Details of Disease

General Information of Disease (ID: DISI9JOI)

Disease Name Periodontitis
Synonyms periodontosis; chronic pericementitis; inflammation of periodontium; periodontium inflammation
Disease Class DA0C: Periodontal disease
Definition An acute or chronic inflammatory process that affects the tissues that surround and support the teeth.
Disease Hierarchy
DISJQHVN: Periodontal disease
DIS184KT: Skin inflammation
DISWD40R: Disease
DISI9JOI: Periodontitis
ICD Code
ICD-11
ICD-11: DA0C
ICD-10
ICD-10: K05.4
ICD-9
ICD-9: 523.5
Expand ICD-11
'DA0C.2
Expand ICD-10
'K05.4
Expand ICD-9
523.5
Disease Identifiers
MONDO ID
MONDO_0005076
MESH ID
D010518
UMLS CUI
C0031099
MedGen ID
45815
HPO ID
HP:0000704
SNOMED CT ID
41565005

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 4 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Bupivacaine DM4PRFC Approved Small molecular drug [1]
Epinephrine DM3KJBC Approved Small molecular drug [2]
Lidocaine DML4ZOT Approved Small molecular drug [3]
Minocycline DMVN5OH Approved Small molecular drug [4]
------------------------------------------------------------------------------------
This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Trafermin DMLKI2B Phase 3 NA [5]
------------------------------------------------------------------------------------
This Disease is Treated as An Indication in 1 Investigative Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Sharon-3000 DM84ESF Investigative NA [6]
------------------------------------------------------------------------------------

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 92 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
APOH TT2OUI9 Limited Biomarker [7]
CMKLR1 TT4UGZL Limited Altered Expression [8]
FFAR1 TTB8FUC Limited Altered Expression [9]
GHRHR TTG4R8V Limited Genetic Variation [10]
GIPR TTYMKBE Limited Biomarker [11]
HDC TTV9GOF Limited Altered Expression [12]
IL31 TT1RJXK Limited Biomarker [13]
ITGAE TTH0Z37 Limited Altered Expression [14]
ITGB6 TTKQSXZ Limited Altered Expression [15]
KCNQ5 TTWVL5Q Limited Genetic Variation [16]
MRGPRX2 TT3YV20 Limited Biomarker [17]
NEK7 TTJ5SWP Limited Biomarker [18]
NLRC5 TTWZC78 Limited Biomarker [19]
P2RX1 TTJW7B3 Limited Biomarker [20]
P2RX3 TT2THBD Limited Biomarker [20]
PANK3 TTFBUWA Limited Biomarker [21]
PLG TTP86E2 Limited Altered Expression [22]
QPCT TTJ7YTV Limited Biomarker [23]
SMAD6 TTON5JB Limited Posttranslational Modification [24]
SOST TTYRO4F Limited Altered Expression [25]
SSTR2 TTZ6T9E Limited Altered Expression [26]
TBX21 TTNF9PH Limited Genetic Variation [27]
TNFSF12 TTBTDM1 Limited Altered Expression [28]
YOD1 TTFSH0K Limited Biomarker [21]
ITGB2 TTIJWR7 Disputed Biomarker [11]
BIRC5 TTTPU1G moderate Genetic Variation [29]
C5 TTKANGO moderate Genetic Variation [30]
CCR1 TTC24WT moderate Biomarker [31]
CD1A TTBGTFN moderate Altered Expression [32]
CTSG TTQAJF1 moderate Biomarker [33]
F2RL1 TTQR74A moderate Altered Expression [34]
FPR1 TT5Y4EM moderate Biomarker [35]
HAX1 TT21BYA moderate Genetic Variation [36]
HMGB1 TTWQYB7 moderate Altered Expression [37]
IL12RB2 TT4SWR8 moderate Genetic Variation [38]
IL17A TTG0MT6 moderate Altered Expression [39]
IL17F TT2B6PS moderate Biomarker [40]
IL1R2 TT51DEV moderate Genetic Variation [41]
MFGE8 TT1GLAJ moderate Biomarker [42]
NCR1 TTQNRJM moderate Biomarker [43]
PLTP TTZF6SN moderate Altered Expression [44]
PNP TTMCF1Y moderate Altered Expression [45]
PTGES2 TTWU04I moderate Biomarker [46]
SLAMF7 TT7ILZ1 moderate Biomarker [43]
TYRO3 TTIEMFN moderate Altered Expression [47]
ADRB1 TTR6W5O Strong Biomarker [48]
AGER TTMO9HF Strong Biomarker [49]
BSG TT5UJWD Strong Biomarker [50]
CAMP TTULOB6 Strong Biomarker [51]
CASP1 TTCQIBE Strong Biomarker [52]
CCR5 TTJIH8Q Strong Genetic Variation [53]
CDK9 TT1LVF2 Strong Biomarker [54]
CSF1 TT0IQER Strong Biomarker [55]
CTSC TT4H0V2 Strong Genetic Variation [56]
CTSS TTUMQVO Strong Altered Expression [57]
CXCL2 TTZF0K2 Strong Biomarker [58]
ELANE TTPLTSQ Strong Biomarker [59]
FCGR2A TTXT21W Strong Genetic Variation [60]
GGT1 TTZVT7O Strong Biomarker [61]
GIP TT40HS5 Strong Altered Expression [62]
IGFBP5 TTDWEA8 Strong Biomarker [63]
IL11 TTGUYTR Strong Altered Expression [64]
IL13 TT0GVCH Strong Genetic Variation [65]
LBP TTVQJLY Strong Biomarker [66]
LTA TTP73TM Strong Genetic Variation [67]
MMP7 TTMTWOS Strong Biomarker [68]
MSMB TTYH1ZK Strong Biomarker [69]
NAMPT TTD1WIG Strong Altered Expression [70]
NTRK1 TTTDVOJ Strong Biomarker [71]
PADI4 TTQHAXM Strong Altered Expression [72]
POSTN TT8ALTZ Strong Biomarker [73]
PPARA TTJ584C Strong Biomarker [74]
PTPN2 TTY8PUS Strong Biomarker [75]
S100A8 TT4AF6N Strong Biomarker [76]
S100A9 TT0TMQG Strong Biomarker [76]
SLC52A2 TT6TKEN Strong Biomarker [77]
TLR1 TTW14D0 Strong Genetic Variation [78]
TNFRSF11A TT3K9S2 Strong Biomarker [79]
TNFSF13 TTOI1RM Strong Biomarker [80]
TNFSF13B TTWMIDN Strong Biomarker [80]
TREM1 TTHZQP0 Strong Biomarker [81]
TREM2 TTQRMSJ Strong Altered Expression [82]
VCAM1 TTHCEF6 Strong Genetic Variation [83]
VIP TTGTWLF Strong Altered Expression [84]
CTSK TTDZN01 Definitive Biomarker [85]
FCGR2B TT5RWKQ Definitive Genetic Variation [86]
FCGR3A TTIFOC0 Definitive Genetic Variation [60]
INPP5D TTTP2Z1 Definitive Genetic Variation [87]
LTF TTSZDQU Definitive Genetic Variation [88]
NOD2 TTYPUHA Definitive Biomarker [89]
PCSK9 TTNIZ2B Definitive Biomarker [90]
PRTN3 TT5MLC4 Definitive Biomarker [91]
------------------------------------------------------------------------------------
⏷ Show the Full List of 92 DTT(s)
This Disease Is Related to 4 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
ABCC11 DTWN7FC Limited Biomarker [92]
