Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLFZHD)

Drug Name
Aclarubicin Drug Info
Synonyms
Aclacin; Aclacur; Aclarubicine; Aclarubicino; Aclarubicinum; Jaclacin; Aclacinomycin A; Aclucinomycin A; Antibiotic MA 144A; Antibiotic MA 144A1; Antibiotic MA 144G1; MA 144G1; Aclarubicine [INN-French]; Aclarubicino [INN-Spanish]; Aclarubicinum [INN-Latin]; Antibiotic MA144-A1; MA 144-A1; MA-144A1; Acene-1-carboxylate; Aclarubicin (USAN/INN); Aclarubicin [USAN:BAN:INN]; Alpha-L-lyxo-hexopyranosyl]-oxy]-1-naphthacenecarboxalic acid methyl ester; 10-epi-Aclacinomycin A
Indication
Disease Entry ICD 11 Status REF
Acute myeloid leukaemia 2A60 Approved [1]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
451415
ChEBI ID
CHEBI:77980
CAS Number
CAS 57576-44-0
TTD Drug ID
DMLFZHD

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting DNA topoisomerase II (TOP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [8]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [9]
Teniposide DMLW57T Acute lymphoblastic leukaemia 2A85 Approved [8]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [10]
Idarubicin DMM0XGL Acute myelogenous leukaemia 2A41 Approved [8]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [8]
Lomefloxacin DMVRH9C Bacterial infection 1A00-1C4Z Approved [11]
Dexrazoxane DMD7X1O Breast cancer 2C60-2C65 Approved [8]
Podofilox DMT2EJP Condyloma 1A95 Approved [12]
Enoxacin DMYTE6L Acute gonococcal cervicitis Approved [13]
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Drug(s) Affected By Superoxide dismutase (SOD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [14]
Haloperidol DM96SE0 Delirium Approved [15]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [16]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [17]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [18]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [19]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [20]
Methotrexate DM2TEOL Anterior urethra cancer Approved [21]
Epinephrine DM3KJBC Acute asthma CA23 Approved [22]
Quercetin DM3NC4M Obesity 5B81 Approved [23]
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Drug(s) Affected By Porphobilinogen deaminase (HMBS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [24]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [25]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [26]
Testosterone DM7HUNW Hot flushes GA30 Approved [27]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [28]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [29]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [31]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [32]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [33]
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Drug(s) Affected By Erythroid transcription factor (GATA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [34]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [35]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [36]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [37]
Pomalidomide DMTGBAX Plasma cell myeloma 2A83.1 Approved [38]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [39]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [40]
phorbol 12-myristate 13-acetate DMJWD62 Acute myeloid leukaemia 2A60 Phase 2 [7]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [41]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [42]
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Drug(s) Affected By Transcription factor NF-E2 45 kDa subunit (NFE2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [43]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [44]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [34]
Leflunomide DMR8ONJ Arthritis FA20 Approved [45]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [46]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [46]
Pomalidomide DMTGBAX Plasma cell myeloma 2A83.1 Approved [38]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [47]
Urethane DM7NSI0 N. A. N. A. Phase 4 [48]
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Drug(s) Affected By Glutathione S-transferase P (GSTP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Busulfan DMXYJ9C Chronic myelogenous leukaemia 2A20.0 Approved [49]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [50]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [51]
Chlorambucil DMRKE63 Chronic lymphocytic leukaemia 2A82.0 Approved [51]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [52]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [53]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [54]
Selenium DM25CGV N. A. N. A. Approved [24]
Etretinate DM2CZFA Keratosis ED56 Approved [55]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [56]
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Drug(s) Affected By DNA fragmentation factor subunit alpha (DFFA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [57]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [25]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [58]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [59]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [37]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [28]
Menthol DMG2KW7 Back pain ME84.Z Approved [60]
Capsaicin DMGMF6V Back pain ME84.Z Approved [61]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [62]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [63]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [64]
Gefitinib DM15F0X Colon adenocarcinoma Approved [65]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [67]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [68]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [69]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [68]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [70]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [71]
Methotrexate DM2TEOL Anterior urethra cancer Approved [72]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [73]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [74]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [75]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [76]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [77]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [78]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [79]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [80]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [81]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [82]
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Drug(s) Affected By Caspase-8 (CASP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [83]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [84]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [85]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [86]
Gefitinib DM15F0X Colon adenocarcinoma Approved [87]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [88]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [67]
Selenium DM25CGV N. A. N. A. Approved [24]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [89]
Methotrexate DM2TEOL Anterior urethra cancer Approved [90]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
DNA topoisomerase II (TOP2) TT0IHXV TOP2A_HUMAN; TOP2B_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [3]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Gene/Protein Processing [3]
DNA fragmentation factor subunit alpha (DFFA) OTFPFMT8 DFFA_HUMAN Protein Interaction/Cellular Processes [4]
E3 ubiquitin-protein ligase XIAP OT24GP9B XIAP_HUMAN Drug Response [5]
Erythroid transcription factor (GATA1) OTX1R7O1 GATA1_HUMAN Gene/Protein Processing [6]
Glutathione S-transferase P (GSTP1) OTLP0A0Y GSTP1_HUMAN Gene/Protein Processing [7]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Gene/Protein Processing [3]
Porphobilinogen deaminase (HMBS) OT3P47DC HEM3_HUMAN Gene/Protein Processing [6]
Superoxide dismutase (SOD1) OT39TA1L SODC_HUMAN Gene/Protein Processing [6]
Transcription factor NF-E2 45 kDa subunit (NFE2) OTLM94BI NFE2_HUMAN Gene/Protein Processing [6]

References

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