Details of the Drug Combination

General Information of Drug Combination (ID: DCR7FY1)

Drug Combination Name
Deguelin Ibrutinib
Indication
Disease Entry Status REF
Diffuse large B cell lymphoma Investigative [1]
Component Drugs Deguelin   DMXT7WG Ibrutinib   DMHZCPO
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: TMD8
Zero Interaction Potency (ZIP) Score: 11.79
Bliss Independence Score: 13.2
Loewe Additivity Score: 6.43
LHighest Single Agent (HSA) Score: 8.22

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Deguelin
Disease Entry ICD 11 Status REF
Esophageal squamous cell carcinoma 2E60.1 Investigative [2]
Deguelin Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Aurora kinase B (AURKB) TT5LS6T AURKB_HUMAN Inhibitor [10]
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Deguelin Interacts with 717 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
CCAAT/enhancer-binding protein alpha (CEBPA) OTOM9OE4 CEBPA_HUMAN Decreases Expression [11]
Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2) OTUE7Z91 MP2K2_HUMAN Decreases Expression [12]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Activity [12]
Glycogen synthase kinase-3 beta (GSK3B) OTL3L14B GSK3B_HUMAN Decreases Phosphorylation [12]
Endothelial PAS domain-containing protein 1 (EPAS1) OTRE3O8U EPAS1_HUMAN Decreases Expression [12]
Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7) OT1Q40TZ MP2K7_HUMAN Decreases Expression [13]
Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1) OTY9R6FZ ERN1_HUMAN Decreases Expression [13]
Metalloproteinase inhibitor 1 (TIMP1) OTOXC51H TIMP1_HUMAN Increases Expression [13]
Interstitial collagenase (MMP1) OTI4I2V1 MMP1_HUMAN Decreases Expression [13]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Increases Phosphorylation [13]
Matrilysin (MMP7) OTVT3SEJ MMP7_HUMAN Decreases Expression [13]
Metalloproteinase inhibitor 2 (TIMP2) OT8S1RRP TIMP2_HUMAN Increases Expression [13]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Affects Phosphorylation [13]
Nitric oxide synthase, inducible (NOS2) OTKKIOJ1 NOS2_HUMAN Decreases Expression [13]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Decreases Expression [13]
Collagenase 3 (MMP13) OTY8BZIE MMP13_HUMAN Decreases Expression [13]
Transforming protein RhoA (RHOA) OT6YOJ9N RHOA_HUMAN Decreases Expression [13]
Son of sevenless homolog 1 (SOS1) OTTCWXC3 SOS1_HUMAN Decreases Expression [13]
Rho-associated protein kinase 1 (ROCK1) OTSXYVW1 ROCK1_HUMAN Decreases Expression [13]
Mitogen-activated protein kinase kinase kinase 3 (MAP3K3) OT53LJGW M3K3_HUMAN Affects Expression [13]
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3) OT0DZGY4 E2AK3_HUMAN Increases Phosphorylation [13]
Putative cytochrome P450 2D7 (CYP2D7) OTYJTL3S CP2D7_HUMAN Decreases Expression [7]
DENN domain-containing protein 3 (DENND3) OTOQJ25X DEND3_HUMAN Decreases Expression [7]
Golgi pH regulator A (GPR89A) OTXXM7I5 GPHRA_HUMAN Increases Expression [7]
Potassium channel subfamily K member 1 (KCNK1) OTBXPTKX KCNK1_HUMAN Decreases Expression [7]
E3 SUMO-protein ligase CBX4 (CBX4) OT4XVRRF CBX4_HUMAN Increases Expression [7]
Pyruvate dehydrogenase protein X component, mitochondrial (PDHX) OTG7O271 ODPX_HUMAN Increases Expression [7]
Importin-5 (IPO5) OTAK40ED IPO5_HUMAN Increases Expression [7]
Dynamin-1-like protein (DNM1L) OTXK1Q1G DNM1L_HUMAN Increases Expression [7]
Interferon-related developmental regulator 1 (IFRD1) OT4SQMLQ IFRD1_HUMAN Increases Expression [7]
Claudin-5 (CLDN5) OTUX60YO CLD5_HUMAN Decreases Expression [7]
Serine/threonine-protein kinase 25 (STK25) OT4YPNTF STK25_HUMAN Decreases Expression [7]
Suppressor of cytokine signaling 2 (SOCS2) OTBPNKJQ SOCS2_HUMAN Decreases Expression [7]
Neurocan core protein (NCAN) OT8OO6ZE NCAN_HUMAN Decreases Expression [7]
Protein arginine N-methyltransferase 5 (PRMT5) OTF6IGJS ANM5_HUMAN Increases Expression [7]