SLC50A1 DTI9CQU Limited Genetic Variation [93]
SLC7A9 DTP7AEQ Strong Genetic Variation [67]
SLC52A1 DT7NOKR Definitive Altered Expression [34]
------------------------------------------------------------------------------------
This Disease Is Related to 3 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
ACP5 DESITDW Limited Altered Expression [94]
LPO DEHX1DZ Limited Altered Expression [95]
SULT1A1 DEYWLRK moderate Biomarker [96]
------------------------------------------------------------------------------------
This Disease Is Related to 114 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
ADAMTS7 OTVKZ1DV Limited Genetic Variation [97]
ASPN OTYJM80N Limited Biomarker [98]
AZU1 OTHXU264 Limited Altered Expression [99]
BFAR OTTBG0V7 Limited Biomarker [100]
CAMTA1 OTAN1S5B Limited Biomarker [101]
CCL25 OTLWJ8CJ Limited Biomarker [102]
CCRL2 OT5PX0RX Limited Altered Expression [8]
CD200R1 OT65Q9M6 Limited Biomarker [103]
CD81 OTQFXNAZ Limited Altered Expression [104]
CRISP3 OTBSWMPL Limited Genetic Variation [105]
DCSTAMP OTFKRP2H Limited Biomarker [106]
DDOST OT39PDMS Limited Altered Expression [107]
DDX53 OTHK3EGZ Limited Biomarker [108]
DEFA1 OT5N1B9B Limited Genetic Variation [109]
DEFA4 OTOQWE4C Limited Altered Expression [110]
DLX5 OTEEFBEU Limited Genetic Variation [108]
DRAM1 OTIJTXEN Limited Biomarker [111]
EDIL3 OTDVVNS0 Limited Biomarker [112]
ENO3 OT3HYKYI Limited Biomarker [113]
FASTK OTTHFZMP Limited Genetic Variation [114]
GPR141 OTJ8WSSW Limited Genetic Variation [16]
HAP1 OT6SG0JQ Limited Genetic Variation [115]
HPX OT14T7Q1 Limited Biomarker [116]
HSPA4L OT181WZB Limited Biomarker [21]
IBSP OT29944Y Limited Genetic Variation [117]
IL17C OTKXIVNQ Limited Biomarker [102]
IL22RA2 OTGOFDCY Limited Biomarker [118]
KLRB1 OTQ2959Y Limited Biomarker [119]
LEPROT OT2EENVA Limited Altered Expression [120]
LRBA OTOUZN9G Limited Biomarker [121]
MAEA OTPA2FDE Limited Genetic Variation [122]
MIXL1 OT584VOQ Limited Biomarker [123]
MSX2 OT1WDKE1 Limited Biomarker [124]
MTG1 OTC9U1LI Limited Genetic Variation [125]
NFYA OTWFFOVH Limited Genetic Variation [115]
NLRC4 OTAIA3NA Limited Biomarker [126]
NLRP10 OTDNZDA0 Limited Biomarker [127]
NLRP6 OTEREN4W Limited Altered Expression [128]
NME8 OT4RULP5 Limited Genetic Variation [16]
P2RX2 OT0LF34A Limited Biomarker [20]
P2RX6 OT1FNTXA Limited Biomarker [20]
PLPPR4 OTBOWTC5 Limited Altered Expression [129]
RCN1 OT3JBGAG Limited Altered Expression [130]
SDC3 OT1P0LJM Limited Altered Expression [131]
SH3BP2 OT90JNBS Limited Biomarker [132]
SLIT3 OTU8MKEU Limited Biomarker [133]
SOCS6 OT2O5ZBK Limited Biomarker [134]
STAT2 OTO9G2RZ Limited Biomarker [135]
TCF12 OTZVONNU Limited Genetic Variation [105]
TOB2 OTEEHL60 Limited Biomarker [136]
ADGRE1 OTQQ9Q7G moderate Genetic Variation [137]
C1QA OT6XKVVA moderate Altered Expression [138]
CRACR2A OTJUGSVE moderate Genetic Variation [139]
CRYGD OTW29JC4 moderate Altered Expression [140]
DEFB1 OT5SV0E4 moderate Genetic Variation [141]
DEFB103B OT8RWY64 moderate Altered Expression [142]
DEFB104A OTLQZR6K moderate Altered Expression [143]
DHX40 OTOL02QN moderate Altered Expression [144]
DSC1 OTNII6GZ moderate Biomarker [145]
DSC3 OTYG47F8 moderate Biomarker [145]
DSG1 OT11HC3A moderate Altered Expression [145]
FGB OT6RKLI9 moderate Genetic Variation [146]
GCHFR OTEOT8GI moderate Altered Expression [147]
GTF2H5 OTRL219S moderate Genetic Variation [148]
JCHAIN OTR8M5TX moderate Biomarker [149]
JMJD6 OTILR7E4 moderate Biomarker [150]
LAD1 OT6YGTVX moderate Biomarker [151]
MCM3AP OT895FEC moderate Genetic Variation [152]
NCR2 OT2H13BX moderate Biomarker [43]
NKAIN2 OTI4H30Z moderate Genetic Variation [29]
PADI2 OTT40K94 moderate Altered Expression [72]
PI3 OT47MTC3 moderate Biomarker [153]
PLEK OTB73XXA moderate Altered Expression [154]
PTGES3 OTPPQWI0 moderate Biomarker [46]
PTPRA OTZA82J1 moderate Biomarker [155]
RCAN1 OT1MVXC7 moderate Biomarker [145]
S100A2 OTTGHJ1H moderate Biomarker [156]
SFXN1 OTL66767 moderate Genetic Variation [157]
SPIB OTO4YKYI moderate Altered Expression [158]
TENM2 OTPLUYEF moderate Genetic Variation [159]
TGM4 OTORRCG6 moderate Genetic Variation [160]
ANP32B OT3SQMLU Strong Biomarker [80]
CLDN1 OT27KV99 Strong Biomarker [161]
DDX39A OT0Z6E1K Strong Genetic Variation [67]
DDX39B OTEVCFVU Strong Genetic Variation [67]
DMP1 OTBWBWW7 Strong Biomarker [162]
FAM20A OT5Z5IW8 Strong Genetic Variation [163]
FAM20C OTW5YZ7X Strong Genetic Variation [163]
GCFC2 OTC7FRXL Strong Biomarker [164]
HNRNPL OT0DJX74 Strong Biomarker [165]
HSPA14 OTZCA5LK Strong Biomarker [166]
KRT13 OTTYSKGX Strong Biomarker [167]
LMLN OTQF0JPY Strong Biomarker [69]
MFSD1 OTPRRXCX Strong Biomarker [168]
MLKL OTDSLC81 Strong Biomarker [169]
NFATC1 OT4TMERS Strong Altered Expression [170]
NFKBIL1 OTYFTPS0 Strong Genetic Variation [67]
ODAM OTT666SJ Strong Biomarker [171]
PTX3 OTPXHRKU Strong Altered Expression [172]
RARRES2 OT1BJE8K Strong Altered Expression [8]
RNASE3 OTVE2XD1 Strong Biomarker [12]
RTL1 OTOT33IM Strong Altered Expression [173]
SERPINF2 OTZGAF8B Strong Biomarker [174]
SETMAR OTE2MIMZ Strong Altered Expression [173]
SFRP5 OTLCVVSH Strong Biomarker [175]
SIGLEC5 OTYC440J Strong Genetic Variation [152]
THNSL2 OTLXYPYV Strong Altered Expression [176]
TIMP3 OTDGQAD1 Strong Altered Expression [177]
TIMP4 OT8A68SW Strong Altered Expression [178]
TLL1 OTK9NM7G Strong Biomarker [162]
TMPRSS13 OTMAOAP3 Strong Biomarker [69]
COL25A1 OT7M23Z9 Definitive Biomarker [179]
IL34 OTZ15VVK Definitive Biomarker [55]
OLFM1 OTOYPEWW Definitive Biomarker [179]
------------------------------------------------------------------------------------
⏷ Show the Full List of 114 DOT(s)

References

