Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9JPUD)

Drug Name
Droloxifene Drug Info
Synonyms E-droloxifene; FK-435; K-060; K-060E; RP-60850; K-21.060E; 3-hydroxytamoxifen
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Discontinued in Phase 2 [1]
Cross-matching ID
PubChem CID
3033767
ChEBI ID
CHEBI:34731
CAS Number
CAS 82413-20-5
TTD Drug ID
DM9JPUD
VARIDT Drug ID
DR01424

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Estrogen receptor (ESR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [7]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [8]
Estrone DM5T6US Acne vulgaris ED80 Approved [8]
Estradiol Valerate DM8MC6O Hormone replacement therapy 8E01 Approved [9]
Estradiol Acetate DM07U2A Hormone replacement therapy 8E01 Approved [9]
Estradiol Cypionate DM27Z5T Hormone replacement therapy 8E01 Approved [9]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [10]
Raloxifene DMDKF3M Osteoporosis FB83.0 Approved [11]
Ospemifene DMC4GEI Dyspareunia GA12 Approved [12]
Toremifene DMQYUWG Breast cancer 2C60-2C65 Approved [13]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [3]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [14]
Methotrexate DM2TEOL Anterior urethra cancer Approved [15]
Folic Acid DMEMBJC Colorectal carcinoma Approved [16]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [15]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [15]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [17]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [15]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [18]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [19]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [20]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [21]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [22]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [23]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [24]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [24]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [25]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [26]
Capsaicin DMGMF6V Back pain ME84.Z Approved [27]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [28]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 3A5 (CYP3A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [20]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [21]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [26]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [26]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [29]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [30]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [31]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [32]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [33]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [34]
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Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [35]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [36]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [37]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [38]
Estrone DM5T6US Acne vulgaris ED80 Approved [39]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [40]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [41]
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [42]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [43]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [44]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sex hormone-binding globulin (SHBG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [45]
Quercetin DM3NC4M Obesity 5B81 Approved [46]
Fructose DM43AN2 Vomiting MD90 Approved [47]
Oxcarbazepine DM5PU6O Epilepsy 8A60-8A68 Approved [48]
Estrone DM5T6US Acne vulgaris ED80 Approved [6]
Testosterone DM7HUNW Hot flushes GA30 Approved [49]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Dienestrol DMBSXI0 Atrophic vaginitis GA30.2 Approved [6]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [6]
Masoprocol DMMVNZ0 Prostate cancer 2C82.0 Approved [6]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein kinase C epsilon type (PRKCE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [51]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [52]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [53]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [54]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [55]
Indomethacin DMSC4A7 Bursitis Approved [56]
Arsenic DMTL2Y1 N. A. N. A. Approved [57]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [58]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [59]
Urethane DM7NSI0 N. A. N. A. Phase 4 [60]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Estrogen receptor (ESR) TTZAYWL ESR1_HUMAN Modulator [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Gene/Protein Processing [4]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Gene/Protein Processing [4]
Cytochrome P450 3A5 (CYP3A5) OTSXFBXB CP3A5_HUMAN Gene/Protein Processing [4]
Protein kinase C epsilon type (PRKCE) OT7J0P9L KPCE_HUMAN Protein Interaction/Cellular Processes [5]
Sex hormone-binding globulin (SHBG) OTPWU5IW SHBG_HUMAN Protein Interaction/Cellular Processes [6]

References

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