Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM03FHA)

Drug Name
LY293111 Drug Info
Synonyms
Etalocib; LY293111; 161172-51-6; UNII-THY6RIW44R; LY 293111; THY6RIW44R; CHEMBL329123; LY-193111; 2-[3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-2-propylphenoxy]benzoic acid; VML295; Etalocib [USAN:INN]; Etalocib (USAN); GTPL2948; SCHEMBL1649516; CTK8E7596; C33H33FO6; VML 295; DTXSID70167073; YFIZRWPXUYFCSN-UHFFFAOYSA-N; MolPort-009-019-411; ZINC3930629; AC1L4328; PDSP2_001221; BDBM50029450; PDSP1_001237; 1758AH; DB12850; RT-013626; D04074; L001468; J-009797; Benzoic acid, 2-(3-(3-((5-ethyl-4'-fluoro-2-hydroxy(1,1'-bipheny
Indication
Disease Entry ICD 11 Status REF
Pancreatic cancer 2C10 Discontinued in Phase 2 [1]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
177941
CAS Number
CAS 161172-51-6
TTD Drug ID
DM03FHA

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Leukotriene B4 receptor 1 (LTB4R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
LTB4 DME26RS Human immunodeficiency virus infection 1C62 Phase 2 [4]
Amelubant DMUMCB9 Pulmonary disease 1B10-1F85 Phase 2 [5]
Biomed 101 DMQ9KZW Kidney cancer 2C90.0 Phase 1 [6]
SB-201993 DMIF4VJ Psoriasis vulgaris EA90 Discontinued in Phase 2 [7]
CI-949 DMN4QSW Asthma CA23 Discontinued in Phase 2 [8]
CP-195543 DM1OSUR Rheumatoid arthritis FA20 Discontinued in Phase 2 [9]
LTB 019 DM6G0PN Asthma CA23 Discontinued in Phase 2 [10]
LY-223982 DMWB7DO Asthma CA23 Discontinued in Phase 2 [11]
CP-105696 DM1C4IN Inflammatory bowel disease DD72 Discontinued in Phase 1 [12]
TAK-683 DMRD8HK Prostate cancer 2C82.0 Discontinued in Phase 1 [13]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [14]
Gefitinib DM15F0X Colon adenocarcinoma Approved [15]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [16]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [17]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [18]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [19]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [18]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [20]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [21]
Methotrexate DM2TEOL Anterior urethra cancer Approved [22]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [23]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [24]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [25]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [26]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [27]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [14]
Verapamil DMA7PEW Angina pectoris BA40 Approved [28]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [29]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [30]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [31]
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Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [14]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [32]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [33]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [19]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [34]
Quercetin DM3NC4M Obesity 5B81 Approved [35]
Fluoxetine DM3PD2C Bipolar depression Approved [36]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [38]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [39]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [40]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [41]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [42]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [30]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [43]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [44]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [45]
Gefitinib DM15F0X Colon adenocarcinoma Approved [46]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [47]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [48]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [49]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [41]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [50]
Paclitaxel DMLB81S Breast carcinoma Approved [51]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [52]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [40]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [27]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [53]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [30]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [43]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [54]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [55]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [56]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [57]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [58]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [59]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [60]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [61]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [62]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [63]
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Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [64]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [65]
Gefitinib DM15F0X Colon adenocarcinoma Approved [66]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [67]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [68]
Quercetin DM3NC4M Obesity 5B81 Approved [69]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [70]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [71]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [68]
Ethacrynic acid DM60QMR Edema MG29 Approved [72]
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Drug(s) Affected By Mitogen-activated protein kinase 9 (MAPK9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [65]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [73]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [68]
Methotrexate DM2TEOL Anterior urethra cancer Approved [74]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [76]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [68]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [77]
Sorbitol DMAN0DE Constipation DD91.1 Approved [78]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [79]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [80]
Gefitinib DM15F0X Colon adenocarcinoma Approved [81]
Prednisone DM2HG4X Acute asthma CA23 Approved [82]
Methotrexate DM2TEOL Anterior urethra cancer Approved [74]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [83]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [84]
Quercetin DM3NC4M Obesity 5B81 Approved [85]
Fluoxetine DM3PD2C Bipolar depression Approved [36]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [86]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [87]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [88]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [89]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [14]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [29]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [90]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [91]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [17]
Meloxicam DM2AR7L Arthritis FA20 Approved [92]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [93]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [94]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [23]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [63]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [14]
Verapamil DMA7PEW Angina pectoris BA40 Approved [28]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [95]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [90]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [96]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [73]
Meloxicam DM2AR7L Arthritis FA20 Approved [97]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [19]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Leukotriene B4 receptor 1 (LTB4R) TTN53ZF LT4R1_HUMAN Antagonist [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Protein Interaction/Cellular Processes [3]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [3]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Protein Interaction/Cellular Processes [3]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Protein Interaction/Cellular Processes [3]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Gene/Protein Processing [3]
E3 ubiquitin-protein ligase XIAP OT24GP9B XIAP_HUMAN Protein Interaction/Cellular Processes [3]
G1/S-specific cyclin-E1 (CCNE1) OTLD7UID CCNE1_HUMAN Gene/Protein Processing [3]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [3]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [3]
Mitogen-activated protein kinase 8 (MAPK8) OTEREYS5 MK08_HUMAN Gene/Protein Processing [3]