1 Bupivacaine FDA Label
2 Epinephrine FDA Label
3 Lidocaine FDA Label
4 Minocycline FDA Label
5 Emerging drugs for diabetic foot ulcers. Expert Opin Emerg Drugs. 2006 Nov;11(4):709-24.
6 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
7 Anticardiolipin (aCL) in sera from periodontitis subjects activate Toll-like receptor 4 (TLR4).PLoS One. 2018 Sep 7;13(9):e0203494. doi: 10.1371/journal.pone.0203494. eCollection 2018.
8 Evaluation of chemerin and its receptors, ChemR23 and CCRL2, in gingival tissues with healthy and periodontitis.Odontology. 2018 Jan;106(1):29-36. doi: 10.1007/s10266-017-0297-2. Epub 2017 Feb 23.
9 Upregulation of free fatty acid receptors in periodontal tissues of patients with metabolic syndrome and periodontitis.J Periodontal Res. 2019 Aug;54(4):356-363. doi: 10.1111/jre.12636. Epub 2018 Dec 30.
10 Immunological and microbiological periodontal profiles in isolated growth hormone deficiency.J Periodontol. 2018 Nov;89(11):1351-1361. doi: 10.1002/JPER.17-0687. Epub 2018 Sep 11.
11 Anti-inflammatory role of glucose-dependent insulinotropic polypeptide in periodontitis.J Diabetes Investig. 2016 Jul;7(4):497-505. doi: 10.1111/jdi.12450. Epub 2016 Jan 7.
12 Eosinophil cationic protein and histamine production by neutrophils from patients with periodontitis.J Periodontol. 2018 Feb;89(2):228-234. doi: 10.1902/jop.2017.160679. Epub 2018 Feb 20.
13 Porphyromonas gingivalis induces the production of interleukin-31 by human mast cells, resulting in dysfunction of the gingival epithelial barrier.Cell Microbiol. 2019 Mar;21(3):e12972. doi: 10.1111/cmi.12972. Epub 2018 Nov 28.
14 Resident memory T cells: Possible players in periodontal disease recurrence.J Periodontal Res. 2020 Apr;55(2):324-330. doi: 10.1111/jre.12709. Epub 2019 Nov 2.
15 Inflammasome and cytokine expression profiling in experimental periodontitis in the integrin 6 null mouse.Cytokine. 2019 Feb;114:135-142. doi: 10.1016/j.cyto.2018.11.011. Epub 2018 Nov 19.
16 A genome-wide association study of periodontitis in a Japanese population.J Dent Res. 2015 Apr;94(4):555-61. doi: 10.1177/0022034515570315. Epub 2015 Feb 11.
17 Differential Regulation of Mas-Related G Protein-Coupled Receptor X2-Mediated Mast Cell Degranulation by Antimicrobial Host Defense Peptides and Porphyromonas gingivalis Lipopolysaccharide.Infect Immun. 2017 Sep 20;85(10):e00246-17. doi: 10.1128/IAI.00246-17. Print 2017 Oct.
18 Metformin ameliorates experimental diabetic periodontitis independently of mammalian target of rapamycin (mTOR) inhibition by reducing NIMA-related kinase 7 (Nek7) expression.J Periodontol. 2019 Sep;90(9):1032-1042. doi: 10.1002/JPER.18-0528. Epub 2019 Jul 1.
19 NLRC5 polymorphism is associated with susceptibility to chronic periodontitis.Immunobiology. 2017 May;222(5):704-708. doi: 10.1016/j.imbio.2017.01.001. Epub 2017 Jan 12.
20 The purinergic receptor P2X5 contributes to bone loss in experimental periodontitis.BMB Rep. 2018 Sep;51(9):468-473. doi: 10.5483/BMBRep.2018.51.9.126.
21 Integrated analysis of long noncoding RNA-associated competing endogenous RNA network in periodontitis.J Periodontal Res. 2018 Aug;53(4):495-505. doi: 10.1111/jre.12539. Epub 2018 Mar 8.
22 Serum, salivary, and tissue levels of plasminogen in familial Mediterranean fever, amyloidosis, and chronic periodontitis.J Periodontol. 2018 Apr;89(4):456-465. doi: 10.1002/JPER.17-0243. Epub 2018 Feb 27.
23 Expression of human and Porphyromonas gingivalis glutaminyl cyclases in periodontitis and rheumatoid arthritis-A pilot study.Arch Oral Biol. 2019 Jan;97:223-230. doi: 10.1016/j.archoralbio.2018.10.022. Epub 2018 Oct 28.
24 Smad6 Methylation Represses NFB Activation and Periodontal Inflammation.J Dent Res. 2018 Jul;97(7):810-819. doi: 10.1177/0022034518755688. Epub 2018 Feb 8.
25 Advanced glycation end-product 2 and Porphyromonas gingivalis lipopolysaccharide increase sclerostin expression in mouse osteocyte-like cells.Bone. 2019 May;122:22-30. doi: 10.1016/j.bone.2019.02.001. Epub 2019 Feb 5.
26 Regulation of somatostatin receptor 2 by proinflammatory, microbial and obesity-related signals in periodontal cells and tissues.Head Face Med. 2019 Jan 4;15(1):2. doi: 10.1186/s13005-018-0185-1.
27 TBX21-1993T/C (rs4794067) polymorphism is associated with increased risk of chronic periodontitis and increased T-bet expression in periodontal lesions, but does not significantly impact the IFN-g transcriptional level or the pattern of periodontophatic bacterial infection.Virulence. 2015;6(3):293-304. doi: 10.1080/21505594.2015.1029828.
28 Evaluation of gingival crevicular fluid and peri-implant crevicular fluid levels of sclerostin, TWEAK, RANKL and OPG.Cytokine. 2019 Jan;113:433-439. doi: 10.1016/j.cyto.2018.10.021. Epub 2018 Oct 28.
29 Genome-wide association study of chronic periodontitis in a general German population.J Clin Periodontol. 2013 Nov;40(11):977-85. doi: 10.1111/jcpe.12154. Epub 2013 Sep 11.
30 Single nucleotide polymorphisms of complement component 5 and periodontitis.J Periodontal Res. 2010 Jun;45(3):301-8. doi: 10.1111/j.1600-0765.2009.01234.x. Epub 2009 Nov 9.
31 Prioritization of candidate genes for periodontitis using multiple computational tools.J Periodontol. 2014 Aug;85(8):1059-69. doi: 10.1902/jop.2014.130523. Epub 2014 Jan 30.
