Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMC7W6R)

Drug Name
Selumetinib Drug Info
Synonyms
Selumetinib; AZD-6244; ARRY142886; AZD6244; ARRY142886; AZD 6244; AZD-6244; 6UH91I579U; ARRY 142886; ARRY-142886; AZD6244 (Selumetinib); AZD6244(Selumetinib); CHEBI:90227; CHEMBL1614701; MEK inhibitors; Selumetinib (AZD6244); UNII-6UH91I579U
Indication
Disease Entry ICD 11 Status REF
Neurofibromatosis type 1 LD2D.10 Approved [1]
Melanoma 2C30 Phase 3 [2]
Thyroid cancer 2D10 Phase 3 [3]
Non-small-cell lung cancer 2C25.Y Phase 2 [4]
Middle East Respiratory Syndrome (MERS) 1D64 Investigative [5]
Severe acute respiratory syndrome (SARS) 1D65 Investigative [5]
Solid tumour/cancer 2A00-2F9Z Investigative [6]
Cross-matching ID
PubChem CID
10127622
ChEBI ID
CHEBI:90227
CAS Number
CAS 606143-52-6
TTD Drug ID
DMC7W6R
ACDINA Drug ID
D01422

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting MAPK/ERK kinase kinase (MAP3K)
Drug Name Drug ID Indication ICD 11 Highest Status REF
ARRY-162 DM1P6FR Melanoma 2C30 Approved [11]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [12]
BAY 86-9766 DMPW5SB Solid tumour/cancer 2A00-2F9Z Phase 3 [13]
MSC1936369B DMH1DYU Colorectal cancer 2B91.Z Phase 2 [14]
RO-5126766 DM3U9BY Non-small-cell lung cancer 2C25 Phase 2 [15]
E6201 DMOSL9P Psoriasis vulgaris EA90 Phase 2 [16]
PD-0325901 DM27D4J Breast cancer 2C60-2C65 Phase 2 [11]
WX-554 DMRABOS Solid tumour/cancer 2A00-2F9Z Phase 1/2 [11]
RG7304 DMGFAVQ Solid tumour/cancer 2A00-2F9Z Phase 1 [17]
BI-847325 DMY4B6J Solid tumour/cancer 2A00-2F9Z Phase 1 [18]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting ERK activator kinase 1 (MEK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Diamidothiazole derivative 1 DM02V5Q N. A. N. A. Patented [19]
Pyridic ketone derivative 1 DM3GU7K N. A. N. A. Patented [20]
RDEA-436 DM0ILRU Solid tumour/cancer 2A00-2F9Z Discontinued in Phase 1 [21]
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole DMN9YOB Discovery agent N.A. Investigative [22]
DEBROMOHYMENIALDISINE DMDLER8 Discovery agent N.A. Investigative [23]
REVERSINE DMWDNOK Discovery agent N.A. Investigative [24]
OROIDIN DMA2DQT Discovery agent N.A. Investigative [23]
PD98059 DMZC90M Cardiac arrest MC82 Investigative [25]
4,5-Dibromo-1H-pyrrole-2-carboxylic acid amide DMDM9UV Discovery agent N.A. Investigative [23]
5-phenylamino-4-cyano-3-hydroxy-isothiazole DMX6R0H Discovery agent N.A. Investigative [26]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting ERK activator kinase 2 (MEK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pyridic ketone derivative 1 DM3GU7K N. A. N. A. Patented [20]
RDEA-436 DM0ILRU Solid tumour/cancer 2A00-2F9Z Discontinued in Phase 1 [21]
PD98059 DMZC90M Cardiac arrest MC82 Investigative [25]
Drug(s) Targeting HUMAN ERK activator kinase 1 (MEK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Trametinib DM2JGQ3 Melanoma 2C30 Approved [5]
Drug(s) Targeting HUMAN ERK activator kinase 2 (MEK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Trametinib DM2JGQ3 Melanoma 2C30 Approved [5]
Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [27]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [28]
Quercetin DM3NC4M Obesity 5B81 Approved [29]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [30]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [31]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [9]
Panobinostat DM58WKG Chronic graft versus host disease Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [33]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [34]
Testosterone DM7HUNW Hot flushes GA30 Approved [35]
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Drug(s) Affected By Protein c-Fos (FOS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [37]
Verapamil DMA7PEW Angina pectoris BA40 Approved [38]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [39]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [38]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [40]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [41]
Methotrexate DM2TEOL Anterior urethra cancer Approved [42]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [43]
Quercetin DM3NC4M Obesity 5B81 Approved [44]
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Drug(s) Affected By Interstitial collagenase (MMP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [45]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [46]
Etretinate DM2CZFA Keratosis ED56 Approved [47]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [48]
Methotrexate DM2TEOL Anterior urethra cancer Approved [49]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [50]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [52]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [53]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [54]
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Drug(s) Affected By 72 kDa type IV collagenase (MMP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [46]
Selenium DM25CGV N. A. N. A. Approved [55]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [56]