Telomerase reverse transcriptase (TERT) OT085VVA TERT_HUMAN Decreases Expression [7]
Serine/threonine-protein kinase Chk1 (CHEK1) OTTTI622 CHK1_HUMAN Increases Expression [7]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Increases Expression [7]
Peripheral plasma membrane protein CASK (CASK) OT8EF7ZF CSKP_HUMAN Increases Expression [7]
Aurora kinase A (AURKA) OTMX0HYT AURKA_HUMAN Increases Expression [7]
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK) OTLF4ZB1 IKKA_HUMAN Increases Expression [7]
Centrin-3 (CETN3) OTG4PL7H CETN3_HUMAN Decreases Expression [7]
V-type proton ATPase subunit e 1 (ATP6V0E1) OTZZIUYY VA0E1_HUMAN Decreases Expression [7]
Nuclear valosin-containing protein-like (NVL) OTWTGVTI NVL_HUMAN Increases Expression [7]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Increases Expression [7]
Glutamate receptor ionotropic, NMDA 2D (GRIN2D) OTTEKYKQ NMDE4_HUMAN Decreases Expression [7]
ATP-binding cassette sub-family C member 4 (ABCC4) OTO27PAL MRP4_HUMAN Increases Expression [7]
ATP-binding cassette sub-family C member 5 (ABCC5) OT34G4US MRP5_HUMAN Decreases Expression [7]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Decreases Expression [14]
Tapasin (TAPBP) OTL81AVZ TPSN_HUMAN Decreases Expression [7]
ATP-dependent RNA helicase DHX15 (DHX15) OT4F98TK DHX15_HUMAN Increases Expression [7]
Ribosomal RNA-processing protein 8 (RRP8) OTGZHVVW RRP8_HUMAN Increases Expression [7]
D-3-phosphoglycerate dehydrogenase (PHGDH) OT1LMRTG SERA_HUMAN Increases Expression [7]
Disintegrin and metalloproteinase domain-containing protein 12 (ADAM12) OTZKOTDB ADA12_HUMAN Decreases Expression [7]
ATM interactor (ATMIN) OTEADE76 ATMIN_HUMAN Decreases Expression [7]
Histone-lysine N-methyltransferase SUV39H1 (SUV39H1) OTDTF5BU SUV91_HUMAN Decreases Expression [7]
Protein Mis18-beta (OIP5) OTI5C2DE MS18B_HUMAN Increases Expression [7]
Aflatoxin B1 aldehyde reductase member 2 (AKR7A2) OTGEDDM2 ARK72_HUMAN Decreases Expression [7]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Decreases Expression [7]
Neuronal migration protein doublecortin (DCX) OTISR7K3 DCX_HUMAN Decreases Expression [7]
Zinc finger protein SNAI2 (SNAI2) OT7Y8EJ2 SNAI2_HUMAN Increases Expression [7]
Dual specificity tyrosine-phosphorylation-regulated kinase 3 (DYRK3) OTX1C2GS DYRK3_HUMAN Decreases Expression [7]
Calumenin (CALU) OTSYQN71 CALU_HUMAN Decreases Expression [7]
Double-strand-break repair protein rad21 homolog (RAD21) OTQS84ZF RAD21_HUMAN Increases Expression [7]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L) OTJKOMXE BNI3L_HUMAN Increases Expression [7]
Kinesin heavy chain isoform 5C (KIF5C) OT35570Y KIF5C_HUMAN Decreases Expression [7]
Catenin delta-1 (CTNND1) OTUMPSHR CTND1_HUMAN Decreases Expression [7]
Histone H2B type 1-K (H2BC12) OTQ8V0KG H2B1K_HUMAN Increases Expression [7]
E3 ubiquitin-protein ligase TRIM13 (TRIM13) OTQIUACB TRI13_HUMAN Decreases Expression [7]
Low-density lipoprotein receptor-related protein 4 (LRP4) OTO4M459 LRP4_HUMAN Increases Expression [7]
Copine-3 (CPNE3) OTCR3WG2 CPNE3_HUMAN Decreases Expression [7]
Reticulon-2 (RTN2) OTTZ5FW0 RTN2_HUMAN Decreases Expression [7]
Hyaluronan mediated motility receptor (HMMR) OT4M0JTZ HMMR_HUMAN Increases Expression [7]
Cell division control protein 45 homolog (CDC45) OT6NNLOD CDC45_HUMAN Decreases Expression [7]
Serine/arginine-rich splicing factor 10 (SRSF10) OTY6IJ11 SRS10_HUMAN Increases Expression [7]
KH domain-containing, RNA-binding, signal transduction-associated protein 3 (KHDRBS3) OTUG02U7 KHDR3_HUMAN Increases Expression [7]
Ribonuclease P protein subunit p40 (RPP40) OTRYY1AP RPP40_HUMAN Increases Expression [7]
ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial (CLPX) OTIT4JL0 CLPX_HUMAN Increases Expression [7]
DNA fragmentation factor subunit beta (DFFB) OTPBW5N5 DFFB_HUMAN Decreases Expression [7]