References

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3 Leukotriene B4 receptor inhibitor LY293111 induces cell cycle arrest and apoptosis in human anaplastic large-cell lymphoma cells via JNK phosphorylation. Leukemia. 2005 Nov;19(11):1977-84. doi: 10.1038/sj.leu.2403929.
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30 Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
31 -Carotene Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cell Lines via the Cav-1/AKT/NF-B Signaling Pathway. J Biochem Mol Toxicol. 2016 Mar;30(3):148-57. doi: 10.1002/jbt.21773. Epub 2016 Jan 6.
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33 Ribavirin inhibits colorectal cancer growth by downregulating PRMT5 expression and H3R8me2s and H4R3me2s accumulation. Toxicol Appl Pharmacol. 2021 Mar 15;415:115450. doi: 10.1016/j.taap.2021.115450. Epub 2021 Feb 9.
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36 Fluoxetine mediates G0/G1 arrest by inducing functional inhibition of cyclin dependent kinase subunit (CKS)1. Biochem Pharmacol. 2008 May 15;75(10):1924-34. doi: 10.1016/j.bcp.2008.02.013. Epub 2008 Feb 17.
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47 Effect of histamine H1 receptor antagonists on TARC/CCL17 and MDC/CCL22 production from CD14+ cells induced by antigenic stimulation in vitro. Int Arch Allergy Immunol. 2011;155(1):38-51. doi: 10.1159/000318720. Epub 2010 Nov 25.
48 SIRT3 Mediates the Antioxidant Effect of Hydrogen Sulfide in Endothelial Cells. Antioxid Redox Signal. 2016 Feb 20;24(6):329-43. doi: 10.1089/ars.2015.6331. Epub 2015 Nov 10.
49 Downregulation of mitogen-activated protein kinases (MAPKs) in chronic ethanol-induced fatty liver. Toxicol Mech Methods. 2020 Jul;30(6):407-416. doi: 10.1080/15376516.2020.1747126. Epub 2020 Apr 1.
50 A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16657-62. doi: 10.1073/pnas.0707936104. Epub 2007 Oct 9.
51 The stent-eluting drugs sirolimus and paclitaxel suppress healing of the endothelium by induction of autophagy. Am J Pathol. 2009 Nov;175(5):2226-34.
52 Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids. J Biol Chem. 2005 Sep 9;280(36):31498-507. doi: 10.1074/jbc.M505537200. Epub 2005 Jul 13.
53 Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
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56 Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPAR-dependent pathway. Oncotarget. 2016 Mar 1;7(9):10345-62. doi: 10.18632/oncotarget.7213.
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