Details of Disease

General Information of Disease (ID: DISIJV47)

• Disease Name: Adult respiratory distress syndrome
• Synonyms: ARDS; respiratory distress syndrome, adult; adult acute respiratory distress syndrome; adult respiratory distress syndrome, ARDS; adult respiratory distress syndrome; adult ARDS; adult RDS
• Disease Class: CB00: Acute respiratory distress syndrome
• Definition: A very severe form of acute pulmonary failure secondary to capillary permeability impairment. The symptoms include dyspnea, hypotension and multivisceral failure. The disease is characterized by bilateral pulmonary infiltrates and severe hypoxemia due to increased alveolar-capillary permeability. The severity depends on the degree of alveolar epithelial injury, with a mortality rate of 30-50%.
• Disease Hierarchy:
  DIS2H763: Acute respiratory distress syndrome
  DISIJV47: Adult respiratory distress syndrome
• ICD Code:
  ICD-11: ICD-11: CB00
  ICD-10: ICD-10: J80
  ICD-9: ICD-9: 518.5, 518.82
  Expand ICD-11: 'CB00
  Expand ICD-10: 'J80
  Expand ICD-9: 518.5,518.82
• Disease Identifiers:
  MONDO ID: MONDO_0100130
  MESH ID: D012128
  UMLS CUI: C0035222
  MedGen ID: 20540
  Orphanet ID: 70578
  SNOMED CT ID: 67782005

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 2 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Calfactant	DM7N16W	Approved	NA	[1]
Salbutamol	DMN9CWF	Approved	Small molecular drug	[2]

This Disease is Treated as An Indication in 2 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
ALT-836	DMGJ71F	Phase 2	NA	[3]
GSK1995057	DMC14KV	Phase 1	Antibody	[4]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 58 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ABCA4	TTLB52K	Limited	Genetic Variation	[5]
ACAA2	TTM3F49	Limited	Biomarker	[6]
ACE2	TTUI5H7	Limited	Altered Expression	[7]
ACO2	TTMTF2P	Limited	Biomarker	[6]
AKR1B1	TTFBNVI	Limited	Biomarker	[6]
ALAD	TTJHKYD	Limited	Biomarker	[6]
ALB	TTFNGC9	Limited	Biomarker	[8]
CCL2	TTNAY0P	Limited	Altered Expression	[9]
CFD	TT8D13I	Limited	Biomarker	[10]
CFP	TTLA0VS	Limited	Biomarker	[10]
EIF2AK1	TTRUJBV	Limited	Biomarker	[6]
FGFR4	TT1KX2S	Limited	Biomarker	[6]
GNRH1	TT0ID4A	Limited	Biomarker	[6]
IGFBP6	TTLAYV8	Limited	Biomarker	[6]
LCN2	TTKTLAI	Limited	Biomarker	[6]
LCT	TTA0OSE	Limited	Biomarker	[6]
PLA2G4A	TTT1JVS	Limited	Biomarker	[11]
S100A4	TTPR5SX	Limited	Biomarker	[6]
S100A9	TT0TMQG	Limited	Biomarker	[6]
SERPINC1	TT4QPUL	Limited	Biomarker	[12]
SERPINH1	TTPSWQG	Limited	Biomarker	[6]
IL36G	TT8SLDN	Disputed	Altered Expression	[13]
PLA2G1B	TT9V5JH	Disputed	Genetic Variation	[14]
PLA2G7	TTDNFMT	Disputed	Genetic Variation	[15]
AGER	TTMO9HF	moderate	Biomarker	[16]
ANGPT2	TTKLQTJ	moderate	Biomarker	[17]
IL1RN	TT6GSR3	moderate	Biomarker	[18]
AGTR1	TT8DBY3	Strong	Biomarker	[19]
C3AR1	TTI6B3F	Strong	Therapeutic	[20]
C5	TTKANGO	Strong	Biomarker	[21]
C5AR1	TTHXFA1	Strong	Therapeutic	[20]
CDH5	TTXLCFO	Strong	Altered Expression	[22]
CHRM3	TTQ13Z5	Strong	Biomarker	[23]
CXCL10	TTQOVYA	Strong	Biomarker	[24]
EDN1	TTJR60Z	Strong	Altered Expression	[25]
ELANE	TTPLTSQ	Strong	Biomarker	[26]
ELAVL1	TTPC9D0	Strong	Altered Expression	[27]
EPHX2	TT7WVHI	Strong	Biomarker	[28]
FER	TTRA9G0	Strong	Genetic Variation	[29]
GJA5	TTFQKZ7	Strong	Biomarker	[30]
LHCGR	TT2O4W9	Strong	Biomarker	[31]
LY96	TT8S9AV	Strong	Altered Expression	[32]
MAP3K1	TTW8TJI	Strong	Genetic Variation	[33]
MAPKAPK2	TTMUG9D	Strong	Biomarker	[34]
NAAA	TTMN4HY	Strong	Genetic Variation	[35]
NAMPT	TTD1WIG	Strong	Biomarker	[36]
NPSR1	TTV1C0Z	Strong	Biomarker	[37]
PLA2G2A	TTO8QRU	Strong	Genetic Variation	[14]
PLD1	TT3T17P	Strong	Altered Expression	[38]
S1PR3	TTDYP7I	Strong	Altered Expression	[39]
SCGB1A1	TTONPVW	Strong	Altered Expression	[40]
SELPLG	TTS5K8U	Strong	Biomarker	[41]
SFTPD	TTGLMU7	Strong	Altered Expression	[42]
SOD2	TT9O4C5	Strong	Biomarker	[6]
TBXA2R	TT2O84V	Strong	Therapeutic	[43]
TFPI	TT068JH	Strong	Genetic Variation	[44]
THBD	TTAPV67	Strong	Altered Expression	[45]
TST	TT51OTS	Strong	Biomarker	[46]