Signal recognition particle subunit SRP72 (SRP72) OTPV73W7 SRP72_HUMAN Increases Expression [7]
Slit homolog 2 protein (SLIT2) OTLS2RJ4 SLIT2_HUMAN Decreases Expression [7]
Transcription factor SOX-30 (SOX30) OTGT38E3 SOX30_HUMAN Increases Expression [8]
G2/mitotic-specific cyclin-B2 (CCNB2) OTIEXTDK CCNB2_HUMAN Increases Expression [7]
Dual specificity protein phosphatase 14 (DUSP14) OTGODFCR DUS14_HUMAN Increases Expression [7]
Elongator complex protein 1 (ELP1) OTYEWBF7 ELP1_HUMAN Decreases Expression [7]
Kinesin-like protein KIF20A (KIF20A) OTXOQHE0 KI20A_HUMAN Increases Expression [7]
SAM pointed domain-containing Ets transcription factor (SPDEF) OTCXQTXT SPDEF_HUMAN Decreases Expression [7]
E3 ubiquitin-protein ligase ARIH2 (ARIH2) OTJYJQJ8 ARI2_HUMAN Increases Expression [7]
Transcription factor SOX-14 (SOX14) OTPEKVOM SOX14_HUMAN Increases Expression [8]
BAG family molecular chaperone regulator 3 (BAG3) OTVXYUDQ BAG3_HUMAN Increases Expression [7]
Zinc finger protein SNAI1 (SNAI1) OTDPYAMC SNAI1_HUMAN Decreases Expression [8]
Protein phosphatase 1 regulatory subunit 17 (PPP1R17) OT19635T PPR17_HUMAN Decreases Expression [7]
G1/S-specific cyclin-E2 (CCNE2) OTBBUKQQ CCNE2_HUMAN Decreases Expression [7]
Glutathione reductase, mitochondrial (GSR) OTM2TUYM GSHR_HUMAN Increases Expression [7]
Hypoxanthine-guanine phosphoribosyltransferase (HPRT1) OTOEEEXG HPRT_HUMAN Increases Expression [7]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Decreases Expression [15]
Phosphoglycerate kinase 1 (PGK1) OT6V1ICH PGK1_HUMAN Decreases Expression [7]
Argininosuccinate synthase (ASS1) OT4ZMG0Q ASSY_HUMAN Increases Expression [7]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Increases Expression [7]
GTPase NRas (NRAS) OTVQ1DG3 RASN_HUMAN Decreases Expression [7]
Platelet-derived growth factor subunit B (PDGFB) OTMFMFC3 PDGFB_HUMAN Decreases Expression [7]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Increases Expression [7]
Ferritin light chain (FTL) OTYQA8A6 FRIL_HUMAN Increases Expression [7]
Ferritin heavy chain (FTH1) OT6IFS0O FRIH_HUMAN Increases Expression [7]
Metallothionein-2 (MT2A) OTHOACHD MT2_HUMAN Increases Expression [7]
NADH-ubiquinone oxidoreductase chain 6 (ND6) OTG47B7B NU6M_HUMAN Decreases Expression [7]
Glucocorticoid receptor (NR3C1) OTCI2YDI GCR_HUMAN Increases Expression [7]
High affinity nerve growth factor receptor (NTRK1) OTJORQAU NTRK1_HUMAN Decreases Expression [7]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Decreases Expression [16]
Metallothionein-1E (MT1E) OTXJKU4Y MT1E_HUMAN Increases Expression [7]
Heat shock protein beta-1 (HSPB1) OTHFZ8ED HSPB1_HUMAN Increases Expression [7]
Guanine nucleotide-binding protein G(i) subunit alpha-2 (GNAI2) OTTLGRGH GNAI2_HUMAN Decreases Expression [7]
Histone H2A type 1-B/E (H2AC4) OTMFQ662 H2A1B_HUMAN Increases Expression [7]
Lupus La protein (SSB) OTCCTPBR LA_HUMAN Increases Expression [7]
Keratin, type I cytoskeletal 18 (KRT18) OTVLQFIP K1C18_HUMAN Increases Expression [17]
Myosin light chain 1/3, skeletal muscle isoform (MYL1) OTDUYR4U MYL1_HUMAN Decreases Expression [7]
Tyrosine-protein kinase Fyn (FYN) OTLSLVZS FYN_HUMAN Decreases Expression [7]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Decreases Expression [18]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Increases Expression [7]
Nucleophosmin (NPM1) OTTBYYT0 NPM_HUMAN Decreases Expression [11]
Beta-hexosaminidase subunit alpha (HEXA) OT48T897 HEXA_HUMAN Decreases Expression [7]
Neurofilament light polypeptide (NEFL) OTQESJV4 NFL_HUMAN Decreases Expression [7]
Histone H1.0 (H1-0) OTRLJK4Z H10_HUMAN Increases Expression [7]
Asialoglycoprotein receptor 1 (ASGR1) OTS99MJO ASGR1_HUMAN Decreases Expression [7]
Cathepsin D (CTSD) OTQZ36F3 CATD_HUMAN Increases Expression [7]
Calpain-1 catalytic subunit (CAPN1) OTK6OQZR CAN1_HUMAN Decreases Expression [7]