32 Induction of the CD1a Langerhans cell marker on human monocytes.Arch Oral Biol. 1995 Feb;40(2):157-60. doi: 10.1016/0003-9969(94)00152-2.
33 Neutrophil serine proteinases activate human nonepithelial cells to produce inflammatory cytokines through protease-activated receptor 2.J Immunol. 2003 Jun 1;170(11):5690-6. doi: 10.4049/jimmunol.170.11.5690.
34 PAR-2 expression in the gingival crevicular fluid reflects chronic periodontitis severity.Braz Oral Res. 2017 Jan 26;31:e16. doi: 10.1590/1807-3107BOR-2017.vol31.0016.
35 Genetic polymorphisms and periodontal disease in populations of African descent: A review.J Periodontal Res. 2018 Apr;53(2):164-173. doi: 10.1111/jre.12505. Epub 2017 Nov 5.
36 Mutations in the ELANE gene are associated with development of periodontitis in patients with severe congenital neutropenia.J Clin Immunol. 2011 Dec;31(6):936-45. doi: 10.1007/s10875-011-9572-0. Epub 2011 Jul 29.
37 Effect of combined periodontal-orthodontic treatment on NOD-like receptor protein 3 and high mobility group box-1 expressions in patients with periodontitis and its clinical significance.Medicine (Baltimore). 2019 Nov;98(44):e17724. doi: 10.1097/MD.0000000000017724.
38 Polymorphisms in the 5' flanking region of IL12RB2 are associated with susceptibility to periodontal diseases in the Japanese population.J Clin Periodontol. 2008 Apr;35(4):317-23. doi: 10.1111/j.1600-051X.2008.01208.x.
39 Functional assessment of peptide-modified PLGA nanoparticles against oral biofilms in a murine model of periodontitis.J Control Release. 2019 Mar 10;297:3-13. doi: 10.1016/j.jconrel.2019.01.036. Epub 2019 Jan 25.
40 Assessment of microRNA-144-5p and its putative targets in inflamed gingiva from chronic periodontitis patients.J Periodontal Res. 2019 Jun;54(3):266-277. doi: 10.1111/jre.12627. Epub 2018 Nov 18.
41 Interleukin-1 receptor gene variants are associated with aggressive periodontitis in the Japanese.Arch Oral Biol. 2014 Jul;59(7):756-63. doi: 10.1016/j.archoralbio.2014.04.006. Epub 2014 Apr 20.
42 Regulation of osteoclast homeostasis and inflammatory bone loss by MFG-E8.J Immunol. 2014 Aug 1;193(3):1383-91. doi: 10.4049/jimmunol.1400970. Epub 2014 Jun 23.
43 Role of the NK cell-activating receptor CRACC in periodontitis.Infect Immun. 2013 Mar;81(3):690-6. doi: 10.1128/IAI.00895-12. Epub 2012 Dec 17.
44 SAA and PLTP activity in plasma of periodontal patients before and after full-mouth tooth extraction.Oral Dis. 2008 Sep;14(6):514-9. doi: 10.1111/j.1601-0825.2007.01411.x.
45 Purine nucleoside phosphorylase activity and expression are upregulated in sites affected by periodontal disease.J Periodontal Res. 2010 Oct;45(5):664-71. doi: 10.1111/j.1600-0765.2010.01282.x. Epub 2010 Jun 20.
46 Expression of prostaglandin E synthases in periodontitis immunolocalization and cellular regulation.Am J Pathol. 2011 Apr;178(4):1676-88. doi: 10.1016/j.ajpath.2010.12.048.
47 The Pros1/Tyro3 axis protects against periodontitis by modulating STAT/SOCS signalling.J Cell Mol Med. 2019 Apr;23(4):2769-2781. doi: 10.1111/jcmm.14183. Epub 2019 Feb 7.
48 Pro-apoptotic effect of anti-1-adrenergic receptor antibodies in periodontitis patients.Int Immunopharmacol. 2012 Dec;14(4):710-21. doi: 10.1016/j.intimp.2012.10.011. Epub 2012 Oct 25.
49 Inhibition of Periodontitis Induction Using a Stimuli-Responsive Hydrogel Carrying Naringin.J Periodontol. 2017 Feb;88(2):190-196. doi: 10.1902/jop.2016.160189. Epub 2016 Oct 14.
50 The role of extracellular matrix metalloproteinase inducer glycosylation in regulating matrix metalloproteinases in periodontitis.J Periodontal Res. 2018 Jun;53(3):391-402. doi: 10.1111/jre.12524. Epub 2018 Jan 5.
51 LL-37-induced human osteoblast cytotoxicity and permeability occurs independently of cellular LL-37 uptake through clathrin-mediated endocytosis.Biochem Biophys Res Commun. 2018 Jun 18;501(1):280-285. doi: 10.1016/j.bbrc.2018.04.235. Epub 2018 May 5.
52 Cranberry Proanthocyanidins Neutralize the Effects of Aggregatibacter actinomycetemcomitans Leukotoxin.Toxins (Basel). 2019 Nov 14;11(11):662. doi: 10.3390/toxins11110662.
53 CCR532 (rs333) polymorphism is associated with decreased risk of chronic and aggressive periodontitis: A case-control analysis based in disease resistance and susceptibility phenotypes.Cytokine. 2018 Mar;103:142-149. doi: 10.1016/j.cyto.2017.09.022. Epub 2017 Sep 30.
54 TLR4 gene in the regulation of periodontitis and its molecular mechanism.Exp Ther Med. 2019 Sep;18(3):1961-1966. doi: 10.3892/etm.2019.7809. Epub 2019 Jul 24.
55 Expression of colony-stimulating factor 1 and interleukin-34 in gingival tissue and gingival fibroblasts from periodontitis patients and controls.J Periodontol. 2020 Jun;91(6):828-835. doi: 10.1002/JPER.19-0296. Epub 2020 Jan 20.
56 Papillon-Lefvre syndrome with homozygous nonsense mutation of cathepsin C gene presenting with late-onset periodontitis.Pediatr Dermatol. 2015 Mar-Apr;32(2):292-4. doi: 10.1111/pde.12357. Epub 2014 Jun 3.
57 Role of Cathepsin S in Periodontal Inflammation and Infection.Mediators Inflamm. 2017;2017:4786170. doi: 10.1155/2017/4786170. Epub 2017 Dec 6.
58 Irsogladine maleate regulates neutrophil migration and E-cadherin expression in gingival epithelium stimulated by Aggregatibacter actinomycetemcomitans.Biochem Pharmacol. 2010 May 15;79(10):1496-505. doi: 10.1016/j.bcp.2010.01.017. Epub 2010 Jan 22.
59 Aggregatibacter actinomycetemcomitans induces detachment and death of human gingival epithelial cells and fibroblasts via elastase release following leukotoxin-dependent neutrophil lysis.Microbiol Immunol. 2019 Mar;63(3-4):100-110. doi: 10.1111/1348-0421.12672. Epub 2019 Mar 27.
60 Associations between FCGR2A rs1801274, FCGR3A rs396991, FCGR3B NA1/NA2 polymorphisms and periodontitis: a meta-analysis.Mol Biol Rep. 2013 Aug;40(8):4985-93. doi: 10.1007/s11033-013-2599-y. Epub 2013 May 7.