Quercetin DM3NC4M Obesity 5B81 Approved [57]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [58]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [59]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [60]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [61]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [62]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [63]
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Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [64]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [65]
Gefitinib DM15F0X Colon adenocarcinoma Approved [66]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [67]
Selenium DM25CGV N. A. N. A. Approved [55]
Pentosan Polysulfate DM2HRKE Interstitial cystitis GC00.3 Approved [68]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [69]
Methotrexate DM2TEOL Anterior urethra cancer Approved [70]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [71]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [72]
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Drug(s) Affected By Cyclic AMP-responsive element-binding protein 1 (CREB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [73]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [74]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [75]
Selenium DM25CGV N. A. N. A. Approved [76]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [79]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [80]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [81]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [82]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [83]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [74]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [84]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [85]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [86]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [87]
Gefitinib DM15F0X Colon adenocarcinoma Approved [88]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [89]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [90]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [91]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [83]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [92]
Paclitaxel DMLB81S Breast carcinoma Approved [93]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [94]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [82]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [95]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [96]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [84]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [85]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
ERK activator kinase 1 (MEK1) TTIDAPM MP2K1_HUMAN Inhibitor [3]
ERK activator kinase 2 (MEK2) TTTW2NY MP2K2_HUMAN Inhibitor [3]
MAPK/ERK kinase kinase (MAP3K) TTROQ37 NOUNIPROTAC Modulator [7]
HUMAN ERK activator kinase 1 (MEK1) TTAW3TO MP2K1_HUMAN Inhibitor [5]
HUMAN ERK activator kinase 2 (MEK2) TTWX403 MP2K2_HUMAN Inhibitor [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
72 kDa type IV collagenase (MMP2) OT5NIWA2 MMP2_HUMAN Gene/Protein Processing [8]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Gene/Protein Processing [9]
Cyclic AMP-responsive element-binding protein 1 (CREB1) OT1MDLA1 CREB1_HUMAN Post-Translational Modifications [8]
Interstitial collagenase (MMP1) OTI4I2V1 MMP1_HUMAN Gene/Protein Processing [8]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Gene/Protein Processing [8]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [10]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [10]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Post-Translational Modifications [8]

References

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2 ClinicalTrials.gov (NCT01933932) Assess Efficacy & Safety of Selumetinib in Combination With Docetaxel in Patients Receiving 2nd Line Treatment for v-Ki-ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Positive NSCLC (SELECT-1)
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5665).
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6 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1479).
7 Intrinsic resistance to selumetinib, a selective inhibitor of MEK1/2, by cAMP-dependent protein kinase A activation in human lung and colorectal cancer cells.Br J Cancer.2012 May 8;106(10):1648-59.
8 Ursonic acid exerts inhibitory effects on matrix metalloproteinases via ERK signaling pathway. Chem Biol Interact. 2020 Jan 5;315:108910. doi: 10.1016/j.cbi.2019.108910. Epub 2019 Nov 29.
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29 Quercetin induced cell apoptosis and altered gene expression in AGS human gastric cancer cells. Environ Toxicol. 2018 Nov;33(11):1168-1181. doi: 10.1002/tox.22623. Epub 2018 Aug 27.
30 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
31 An in vitro study on anti-carcinogenic effect of remdesivir in human ovarian cancer cells via generation of reactive oxygen species. Hum Exp Toxicol. 2022 Jan-Dec;41:9603271221089257. doi: 10.1177/09603271221089257.
32 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
33 Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status. Mol Biol Rep. 2008 Sep;35(3):421-9.
