Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRJLAT)

Drug Name
Osimertinib Drug Info
Synonyms Tagrisso
Indication
Disease Entry ICD 11 Status REF
Non-small-cell lung cancer 2C25.Y Approved [1]
Melanoma 2C30 Phase 3 [2]
Cross-matching ID
PubChem CID
71496458
ChEBI ID
CHEBI:90943
CAS Number
CAS 1421373-65-0
TTD Drug ID
DMRJLAT
VARIDT Drug ID
DR00655
ACDINA Drug ID
D00495

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Epidermal growth factor receptor (EGFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [10]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [11]
Gefitinib DM15F0X Colon adenocarcinoma Approved [12]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [13]
Vandetanib DMRICNP Solid tumour/cancer 2A00-2F9Z Approved [14]
Dacomitinib DMOH8VY Non-small-cell lung cancer 2C25.Y Approved [15]
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [16]
SKI-758 DMQ8E9R Ischemia 8B10-8B11 Approved [17]
Epidermal growth factor DMVONE6 Vulnerary ND56.Z Approved [15]
Merimepodib DM0HS92 Breast cancer 2C60-2C65 Approved [18]
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [29]
Gefitinib DM15F0X Colon adenocarcinoma Approved [30]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [31]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [32]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [33]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [34]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [35]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [36]
Selenium DM25CGV N. A. N. A. Approved [37]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [38]
⏷ Show the Full List of 20 Drug(s)
Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [19]
Gefitinib DM15F0X Colon adenocarcinoma Approved [20]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [21]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [22]
Etretinate DM2CZFA Keratosis ED56 Approved [23]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [24]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [25]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [26]
Quercetin DM3NC4M Obesity 5B81 Approved [27]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [28]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [39]
Gefitinib DM15F0X Colon adenocarcinoma Approved [40]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [41]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [22]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [42]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [43]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [42]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [44]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [45]
Methotrexate DM2TEOL Anterior urethra cancer Approved [46]
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Drug(s) Affected By Alanine aminotransferase 1 (GPT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Halothane DM80OZ5 Anaesthesia 9A78.6 Approved [47]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [48]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [49]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [47]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [47]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [47]
Gefitinib DM15F0X Colon adenocarcinoma Approved [4]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [4]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [4]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [51]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [52]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [53]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [54]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [55]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [56]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [57]
Gefitinib DM15F0X Colon adenocarcinoma Approved [58]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [59]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [60]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [61]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [52]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [62]
Paclitaxel DMLB81S Breast carcinoma Approved [63]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [64]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [51]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [47]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [65]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [54]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [55]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [66]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [67]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [68]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [69]
Gefitinib DM15F0X Colon adenocarcinoma Approved [5]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [70]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [71]
Selenium DM25CGV N. A. N. A. Approved [72]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [73]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [74]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [75]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [76]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [77]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [78]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [79]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [80]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [81]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [82]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [83]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [84]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sequestosome-1 (SQSTM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [85]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [86]
Gefitinib DM15F0X Colon adenocarcinoma Approved [87]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [88]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [89]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [24]
Methotrexate DM2TEOL Anterior urethra cancer Approved [90]
Quercetin DM3NC4M Obesity 5B81 Approved [91]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [92]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [93]
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Drug(s) Affected By Catalase (CAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [94]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [95]
Haloperidol DM96SE0 Delirium Approved [47]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [96]
Selenium DM25CGV N. A. N. A. Approved [97]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [98]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [99]
Methotrexate DM2TEOL Anterior urethra cancer Approved [100]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [101]
Quercetin DM3NC4M Obesity 5B81 Approved [91]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
EGFR T790M mutant (EGFR T790M) TTZ04AF EGFR_HUMAN Inhibitor [3]
Epidermal growth factor receptor (EGFR) TTGKNB4 EGFR_HUMAN Inhibitor [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Alanine aminotransferase 1 (GPT) OTOXOA0Q ALAT1_HUMAN Protein Interaction/Cellular Processes [4]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Gene/Protein Processing [5]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [6]
Catalase (CAT) OTHEBX9R CATA_HUMAN Drug Response [6]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Gene/Protein Processing [6]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [7]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [7]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Protein Interaction/Cellular Processes [8]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Post-Translational Modifications [5]
Sequestosome-1 (SQSTM1) OTGY5D5J SQSTM_HUMAN Gene/Protein Processing [9]

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28 Troglitazone sensitizes tumor cells to TRAIL-induced apoptosis via down-regulation of FLIP and Survivin. Apoptosis. 2006 Sep;11(9):1503-12. doi: 10.1007/s10495-006-8896-3.
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33 A fine-needle aspirate-based vulnerability assay identifies polo-like kinase 1 as a mediator of gemcitabine resistance in pancreatic cancer. Mol Cancer Ther. 2010 Feb;9(2):311-8. doi: 10.1158/1535-7163.MCT-09-0693. Epub 2010 Jan 26.
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60 SIRT3 Mediates the Antioxidant Effect of Hydrogen Sulfide in Endothelial Cells. Antioxid Redox Signal. 2016 Feb 20;24(6):329-43. doi: 10.1089/ars.2015.6331. Epub 2015 Nov 10.
61 Downregulation of mitogen-activated protein kinases (MAPKs) in chronic ethanol-induced fatty liver. Toxicol Mech Methods. 2020 Jul;30(6):407-416. doi: 10.1080/15376516.2020.1747126. Epub 2020 Apr 1.
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63 The stent-eluting drugs sirolimus and paclitaxel suppress healing of the endothelium by induction of autophagy. Am J Pathol. 2009 Nov;175(5):2226-34.
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65 Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
66 Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells. Oncogene. 2016 Aug 25;35(34):4518-28. doi: 10.1038/onc.2015.511. Epub 2016 Feb 8.
67 Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent. Mol Cancer. 2010 Aug 20;9:220.
68 Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget. 2019 Jan 1;10(1):45-59. doi: 10.18632/oncotarget.26534. eCollection 2019 Jan 1.
69 -Carotene Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cell Lines via the Cav-1/AKT/NF-B Signaling Pathway. J Biochem Mol Toxicol. 2016 Mar;30(3):148-57. doi: 10.1002/jbt.21773. Epub 2016 Jan 6.
70 Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cells. Toxicol Sci. 2009 Aug;110(2):376-88. doi: 10.1093/toxsci/kfp101. Epub 2009 May 18.
71 Effect of toll-like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma. Liver Int. 2015 Mar;35(3):1063-76. doi: 10.1111/liv.12626. Epub 2014 Jul 30.
72 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
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