61 The influence of gingival margin recession on loss of clinical attachment in alcohol-dependent patients without medical disorders.J Periodontol. 2003 Apr;74(4):485-93. doi: 10.1902/jop.2003.74.4.485.
62 Periodontitis affects glucoregulatory hormones in severely obese individuals.Int J Obes (Lond). 2019 May;43(5):1125-1129. doi: 10.1038/s41366-018-0253-4. Epub 2018 Nov 19.
63 Local application of IGFBP5 protein enhanced periodontal tissue regeneration via increasing the migration, cell proliferation and osteo/dentinogenic differentiation of mesenchymal stem cells in an inflammatory niche.Stem Cell Res Ther. 2017 Sep 29;8(1):210. doi: 10.1186/s13287-017-0663-6.
64 Interleukin-11, interleukin-1beta, interleukin-12 and the pathogenesis of inflammatory periodontal diseases.J Clin Periodontol. 2008 May;35(5):365-70. doi: 10.1111/j.1600-051X.2008.01212.x.
65 IL-13 -1112 polymorphism and periodontitis susceptibility: a meta-analysis.BMC Oral Health. 2018 Feb 7;18(1):21. doi: 10.1186/s12903-018-0481-y.
66 Altered gene expression in gingival tissues and enhanced bone loss in rats with diabetes with experimental periodontitis.J Periodontol. 2014 Mar;85(3):455-64. doi: 10.1902/jop.2013.120705. Epub 2013 Jun 3.
67 Genetic variation on the BAT1-NFKBIL1-LTA region of major histocompatibility complex class III associates with periodontitis. Infect Immun. 2014 May;82(5):1939-48.
68 Matrix metalloproteinase-7 in periodontitis with type 2 diabetes mellitus.J Periodontal Res. 2018 Oct;53(5):916-923. doi: 10.1111/jre.12583. Epub 2018 Jul 4.
69 Relationship between severity of periodontitis and masseter muscle activity during waking and sleeping hours.Arch Oral Biol. 2018 Jun;90:13-18. doi: 10.1016/j.archoralbio.2018.02.021. Epub 2018 Mar 1.
70 NAMPT enzyme activity regulates catabolic gene expression in gingival fibroblasts during periodontitis.Exp Mol Med. 2017 Aug 18;49(8):e368. doi: 10.1038/emm.2017.116.
71 Salivary and serum biomarkers of inflammation in a man with metastatic medullary thyroid carcinoma and hyperreactive gingiva: a fourteen year odyssey.Biotech Histochem. 2019 Aug;94(6):389-397. doi: 10.1080/10520295.2019.1649463. Epub 2019 Aug 19.
72 Increased citrullination and expression of peptidylarginine deiminases independently of P. gingivalis and A. actinomycetemcomitans in gingival tissue of patients with periodontitis.J Transl Med. 2018 Jul 31;16(1):214. doi: 10.1186/s12967-018-1588-2.
73 Periostin as a modulator of chronic cardiac remodeling after myocardial infarction.Clinics (Sao Paulo). 2013 Oct;68(10):1344-9. doi: 10.6061/clinics/2013(10)09.
74 WY-14643, a Potent Peroxisome Proliferator Activator Receptor- PPAR- Agonist Ameliorates the Inflammatory Process Associated to Experimental Periodontitis.PPAR Res. 2010;2010:193019. doi: 10.1155/2010/193019. Epub 2010 Dec 27.
75 Tyrosine-protein phosphatase non-receptor type 2 inhibits alveolar bone resorption in diabetic periodontitis via dephosphorylating CSF1 receptor.J Cell Mol Med. 2019 Oct;23(10):6690-6699. doi: 10.1111/jcmm.14545. Epub 2019 Aug 2.
76 Salivary S100 proteins screen periodontitis among Korean adults.J Clin Periodontol. 2019 Feb;46(2):181-188. doi: 10.1111/jcpe.13059. Epub 2019 Jan 28.
77 The role of toll-like and protease-activated receptors and associated intracellular signaling in Porphyromonas gingivalis-infected gingival fibroblasts.APMIS. 2017 Feb;125(2):157-169. doi: 10.1111/apm.12645.
78 Pattern recognition receptor polymorphisms in early periodontitis.J Periodontol. 2019 Jun;90(6):647-654. doi: 10.1002/JPER.18-0547. Epub 2018 Dec 19.
79 Evaluation of the effect of topical and systemic ozone application in periodontitis: an experimental study in rats.J Appl Oral Sci. 2019 Nov 28;28:e20190140. doi: 10.1590/1678-7757-2019-0140. eCollection 2020.
80 The emerging roles of B cells as partners and targets in periodontitis.Autoimmunity. 2017 Feb;50(1):61-70. doi: 10.1080/08916934.2016.1261841. Epub 2016 Dec 26.
81 TREM-1 Is Upregulated in Experimental Periodontitis, and Its Blockade Inhibits IL-17A and RANKL Expression and Suppresses Bone loss.J Clin Med. 2019 Oct 1;8(10):1579. doi: 10.3390/jcm8101579.
82 Increased expression of triggering receptor expressed on myeloid cells 1 and 2 in inflamed human gingiva.J Periodontal Res. 2017 Jun;52(3):512-521. doi: 10.1111/jre.12417. Epub 2016 Sep 14.
83 Evaluation of ICAM-1 and VCAM-1 Gene Polymorphisms in Patients with Periodontal Disease.Med Sci Monit. 2016 Jul 8;22:2386-91. doi: 10.12659/msm.896979.
84 Salivary neuropeptides, stress, and periodontitis.J Periodontol. 2018 Jan;89(1):9-18. doi: 10.1902/jop.2017.170249.
85 Inhibition of Ctsk modulates periodontitis with arthritis via downregulation of TLR9 and autophagy.Cell Prolif. 2020 Jan;53(1):e12722. doi: 10.1111/cpr.12722. Epub 2019 Nov 18.
86 Association of the FcRIIB-nt645+25A/G polymorphism with the expression level of the FcRIIb receptor, the antibody response to Porphyromonas gingivalis and the severity of periodontitis.J Periodontal Res. 2012 Feb;47(1):105-13. doi: 10.1111/j.1600-0765.2011.01411.x. Epub 2011 Sep 12.
87 Age-dependent distribution of periodontitis in two countries: Findings from NHANES 2009 to 2014 and SHIP-TREND 2008 to 2012.J Clin Periodontol. 2018 Jun;45 Suppl 20:S130-S148. doi: 10.1111/jcpe.12944.
88 LTF and DEFB1 polymorphisms are associated with susceptibility toward chronic periodontitis development.Oral Dis. 2017 Oct;23(7):1001-1008. doi: 10.1111/odi.12689. Epub 2017 Jun 5.
89 Intracellular adhesion molecule-1 is regulated by porphyromonas gingivalis through nucleotide binding oligomerization domain-containing proteins 1 and 2 molecules in periodontal fibroblasts.J Periodontol. 2014 Feb;85(2):358-68. doi: 10.1902/jop.2013.130152. Epub 2013 May 20.
90 Increased serum PCSK9, a potential biomarker to screen for periodontitis, and decreased total bilirubin associated with probing depth in a Japanese community survey.J Periodontal Res. 2018 Jun;53(3):446-456. doi: 10.1111/jre.12533. Epub 2018 Mar 8.
