Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMPZSV1)

Drug Name
oxalacetic acid Drug Info
Synonyms oxaloacetate
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
970
ChEBI ID
CHEBI:30744
CAS Number
CAS 328-42-7
TTD Drug ID
DMPZSV1
INTEDE Drug ID
DR2118

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DME
DOT
Drug Status:
Investigative Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Metabolized By Phosphoenolpyruvate carboxykinase (PCK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Phosphoenolpyruvate DM2D947 Discovery agent N.A. Investigative [2]
Drug(s) Affected By Cytochrome c oxidase subunit 2 (COX2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [6]
Quercetin DM3NC4M Obesity 5B81 Approved [7]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [8]
Clarithromycin DM4M1SG Acute maxillary sinusitis Approved [9]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [10]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [11]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [12]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [9]
Menthol DMG2KW7 Back pain ME84.Z Approved [13]
Didanosine DMI2QPE Human immunodeficiency virus infection 1C62 Approved [14]
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Drug(s) Affected By Aspartate aminotransferase, cytoplasmic (GOT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [15]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [16]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [17]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [18]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [18]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [18]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [19]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [12]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [20]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [18]
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Drug(s) Affected By Malate dehydrogenase, cytoplasmic (MDH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [21]
Quercetin DM3NC4M Obesity 5B81 Approved [7]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [22]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [23]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [24]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [26]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [12]
Benzatropine DMF7EXL Parkinsonian disorder Approved [27]
Clozapine DMFC71L Schizophrenia 6A20 Approved [27]
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Drug(s) Affected By Transcription factor A, mitochondrial (TFAM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [28]
Quercetin DM3NC4M Obesity 5B81 Approved [29]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [30]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [31]
Testosterone DM7HUNW Hot flushes GA30 Approved [32]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [35]
Zalcitabine DMH7MUV Human immunodeficiency virus infection 1C62 Approved [36]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [37]
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Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PPRC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [38]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [39]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [24]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [26]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [40]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [38]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [41]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [42]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [43]
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Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPARGC1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [38]
Quercetin DM3NC4M Obesity 5B81 Approved [44]
Panobinostat DM58WKG Chronic graft versus host disease Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [19]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [46]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [40]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [38]
Arsenic DMTL2Y1 N. A. N. A. Approved [47]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [48]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [49]
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Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [50]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [30]
Fructose DM43AN2 Vomiting MD90 Approved [51]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [52]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [53]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [16]
Ketotifen DM74XKS Allergic conjunctivitis 9A60.02 Approved [54]
Riboflavin DM8YMWE Acne vulgaris ED80 Approved [5]
Leflunomide DMR8ONJ Arthritis FA20 Approved [55]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Phosphoenolpyruvate carboxykinase (PCK1) DEPLH5Z PCKGC_HUMAN Substrate [2]
Oxaloacetate decarboxylase (FAHD1) DENCJTA FAHD1_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Aspartate aminotransferase, cytoplasmic (GOT1) OTZLM5UB AATC_HUMAN Gene/Protein Processing [4]
Cytochrome c oxidase subunit 2 (COX2) OTTMVBJJ COX2_HUMAN Gene/Protein Processing [4]
Malate dehydrogenase, cytoplasmic (MDH1) OTJEO4E8 MDHC_HUMAN Gene/Protein Processing [4]
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) OTHCDQ22 PRGC1_HUMAN Gene/Protein Processing [5]
Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPARGC1B) OTN6FKCB PRGC2_HUMAN Gene/Protein Processing [4]
Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PPRC1) OT6GB3WR PPRC1_HUMAN Gene/Protein Processing [4]
Transcription factor A, mitochondrial (TFAM) OTXXV5V7 TFAM_HUMAN Gene/Protein Processing [4]

References

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3 Identification of FAH domain-containing protein 1 (FAHD1) as oxaloacetate decarboxylase. J Biol Chem. 2015 Mar 13;290(11):6755-62.
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17 Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
18 Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
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20 NOTCH signaling is activated in and contributes to resistance in enzalutamide-resistant prostate cancer cells. J Biol Chem. 2019 May 24;294(21):8543-8554. doi: 10.1074/jbc.RA118.006983. Epub 2019 Apr 2.
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26 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
27 Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
28 Trans-Resveratrol in Gnetum gnemon protects against oxidative-stress-induced endothelial senescence. J Nat Prod. 2013 Jul 26;76(7):1242-7.
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34 Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
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