This Disease Is Related to 7 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC25A11	DT0YAUQ	Limited	Biomarker	[6]
ABCA3	DT2T6VQ	moderate	Genetic Variation	[47]
SLC12A2	DTHKL3Q	Strong	Biomarker	[48]
SLC22A4	DT2EG60	Strong	Biomarker	[49]
SLC27A5	DT0TQS3	Strong	Biomarker	[50]
SLC2A10	DT3BI6S	Strong	Biomarker	[51]
SLC50A1	DTI9CQU	Strong	Biomarker	[52]

This Disease Is Related to 4 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
CES3	DEMI4VE	Limited	Biomarker	[6]
CYB5A	DE9A2LB	Limited	Biomarker	[6]
MT2A	DEFKGT7	Limited	Biomarker	[6]
CYP3A7	DERD86B	Strong	Genetic Variation	[53]

This Disease Is Related to 90 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
APC	OTKV0TIK	Limited	Biomarker	[6]
CELF2	OTLJJ4VT	Limited	Genetic Variation	[54]
EBF1	OTZ61YYH	Limited	Biomarker	[6]
FBLN5	OTLVNZ8U	Limited	Biomarker	[6]
GABRB1	OT4L2SSB	Limited	Biomarker	[6]
IFRD1	OT4SQMLQ	Limited	Biomarker	[6]
LIM2	OTK7R6HC	Limited	Biomarker	[6]
MDH1	OTJEO4E8	Limited	Biomarker	[6]
MT3	OTVCZ7HI	Limited	Biomarker	[23]
PRDX6	OTS8KC8A	Limited	Biomarker	[6]
PROS1	OTXQWNOI	Limited	Biomarker	[6]
PSMA4	OTAD2XXI	Limited	Biomarker	[6]
SFTPA2	OT6SFOMU	Limited	Genetic Variation	[55]
SFTPC	OTIZJD09	Limited	Biomarker	[56]
TIA1	OTGPN3P8	Limited	Genetic Variation	[54]
TIMP1	OTOXC51H	Limited	Biomarker	[6]
TSPAN8	OT1F68WQ	Limited	Biomarker	[6]
PLB1	OTZ6TTYV	Disputed	Genetic Variation	[14]
SARS1	OTFKXQ1O	Disputed	Biomarker	[57]
SARS2	OTU4T99W	Disputed	Biomarker	[57]
BTBD8	OT3A3RD7	moderate	Biomarker	[58]
PROCR	OTRHED17	moderate	Altered Expression	[59]
SFTPB	OTOHS07E	moderate	Biomarker	[60]
ADCY9	OT1IZT5K	Strong	Genetic Variation	[53]
ANKS4B	OT1MREUS	Strong	Biomarker	[61]
ANLN	OTXJY54C	Strong	Biomarker	[62]
AQP5	OT77GBY8	Strong	Altered Expression	[63]
ARID5A	OTQT7CG9	Strong	Altered Expression	[64]
ARSD	OTAHW9M8	Strong	Genetic Variation	[65]
CARMIL1	OT1A5IX5	Strong	Altered Expression	[35]
CBLIF	OTNE20WU	Strong	Biomarker	[23]
CCNB2	OTIEXTDK	Strong	Genetic Variation	[66]
CENPJ	OTZCQZN5	Strong	Biomarker	[46]
CIRBP	OTXWTPBL	Strong	Biomarker	[67]
CLEC1B	OTO38TRG	Strong	Biomarker	[68]
CNMD	OTHND8EL	Strong	Biomarker	[69]
COL4A5	OTHG60RE	Strong	Biomarker	[51]