91 Proinflammatory cytokines induce proteinase 3 as membrane-bound and secretory forms in human oral epithelial cells and antibodies to proteinase 3 activate the cells through protease-activated receptor-2.J Immunol. 2004 Sep 15;173(6):4179-89. doi: 10.4049/jimmunol.173.6.4179.
92 Salivary chromogranin A and myeloid-related protein-8/14 from periodontitis patients with type 2 diabetes.Quintessence Int. 2019;50(10):808-814. doi: 10.3290/j.qi.a43233.
93 The ratios of pro-inflammatory to anti-inflammatory cytokines in the serum of chronic periodontitis patients with and without type 2 diabetes and/or smoking habit.Clin Oral Investig. 2019 Feb;23(2):641-650. doi: 10.1007/s00784-018-2471-5. Epub 2018 May 8.
94 Effect of locally administered novel biodegradable chitosan based risedronate/zinc-hydroxyapatite intra-pocket dental film on alveolar bone density in rat model of periodontitis.J Biomater Sci Polym Ed. 2018 Jan;29(1):74-91. doi: 10.1080/09205063.2017.1400145. Epub 2017 Nov 8.
95 Association of salivary peroxidase activity and concentration with periodontal health: A validity study.J Clin Periodontol. 2017 Aug;44(8):803-812. doi: 10.1111/jcpe.12754. Epub 2017 Jul 5.
96 Effect of the interleukin-1 genotype on monocyte IL-1beta expression in subjects with adult periodontitis.J Periodontal Res. 2000 Jun;35(3):172-7. doi: 10.1034/j.1600-0765.2000.035003172.x.
97 Genome-wide association meta-analysis of coronary artery disease and periodontitis reveals a novel shared risk locus.Sci Rep. 2018 Sep 12;8(1):13678. doi: 10.1038/s41598-018-31980-8.
98 Periodontal ligament-associated protein-1 gets involved in experimental periodontitis.J Periodontal Res. 2019 Apr;54(2):180-189. doi: 10.1111/jre.12618. Epub 2018 Oct 8.
99 Azurocidin in gingival crevicular fluid as a potential biomarker of chronic periodontitis.J Periodontal Res. 2020 Apr;55(2):209-214. doi: 10.1111/jre.12703. Epub 2019 Oct 14.
100 BAR-encapsulated nanoparticles for the inhibition and disruption of Porphyromonas gingivalis-Streptococcus gordonii biofilms.J Nanobiotechnology. 2018 Sep 15;16(1):69. doi: 10.1186/s12951-018-0396-4.
101 Genetic evidence for PLASMINOGEN as a shared genetic risk factor of coronary artery disease and periodontitis.Circ Cardiovasc Genet. 2015 Feb;8(1):159-67. doi: 10.1161/CIRCGENETICS.114.000554. Epub 2014 Dec 2.
102 Epigenetic characteristics in inflammatory candidate genes in aggressive periodontitis.Hum Immunol. 2016 Jan;77(1):71-75. doi: 10.1016/j.humimm.2015.10.007. Epub 2015 Oct 21.
103 Gingival Tissue Inflammation Promotes Increased Matrix Metalloproteinase-12 Production by CD200R(low) Monocyte-Derived Cells in Periodontitis.J Immunol. 2017 Dec 15;199(12):4023-4035. doi: 10.4049/jimmunol.1700672. Epub 2017 Nov 3.
104 Decreased salivary concentration of CD9 and CD81 exosome-related tetraspanins may be associated with the periodontal clinical status.J Clin Periodontol. 2019 Apr;46(4):470-480. doi: 10.1111/jcpe.13099. Epub 2019 Apr 15.
105 Salivary Cytokine Biomarker Concentrations in Relation to Obesity and Periodontitis.J Clin Med. 2019 Dec 5;8(12):2152. doi: 10.3390/jcm8122152.
106 DC-STAMP Is an Osteoclast Fusogen Engaged in Periodontal Bone Resorption.J Dent Res. 2017 Jun;96(6):685-693. doi: 10.1177/0022034517690490. Epub 2017 Feb 15.
107 Soluble Forms of the Receptor for Advanced Glycation Endproducts (RAGE) in Periodontitis.Sci Rep. 2019 Jun 3;9(1):8170. doi: 10.1038/s41598-019-44608-2.
108 Transcriptome analysis of periodontitis-associated fibroblasts by CAGE sequencing identified DLX5 and RUNX2 long variant as novel regulators involved in periodontitis.Sci Rep. 2016 Sep 20;6:33666. doi: 10.1038/srep33666.
109 A genome-wide association study identifies nucleotide variants at SIGLEC5 and DEFA1A3 as risk loci for periodontitis.Hum Mol Genet. 2017 Jul 1;26(13):2577-2588. doi: 10.1093/hmg/ddx151.
110 Antimicrobial peptide gene expression in periodontitis patients: A pilot study.J Clin Periodontol. 2018 May;45(5):524-537. doi: 10.1111/jcpe.12879. Epub 2018 Mar 23.
111 Damage-regulated autophagy modulator 1 in oral inflammation and infection.Clin Oral Investig. 2018 Nov;22(8):2933-2941. doi: 10.1007/s00784-018-2381-6. Epub 2018 Feb 13.
112 DEL-1-Regulated Immune Plasticity and Inflammatory Disorders.Trends Mol Med. 2019 May;25(5):444-459. doi: 10.1016/j.molmed.2019.02.010. Epub 2019 Mar 15.
113 Dysbiosis in chronic periodontitis: Key microbial players and interactions with the human host.Sci Rep. 2017 Jun 16;7(1):3703. doi: 10.1038/s41598-017-03804-8.
114 Genomewide Association Study Identifies Cxcl Family Members as Partial Mediators of LPS-Induced Periodontitis.J Bone Miner Res. 2018 Aug;33(8):1450-1463. doi: 10.1002/jbmr.3440. Epub 2018 May 22.
115 The ATC/TTC haplotype in the Interleukin 8 gene in response to Gram-negative bacteria: A pilot study.Arch Oral Biol. 2019 Nov;107:104508. doi: 10.1016/j.archoralbio.2019.104508. Epub 2019 Jul 24.
116 Assessing a multiplex-targeted proteomics approach for the clinical diagnosis of periodontitis using saliva samples.Bioanalysis. 2018 Jan;10(1):35-45. doi: 10.4155/bio-2017-0218. Epub 2017 Dec 15.
117 Periodontal diagnosis in the context of the BSP implementation plan for the 2017 classification system of periodontal diseases and conditions: presentation of a patient with a history of periodontal treatment.Br Dent J. 2019 Feb;226(4):265-267. doi: 10.1038/s41415-019-0015-2.
118 Temporal expression of interleukin-22, interleukin-22 receptor 1 and interleukin-22-binding protein during experimental periodontitis in rats.J Periodontal Res. 2018 Apr;53(2):250-257. doi: 10.1111/jre.12512. Epub 2017 Oct 28.
119 Interleukin-17-producing Tcells and interleukin-17 mRNA expression in periodontitis and long-standing gingivitis lesions.J Periodontol. 2019 May;90(5):516-521. doi: 10.1002/JPER.18-0326. Epub 2019 Jan 8.
