.3.1373-1382.2000.
• [11] Chemokines and matrix metalloproteinases in cerebrospinal fluid of patients with central nervous system complications caused by varicella-zoster virus.J Neuroinflammation. 2019 Feb 18;16(1):42. doi: 10.1186/s12974-019-1428-1.
• [12] CXCL13 Is A Biomarker Of Anti-Leucine-Rich Glioma-Inactivated Protein 1 Encephalitis Patients.Neuropsychiatr Dis Treat. 2019 Oct 11;15:2909-2915. doi: 10.2147/NDT.S222258. eCollection 2019.
• [13] Role of CD23 in astrocytes inflammatory reaction during HIV-1 related encephalitis. Cytokine. 2001 Jul 21;15(2):96-107. doi: 10.1006/cyto.2001.0896.
• [14] Anatomical hemispherectomy revisited-outcome, blood loss, hydrocephalus, and absence of chronic hemosiderosis.Childs Nerv Syst. 2019 Aug;35(8):1341-1349. doi: 10.1007/s00381-019-04256-3. Epub 2019 Jun 26.
• [15] Astrocytic damage in glial fibrillary acidic protein astrocytopathy during initial attack.Mult Scler Relat Disord. 2019 Apr;29:94-99. doi: 10.1016/j.msard.2019.01.036. Epub 2019 Jan 24.
• [16] Encephalitis with mGluR5 antibodies: Symptoms and antibody effects.Neurology. 2018 May 29;90(22):e1964-e1972. doi: 10.1212/WNL.0000000000005614. Epub 2018 Apr 27.
• [17] Dysregulation of sonic hedgehog pathway and pericytes in the brain after lentiviral infection.J Neuroinflammation. 2019 Apr 13;16(1):86. doi: 10.1186/s12974-019-1463-y.
• [18] The intrathecal expression and pathogenetic role of Th17 cytokines and CXCR2-binding chemokines in tick-borne encephalitis.J Neuroinflammation. 2018 Apr 20;15(1):115. doi: 10.1186/s12974-018-1138-0.
• [19] Influence of the course of brain inflammation on the endogenous IL-1beta/IL-1Ra balance in the model of brain delayed-type hypersensitivity response to bacillus Calmette-Gurin in Lewis rats.J Neuroimmunol. 2004 Apr;149(1-2):22-30. doi: 10.1016/j.jneuroim.2003.12.005.
• [20] Impact of a multiplex PCR assay (FilmArray) on the management of patients with suspected central nervous system infections.Eur J Clin Microbiol Infect Dis. 2020 Feb;39(2):293-297. doi: 10.1007/s10096-019-03724-7. Epub 2019 Nov 12.
• [21] Association between maternal periapical lesions and brain inflammation in rat pups.Arch Oral Biol. 2013 Mar;58(3):266-71. doi: 10.1016/j.archoralbio.2012.11.007. Epub 2012 Dec 12.
• [22] MOG-IgG-associated demyelination: focus on atypical features, brain histopathology and concomitant autoimmunity.J Neurol. 2020 Feb;267(2):359-368. doi: 10.1007/s00415-019-09586-5. Epub 2019 Oct 22.
• [23] The signal transduction pathways involved in hepatic cytochrome P450 regulation in the rat during a lipopolysaccharide-induced model of central nervous system inflammation.Drug Metab Dispos. 2005 Oct;33(10):1521-31. doi: 10.1124/dmd.105.004564. Epub 2005 Jul 8.
• [24] NADPH oxidase 2-mediated NLRP1 inflammasome activation involves in neuronal senescence in hippocampal neurons in vitro.Int Immunopharmacol. 2019 Apr;69:60-70. doi: 10.1016/j.intimp.2019.01.025. Epub 2019 Jan 21.
• [25] Multiple virulence factors of Cryptococcus neoformans are dependent on VPH1.Mol Microbiol. 2001 Nov;42(4):1121-31. doi: 10.1046/j.1365-2958.2001.02712.x.
• [26] Tripeptidyl-peptidase II: Update on an oldie that still counts.Biochimie. 2019 Nov;166:27-37. doi: 10.1016/j.biochi.2019.05.012. Epub 2019 May 17.
• [27] [(18) F]GE180 positron emission tomographic imaging indicates a potential double-hit insult in the intrahippocampal kainate mouse model of temporal lobe epilepsy.Epilepsia. 2018 Mar;59(3):617-626. doi: 10.1111/epi.14009. Epub 2018 Jan 24.
