Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5BAJ9)

Drug Name
20-HETE Drug Info
Synonyms 20-hydroxyeicosatetraenoic acid
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
5283157
ChEBI ID
CHEBI:34306
CAS Number
CAS 79551-86-3
TTD Drug ID
DM5BAJ9

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Investigative Drug(s)
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Short transient receptor potential channel 6 (TRPC6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
2-APB DM9AKVR Discovery agent N.A. Investigative [2]
lysophosphatidylcholine DMOGFVH Discovery agent N.A. Investigative [2]
ACAA DMACYPW Discovery agent N.A. Investigative [2]
OAG DMOP8IJ Discovery agent N.A. Investigative [8]
KB-R7943 DMMD5W3 Discovery agent N.A. Investigative [2]
flufenamate DMN8AP0 Discovery agent N.A. Investigative [2]
SAG DMHOG7W Discovery agent N.A. Investigative [8]
ML9 DMP13VE Discovery agent N.A. Investigative [2]
hyp 9 DM0U8IV Discovery agent N.A. Investigative [9]
SLG DMEBPCO Discovery agent N.A. Investigative [8]
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Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [10]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [11]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [12]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [13]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [14]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [15]
Prednisone DM2HG4X Acute asthma CA23 Approved [16]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [17]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [18]
Methotrexate DM2TEOL Anterior urethra cancer Approved [19]
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Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [11]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [20]
Diazepam DM08E9O Alcohol withdrawal Approved [21]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [22]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [23]
Methotrexate DM2TEOL Anterior urethra cancer Approved [24]
Ceruletide DM2WE5K Caerulein stimulated gastric and pancreatic secretion 5A4Y Approved [25]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [26]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [27]
Quercetin DM3NC4M Obesity 5B81 Approved [28]
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Drug(s) Affected By Actin, aortic smooth muscle (ACTA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [29]
Quercetin DM3NC4M Obesity 5B81 Approved [30]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [31]
Panobinostat DM58WKG Chronic graft versus host disease Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [33]
Pirfenidone DM6VZFQ Idiopathic pulmonary fibrosis CB03.4 Approved [34]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [35]
Testosterone DM7HUNW Hot flushes GA30 Approved [36]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [37]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [36]
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Drug(s) Affected By Mothers against decapentaplegic homolog 3 (SMAD3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [38]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [39]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [42]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [43]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [44]
Ethanol DMDRQZU Chronic pain MG30 Approved [45]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [46]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [47]
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Drug(s) Affected By Nuclear factor of activated T-cells, cytoplasmic 4 (NFATC4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [48]
Panobinostat DM58WKG Chronic graft versus host disease Approved [49]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [48]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
Ethanol DMDRQZU Chronic pain MG30 Approved [51]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [52]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [53]
Phenylephrine DMZHUO5 Allergic rhinitis CA08.0 Approved [6]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [49]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [54]
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Drug(s) Affected By Cytochrome P450 4F2 (CYP4F2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Warfarin DMJYCVW Atrial fibrillation BC81.3 Approved [55]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [56]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [31]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [57]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [58]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [59]
Ethanol DMDRQZU Chronic pain MG30 Approved [60]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [56]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [61]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [58]
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Drug(s) Affected By Cytochrome P450 4Z1 (CYP4Z1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [62]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [62]
Lauric Acid DM9C8KQ Discovery agent N.A. Investigative [5]
MYRISTIC ACID DMYX0BL Discovery agent N.A. Investigative [5]
Drug(s) Affected By Cytochrome P450 4A11 (CYP4A11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [63]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [64]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [64]
Methotrexate DM2TEOL Anterior urethra cancer Approved [19]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [65]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [66]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [66]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [64]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [64]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [64]
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Drug(s) Affected By Cytochrome P450 4F3 (CYP4F3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [19]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [65]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [67]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [59]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [69]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [70]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [71]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [72]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Short transient receptor potential channel 6 (TRPC6) TTRBT3W TRPC6_HUMAN Activator [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Actin, aortic smooth muscle (ACTA2) OTEDLG8E ACTA_HUMAN Gene/Protein Processing [3]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Gene/Protein Processing [3]
Cytochrome P450 4A11 (CYP4A11) OTPU5J0S CP4AB_HUMAN Biotransformations [4]
Cytochrome P450 4F2 (CYP4F2) OTKILAER CP4F2_HUMAN Biotransformations [4]
Cytochrome P450 4F3 (CYP4F3) OTYNSQAM CP4F3_HUMAN Biotransformations [4]
Cytochrome P450 4Z1 (CYP4Z1) OTKRGJBG CP4Z1_HUMAN Regulation of Drug Effects [5]
Mothers against decapentaplegic homolog 3 (SMAD3) OTNA96MR SMAD3_HUMAN Post-Translational Modifications [3]
Nuclear factor of activated T-cells, cytoplasmic 4 (NFATC4) OTTDCUAO NFAC4_HUMAN Protein Interaction/Cellular Processes [6]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Gene/Protein Processing [3]
UDP-glucuronosyltransferase 1A1 OTH1C8OJ UD11_HUMAN Biotransformations [7]

References

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2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 491).
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