120 Upregulated Leptin in Periodontitis Promotes Inflammatory Cytokine Expression in Periodontal Ligament Cells.J Periodontol. 2015 Jul;86(7):917-26. doi: 10.1902/jop.2015.150030. Epub 2015 Apr 16.
121 Life in the fast lane: Settled pastoralism in the Central Eurasian Steppe during the Middle Bronze Age.Am J Hum Biol. 2018 Jul;30(4):e23129. doi: 10.1002/ajhb.23129. Epub 2018 Apr 19.
122 MAEA rs6815464 polymorphism and periodontitis in postmenopausal Japanese females: A cross-sectional study.Arch Oral Biol. 2019 Jun;102:128-134. doi: 10.1016/j.archoralbio.2019.04.008. Epub 2019 Apr 15.
123 Indications for Extraction before Implant Therapy: Focus on Endodontic Status.J Endod. 2019 May;45(5):532-537. doi: 10.1016/j.joen.2019.01.008. Epub 2019 Mar 8.
124 Experimental periodontitis in Msx2 mutant mice induces alveolar bone necrosis.J Periodontol. 2020 May;91(5):693-704. doi: 10.1002/JPER.16-0435. Epub 2019 Oct 15.
125 Periodontal disease, peri-implant disease and levels of salivary biomarkers IL-1, IL-10, RANK, OPG, MMP-2, TGF- and TNF-: follow-up over 5 years.J Appl Oral Sci. 2019 Feb 21;27:e20180316. doi: 10.1590/1678-7757-2018-0316.
126 NLRC4 inflammasome has a protective role on inflammatory bone resorption in a murine model of periodontal disease.Immunobiology. 2020 Jan;225(1):151855. doi: 10.1016/j.imbio.2019.10.004. Epub 2019 Nov 30.
127 Involvement of NLRP10 in IL-1 induction of oral epithelial cells by periodontal pathogens.Innate Immun. 2017 Oct;23(7):569-577. doi: 10.1177/1753425917722610. Epub 2017 Aug 2.
128 NLRP6 Induces Pyroptosis by Activation of Caspase-1 in Gingival Fibroblasts.J Dent Res. 2018 Nov;97(12):1391-1398. doi: 10.1177/0022034518775036. Epub 2018 May 23.
129 Porphyromonas gingivalis Tyrosine Phosphatase Php1 Promotes Community Development and Pathogenicity.mBio. 2019 Sep 24;10(5):e02004-19. doi: 10.1128/mBio.02004-19.
130 Loss of alveolar bone density in postmenopausal, osteopenic women is associated with circulating levels of gelatinases.J Periodontal Res. 2019 Oct;54(5):525-532. doi: 10.1111/jre.12656. Epub 2019 Apr 29.
131 Soluble syndecan-3 binds chemokines, reduces leukocyte migration in vitro and ameliorates disease severity in models of rheumatoid arthritis.Arthritis Res Ther. 2019 Jul 12;21(1):172. doi: 10.1186/s13075-019-1939-2.
132 Alveolar Bone Protection by Targeting the SH3BP2-SYK Axis in Osteoclasts.J Bone Miner Res. 2020 Feb;35(2):382-395. doi: 10.1002/jbmr.3882. Epub 2019 Oct 24.
133 Gingival crevicular fluid levels of SLIT3 are increased in periodontal disease.Oral Dis. 2020 Jan;26(1):182-192. doi: 10.1111/odi.13227. Epub 2019 Nov 26.
134 Abnormal expression of long noncoding RNA FGD5-AS1 affects the development of periodontitis through regulating miR-142-3p/SOCS6/NF-B pathway.Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):2098-2106. doi: 10.1080/21691401.2019.1620256.
135 Preventive effects of the novel antimicrobial peptide Nal-P-113 in a rat Periodontitis model by limiting the growth of Porphyromonas gingivalis and modulating IL-1 and TNF- production.BMC Complement Altern Med. 2017 Aug 29;17(1):426. doi: 10.1186/s12906-017-1931-9.
136 MicroRNA-543 functions as an osteogenesis promoter in human periodontal ligament-derived stem cells by inhibiting transducer of ERBB2, 2.J Periodontal Res. 2018 Oct;53(5):832-841. doi: 10.1111/jre.12572. Epub 2018 May 31.
137 Exploring the genetic basis of chronic periodontitis: a genome-wide association study.Hum Mol Genet. 2013 Jun 1;22(11):2312-24. doi: 10.1093/hmg/ddt065. Epub 2013 Mar 4.
138 Amyloid beta (A4) precursor protein expression in human periodontitis-affected gingival tissues.Arch Oral Biol. 2014 Jun;59(6):586-94. doi: 10.1016/j.archoralbio.2014.03.004. Epub 2014 Mar 19.
139 A genome-wide association study identifies an association between variants in EFCAB4B gene and periodontal disease in an Italian isolated population.J Periodontal Res. 2018 Dec;53(6):992-998. doi: 10.1111/jre.12598. Epub 2018 Oct 4.
140 Rheumatoid arthritis and periodontal disease.Joint Bone Spine. 2010 Dec;77(6):537-41. doi: 10.1016/j.jbspin.2010.04.015. Epub 2010 Jun 19.
141 Association between Periodontitis and Gene polymorphisms of hBD-1 and CD14: a meta-analysis.Arch Oral Biol. 2019 Aug;104:141-149. doi: 10.1016/j.archoralbio.2019.05.029. Epub 2019 Jun 1.
142 EB 2017 Article: Changes in advanced glycation end products, beta-defensin-3, and interleukin-17 during diabetic periodontitis development in rhesus monkeys.Exp Biol Med (Maywood). 2018 May;243(8):684-694. doi: 10.1177/1535370218766512. Epub 2018 Mar 27.
143 Beta-defensin-2 genomic copy number variation and chronic periodontitis.J Dent Res. 2013 Nov;92(11):1035-40. doi: 10.1177/0022034513504217. Epub 2013 Sep 9.
144 The peptidylarginine deiminase gene is a conserved feature of Porphyromonas gingivalis.Sci Rep. 2015 Sep 25;5:13936. doi: 10.1038/srep13936.
145 Altered gene expression in leukocyte transendothelial migration and cell communication pathways in periodontitis-affected gingival tissues.J Periodontal Res. 2011 Jun;46(3):345-53. doi: 10.1111/j.1600-0765.2011.01349.x. Epub 2011 Mar 7.
146 Association of increased levels of fibrinogen and the -455G/A fibrinogen gene polymorphism with chronic periodontitis.J Periodontol. 2003 Mar;74(3):329-37. doi: 10.1902/jop.2003.74.3.329.
147 Elevated expression of IL-17 and IL-12 genes in chronic inflammatory periodontal disease.Clin Chim Acta. 2008 Sep;395(1-2):137-41. doi: 10.1016/j.cca.2008.06.003. Epub 2008 Jun 8.
148 Polymorphisms and haplotypes in the interleukin-4 gene are associated with chronic periodontitis in a Brazilian population.J Periodontol. 2010 Mar;81(3):392-402. doi: 10.1902/jop.2009.090392.
149 Humoral immune responses in periodontal disease may have mucosal and systemic immune features.Clin Exp Immunol. 1999 Mar;115(3):534-41. doi: 10.1046/j.1365-2249.1999.00819.x.
