Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMM10TG)

Drug Name
Cirsimarin Drug Info
Synonyms
Cirsimarin; Cirsitakaoside; 13020-19-4; CHEMBL517637; 2-(4-(beta-D-Glucopyranosyloxy)phenyl)-5-hydroxy-6,7-dimethoxy-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one, 2-(4-(beta-D-glucopyranosyloxy)phenyl)-5-hydroxy-6,7-dimethoxy-; AC1L4LVL; AC1Q6CLV; SCHEMBL2016369; MolPort-019-937-034; BDBM50250467; ZINC31459932; MCULE-1339456605; 4-(5-hydroxy-6,7-dimethoxy-4-oxo-4h-chromen-2-yl)phenyl; LS-39681
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
159460
CAS Number
CAS 13020-19-4
TTD Drug ID
DMM10TG

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Adenosine A1 receptor (ADORA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Caffeine DMKBJWP Allergic rhinitis CA08.0 Approved [3]
Rolofylline DMSZPR3 Heart failure BD10-BD13 Phase 3 [4]
Tonapofylline DMBH316 Acute and chronic heart failure BD1Z Phase 2 [5]
AMP-579 DMJ4GPR Hyperlipidaemia 5C80 Phase 2 [6]
SELODENOSON DMQM3IX Cardiac arrhythmias BC9Z Phase 2 [7]
Apaxifylline DMQMV9F Cognitive impairment 6D71 Phase 2 [8]
SLV320 DM867BJ Heart failure BD10-BD13 Phase 2 [9]
DTI-0009 DMV84OK Atrial fibrillation BC81.3 Phase 2 [7]
Capadenoson DMYWO62 Atrial fibrillation BC81.3 Phase 2 [10]
BAY 1067197 DM4JGNH Heart failure BD10-BD13 Phase 2 [11]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [12]
Gefitinib DM15F0X Colon adenocarcinoma Approved [13]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [14]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [15]
Etretinate DM2CZFA Keratosis ED56 Approved [16]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [17]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [18]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [19]
Quercetin DM3NC4M Obesity 5B81 Approved [20]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [21]
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Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [22]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [23]
Fructose DM43AN2 Vomiting MD90 Approved [24]
Ketoprofen DMRKXPT Bursitis Approved [24]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [25]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [26]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [27]
Gefitinib DM15F0X Colon adenocarcinoma Approved [28]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [29]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [30]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [31]
Methotrexate DM2TEOL Anterior urethra cancer Approved [32]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [33]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [34]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [35]
Paclitaxel DMLB81S Breast carcinoma Approved [36]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [37]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [38]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [39]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [40]
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Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [41]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [42]
Selenium DM25CGV N. A. N. A. Approved [43]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [44]
Methotrexate DM2TEOL Anterior urethra cancer Approved [45]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [46]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [47]
Quercetin DM3NC4M Obesity 5B81 Approved [48]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [49]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [50]
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Drug(s) Affected By Cadherin-1 (CDH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [51]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [52]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [53]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [54]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [55]
Quercetin DM3NC4M Obesity 5B81 Approved [56]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [57]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [58]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [59]
Panobinostat DM58WKG Chronic graft versus host disease Approved [60]
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Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [61]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [62]
Gefitinib DM15F0X Colon adenocarcinoma Approved [28]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [30]
Selenium DM25CGV N. A. N. A. Approved [63]
Pentosan Polysulfate DM2HRKE Interstitial cystitis GC00.3 Approved [64]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [65]
Methotrexate DM2TEOL Anterior urethra cancer Approved [66]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [67]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [68]
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Drug(s) Affected By Cyclin-A2 (CCNA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [69]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [70]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [71]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [72]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [73]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [74]
Methotrexate DM2TEOL Anterior urethra cancer Approved [75]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [76]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [77]
Quercetin DM3NC4M Obesity 5B81 Approved [56]
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Drug(s) Affected By Stromelysin-3 (MMP11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [78]
Quercetin DM3NC4M Obesity 5B81 Approved [56]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [80]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [81]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [82]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [83]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [84]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [85]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [86]
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Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [87]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [88]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [89]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [90]
Gefitinib DM15F0X Colon adenocarcinoma Approved [91]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [92]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [93]
Selenium DM25CGV N. A. N. A. Approved [94]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [95]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [96]
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Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [97]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [70]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [98]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [99]
Selenium DM25CGV N. A. N. A. Approved [43]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [100]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [101]
Methotrexate DM2TEOL Anterior urethra cancer Approved [66]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [46]
Quercetin DM3NC4M Obesity 5B81 Approved [48]
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Drug(s) Affected By C-C chemokine receptor type 5 (CCR5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [102]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [103]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [104]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [105]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [106]
I3C DMIGFOR Breast cancer 2C60-2C65 Phase 3 [107]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [108]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [109]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [106]
EUGENOL DM7US1H Discovery agent N.A. Patented [103]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [110]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [111]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [112]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [113]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [114]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [115]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [15]
Meloxicam DM2AR7L Arthritis FA20 Approved [116]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [117]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [118]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [119]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [120]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [112]
Verapamil DMA7PEW Angina pectoris BA40 Approved [121]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [51]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [114]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [92]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [78]
Meloxicam DM2AR7L Arthritis FA20 Approved [122]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [100]
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Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [38]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [123]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [15]
Selenium DM25CGV N. A. N. A. Approved [94]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [124]
Methotrexate DM2TEOL Anterior urethra cancer Approved [45]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [125]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [126]
Quercetin DM3NC4M Obesity 5B81 Approved [127]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [128]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Adenosine A1 receptor (ADORA1) TTK25J1 AA1R_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [2]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Gene/Protein Processing [2]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [2]
C-C chemokine receptor type 5 (CCR5) OTP5FMZ4 CCR5_HUMAN Gene/Protein Processing [2]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Gene/Protein Processing [2]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Gene/Protein Processing [2]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [2]
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Gene/Protein Processing [2]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Gene/Protein Processing [2]
Cyclin-dependent kinase 4 (CDK4) OT7EP05T CDK4_HUMAN Gene/Protein Processing [2]

References

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49 Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
50 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
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52 Manganese superoxide dismutase induces migration and invasion of tongue squamous cell carcinoma via H2O2-dependent Snail signaling. Free Radic Biol Med. 2012 Jul 1;53(1):44-50. doi: 10.1016/j.freeradbiomed.2012.04.031. Epub 2012 May 9.
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