Beta-hexosaminidase subunit beta (HEXB) OTROYLCR HEXB_HUMAN Increases Expression [7]
Heat shock protein HSP 90-alpha (HSP90AA1) OTLG1WPK HS90A_HUMAN Increases Expression [7]
Insulin-like growth factor 1 receptor (IGF1R) OTXJIF13 IGF1R_HUMAN Decreases Expression [7]
Amino acid transporter heavy chain SLC3A2 (SLC3A2) OTBR33M9 4F2_HUMAN Increases Expression [7]
Heat shock protein HSP 90-beta (HSP90AB1) OTR69EG7 HS90B_HUMAN Increases Expression [7]
Asparagine synthetase (ASNS) OT8R922G ASNS_HUMAN Increases Expression [7]
Synaptophysin (SYP) OTFJKMO4 SYPH_HUMAN Decreases Expression [7]
72 kDa type IV collagenase (MMP2) OT5NIWA2 MMP2_HUMAN Decreases Expression [19]
Collagen alpha-2(IV) chain (COL4A2) OTJK1LKN CO4A2_HUMAN Increases Expression [7]
Fibroblast growth factor 2 (FGF2) OT7YUJ9F FGF2_HUMAN Increases Expression [7]
Gamma-enolase (ENO2) OTRODL0T ENOG_HUMAN Decreases Expression [7]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Increases Expression [7]
Complement C1s subcomponent (C1S) OTCIZU2A C1S_HUMAN Decreases Expression [7]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Expression [15]
Histone H2A type 1 (H2AC11) OTN9P0BO H2A1_HUMAN Increases Expression [7]
Pepsin A-5 (PGA5) OTD78UC6 PEPA5_HUMAN Increases Expression [7]
Heat shock 70 kDa protein 1A (HSPA1A) OTKGIE76 HS71A_HUMAN Increases Expression [7]
Calmodulin-1 (CALM2) OTNYA92F CALM1_HUMAN Decreases Expression [7]
Transcriptional activator GLI3 (GLI3) OTKDOE94 GLI3_HUMAN Decreases Expression [7]
Myb-related protein A (MYBL1) OTBJMC2P MYBA_HUMAN Decreases Expression [7]
Lysosomal alpha-glucosidase (GAA) OT03PU29 LYAG_HUMAN Decreases Expression [7]
Retinoic acid receptor alpha (RARA) OT192V9V RARA_HUMAN Increases Expression [7]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [20]
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (DLAT) OT9LBJVN ODP2_HUMAN Increases Expression [7]
Receptor-type tyrosine-protein phosphatase F (PTPRF) OTH5KF2D PTPRF_HUMAN Decreases Expression [7]
COUP transcription factor 1 (NR2F1) OTGWZWYL COT1_HUMAN Decreases Expression [7]
Transforming growth factor beta-3 proprotein (TGFB3) OT2LOUQ1 TGFB3_HUMAN Decreases Expression [7]
cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A) OT589JA2 KAP0_HUMAN Decreases Expression [7]
Mast/stem cell growth factor receptor Kit (KIT) OTHUY3VZ KIT_HUMAN Decreases Expression [7]
60 kDa heat shock protein, mitochondrial (HSPD1) OTTO1Y11 CH60_HUMAN Increases Expression [7]
Microtubule-associated protein 2 (MAP2) OT6UYT3X MTAP2_HUMAN Decreases Expression [7]
Heat shock cognate 71 kDa protein (HSPA8) OTJI2RCI HSP7C_HUMAN Increases Expression [7]
Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1) OTA675TJ GTR1_HUMAN Increases Expression [7]
Ras-related protein Ral-A (RALA) OT734R7X RALA_HUMAN Increases Expression [7]
Lysosome-associated membrane glycoprotein 1 (LAMP1) OTYE92QY LAMP1_HUMAN Decreases Expression [7]
DNA topoisomerase 2-alpha (TOP2A) OT6LPS08 TOP2A_HUMAN Increases Expression [7]
Glucose-6-phosphate 1-dehydrogenase (G6PD) OT300SMK G6PD_HUMAN Decreases Expression [7]
C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) OTMKHVWC C1TC_HUMAN Increases Expression [7]
Cyclin-dependent kinase 4 (CDK4) OT7EP05T CDK4_HUMAN Decreases Expression [15]
Ornithine decarboxylase (ODC1) OTNDAGRR DCOR_HUMAN Increases Activity [21]
Neurofilament heavy polypeptide (NEFH) OTMSCW5I NFH_HUMAN Decreases Expression [7]
ADP/ATP translocase 1 (SLC25A4) OTKYLK2J ADT1_HUMAN Decreases Expression [7]
ADP/ATP translocase 3 (SLC25A6) OT9KAJP7 ADT3_HUMAN Increases Expression [7]
Myosin light chain 4 (MYL4) OTURFCSE MYL4_HUMAN Decreases Expression [7]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Increases Expression [17]
Proto-oncogene tyrosine-protein kinase Src (SRC) OTETYX40 SRC_HUMAN Increases Activity [15]
Metallothionein-1G (MT1G) OTAV1OCR MT1G_HUMAN Increases Expression [7]
