Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGO7QT)

Drug Name
INK128 Drug Info
Synonyms
1224844-38-5; Sapanisertib; INK-128; INK 128; INK 128 (MLN0128); TAK-228; UNII-JGH0DF1U03; JGH0DF1U03; 5-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzo[d]oxazol-2-amine; INK-0128; 3-(2-Amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; C15H15N7O; 5-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine; 5-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]-pyrimidin-3-yl)benzo[d]oxazol-2-amine; Sapanisertib (USAN/INN)
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Phase 2 [1]
Multiple myeloma 2A83 Phase 2 [2]
Cross-matching ID
PubChem CID
45375953
ChEBI ID
CHEBI:91450
CAS Number
CAS 1224844-38-5
TTD Drug ID
DMGO7QT

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Serine/threonine-protein kinase mTOR (mTOR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sirolimus DMGW1ID Advanced cancer 2A00-2F9Z Approved [5]
Temsirolimus DMS104F Renal cell carcinoma 2C90 Approved [6]
PF-04449913 DMSB068 Chronic myelomonocytic leukaemia 2A40 Approved [7]
Everolimus DM8X2EH Advanced cancer 2A00-2F9Z Approved [8]
Novolimus DM6ZPLQ Artery stenosis BD52 Approved [9]
Zotarolimus DMRMCXW Solid tumour/cancer 2A00-2F9Z Approved [10]
Ridaforolimus DMLHEU7 Sarcoma 2A60-2C35 Phase 3 [11]
AZD2014 DMOEARH Solid tumour/cancer 2A00-2F9Z Phase 2 [12]
MM-141 DM2RJ4D Pancreatic cancer 2C10 Phase 2 [1]
PQR309 DMMCYZ8 Squamous head and neck cell carcinom 2D60.0 Phase 2 [9]
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Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [13]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [14]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [15]
Gefitinib DM15F0X Colon adenocarcinoma Approved [16]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [17]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [18]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [19]
Quercetin DM3NC4M Obesity 5B81 Approved [20]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [21]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [22]
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Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [23]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [24]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [27]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [28]
Panobinostat DM58WKG Chronic graft versus host disease Approved [29]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [30]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [31]
Testosterone DM7HUNW Hot flushes GA30 Approved [32]
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Drug(s) Affected By Forkhead box protein O3 (FOXO3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [33]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [34]
Quercetin DM3NC4M Obesity 5B81 Approved [35]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [36]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [27]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [37]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [38]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [39]
Leflunomide DMR8ONJ Arthritis FA20 Approved [40]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [41]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [42]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [43]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [44]
Gefitinib DM15F0X Colon adenocarcinoma Approved [45]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [46]
Selenium DM25CGV N. A. N. A. Approved [47]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [18]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [24]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [48]
Methotrexate DM2TEOL Anterior urethra cancer Approved [49]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [50]
Gefitinib DM15F0X Colon adenocarcinoma Approved [51]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [52]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [53]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [54]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [55]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [54]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [56]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [57]
Methotrexate DM2TEOL Anterior urethra cancer Approved [58]
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Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [59]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [15]
Gefitinib DM15F0X Colon adenocarcinoma Approved [16]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [60]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [24]
Quercetin DM3NC4M Obesity 5B81 Approved [61]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [62]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [63]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [64]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [65]
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Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [66]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [68]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [69]
Gefitinib DM15F0X Colon adenocarcinoma Approved [70]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [71]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [72]
Selenium DM25CGV N. A. N. A. Approved [73]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [18]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [74]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [75]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [76]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [77]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [68]
Gefitinib DM15F0X Colon adenocarcinoma Approved [78]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [60]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [79]
Selenium DM25CGV N. A. N. A. Approved [73]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [80]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [18]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [81]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [82]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [83]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [84]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [85]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [86]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [87]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [88]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [89]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [90]
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Drug(s) Affected By Proliferation marker protein Ki-67 (MKI67)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [91]
Methotrexate DM2TEOL Anterior urethra cancer Approved [92]
Quercetin DM3NC4M Obesity 5B81 Approved [93]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [94]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [95]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [27]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [96]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [97]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [98]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [99]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [100]
Gefitinib DM15F0X Colon adenocarcinoma Approved [70]
Prednisone DM2HG4X Acute asthma CA23 Approved [101]
Methotrexate DM2TEOL Anterior urethra cancer Approved [102]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [103]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [104]
Quercetin DM3NC4M Obesity 5B81 Approved [105]
Fluoxetine DM3PD2C Bipolar depression Approved [106]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [107]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [108]
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Drug(s) Affected By Caspase-7 (CASP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [109]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [43]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [110]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [111]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [112]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [112]
Methotrexate DM2TEOL Anterior urethra cancer Approved [113]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [114]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [115]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [116]
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Drug(s) Affected By Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [117]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [18]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [118]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [119]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [120]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [121]
Testosterone DM7HUNW Hot flushes GA30 Approved [122]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [123]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [41]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [124]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Serine/threonine-protein kinase mTOR (mTOR) TTCJG29 MTOR_HUMAN Inhibitor [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Gene/Protein Processing [4]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Protein Interaction/Cellular Processes [4]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Protein Interaction/Cellular Processes [4]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Gene/Protein Processing [4]
Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1) OTHBQVD5 4EBP1_HUMAN Post-Translational Modifications [4]
Forkhead box protein O3 (FOXO3) OTHXQG4P FOXO3_HUMAN Protein Interaction/Cellular Processes [4]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Gene/Protein Processing [4]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Gene/Protein Processing [4]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Protein Interaction/Cellular Processes [4]
Proliferation marker protein Ki-67 (MKI67) OTA8N1QI KI67_HUMAN Gene/Protein Processing [4]

References

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3 2011 Pipeline of Intellikine.