• [28] Debilitating progressive encephalitis in a patient with BTK deficiency.Acta Microbiol Immunol Hung. 2012 Sep;59(3):335-42. doi: 10.1556/AMicr.59.2012.3.4.
• [29] Both IRF3 and especially IRF7 play a key role to orchestrate an effective cerebral inflammatory response in a mouse model of herpes simplex virus encephalitis.J Neurovirol. 2018 Dec;24(6):761-768. doi: 10.1007/s13365-018-0666-9. Epub 2018 Aug 9.
• [30] NEMO is a key component of NF-B- and IRF-3-dependent TLR3-mediated immunity to herpes simplex virus.J Allergy Clin Immunol. 2011 Sep;128(3):610-7.e1-4. doi: 10.1016/j.jaci.2011.04.059. Epub 2011 Jul 1.
• [31] Recurrent Herpes Zoster Ophthalmicus in a Patient With a Novel Toll-Like Receptor 3 Variant Linked to Compromised Activation Capacity in Fibroblasts.J Infect Dis. 2020 Mar 28;221(8):1295-1303. doi: 10.1093/infdis/jiz229.
• [32] Cerebrospinal fluid matrix metalloproteinases are elevated in cerebral adrenoleukodystrophy and correlate with MRI severity and neurologic dysfunction.PLoS One. 2012;7(11):e50430. doi: 10.1371/journal.pone.0050430. Epub 2012 Nov 21.
• [33] Inhibition of semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 reduces lipopolysaccharide-induced neuroinflammation.Br J Pharmacol. 2017 Jul;174(14):2302-2317. doi: 10.1111/bph.13832. Epub 2017 Jun 10.
• [34] Medical and developmental risk factors of catatonia in children and adolescents: a prospective case-control study.Schizophr Res. 2012 May;137(1-3):151-8. doi: 10.1016/j.schres.2012.02.012. Epub 2012 Mar 7.
• [35] CXCL11 production in cerebrospinal fluid distinguishes herpes simplex meningitis from herpes simplex encephalitis.J Neuroinflammation. 2017 Jul 10;14(1):134. doi: 10.1186/s12974-017-0907-5.
• [36] Association of the Polymorphism of rs1799822 on Carnitine Palmitoyltransferase II Gene with Severe Enterovirus 71 Encephalitis in Chinese Children.J Mol Neurosci. 2019 Oct;69(2):188-196. doi: 10.1007/s12031-019-01348-2. Epub 2019 Jun 14.
• [37] Inflammatory flaccid myelitis in a patient with both anti-CRMP-5 IgG and CNS HIV escape.BMJ Case Rep. 2019 May 21;12(5):e228378. doi: 10.1136/bcr-2018-228378.
• [38] Polymorphism of OAS2 rs739901 C/A Involves the Susceptibility to EV71 Infection in Chinese Children.Curr Med Sci. 2018 Aug;38(4):640-647. doi: 10.1007/s11596-018-1925-y. Epub 2018 Aug 20.
• [39] Peli1 facilitates virus replication and promotes neuroinflammation during West Nile virus infection.J Clin Invest. 2018 Nov 1;128(11):4980-4991. doi: 10.1172/JCI99902. Epub 2018 Sep 24.
• [40] Chitinase-3-like protein 1 may be a potential biomarker in patients with drug-resistant epilepsy.Neurochem Int. 2019 Mar;124:62-67. doi: 10.1016/j.neuint.2018.12.013. Epub 2018 Dec 22.
• [41] PACT is required for MDA5-mediated immunoresponses triggered by Cardiovirus infection via interaction with LGP2.Biochem Biophys Res Commun. 2017 Dec 9;494(1-2):227-233. doi: 10.1016/j.bbrc.2017.10.048. Epub 2017 Oct 12.
• [42] Antigliadin Antibodies (AGA IgG) Are Related to Neurochemistry in Schizophrenia.Front Psychiatry. 2017 Jun 19;8:104. doi: 10.3389/fpsyt.2017.00104. eCollection 2017.
• [43] Cerebrospinal fluid T cell frequency is age-related: a case-control study of 435 children with inflammatory and non-inflammatory neurological disorders.Clin Exp Immunol. 2018 Jul;193(1):103-112. doi: 10.1111/cei.13122. Epub 2018 Mar 24.
