Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3TPMO)

• Drug Name: 5'-(N-ethyl-N-isopropyl)amiloride Drug Info
• Synonyms: EIPA; 5-(N-Ethyl-N-isopropyl)amiloride; 1154-25-2; Ethylisopropylamiloride; 5-(Ethylisopropyl)amiloride; Ethyl isopropyl amiloride; 5-(N-ethyl-N-isopropyl)-Amiloride; 3-Amino-N-(aminoiminomethyl)-6-chloro-5-[ethyl(1-methylethyl)amino]-2-pyrazinecarboxamide; N-Amidino-3-amino-5-ethylisopropylamino-6-chloropyrazine carboxamide; C11H18ClN7O; CHEMBL517986; 5-(N-Ethyl-N-isopropyl) Amiloride; 3-Amino-N-(aminoiminomethyl)-6-chloro-5-(ethyl(1-methylethyl)amino)pyrazinecarboxamide

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 1795
  ChEBI ID: CHEBI:136538
  CAS Number: CAS 1154-25-2
  TTD Drug ID: DM3TPMO
  VARIDT Drug ID: DR00893

Molecule-Related Drug Atlas

Drug(s) Targeting Sodium/hydrogen exchanger 1 (SLC9A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zoniporide hydrochloride	DM8L7JD	Angina pectoris	BA40	Phase 3	[10]
CARIPORIDE	DMV2DY3	Angina pectoris	BA40	Discontinued in Phase 2	[11]
ENIPORIDE	DME7OCX	Cardiac arrhythmias	BC9Z	Discontinued in Phase 2	[12]
HOE-694	DML0B97	Heart arrhythmia	BC65	Terminated	[13]
N-(3-Methanesulfonyl-4-methyl-benzoyl)-guanidine	DMSVQJP	Discovery agent	N.A.	Investigative	[13]
N-(4-Chloro-3-methanesulfonyl-benzoyl)-guanidine	DMFG6MU	Discovery agent	N.A.	Investigative	[13]
N-(4-Cyano-3-methanesulfonyl-benzoyl)-guanidine	DMGI9EA	Discovery agent	N.A.	Investigative	[13]
N-(4-Bromo-3-methanesulfonyl-benzoyl)-guanidine	DMC28SN	Discovery agent	N.A.	Investigative	[13]
N-(3-Methanesulfonyl-4-methoxy-benzoyl)-guanidine	DM0H8CK	Discovery agent	N.A.	Investigative	[13]
N-(5-Methanesulfonyl-2-methyl-benzoyl)-guanidine	DM91463	Discovery agent	N.A.	Investigative	[13]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[67]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[71]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[72]

Drug(s) Affected By Diamine oxidase (AOC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Amiloride	DMRTSGP	Congestive heart failure	BD10	Approved	[5]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[16]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[17]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[18]
Aminoguanidine	DMJQDUC	Diabetic retinopathy	9B71.0	Phase 1	[5]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[19]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[20]
Putrescine	DMWE6V1	Burn and burn infection	ND90-NE2Z	Discontinued in Phase 2	[5]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[21]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[22]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[23]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[24]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[26]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[27]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[28]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[29]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[30]

Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[31]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[31]
Etoricoxib	DM6A4NW	Rheumatoid arthritis	FA20	Approved	[31]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[32]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[33]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[34]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[35]
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[36]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[37]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[38]

Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[22]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[39]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[40]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[41]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[42]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[43]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[44]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[45]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[46]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[47]

Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[48]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[38]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[49]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[50]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[51]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[52]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[53]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[54]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[55]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[56]

Drug(s) Affected By Fumarylacetoacetase (FAH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[58]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[59]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[60]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[61]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[62]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[63]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[64]

Drug(s) Affected By Serine/arginine-rich splicing factor 3 (SRSF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[58]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[77]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[78]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[48]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[74]

Drug(s) Affected By Survival motor neuron protein (SMN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amikacin	DM5PDRB	Bacteremia	1A73	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[59]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[77]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[81]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[72]
Tobramycin	DMUI0CH	Bacteremia	1A73	Approved	[79]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[82]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[83]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Sodium/hydrogen exchanger 1 (SLC9A1)	TTGSEFH	SL9A1_HUMAN	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Protein Interaction/Cellular Processes	[3]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Gene/Protein Processing	[4]
Cytochrome P450 1A2 (CYP1A2)	OTLLBX48	CP1A2_HUMAN	Gene/Protein Processing	[4]
Cytochrome P450 1B1 (CYP1B1)	OTYXFLSD	CP1B1_HUMAN	Gene/Protein Processing	[4]
Diamine oxidase (AOC1)	OTRC220K	AOC1_HUMAN	Gene/Protein Processing	[5]
Fumarylacetoacetase (FAH)	OTGZA1YR	FAAA_HUMAN	Gene/Protein Processing	[6]
Serine/arginine-rich splicing factor 3 (SRSF3)	OTOFT707	SRSF3_HUMAN	Gene/Protein Processing	[7]
Sodium/hydrogen exchanger 1 (SLC9A1)	OT6HNHFV	SL9A1_HUMAN	Gene/Protein Processing	[8]
Survival motor neuron protein (SMN2)	OT54RLO1	SMN_HUMAN	Gene/Protein Processing	[7]
Vascular endothelial growth factor A, long form	OTIM9MZ3	VEGFA_HUMAN	Gene/Protein Processing	[9]

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