Details of the Drug-Related molecule(s) Interaction Atlas

CS-600G Drug Info

Koloxo; Loxoprofen; Loxoprofen (INN); Loxoprofen [INN]; Loxoprofen sodium hydrate; Loxoprofene; Loxoprofene [French]; Loxoprofeno; Loxoprofeno [Spanish]; Loxoprofenum; Loxoprofenum [Latin]; YMBXTVYHTMGZDW-UHFFFAOYSA-N; sodium loxoprofen; yl]-propionic acid; 2-(4-((2-Oxocyclopentyl)methyl)phenyl)propanoic acid; 2-[4-(2-Oxo-cyclopentylmethyl)-phen; 2-[4-[(2-oxocyclopentyl)methyl]phenyl]propanoic acid; 2-{4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid; 68767-14-6; CHEBI:76172; CHEMBL19299; CS-600; MFCD00864331; Oxeno

Cross-matching ID

PubChem CID

3965

ChEBI ID

CHEBI:76172

CAS Number

CAS 68767-14-6

TTD Drug ID

DM1PV4Y

INTEDE Drug ID

DR0990

General Information of Drug (ID: DM1PV4Y)

Molecule-Related Drug Atlas

Molecule Type:

DME

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Metabolized By UDP-glucuronosyltransferase 2B7 (UGT2B7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[4]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[5]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[7]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[8]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[6]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[9]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[10]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[11]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[12]
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Drug(s) Affected By Claudin-5 (CLDN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[13]
Guanfacine extended release	DMB1CZ8	Attention deficit hyperactivity disorder	6A05.Z	Approved	[14]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[15]
Glycine	DMIOZ29	Allergic rhinitis	CA08.0	Approved	[16]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[17]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[18]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[19]
LY294002	DMY1AFS	Neuroblastoma	2D11.2	Phase 1	[20]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[16]
JWH-133	DM1DEYU	Discovery agent	N.A.	Investigative	[21]
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Drug(s) Affected By Claudin-3 (CLDN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[22]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[24]
Guanfacine extended release	DMB1CZ8	Attention deficit hyperactivity disorder	6A05.Z	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[15]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[26]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[27]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[22]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[28]
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Drug(s) Affected By Claudin-1 (CLDN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[30]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[31]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[32]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[33]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[35]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[36]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[38]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[39]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[40]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[41]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[42]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[43]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[44]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[45]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[46]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[47]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[49]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[40]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[50]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[51]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[52]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[39]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[53]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[54]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[42]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[43]
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Drug(s) Affected By Cytochrome P450 4A11 (CYP4A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[55]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[3]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[3]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[56]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[58]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[3]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[3]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
UDP-glucuronosyltransferase 2B7 (UGT2B7)^{Main DME}	DEB3CV1	UD2B7_HUMAN	Substrate	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Claudin-1 (CLDN1)	OT27KV99	CLD1_HUMAN	Gene/Protein Processing	[2]
Claudin-3 (CLDN3)	OT71MN9S	CLD3_HUMAN	Gene/Protein Processing	[2]
Claudin-5 (CLDN5)	OTUX60YO	CLD5_HUMAN	Gene/Protein Processing	[2]
Cytochrome P450 4A11 (CYP4A11)	OTPU5J0S	CP4AB_HUMAN	Gene/Protein Processing	[3]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Post-Translational Modifications	[2]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Post-Translational Modifications	[2]

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