• [44] Paraneoplastic autoimmune movement disorders.Parkinsonism Relat Disord. 2017 Nov;44:106-109. doi: 10.1016/j.parkreldis.2017.08.017. Epub 2017 Oct 13.
• [45] Utilisation of ISA Reverse Genetics and Large-Scale Random Codon Re-Encoding to Produce Attenuated Strains of Tick-Borne Encephalitis Virus within Days.PLoS One. 2016 Aug 22;11(8):e0159564. doi: 10.1371/journal.pone.0159564. eCollection 2016.
• [46] Novel treatment with neuroprotective and antiviral properties against a neuroinvasive human respiratory virus.J Virol. 2014 Feb;88(3):1548-63. doi: 10.1128/JVI.02972-13. Epub 2013 Nov 13.
• [47] Environmental Correlation Analysis for Genes Associated with Protection against Malaria.Mol Biol Evol. 2016 May;33(5):1188-204. doi: 10.1093/molbev/msw004. Epub 2016 Jan 6.
• [48] Human SNORA31 variations impair cortical neuron-intrinsic immunity to HSV-1 and underlie herpes simplex encephalitis.Nat Med. 2019 Dec;25(12):1873-1884. doi: 10.1038/s41591-019-0672-3. Epub 2019 Dec 5.
• [49] ELF4 is critical for induction of type I interferon and the host antiviral response.Nat Immunol. 2013 Dec;14(12):1237-46. doi: 10.1038/ni.2756. Epub 2013 Nov 3.
• [50] First description of enhanced expression of glia maturation factor-beta in experimental toxoplasmic encephalitis.J Int Med Res. 2017 Dec;45(6):1670-1679. doi: 10.1177/0300060517700320. Epub 2017 Aug 4.
• [51] Rho-mediated regulation of tight junctions during monocyte migration across the blood-brain barrier in HIV-1 encephalitis (HIVE).Blood. 2006 Jun 15;107(12):4770-80. doi: 10.1182/blood-2005-11-4721. Epub 2006 Feb 14.
• [52] Anti-LGI1 encephalitis is strongly associated with HLA-DR7 and HLA-DRB4.Ann Neurol. 2017 Feb;81(2):193-198. doi: 10.1002/ana.24858. Epub 2017 Jan 27.
• [53] The expanded clinical spectrum of anti-GABABR encephalitis and added value of KCTD16 autoantibodies.Brain. 2019 Jun 1;142(6):1631-1643. doi: 10.1093/brain/awz094.
• [54] Conditional expression of human -hexosaminidase in the neurons of Sandhoff disease rescues mice from neurodegeneration but not neuroinflammation.J Neuroinflammation. 2012 Aug 4;9:186. doi: 10.1186/1742-2094-9-186.
• [55] Influenza-Associated Acute Necrotizing Encephalopathy in Siblings.J Pediatric Infect Dis Soc. 2018 Aug 17;7(3):e172-e177. doi: 10.1093/jpids/piy033.
• [56] Encephalitis is mediated by ROP18 of Toxoplasma gondii, a severe pathogen in AIDS patients.Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):E5344-E5352. doi: 10.1073/pnas.1801118115. Epub 2018 May 21.
• [57] Lentiviral infection of proliferating brain macrophages in HIV and simian immunodeficiency virus encephalitis despite sterile alpha motif and histidine-aspartate domain-containing protein 1 expression.AIDS. 2018 May 15;32(8):965-974. doi: 10.1097/QAD.0000000000001793.
• [58] -synuclein at the "synapse" of encephalitis and neurodegeneration in multiple sclerosis?.Immunol Cell Biol. 2019 Jul;97(6):523-525. doi: 10.1111/imcb.12270. Epub 2019 Jun 12.
• [59] The inhibitory role of intracellular free zinc in the regulation of Arg-1 expression in interleukin-4-induced activation of M2 microglia.Metallomics. 2018 Oct 17;10(10):1501-1509. doi: 10.1039/c8mt00248g. Epub 2018 Sep 12.
• [60] Encephalitis is an important clinical component of myelin oligodendrocyte glycoprotein antibody associated demyelination: a single-center cohort study in Shanghai, China.Eur J Neurol. 2019 Jan;26(1):168-174. doi: 10.1111/ene.13790. Epub 2018 Sep 24.