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (MTHFD2) OT1LQSGX MTDC_HUMAN Increases Expression [7]
D(2) dopamine receptor (DRD2) OTBLXKEG DRD2_HUMAN Decreases Expression [7]
G2/mitotic-specific cyclin-B1 (CCNB1) OT19S7E5 CCNB1_HUMAN Increases Expression [7]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Decreases Expression [19]
Protein C-ets-1 (ETS1) OT4LVGDN ETS1_HUMAN Increases Expression [7]
Aldo-keto reductase family 1 member B1 (AKR1B1) OTRX72TH ALDR_HUMAN Decreases Expression [7]
B-lymphocyte antigen CD19 (CD19) OTCPF9NF CD19_HUMAN Decreases Expression [7]
Fos-related antigen 1 (FOSL1) OT9YTYMB FOSL1_HUMAN Increases Expression [7]
NAD(P)H dehydrogenase 1 (NQO1) OTZGGIVK NQO1_HUMAN Increases Expression [7]
Small ribosomal subunit protein uS5 (RPS2) OTSMTZVB RS2_HUMAN Increases Expression [7]
N-chimaerin (CHN1) OTM196M3 CHIN_HUMAN Increases Expression [7]
Transcription factor 4 (TCF4) OTB9ASTK ITF2_HUMAN Decreases Expression [7]
Mucin-1 (MUC1) OTHQI7IY MUC1_HUMAN Decreases Expression [7]
CD44 antigen (CD44) OT9TTJ41 CD44_HUMAN Decreases Expression [19]
Carbonyl reductase 1 (CBR1) OTQ3A541 CBR1_HUMAN Decreases Expression [7]
SH2/SH3 adapter protein NCK1 (NCK1) OTKYZ4OP NCK1_HUMAN Increases Expression [7]
Histone H1.2 (H1-2) OT0AVI4M H12_HUMAN Increases Expression [7]
Methylated-DNA--protein-cysteine methyltransferase (MGMT) OT40A9WH MGMT_HUMAN Decreases Expression [16]
Heat shock 70 kDa protein 6 (HSPA6) OTH4S7WB HSP76_HUMAN Increases Expression [7]
Aspartate aminotransferase, cytoplasmic (GOT1) OTZLM5UB AATC_HUMAN Increases Expression [7]
Transcription factor JunB (JUNB) OTG2JXV5 JUNB_HUMAN Decreases Expression [7]
cAMP-dependent protein kinase catalytic subunit alpha (PRKACA) OTAKDCMR KAPCA_HUMAN Decreases Expression [7]
CCAAT/enhancer-binding protein beta (CEBPB) OTM9MQIA CEBPB_HUMAN Increases Expression [7]
Neuromodulin (GAP43) OT2OTGGV NEUM_HUMAN Decreases Expression [7]
Neuronal acetylcholine receptor subunit beta-2 (CHRNB2) OTNAT2M5 ACHB2_HUMAN Decreases Expression [7]
CTP synthase 1 (CTPS1) OTZ9J6ZG PYRG1_HUMAN Decreases Expression [7]
ATP-dependent 6-phosphofructokinase, liver type (PFKL) OTVHGAT7 PFKAL_HUMAN Decreases Expression [7]
Insulin-like growth factor-binding protein 2 (IGFBP2) OTG1P60E IBP2_HUMAN Decreases Expression [7]
Arylamine N-acetyltransferase 1 (NAT1) OTCCNQ3H ARY1_HUMAN Decreases Expression [7]
Large ribosomal subunit protein uL22 (RPL17) OTTYMPS6 RL17_HUMAN Increases Expression [7]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) OTRFV19J ATF4_HUMAN Increases Expression [7]
Cadherin-2 (CDH2) OTH0Y56P CADH2_HUMAN Decreases Expression [7]
DNA-directed RNA polymerases I, II, and III subunit RPABC1 (POLR2E) OTH5IL2A RPAB1_HUMAN Decreases Expression [7]
Eukaryotic translation initiation factor 2 subunit 2 (EIF2S2) OTXF0B09 IF2B_HUMAN Increases Expression [7]
Annexin A7 (ANXA7) OTLMD0TK ANXA7_HUMAN Increases Expression [7]
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Increases Expression [7]
Aromatic-L-amino-acid decarboxylase (DDC) OT0TSW09 DDC_HUMAN Decreases Expression [7]
Calpastatin (CAST) OTBXZZGF ICAL_HUMAN Decreases Expression [7]
Cytochrome P450 3A5 (CYP3A5) OTSXFBXB CP3A5_HUMAN Affects Expression [22]
V-type proton ATPase subunit B, brain isoform (ATP6V1B2) OTNX2V4Z VATB2_HUMAN Decreases Expression [7]
Filamin-A (FLNA) OTYZ9JXM FLNA_HUMAN Increases Expression [7]
Synaptotagmin-1 (SYT1) OTVTPOI6 SYT1_HUMAN Decreases Expression [7]
Catechol O-methyltransferase (COMT) OTPWKTQG COMT_HUMAN Increases Expression [7]
Cadherin-3 (CDH3) OTKNLQU7 CADH3_HUMAN Increases Expression [8]
cAMP-dependent protein kinase catalytic subunit beta (PRKACB) OT6RMDCE KAPCB_HUMAN Increases Expression [7]
NAD-dependent malic enzyme, mitochondrial (ME2) OTO4LL76 MAOM_HUMAN Increases Expression [7]
Glycine dehydrogenase (GLDC) OTVVDNW0 GCSP_HUMAN Decreases Expression [7]