CORO7	OTG7MEAJ	Strong	Altered Expression	[40]
CRYGD	OTW29JC4	Strong	Biomarker	[70]
CXCL5	OTZOUPCA	Strong	Biomarker	[71]
DOK3	OT842U3C	Strong	Altered Expression	[72]
FXYD1	OTNKT6GP	Strong	Altered Expression	[73]
GSDMD	OTH39BKI	Strong	Altered Expression	[74]
GZMA	OT43R33L	Strong	Altered Expression	[75]
HABP2	OTAUIPW0	Strong	Biomarker	[76]
HADHA	OTO557N2	Strong	Biomarker	[77]
HAP1	OT6SG0JQ	Strong	Genetic Variation	[78]
HCST	OTILCB4K	Strong	Biomarker	[79]
HRG	OTPLUFOG	Strong	Biomarker	[80]
HSPA4	OT5HR0AR	Strong	Biomarker	[81]
IFI44L	OTXKORJP	Strong	Biomarker	[79]
IFIT1	OTXOQDSG	Strong	Biomarker	[82]
IL17RC	OTEFOBSS	Strong	Biomarker	[83]
INO80C	OTKXHGET	Strong	Biomarker	[84]
ITM2B	OTMXEPXB	Strong	Genetic Variation	[69]
KAT8	OT5LPQTR	Strong	Biomarker	[85]
KPNA6	OTJ3OX6P	Strong	Biomarker	[86]
LY6E	OTMG16BZ	Strong	Biomarker	[79]
MFN1	OTCBXQZF	Strong	Therapeutic	[87]
MPP1	OTA2ENZQ	Strong	Biomarker	[88]
NFYA	OTWFFOVH	Strong	Genetic Variation	[78]
NSMCE3	OTBD4MSP	Strong	Genetic Variation	[89]
OAS3	OT6E5FYS	Strong	Biomarker	[79]
PANK2	OTFBW889	Strong	Biomarker	[61]
PARP9	OT7K4494	Strong	Biomarker	[50]
PDPN	OTBUV19I	Strong	Biomarker	[68]
PELI2	OT7AFILK	Strong	Biomarker	[90]
PI3	OT47MTC3	Strong	Biomarker	[91]
PIEZO1	OTBG1FU4	Strong	Altered Expression	[92]
PLA2G10	OTRZ2L5A	Strong	Genetic Variation	[93]
PLCL1	OTJL2C79	Strong	Biomarker	[71]
POLD4	OTG578YH	Strong	Biomarker	[94]
POLE4	OTCMWUT6	Strong	Biomarker	[94]
POLG2	OTDBMZJB	Strong	Biomarker	[88]
POPDC3	OTN4FJ5J	Strong	Genetic Variation	[95]
PPP6R3	OTIXD60Q	Strong	Biomarker	[96]
PRPH2	OTNH2G5H	Strong	Biomarker	[46]
PSMD12	OTWICA51	Strong	Biomarker	[88]
RAB27A	OT9SQRWY	Strong	Biomarker	[97]
RAMAC	OTAFAKPR	Strong	Biomarker	[97]
RAMP2	OTGQXLH5	Strong	Biomarker	[6]
SERPINA12	OTS1E6IP	Strong	Biomarker	[98]
SFTPA1	OT87XL1U	Strong	Genetic Variation	[55]
SH2B2	OTEDHHDH	Strong	Biomarker	[99]
SMARCAL1	OTTKXLUZ	Strong	Biomarker	[61]
SPATS2L	OTFO07H8	Strong	Biomarker	[79]
TAPBP	OTL81AVZ	Strong	Genetic Variation	[100]
TAS1R3	OTOVM44D	Strong	Altered Expression	[101]
TM7SF2	OTILU5S7	Strong	Biomarker	[19]
TREML1	OTMJD2HI	Strong	Altered Expression	[102]

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