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11 A novel c-Met inhibitor, MK8033, synergizes with carboplatin plus paclitaxel to inhibit ovarian cancer cell growth. Oncol Rep. 2013 May;29(5):2011-8.
12 Dramatic suppression of colorectal cancer cell growth by the dual mTORC1 and mTORC2 inhibitor AZD-2014. Biochem Biophys Res Commun. 2014 Jan 10;443(2):406-12.
13 eIF4E is a critical regulator of human papillomavirus (HPV)-immortalized cervical epithelial (H8) cell growth induced by nicotine. Toxicology. 2019 May 1;419:1-10. doi: 10.1016/j.tox.2019.02.017. Epub 2019 Mar 2.
14 Transcriptomic Analysis of Stem Cells Treated with Moringin or Cannabidiol: Analogies and Differences in Inflammation Pathways. Int J Mol Sci. 2019 Nov 30;20(23):6039. doi: 10.3390/ijms20236039.
15 Antidepressant drug sertraline modulates AMPK-MTOR signaling-mediated autophagy via targeting mitochondrial VDAC1 protein. Autophagy. 2021 Oct;17(10):2783-2799. doi: 10.1080/15548627.2020.1841953. Epub 2020 Nov 9.
16 EGFR tyrosine kinase inhibitors activate autophagy as a cytoprotective response in human lung cancer cells. PLoS One. 2011;6(6):e18691. doi: 10.1371/journal.pone.0018691. Epub 2011 Jun 2.
17 Repression of Kisspeptin1 weakens hydrogen peroxide-caused injury in HTR8 cells via adjusting PI3K/AKT/mTOR pathway. J Biochem Mol Toxicol. 2020 May;34(5):e22461. doi: 10.1002/jbt.22461. Epub 2020 Feb 11.
18 Ribavirin augments doxorubicin's efficacy in human hepatocellular carcinoma through inhibiting doxorubicin-induced eIF4E activation. J Biochem Mol Toxicol. 2018 Jan;32(1). doi: 10.1002/jbt.22007. Epub 2017 Nov 7.
19 Establishment of a 13 genes-based molecular prediction score model to discriminate the neurotoxic potential of food relevant-chemicals. Toxicol Lett. 2022 Feb 1;355:1-18. doi: 10.1016/j.toxlet.2021.10.013. Epub 2021 Nov 5.
20 Quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR- 2 regulated AKT/mTOR/P70S6K signaling pathways. PLoS One. 2012;7(10):e47516. doi: 10.1371/journal.pone.0047516. Epub 2012 Oct 18.
21 A comprehensive analysis of Wnt/beta-catenin signaling pathway-related genes and crosstalk pathways in the treatment of As2O3 in renal cancer. Ren Fail. 2018 Nov;40(1):331-339.
22 Hydroquinone-induced endoplasmic reticulum stress affects TK6 cell autophagy and apoptosis via ATF6-mTOR. Environ Toxicol. 2023 Aug;38(8):1874-1890. doi: 10.1002/tox.23814. Epub 2023 May 6.
23 Selenium sensitizes MCF-7 breast cancer cells to doxorubicin-induced apoptosis through modulation of phospho-Akt and its downstream substrates. Mol Cancer Ther. 2007 Mar;6(3):1031-8. doi: 10.1158/1535-7163.MCT-06-0643. Epub 2007 Mar 5.