Small ribosomal subunit protein uS3 (RPS3) OT0K3TMH RS3_HUMAN Increases Expression [7]
Ribosomal protein S6 kinase beta-1 (RPS6KB1) OTAELNGX KS6B1_HUMAN Decreases Expression [15]
Brain-derived neurotrophic factor (BDNF) OTLGH7EW BDNF_HUMAN Increases Expression [7]
Eukaryotic translation initiation factor 4B (EIF4B) OTE8TXA8 IF4B_HUMAN Increases Expression [7]
Endothelial transcription factor GATA-2 (GATA2) OTBP2QQ2 GATA2_HUMAN Increases Expression [7]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Decreases Expression [18]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Increases Expression [7]
Elongation factor 1-beta (EEF1B2) OTW64NPU EF1B_HUMAN Increases Expression [7]
Tenascin (TNC) OTK4FSHR TENA_HUMAN Decreases Expression [7]
G1/S-specific cyclin-E1 (CCNE1) OTLD7UID CCNE1_HUMAN Decreases Expression [23]
Signal transducer CD24 (CD24) OT7CODJ4 CD24_HUMAN Decreases Expression [7]
Guanylyl cyclase C (GUCY2C) OTHYISW6 GUC2C_HUMAN Decreases Expression [7]
DNA replication licensing factor MCM3 (MCM3) OTOOHQPM MCM3_HUMAN Decreases Expression [7]
Bromodomain-containing protein 2 (BRD2) OTQP2MVJ BRD2_HUMAN Increases Expression [7]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Increases Expression [7]
DnaJ homolog subfamily B member 1 (DNAJB1) OTCOSEVH DNJB1_HUMAN Increases Expression [7]
Cathepsin S (CTSS) OT3PXIPM CATS_HUMAN Decreases Expression [7]
Proteasome subunit alpha type-1 (PSMA1) OTNBVM2U PSA1_HUMAN Increases Expression [7]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Expression [7]
Aryl hydrocarbon receptor nuclear translocator (ARNT) OTMSIEZY ARNT_HUMAN Increases Expression [7]
Calreticulin (CALR) OTYD2TR1 CALR_HUMAN Decreases Expression [7]
Calnexin (CANX) OTYP1F6J CALX_HUMAN Increases Expression [7]
Glutathione S-transferase Mu 2 (GSTM2) OTG4WT05 GSTM2_HUMAN Decreases Expression [7]
Progranulin (GRN) OTXXSJ53 GRN_HUMAN Decreases Expression [7]
Transcription initiation factor IIE subunit beta (GTF2E2) OTDHCCCR T2EB_HUMAN Increases Expression [7]
Ephrin type-B receptor 2 (EPHB2) OT8VZ6C5 EPHB2_HUMAN Decreases Expression [7]
AT-rich interactive domain-containing protein 4A (ARID4A) OT1XKBZ0 ARI4A_HUMAN Decreases Expression [7]
Nitric oxide synthase 3 (NOS3) OTLDT7NR NOS3_HUMAN Increases Expression [22]
Serpin B3 (SERPINB3) OTSR2UBI SPB3_HUMAN Decreases Secretion [19]
Leiomodin-1 (LMOD1) OTZ2MEMG LMOD1_HUMAN Decreases Expression [7]
Myristoylated alanine-rich C-kinase substrate (MARCKS) OT7N056G MARCS_HUMAN Decreases Expression [7]
Thioredoxin-dependent peroxide reductase, mitochondrial (PRDX3) OTLB2WEU PRDX3_HUMAN Decreases Expression [7]
Phosphatidylethanolamine-binding protein 1 (PEBP1) OTQ5FEI0 PEBP1_HUMAN Decreases Expression [7]
G1/S-specific cyclin-D3 (CCND3) OTNKPQ22 CCND3_HUMAN Decreases Expression [7]
Coronin-1A (CORO1A) OTVAZOHC COR1A_HUMAN Decreases Expression [7]
S-adenosylmethionine synthase isoform type-2 (MAT2A) OTFJMIQR METK2_HUMAN Decreases Expression [7]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Decreases Expression [7]
Bifunctional purine biosynthesis protein ATIC (ATIC) OT8XE052 PUR9_HUMAN Increases Expression [7]
Neural cell adhesion molecule L1 (L1CAM) OTNWAQ4Y L1CAM_HUMAN Decreases Expression [7]
Deoxycytidylate deaminase (DCTD) OT4FLFT4 DCTD_HUMAN Increases Expression [7]
Cystathionine gamma-lyase (CTH) OTC90LA0 CGL_HUMAN Increases Expression [7]
Large ribosomal subunit protein uL6 (RPL9) OTKE01O8 RL9_HUMAN Increases Expression [7]
Cyclin-dependent kinases regulatory subunit 2 (CKS2) OTPTMHIV CKS2_HUMAN Increases Expression [7]
Histone H2B type 1-B (H2BC3) OT1BLFJO H2B1B_HUMAN Increases Expression [7]
Dual specificity protein kinase TTK (TTK) OTBY1Z5H TTK_HUMAN Increases Expression [7]
Heat shock 70 kDa protein 4 (HSPA4) OT5HR0AR HSP74_HUMAN Increases Expression [7]
Glypican-1 (GPC1) OTQKRSSV GPC1_HUMAN Decreases Expression [7]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Decreases Expression [7]
