Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNHTZI)

Drug Name
Protriptyline Drug Info
Synonyms
Amimetilina; Impril; Maximed; Novopramine; Protriptilina; Protriptylinum; Protryptyline; Rhotrimine; Triptil; Triptyl; Vivactil; Vivactyl; Triptil hydrochloride; Normethyl EX4442; Triadapin 5; Apo-Imipramine; Apo-Trimip; Novo-Doxepin; Novo-Tripramine; Protriptilina [INN-Spanish]; Protriptyline (INN); Protriptyline [INN:BAN]; Protriptylinum [INN-Latin]; Vivactil (TN); N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propanamine; N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propylamine; N-Methyl-5H-dibenzo(a,d)cycloheptene-5-propylamine; N-3-(5H-Dibenzo(a,d)cyclohepten-5-yl)propyl-N-methylamine; 3-(5H-Dibenzo[a,d]cyclohepten-5-yl)-N-methyl-1-propanamine; 3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-1-amine; 5-(3-Methylaminopropyl)-5H-Dibenzo[a,d]cycloheptene; 5-(3-Methylaminopropyl)-5H-dibenzo(a,d)cycloheptene; 5H-Dibenzo[a, d]cycloheptene-5-propanamine, N-methyl-, hydrochloride; 7-(3-Methylaminopropyl)-1,2:5,6-dibenzocycloheptatriene
Indication
Disease Entry ICD 11 Status REF
Depression 6A70-6A7Z Approved [1]
Therapeutic Class
Antidepressants
Cross-matching ID
PubChem CID
4976
ChEBI ID
CHEBI:8597
CAS Number
CAS 438-60-8
TTD Drug ID
DMNHTZI
VARIDT Drug ID
DR00486
ACDINA Drug ID
D00567

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Norepinephrine transporter (NET)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [6]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [7]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [8]
Desipramine DMT2FDC Attention deficit hyperactivity disorder 6A05.Z Approved [6]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [9]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [10]
Tapentadol hydrochloride DMXLSH3 Acute pain MG31 Approved [11]
Venlafaxine DMR6QH0 Anxiety disorder 6B00-6B0Z Approved [10]
Trimipramine DM1SC8M Major depressive disorder 6A70.3 Approved [12]
Duloxetine DM9BI7M Depression 6A70-6A7Z Approved [13]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [14]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [15]
Methotrexate DM2TEOL Anterior urethra cancer Approved [16]
Folic Acid DMEMBJC Colorectal carcinoma Approved [17]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [16]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [16]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [18]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [16]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [19]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [20]
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Drug(s) Affected By Proepiregulin (EREG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [21]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [4]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [22]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [4]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [4]
Methotrexate DM2TEOL Anterior urethra cancer Approved [23]
Quercetin DM3NC4M Obesity 5B81 Approved [24]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [25]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [4]
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Drug(s) Affected By Antileukoproteinase (SLPI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [4]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [4]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [22]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [4]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [4]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [4]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [4]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [27]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [4]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [4]
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Drug(s) Affected By Hepatocyte growth factor receptor (MET)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cabozantinib DMIYDT4 Medullary thyroid gland carcinoma Approved [28]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [29]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [4]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [4]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [4]
Methotrexate DM2TEOL Anterior urethra cancer Approved [30]
Quercetin DM3NC4M Obesity 5B81 Approved [24]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [4]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [31]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [30]
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Drug(s) Affected By Phosphatidylcholine translocator ABCB4 (ABCB4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [32]
Verapamil DMA7PEW Angina pectoris BA40 Approved [33]
Methysergide DM1EF73 Migraine 8A80 Approved [5]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [34]
Methotrexate DM2TEOL Anterior urethra cancer Approved [35]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [5]
Quercetin DM3NC4M Obesity 5B81 Approved [24]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [36]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [37]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [38]
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Drug(s) Affected By Bone morphogenetic protein 6 (BMP6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [4]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [4]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [39]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [4]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [4]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [4]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [4]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [40]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [4]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [41]
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Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [42]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [43]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [44]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [45]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [46]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [47]
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [48]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [49]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [4]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
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Drug(s) Affected By Interleukin-24 (IL24)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [51]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [4]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [52]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [4]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [4]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [53]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [25]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [54]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [54]
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Drug(s) Affected By PTB-containing, cubilin and LRP1-interacting protein (PID1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [4]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [4]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [4]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [4]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [4]
Amikacin DM5PDRB Bacteremia 1A73 Approved [4]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [4]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [4]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [4]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [55]
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Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [56]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [4]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [57]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [4]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [4]
Methotrexate DM2TEOL Anterior urethra cancer Approved [30]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [58]
Quercetin DM3NC4M Obesity 5B81 Approved [24]
Fluoxetine DM3PD2C Bipolar depression Approved [59]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Norepinephrine transporter (NET) TTAWNKZ SC6A2_HUMAN Inhibitor [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Antileukoproteinase (SLPI) OTUNFUU8 SLPI_HUMAN Gene/Protein Processing [4]
Bone morphogenetic protein 6 (BMP6) OT9WN536 BMP6_HUMAN Gene/Protein Processing [4]
Cystine/glutamate transporter (SLC7A11) OTKJ6PXW XCT_HUMAN Gene/Protein Processing [4]
Hepatocyte growth factor receptor (MET) OT7K55MU MET_HUMAN Gene/Protein Processing [4]
Interleukin-24 (IL24) OT4VUWH1 IL24_HUMAN Gene/Protein Processing [4]
Phosphatidylcholine translocator ABCB4 (ABCB4) OTE6PY83 MDR3_HUMAN Gene/Protein Processing [5]
Proepiregulin (EREG) OTRM4NQY EREG_HUMAN Gene/Protein Processing [4]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Gene/Protein Processing [4]
PTB-containing, cubilin and LRP1-interacting protein (PID1) OT5YJ7FI PCLI1_HUMAN Gene/Protein Processing [4]

References

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