150 Clinical periodontal and microbiologic parameters in patients with rheumatoid arthritis.J Periodontol. 2011 Oct;82(10):1424-32. doi: 10.1902/jop.2011.100481. Epub 2011 Mar 15.
151 Subgingival microbial communities in Leukocyte Adhesion Deficiency and their relationship with local immunopathology.PLoS Pathog. 2015 Mar 5;11(3):e1004698. doi: 10.1371/journal.ppat.1004698. eCollection 2015 Mar.
152 Meta-analysis of genome-wide association studies of aggressive and chronic periodontitis identifies two novel risk loci.Eur J Hum Genet. 2019 Jan;27(1):102-113. doi: 10.1038/s41431-018-0265-5. Epub 2018 Sep 14.
153 Alarm anti-protease trappin-2 negatively correlates with proinflammatory cytokines in patients with periodontitis.J Periodontol. 2018 Jan;89(1):58-66. doi: 10.1902/jop.2017.170245.
154 Transcriptome analysis reveals mucin 4 to be highly associated with periodontitis and identifies pleckstrin as a link to systemic diseases.Sci Rep. 2015 Dec 21;5:18475. doi: 10.1038/srep18475.
155 Role of PTP in the destruction of periodontal connective tissues.PLoS One. 2013 Aug 5;8(8):e70659. doi: 10.1371/journal.pone.0070659. Print 2013.
156 S100A2 level changes are related to human periodontitis.Mol Cells. 2011 Nov;32(5):445-50. doi: 10.1007/s10059-011-0132-5. Epub 2011 Sep 9.
157 IL4 gene polymorphisms and their relation to periodontal disease in a Macedonian population.Hum Immunol. 2011 May;72(5):446-50. doi: 10.1016/j.humimm.2011.02.005. Epub 2011 Feb 25.
158 Increased levels of the T-helper 22-associated cytokine (interleukin-22) and transcription factor (aryl hydrocarbon receptor) in patients with periodontitis are associated with osteoclast resorptive activity and severity of the disease.J Periodontal Res. 2017 Oct;52(5):893-902. doi: 10.1111/jre.12461. Epub 2017 Apr 10.
159 Genome-wide association study of periodontal pathogen colonization.J Dent Res. 2012 Jul;91(7 Suppl):21S-28S. doi: 10.1177/0022034512447951.
160 IL1 gene polymorphisms and unsuccessful dental implants.Clin Oral Implants Res. 2012 Dec;23(12):1404-13. doi: 10.1111/j.1600-0501.2011.02322.x. Epub 2011 Nov 10.
161 Loss of claudin-1 in lipopolysaccharide-treated periodontal epithelium.J Periodontal Res. 2012 Apr;47(2):222-7. doi: 10.1111/j.1600-0765.2011.01424.x. Epub 2011 Nov 18.
162 BMP1 and TLL1 Are Required for Maintaining Periodontal Homeostasis.J Dent Res. 2017 May;96(5):578-585. doi: 10.1177/0022034516686558. Epub 2017 Jan 9.
163 Periodontal disease and FAM20A mutations.J Hum Genet. 2017 Jul;62(7):679-686. doi: 10.1038/jhg.2017.26. Epub 2017 Mar 16.
164 Peri-Implantitis Diagnosis and Prognosis Using Biomarkers in Peri-Implant Crevicular Fluid: A Narrative Review.Diagnostics (Basel). 2019 Dec 7;9(4):214. doi: 10.3390/diagnostics9040214.
165 HnRNPL inhibits the osteogenic differentiation of PDLCs stimulated by SrCl(2) through repressing Setd2.J Cell Mol Med. 2019 Apr;23(4):2667-2677. doi: 10.1111/jcmm.14166. Epub 2019 Feb 12.
166 Natural Monoclonal Antibody to Oxidized Low-Density Lipoprotein and Aggregatibacter actinomycetemcomitans.Methods Mol Biol. 2017;1643:155-167. doi: 10.1007/978-1-4939-7180-0_12.
167 Association of Distinct Fine Specificities of Anti-Citrullinated Peptide Antibodies With Elevated Immune Responses to Prevotella intermedia in a Subgroup of Patients With Rheumatoid Arthritis and Periodontitis.Arthritis Rheumatol. 2017 Dec;69(12):2303-2313. doi: 10.1002/art.40227. Epub 2017 Oct 30.
168 Screening of Genetic Factor in the Interaction Between Periodontitis and Metabolic Traits Using Candidate Gene Association Study (CGAS).Biochem Genet. 2019 Jun;57(3):466-474. doi: 10.1007/s10528-018-9899-9. Epub 2018 Dec 13.
169 Loss of periodontal ligament fibroblasts by RIPK3-MLKL-mediated necroptosis in the progress of chronic periodontitis.Sci Rep. 2019 Feb 27;9(1):2902. doi: 10.1038/s41598-019-39721-1.
170 Periodontitis May Restrain the Mandibular Bone Healing via Disturbing Osteogenic and Osteoclastic Balance.Inflammation. 2018 Jun;41(3):972-983. doi: 10.1007/s10753-018-0751-5.
171 The sensitive detection of ODAM by using sandwich-type biosensors with a cognate pair of aptamers for the early diagnosis of periodontal disease.Biosens Bioelectron. 2019 Feb 1;126:122-128. doi: 10.1016/j.bios.2018.10.040. Epub 2018 Oct 23.
172 Severe periodontitis is linked with increased peripheral levels of sTWEAK and PTX3 in chronic migraineurs.Clin Oral Investig. 2020 Feb;24(2):597-606. doi: 10.1007/s00784-019-02950-9. Epub 2019 May 20.
173 Salivary levels of specialized pro-resolving lipid mediators as indicators of periodontal health/disease status.J Clin Periodontol. 2019 Oct;46(10):978-990. doi: 10.1111/jcpe.13173. Epub 2019 Aug 20.
174 Obesity and periodontitis in Australian adults: A population-based cross-sectional study.Int Dent J. 2020 Feb;70(1):53-61. doi: 10.1111/idj.12514. Epub 2019 Aug 30.
175 Secreted frizzled-related protein 5 serum levels in human periodontitis-A nested case-control study.J Clin Periodontol. 2019 May;46(5):522-528. doi: 10.1111/jcpe.13087. Epub 2019 Apr 22.
176 Secreted osteoclastogenic factor of activated T cells (SOFAT), a novel osteoclast activator, in chronic periodontitis.Hum Immunol. 2013 Jul;74(7):861-6. doi: 10.1016/j.humimm.2013.04.013. Epub 2013 Apr 22.
177 Gene and protein localisation of tumour necrosis factor (TNF)- converting enzyme in gingival tissues from periodontitis patients with drug-induced gingival overgrowth.Arch Oral Biol. 2013 Aug;58(8):1014-20. doi: 10.1016/j.archoralbio.2013.02.011. Epub 2013 Mar 16.
178 Differential gene and protein expression of tissue inhibitors of metalloproteinases (TIMP)-3 and TIMP-4 in gingival tissues from drug induced gingival overgrowth.Arch Oral Biol. 2009 Jul;54(7):634-41. doi: 10.1016/j.archoralbio.2009.04.002. Epub 2009 May 17.
179 Complement-Dependent Mechanisms and Interventions in Periodontal Disease.Front Immunol. 2019 Mar 12;10:406. doi: 10.3389/fimmu.2019.00406. eCollection 2019.