Basigin (BSG) OTD0CVEC BASI_HUMAN Increases Expression [7]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Increases Expression [7]
Transcription factor SOX-5 (SOX5) OTEVJHMZ SOX5_HUMAN Increases Expression [8]
Glutaredoxin-1 (GLRX) OT0QHTAR GLRX1_HUMAN Decreases Expression [7]
Choline kinase alpha (CHKA) OT7FVO3Z CHKA_HUMAN Increases Expression [7]
Vascular endothelial growth factor receptor 2 (KDR) OT15797V VGFR2_HUMAN Decreases Expression [15]
Large ribosomal subunit protein uL4 (RPL4) OTTYJB0X RL4_HUMAN Increases Expression [7]
Phosphoglucomutase-1 (PGM1) OT3VM4JX PGM1_HUMAN Increases Expression [7]
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PPP1CC) OTRZO26U PP1G_HUMAN Increases Expression [7]
TGF-beta receptor type-2 (TGFBR2) OT3P7GZP TGFR2_HUMAN Decreases Expression [7]
Alpha-synuclein (SNCA) OTPWC1MR SYUA_HUMAN Decreases Expression [7]
Breast cancer type 1 susceptibility protein (BRCA1) OT5BN6VH BRCA1_HUMAN Decreases Expression [16]
DNA-binding protein SMUBP-2 (IGHMBP2) OTAZFPF5 SMBP2_HUMAN Decreases Expression [7]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [23]
Large ribosomal subunit protein uL3 (RPL3) OTX6VXLB RL3_HUMAN Increases Expression [7]
T-complex protein 1 subunit zeta (CCT6A) OTCYWL5F TCPZ_HUMAN Increases Expression [7]
ADP-ribosylation factor-like protein 1 (ARL1) OTB6N6BR ARL1_HUMAN Increases Expression [7]
Signal transducer and activator of transcription 3 (STAT3) OTAAGKYZ STAT3_HUMAN Increases Activity [15]
DNA-binding protein inhibitor ID-1 (ID1) OTKGNZN5 ID1_HUMAN Decreases Expression [7]
Eukaryotic translation initiation factor 1 (EIF1) OTB4GZ0V EIF1_HUMAN Increases Expression [7]
Signal transducer and activator of transcription 6 (STAT6) OTCKMP49 STAT6_HUMAN Increases Phosphorylation [15]
Glutamate receptor 2 (GRIA2) OT5N1WB7 GRIA2_HUMAN Decreases Expression [7]
Aldo-keto reductase family 1 member C3 (AKR1C3) OTU2SXBA AK1C3_HUMAN Increases Expression [7]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA) OTTOMI8J PK3CA_HUMAN Decreases Expression [15]
Serine/threonine-protein kinase mTOR (MTOR) OTHH8KU7 MTOR_HUMAN Decreases Expression [15]
Epidermal growth factor receptor substrate 15 (EPS15) OT7NPP8U EPS15_HUMAN Increases Expression [7]
Neuronal vesicle trafficking-associated protein 1 (NSG1) OTRIMA50 NSG1_HUMAN Decreases Expression [7]
Excitatory amino acid transporter 2 (SLC1A2) OTEP3QGN EAA2_HUMAN Decreases Expression [7]
Platelet-activating factor acetylhydrolase IB subunit beta (PAFAH1B1) OT9T2TCJ LIS1_HUMAN Increases Expression [7]
Translocon-associated protein subunit alpha (SSR1) OTQ6GDL2 SSRA_HUMAN Decreases Expression [7]
Nuclear receptor subfamily 4 group A member 2 (NR4A2) OT3F9IR2 NR4A2_HUMAN Decreases Expression [7]
Nicotinamide phosphoribosyltransferase (NAMPT) OTVJR3GL NAMPT_HUMAN Increases Expression [7]
Neuronal acetylcholine receptor subunit alpha-4 (CHRNA4) OT1H0ZXC ACHA4_HUMAN Decreases Expression [7]
Proliferation marker protein Ki-67 (MKI67) OTA8N1QI KI67_HUMAN Decreases Expression [14]
Adapter molecule crk (CRK) OT9Q5YSN CRK_HUMAN Decreases Expression [7]
Crk-like protein (CRKL) OTOYSD1R CRKL_HUMAN Increases Expression [7]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Increases Expression [7]
Large ribosomal subunit protein eL28 (RPL28) OTEVRCBO RL28_HUMAN Increases Expression [7]
Small ribosomal subunit protein uS7 (RPS5) OTPSWQRS RS5_HUMAN Increases Expression [7]
Microtubule-associated protein 1B (MAP1B) OTVXW089 MAP1B_HUMAN Decreases Expression [7]
Glucosamine-6-phosphate isomerase 1 (GNPDA1) OT8X4127 GNPI1_HUMAN Decreases Expression [7]
Ras GTPase-activating-like protein IQGAP1 (IQGAP1) OTZRWTGA IQGA1_HUMAN Increases Expression [7]
NADP-dependent malic enzyme (ME1) OTSVEUQE MAOX_HUMAN Increases Expression [7]
Lanosterol synthase (LSS) OT9W2SFH LSS_HUMAN Decreases Expression [7]
