Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTW29JC4)

• DOT Name: Gamma-crystallin D (CRYGD)
• Synonyms: Gamma-D-crystallin; Gamma-crystallin 4
• Gene Name: CRYGD
• Related Disease:
  Anxiety
  Anxiety disorder
  Lung adenocarcinoma
  Adult respiratory distress syndrome
  Advanced cancer
  Anemia
  Ataxia-telangiectasia
  Autoimmune disease
  Cataract 2, multiple types
  Cataract 20 multiple types
  Cataract 4 multiple types
  Cataract 9 multiple types
  Clear cell renal carcinoma
  Coagulation defect
  Colitis
  Dementia
  Depression
  Hepatitis C virus infection
  Juvenile idiopathic arthritis
  Lung cancer
  Lung carcinoma
  Male infertility
  Multiple sclerosis
  Neoplasm
  Neuroblastoma
  Osteoarthritis
  Paraganglioma
  Propionic acidemia
  Prostate cancer
  Prostate carcinoma
  Renal cell carcinoma
  Schizophrenia
  Systemic lupus erythematosus
  Systemic sclerosis
  Ulcerative colitis
  Cardiovascular disease
  Periodontitis
  Thyroid cancer
  Thyroid gland carcinoma
  Thyroid tumor
  Cataract - microcornea syndrome
  Cerulean cataract
  Early-onset lamellar cataract
  Early-onset nuclear cataract
  Obsolete coralliform cataract
  Pulverulent cataract
  Subarachnoid hemorrhage
  Chromosomal disorder
  Synovitis
  Type-1 diabetes
• UniProt ID: CRGD_HUMAN
• PDB ID: 1H4A; 1HK0; 2G98; 2KFB; 2KLJ; 4GR7; 4JGF; 6ETA; 6ETC; 6W5B; 6WCY; 7P53; 8BD0; 8BPI
• Pfam ID: PF00030
• Sequence:
  MGKITLYEDRGFQGRHYECSSDHPNLQPYLSRCNSARVDSGCWMLYEQPNYSGLQYFLRR
  GDYADHQQWMGLSDSVRSCRLIPHSGSHRIRLYEREDYRGQMIEFTEDCSCLQDRFRFNE
  IHSLNVLEGSWVLYELSNYRGRQYLLMPGDYRRYQDWGATNARVGSLRRVIDFS
• Function: Crystallins are the dominant structural components of the vertebrate eye lens.

Molecular Interaction Atlas (MIA) of This DOT

50 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance	REF
Anxiety	DISIJDBA	Definitive	Biomarker	[1]
Anxiety disorder	DISBI2BT	Definitive	Biomarker	[1]
Lung adenocarcinoma	DISD51WR	Definitive	Altered Expression	[2]
Adult respiratory distress syndrome	DISIJV47	Strong	Biomarker	[3]
Advanced cancer	DISAT1Z9	Strong	Biomarker	[4]
Anemia	DISTVL0C	Strong	Biomarker	[5]
Ataxia-telangiectasia	DISP3EVR	Strong	Biomarker	[6]
Autoimmune disease	DISORMTM	Strong	Biomarker	[7]
Cataract 2, multiple types	DISF9EJ8	Strong	Biomarker	[8]
Cataract 20 multiple types	DISN0IHS	Strong	Biomarker	[9]
Cataract 4 multiple types	DISZBGUD	Strong	Autosomal dominant	[10]
Cataract 9 multiple types	DIS9JQ8P	Strong	Genetic Variation	[11]
Clear cell renal carcinoma	DISBXRFJ	Strong	Biomarker	[12]
Coagulation defect	DIS9X3H6	Strong	Biomarker	[13]
Colitis	DISAF7DD	Strong	Biomarker	[14]
Dementia	DISXL1WY	Strong	Altered Expression	[15]
Depression	DIS3XJ69	Strong	Biomarker	[16]
Hepatitis C virus infection	DISQ0M8R	Strong	Biomarker	[17]
Juvenile idiopathic arthritis	DISQZGBV	Strong	Biomarker	[18]
Lung cancer	DISCM4YA	Strong	Genetic Variation	[19]
Lung carcinoma	DISTR26C	Strong	Genetic Variation	[19]
Male infertility	DISY3YZZ	Strong	Biomarker	[20]
Multiple sclerosis	DISB2WZI	Strong	Genetic Variation	[21]
Neoplasm	DISZKGEW	Strong	Biomarker	[22]
Neuroblastoma	DISVZBI4	Strong	Genetic Variation	[12]
Osteoarthritis	DIS05URM	Strong	Altered Expression	[23]
Paraganglioma	DIS2XXH5	Strong	Biomarker	[24]
Propionic acidemia	DIS56N48	Strong	Genetic Variation	[25]
Prostate cancer	DISF190Y	Strong	Altered Expression	[26]
Prostate carcinoma	DISMJPLE	Strong	Altered Expression	[26]
Renal cell carcinoma	DISQZ2X8	Strong	Biomarker	[12]
Schizophrenia	DISSRV2N	Strong	Genetic Variation	[27]
Systemic lupus erythematosus	DISI1SZ7	Strong	Biomarker	[6]
Systemic sclerosis	DISF44L6	Strong	Biomarker	[28]
Ulcerative colitis	DIS8K27O	Strong	Altered Expression	[29]
Cardiovascular disease	DIS2IQDX	moderate	Biomarker	[30]
Periodontitis	DISI9JOI	moderate	Altered Expression	[31]
Thyroid cancer	DIS3VLDH	moderate	Genetic Variation	[32]
Thyroid gland carcinoma	DISMNGZ0	moderate	Genetic Variation	[32]
Thyroid tumor	DISLVKMD	moderate	Genetic Variation	[32]
Cataract - microcornea syndrome	DISL51AQ	Supportive	Autosomal dominant	[33]
Cerulean cataract	DIS5D1OI	Supportive	Autosomal dominant	[34]
Early-onset lamellar cataract	DISR7WXX	Supportive	Autosomal dominant	[35]
Early-onset nuclear cataract	DISGIHUY	Supportive	Autosomal dominant	[36]
Obsolete coralliform cataract	DIS7J5IH	Supportive	Autosomal dominant	[37]
Pulverulent cataract	DISMJ2AH	Supportive	Autosomal dominant	[38]
Subarachnoid hemorrhage	DISI7I8Y	Disputed	Biomarker	[39]
Chromosomal disorder	DISM5BB5	Limited	Genetic Variation	[40]
Synovitis	DISW2GPY	Limited	Biomarker	[41]
Type-1 diabetes	DIS7HLUB	Limited	Biomarker	[42]

2 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Oxidized glutathione	DM9EQC0	Approved	Oxidized glutathione increases the oxidation of Gamma-crystallin D (CRYGD).	[9]
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene affects the methylation of Gamma-crystallin D (CRYGD).	[44]

References

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• [34] Gamma-D crystallin gene (CRYGD) mutation causes autosomal dominant congenital cerulean cataracts. J Med Genet. 2003 Apr;40(4):262-7. doi: 10.1136/jmg.40.4.262.
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