Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMO946V)

Drug Name
Ticlopidine Drug Info
Synonyms
Ticlid; Ticlopidina; Ticlopidinum; PCR 5332; Ticlid (TN); Ticlopidin-Puren; Ticlopidina [INN-Spanish]; Ticlopidine (INN); Ticlopidine [INN:BAN]; Ticlopidinum [INN-Latin]; Ticlopidin-Puren (TN); 5-((2-Chlorophenyl)methyl)-4,5,6,7-tetrahydrothieno(3,2-c)pyridine; 5-(2-Chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine; 5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridine; 5-[(2-chlorophenyl)methyl]-6,7-dihydro-4H-thieno[3,2-c]pyridine
Indication
Disease Entry ICD 11 Status REF
Acute coronary syndrome BA41 Approved [1]
Myocardial infarction BA41-BA43 Approved [1]
Stroke 8B20 Approved [2]
Therapeutic Class
Fibrinolytic Agents
Cross-matching ID
PubChem CID
5472
ChEBI ID
CHEBI:9588
CAS Number
CAS 55142-85-3
TTD Drug ID
DMO946V
VARIDT Drug ID
DR00842
INTEDE Drug ID
DR1592
ACDINA Drug ID
D00675

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Platelet-activating factor receptor (PTAFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
RUPATADINE DMBPN7T N. A. N. A. Phase 4 [7]
ISRAPAFANT DMP61YB Asthma CA23 Phase 3 [8]
CMI-392 DM1NCUY Psoriasis vulgaris EA90 Phase 2 [9]
Lexipafant DMZ2YBE Nerve injury ND56.4 Phase 2 [10]
YM-264 DMAZNVX Sepsis 1G40-1G41 Phase 2 [11]
Dersalazine DMH96JW Inflammatory bowel disease DD72 Phase 2 [12]
60P002 DMHBN8X Dengue 1D20-1D2Z Phase 2 [13]
PegCNTF DMW7VGZ Obesity 5B81 Phase 1 [14]
FOROPAFANT DML1DGP Asthma CA23 Discontinued in Phase 3 [15]
BN 50730 DMZK70E Asthma CA23 Discontinued in Phase 3 [16]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [17]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [18]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [19]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [20]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [5]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [21]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [22]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [23]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [24]
Propranolol DM79NTF Angina pectoris BA40 Approved [25]
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Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [26]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [27]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [28]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [29]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [30]
Verapamil DMA7PEW Angina pectoris BA40 Approved [31]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [32]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [33]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [34]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [35]
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Drug(s) Metabolized By Myeloperoxidase (MPO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [36]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [37]
Dapsone DM4LT8A Acne vulgaris ED80 Approved [5]
Carboplatin DMG281S Adenocarcinoma 2D40 Approved [37]
Cysteamine DMSYFM8 Nephropathic cystinosis 5C60 Approved [38]
Glutethimide DMGE0CW Insomnia 7A00-7A0Z Approved [39]
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Drug(s) Affected By HLA class I histocompatibility antigen, A alpha chain (HLA-A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [40]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [41]
Allopurinol DMLPAOB Gout FA25 Approved [42]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [43]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [44]
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [44]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [45]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [46]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [46]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [46]
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Drug(s) Affected By HLA class I histocompatibility antigen, B alpha chain (HLA-B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [47]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [41]
Allopurinol DMLPAOB Gout FA25 Approved [48]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [51]
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [46]
Abacavir DMMN36E Human immunodeficiency virus infection 1C62 Approved [52]
Flucloxacillin DMNUWST Bacterial infection 1A00-1C4Z Approved [53]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [44]
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Drug(s) Affected By HLA class I histocompatibility antigen, C alpha chain (HLA-C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [54]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [41]
Allopurinol DMLPAOB Gout FA25 Approved [43]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [49]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [55]
Selenium DM25CGV N. A. N. A. Approved [56]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [57]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [58]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [59]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [60]
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Drug(s) Affected By HLA class II histocompatibility antigen, DQ beta 1 chain (HLA-DQB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [61]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [46]
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [46]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [49]
Allopurinol DMLPAOB Gout FA25 Approved [43]
Selenium DM25CGV N. A. N. A. Approved [56]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [46]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [62]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [63]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [46]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Platelet-activating factor receptor (PTAFR) TTQL5VC PTAFR_HUMAN Modulator [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [4]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Substrate [5]
Myeloperoxidase (MPO) DEA3U9Y PERM_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
HLA class I histocompatibility antigen, A alpha chain (HLA-A) OTAH14LU HLAA_HUMAN Drug Response [6]
HLA class I histocompatibility antigen, B alpha chain (HLA-B) OTNXFWY2 HLAB_HUMAN Drug Response [6]
HLA class I histocompatibility antigen, C alpha chain (HLA-C) OTV38BUJ HLAC_HUMAN Drug Response [6]
HLA class II histocompatibility antigen, DQ beta 1 chain (HLA-DQB1) OTVVI3UI DQB1_HUMAN Drug Response [6]

References

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8 Amino acid residues critical for endoplasmic reticulum export and trafficking of platelet-activating factor receptor. J Biol Chem. 2010 Feb 19;285(8):5931-40.
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10 Lexipafant and acute pancreatitis: a critical appraisal of the clinical trials.Eur J Surg.2002;168(4):215-9.
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