24 Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner. Clin Cancer Res. 2012 Aug 15;18(16):4345-55. doi: 10.1158/1078-0432.CCR-11-3227. Epub 2012 Jun 25.
25 Quercetin induced cell apoptosis and altered gene expression in AGS human gastric cancer cells. Environ Toxicol. 2018 Nov;33(11):1168-1181. doi: 10.1002/tox.22623. Epub 2018 Aug 27.
26 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
27 An in vitro study on anti-carcinogenic effect of remdesivir in human ovarian cancer cells via generation of reactive oxygen species. Hum Exp Toxicol. 2022 Jan-Dec;41:9603271221089257. doi: 10.1177/09603271221089257.
28 Antitumor action of the MET tyrosine kinase inhibitor crizotinib (PF-02341066) in gastric cancer positive for MET amplification. Mol Cancer Ther. 2012 Jul;11(7):1557-64. doi: 10.1158/1535-7163.MCT-11-0934. Epub 2012 Jun 22.
29 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
30 Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status. Mol Biol Rep. 2008 Sep;35(3):421-9.
31 Aspirin induces apoptosis in human leukemia cells independently of NF-kappaB and MAPKs through alteration of the Mcl-1/Noxa balance. Apoptosis. 2010 Feb;15(2):219-29. doi: 10.1007/s10495-009-0424-9.
32 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
33 Estrogen-mediated inactivation of FOXO3a by the G protein-coupled estrogen receptor GPER. BMC Cancer. 2015 Oct 15;15:702. doi: 10.1186/s12885-015-1699-6.
34 Differential expression of FOXO1 and FOXO3a confers resistance to oxidative cell death upon endometrial decidualization. Mol Endocrinol. 2006 Oct;20(10):2444-55. doi: 10.1210/me.2006-0118. Epub 2006 May 18.
35 Quercetin and Its Fermented Extract as a Potential Inhibitor of Bisphenol A-Exposed HT-29 Colon Cancer Cells' Viability. Int J Mol Sci. 2023 Mar 15;24(6):5604. doi: 10.3390/ijms24065604.
36 Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
37 Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
38 Involvement of mitochondrial dysfunction in nefazodone-induced hepatotoxicity. Food Chem Toxicol. 2016 Aug;94:148-58. doi: 10.1016/j.fct.2016.06.001. Epub 2016 Jun 8.
39 Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Toxicol Appl Pharmacol. 2012 Jun 1;261(2):204-16.
40 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
41 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
42 Acetaminophen-induced proliferation of estrogen-responsive breast cancer cells is associated with increases in c-myc RNA expression and NF-kappaB activity. Toxicol Sci. 2002 Apr;66(2):233-43. doi: 10.1093/toxsci/66.2.233.
43 Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
44 Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
45 ZD1839 induces p15INK4b and causes G1 arrest by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway. Mol Cancer Ther. 2007 May;6(5):1579-87. doi: 10.1158/1535-7163.MCT-06-0814.
46 Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
47 Selenite and selenomethionine promote HL-60 cell cycle progression. J Nutr. 2002 Apr;132(4):674-9. doi: 10.1093/jn/132.4.674.
48 Novel detection and differential utilization of a c-myc transcriptional block in colon cancer chemoprevention. Cancer Res. 2002 Nov 1;62(21):6006-10.
49 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
50 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
51 Evidence of securin-mediated resistance to gefitinib-induced apoptosis in human cancer cells. Chem Biol Interact. 2013 Apr 25;203(2):412-22. doi: 10.1016/j.cbi.2013.03.011. Epub 2013 Mar 22.
52 Cigarette smoke and asbestos activate poly-ADP-ribose polymerase in alveolar epithelial cells. J Investig Med. 2001 Jan;49(1):68-76. doi: 10.2310/6650.2001.34092.
53 Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
54 The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation. J Biochem Mol Toxicol. 1999;13(6):338-47. doi: 10.1002/(sici)1099-0461(1999)13:6<338::aid-jbt8>3.0.co;2-7.
55 Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line. Clin Cancer Res. 2000 Mar;6(3):891-900.
56 Investigation of molecular mechanisms underlying the antiproliferative effects of colchicine against PC3 prostate cancer cells. Toxicol In Vitro. 2021 Jun;73:105138. doi: 10.1016/j.tiv.2021.105138. Epub 2021 Mar 6.
57 Sulindac enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human lung cancer. Mol Cancer Ther. 2005 Feb;4(2):291-304.
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