34 Aspirin induces apoptosis in human leukemia cells independently of NF-kappaB and MAPKs through alteration of the Mcl-1/Noxa balance. Apoptosis. 2010 Feb;15(2):219-29. doi: 10.1007/s10495-009-0424-9.
35 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
36 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
37 Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
38 Selection of drugs to test the specificity of the Tg.AC assay by screening for induction of the gadd153 promoter in vitro. Toxicol Sci. 2003 Aug;74(2):260-70. doi: 10.1093/toxsci/kfg113. Epub 2003 May 2.
39 Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
40 Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
41 Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
42 Methotrexate induces production of IL-1 and IL-6 in the monocytic cell line U937. Arthritis Res Ther. 2014 Jan 20;16(1):R17. doi: 10.1186/ar4444.
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44 The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells. J Biol Chem. 2004 Jun 25;279(26):27008-16. doi: 10.1074/jbc.M403588200. Epub 2004 Apr 16.
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50 Simvastatin reduces MMP1 expression in human smooth muscle cells cultured on polymerized collagen by inhibiting Rac1 activation. Arterioscler Thromb Vasc Biol. 2007 May;27(5):1043-9. doi: 10.1161/ATVBAHA.107.139881. Epub 2007 Feb 15.
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55 Inhibition of invasion and induction of apoptosis by selenium in human malignant brain tumour cells in vitro. Int J Oncol. 2007 May;30(5):1263-71.
56 Impaired migration of trophoblast cells caused by simvastatin is associated with decreased membrane IGF-I receptor, MMP2 activity and HSP27 expression. Hum Reprod. 2007 Apr;22(4):1161-7. doi: 10.1093/humrep/del464. Epub 2006 Dec 11.
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60 Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
61 Arsenic trioxide (As2O3) inhibits invasion of HT1080 human fibrosarcoma cells: role of nuclear factor-kappaB and reactive oxygen species. J Cell Biochem. 2005 Aug 1;95(5):955-69. doi: 10.1002/jcb.20452.
62 Aspirin inhibits MMP-2 and MMP-9 expressions and activities through upregulation of PPARalpha/gamma and TIMP gene expressions in ox-LDL-stimulated macrophages derived from human monocytes. Pharmacology. 2009;83(1):18-25. doi: 10.1159/000166183. Epub 2008 Oct 30.
63 Repetitive nonlethal oxidant injury to retinal pigment epithelium decreased extracellular matrix turnover in vitro and induced sub-RPE deposits in vivo. Invest Ophthalmol Vis Sci. 2006 Sep;47(9):4098-112. doi: 10.1167/iovs.05-1230.
64 Cannabidiol Effectively Promoted Cell Death in Bladder Cancer and the Improved Intravesical Adhesion Drugs Delivery Strategy Could Be Better Used for Treatment. Pharmaceutics. 2021 Sep 7;13(9):1415. doi: 10.3390/pharmaceutics13091415.
65 Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
66 Frankincense myrrh attenuates hepatocellular carcinoma by regulating tumor blood vessel development through multiple epidermal growth factor receptor-mediated signaling pathways. World J Gastrointest Oncol. 2022 Feb 15;14(2):450-477. doi: 10.4251/wjgo.v14.i2.450.
67 Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts. Biomed Res Int. 2015;2015:257090. doi: 10.1155/2015/257090. Epub 2015 Aug 3.
68 Pentosan polysulfate decreases proliferation and extracellular matrix deposition by vascular smooth muscle cells isolated from failed hemodialysis access grafts. Clin Nephrol. 2000 Aug;54(2):121-7.
69 Investigation of molecular mechanisms underlying the antiproliferative effects of colchicine against PC3 prostate cancer cells. Toxicol In Vitro. 2021 Jun;73:105138. doi: 10.1016/j.tiv.2021.105138. Epub 2021 Mar 6.
70 Peripheral blood expression of nuclear factor-kappab-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-alpha versus methotrexate. J Rheumatol. 2007 Sep;34(9):1817-22. Epub 2007 Aug 1.
71 Matrix metalloproteinase-9 is involved in chronic lymphocytic leukemia cell response to fludarabine and arsenic trioxide. PLoS One. 2014 Jun 23;9(6):e99993. doi: 10.1371/journal.pone.0099993. eCollection 2014.
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