• [61] Posterior reversible encephalopathy syndrome concurrent with human herpesvirus-6B encephalitis after allogeneic hematopoietic stem cell transplantation.J Infect Chemother. 2020 Feb;26(2):265-268. doi: 10.1016/j.jiac.2019.07.016. Epub 2019 Aug 14.
• [62] Serum time course of two brain-specific proteins, alpha(1) brain globulin and neuron-specific enolase, in tick-born encephalitis and Lyme disease.Clin Chim Acta. 2002 Jun;320(1-2):117-25. doi: 10.1016/s0009-8981(02)00057-8.
• [63] Neuroimmunological antibody-mediated encephalitis and implications for diagnosis and therapy in neuropsychiatry.Acta Neuropsychiatr. 2020 Aug;32(4):177-185. doi: 10.1017/neu.2019.50. Epub 2019 Dec 3.
• [64] IgLON5-Associated Encephalitis With Atypical Brain Magnetic Resonance Imaging and Cerebrospinal Fluid Changes.Front Neurol. 2018 May 17;9:329. doi: 10.3389/fneur.2018.00329. eCollection 2018.
• [65] Peroxisome proliferator-activated receptor-gamma: potential molecular therapeutic target for HIV-1-associated brain inflammation.J Neuroinflammation. 2017 Sep 8;14(1):183. doi: 10.1186/s12974-017-0957-8.
• [66] A Protective Role for Interleukin-1 Signaling during Mouse Adenovirus Type 1-Induced Encephalitis.J Virol. 2017 Jan 31;91(4):e02106-16. doi: 10.1128/JVI.02106-16. Print 2017 Feb 15.
• [67] Randomized Placebo-Controlled Trial of Intravenous Immunoglobulin in Autoimmune LGI1/CASPR2 Epilepsy.Ann Neurol. 2020 Feb;87(2):313-323. doi: 10.1002/ana.25655. Epub 2019 Dec 14.
• [68] Serum and CSF neurofilament light chain levels in antibody-mediated encephalitis.J Neurol. 2019 Jul;266(7):1643-1648. doi: 10.1007/s00415-019-09306-z. Epub 2019 Apr 3.
• [69] [Expression of neuroglobin in rats with brain injury induced by LPS].Zhonghua Shao Shang Za Zhi. 2009 Jun;25(3):222-6.
• [70] Astrocytic Orosomucoid-2 Modulates Microglial Activation and Neuroinflammation.J Neurosci. 2017 Mar 15;37(11):2878-2894. doi: 10.1523/JNEUROSCI.2534-16.2017. Epub 2017 Feb 13.
• [71] Rab32 connects ER stress to mitochondrial defects in multiple sclerosis.J Neuroinflammation. 2017 Jan 23;14(1):19. doi: 10.1186/s12974-016-0788-z.
• [72] Myeloid-Related Protein 8/14 Participates in the Progression of Experimental Pneumococcal Meningitis by Augmentation of Inflammation.J Mol Neurosci. 2019 Aug;68(4):631-639. doi: 10.1007/s12031-019-01314-y. Epub 2019 May 2.
• [73] Strategies of highly pathogenic RNA viruses to block dsRNA detection by RIG-I-like receptors: hide, mask, hit.Antiviral Res. 2013 Dec;100(3):615-35. doi: 10.1016/j.antiviral.2013.10.002. Epub 2013 Oct 12.
• [74] OAS Gene Family Expression Is Associated with HIV-Related Neurocognitive Disorders.Mol Neurobiol. 2018 Mar;55(3):1905-1914. doi: 10.1007/s12035-017-0460-3. Epub 2017 Feb 24.
• [75] Upregulation of SYF2 is associated with neuronal apoptosis caused by reactive astrogliosis to neuroinflammation.J Neurosci Res. 2014 Mar;92(3):318-28. doi: 10.1002/jnr.23312. Epub 2013 Dec 2.
• [76] Neuroprotective effect of apolipoprotein D against human coronavirus OC43-induced encephalitis in mice.J Neurosci. 2008 Oct 8;28(41):10330-8. doi: 10.1523/JNEUROSCI.2644-08.2008.
• [77] Daratumumab treatment for therapy-refractory anti-CASPR2 encephalitis.J Neurol. 2020 Feb;267(2):317-323. doi: 10.1007/s00415-019-09585-6. Epub 2019 Oct 19.