Details of the Drug-Related molecule(s) Interaction Atlas

BMS 536924 Drug Info

BMS-536924; BMS 536924; BMS536924; UNII-40E3AZG1MX; 4-[[(2S)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]-3-[7-methyl-5-(4-morpholinyl)-1H-benzimidazol-2-yl]-2(1H)-pyridinone; 40E3AZG1MX; CHEMBL401930; CS-0117; HY-10262; MLS006011171; SCHEMBL4132577; SCHEMBL15974144; BDBM27879; BCP02116; ZINC6718468; 2278AH; s1012; ABP000159; ZINC140935730; AKOS024458339; AKOS025149514; SB19378; RL03740; KIN0000061; NCGC00346460-05; NCGC00346460-02; SMR004702940; BMS-536924/BMS536924; A2238; X5078; SW218124-2; S-7752

Cross-matching ID

PubChem CID

135440466

ChEBI ID

CHEBI:91454

CAS Number

CAS 468740-43-4

TTD Drug ID

DMDJH2L

VARIDT Drug ID

DR01619

General Information of Drug (ID: DMDJH2L)

Molecule-Related Drug Atlas

Molecule Type:

DTP

DOT

Drug Status:

Approved Drug(s)

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Drug(s) Transported By Breast cancer resistance protein (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[3]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[4]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[5]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[6]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[7]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[8]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[9]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[8]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[10]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[11]
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Drug(s) Affected By Insulin-like growth factor 1 receptor (IGF1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[12]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[13]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[14]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[15]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[17]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[18]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[19]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[19]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[20]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[21]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[22]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[23]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[24]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[25]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[26]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[27]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[28]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[29]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[27]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[30]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[31]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[32]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[33]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[34]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[35]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[36]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[37]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[38]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[39]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[40]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[31]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[41]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[42]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[43]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[30]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[44]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[45]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[33]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[34]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[46]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[47]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[48]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[49]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[50]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[52]
Selenium	DM25CGV	N. A.	N. A.	Approved	[53]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[14]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[54]
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Drug(s) Affected By ATP-binding cassette sub-family C member 2 (ABCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lopinavir	DMITQS0	Human immunodeficiency virus infection	1C62	Approved	[55]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[56]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[57]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[58]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[60]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[61]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[62]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[63]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
ATP-binding cassette sub-family C member 2 (ABCC2)	OTJSIGV5	MRP2_HUMAN	Gene/Protein Processing	[2]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Gene/Protein Processing	[2]
Insulin-like growth factor 1 receptor (IGF1R)	OTXJIF13	IGF1R_HUMAN	Post-Translational Modifications	[2]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Post-Translational Modifications	[2]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Post-Translational Modifications	[2]
RAC-alpha serine/threonine-protein kinase (AKT1)	OT8H2YY7	AKT1_HUMAN	Post-Translational Modifications	[2]

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