Glutamate--cysteine ligase catalytic subunit (GCLC) OTESDI4D GSH1_HUMAN Increases Expression [7]
Glutamate--cysteine ligase regulatory subunit (GCLM) OT6CP234 GSH0_HUMAN Increases Expression [7]
Nuclear receptor-interacting protein 1 (NRIP1) OTIZOJQV NRIP1_HUMAN Increases Expression [7]
Casein kinase I isoform alpha (CSNK1A1) OTJ6O1IC KC1A_HUMAN Decreases Expression [7]
Natural resistance-associated macrophage protein 2 (SLC11A2) OTMEUHE8 NRAM2_HUMAN Decreases Expression [7]
Fatty acid synthase (FASN) OTFII9KG FAS_HUMAN Decreases Expression [7]
Large ribosomal subunit protein bL19m (MRPL19) OTRBKF6R RM19_HUMAN Increases Expression [7]
Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1) OTV57BZD AL7A1_HUMAN Decreases Expression [7]
Centromere protein F (CENPF) OT7AG0SW CENPF_HUMAN Increases Expression [7]
Cysteine--tRNA ligase, cytoplasmic (CARS1) OTOUZF6O SYCC_HUMAN Increases Expression [7]
Dual specificity protein kinase CLK1 (CLK1) OTG1LACW CLK1_HUMAN Increases Expression [7]
Placenta growth factor (PGF) OT5MF5DJ PLGF_HUMAN Decreases Expression [7]
Presenilin-1 (PSEN1) OTKL39RT PSN1_HUMAN Increases Expression [7]
Presenilin-2 (PSEN2) OTOW778B PSN2_HUMAN Decreases Expression [7]
Isocitrate dehydrogenase subunit alpha, mitochondrial (IDH3A) OT5QQB5L IDH3A_HUMAN Increases Expression [7]
Sulfotransferase 1A1 (SULT1A1) OT0K7JIE ST1A1_HUMAN Decreases Expression [7]
ETS translocation variant 1 (ETV1) OT6PMJIK ETV1_HUMAN Decreases Expression [7]
Achaete-scute homolog 1 (ASCL1) OTI4X44G ASCL1_HUMAN Increases Expression [7]
Dual specificity protein phosphatase 3 (DUSP3) OTPJX9B4 DUS3_HUMAN Increases Expression [7]
Amyloid beta precursor like protein 1 (APLP1) OTD176ZS APLP1_HUMAN Decreases Expression [7]
Cyclin-H (CCNH) OTKDU3SR CCNH_HUMAN Increases Expression [7]
Serine/threonine-protein kinase Nek2 (NEK2) OT1H27HO NEK2_HUMAN Decreases Expression [24]
Cyclin-G1 (CCNG1) OT17IA9L CCNG1_HUMAN Increases Expression [7]
Heterogeneous nuclear ribonucleoprotein M (HNRNPM) OTFU3OEZ HNRPM_HUMAN Decreases Expression [7]
DNA-directed RNA polymerases I, II, and III subunit RPABC3 (POLR2H) OTG7IQ2V RPAB3_HUMAN Increases Expression [7]
DNA mismatch repair protein Msh6 (MSH6) OT46FP09 MSH6_HUMAN Increases Expression [7]
High mobility group protein HMGI-C (HMGA2) OTBMBHHL HMGA2_HUMAN Increases Expression [7]
Nuclear pore complex protein Nup98-Nup96 (NUP98) OTNT12G2 NUP98_HUMAN Decreases Expression [25]
Geranylgeranyl transferase type-2 subunit beta (RABGGTB) OTZ25I2W PGTB2_HUMAN Increases Expression [7]
Mitogen-activated protein kinase 12 (MAPK12) OTTCKE27 MK12_HUMAN Decreases Expression [7]
Ornithine decarboxylase antizyme 1 (OAZ1) OTPT0PKZ OAZ1_HUMAN Increases Expression [7]
Branched-chain-amino-acid aminotransferase, cytosolic (BCAT1) OTYHXLWZ BCAT1_HUMAN Increases Expression [7]
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (PDE1A) OTU7J3F7 PDE1A_HUMAN Decreases Expression [7]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Increases Expression [15]
BH3-interacting domain death agonist (BID) OTOSHSHU BID_HUMAN Decreases Expression [7]
NADH dehydrogenase flavoprotein 3, mitochondrial (NDUFV3) OTSCYB9P NDUV3_HUMAN Increases Expression [7]
P2X purinoceptor 3 (P2RX3) OTKRSLV2 P2RX3_HUMAN Decreases Expression [7]
T-cell leukemia translocation-altered gene protein (TCTA) OT0AH12O TCTA_HUMAN Decreases Expression [7]
Claudin-2 (CLDN2) OTRF3D6Y CLD2_HUMAN Increases Expression [8]
Sestrin-2 (SESN2) OT889IXY SESN2_HUMAN Increases Expression [7]
Neurexin-1-beta (NRXN1) OTJN1JQA NRX1B_HUMAN Decreases Expression [7]
Histone H2B type 1-D (H2BC5) OTXDTDHN H2B1D_HUMAN Increases Expression [7]
Triosephosphate isomerase (TPI1) OT14KP4B TPIS_HUMAN Decreases Expression [7]
Synaptosomal-associated protein 25 (SNAP25) OTUIQ81Q SNP25_HUMAN Decreases Expression [7]
Cyclin-dependent kinases regulatory subunit 1 (CKS1B) OTNUPLUJ CKS1_HUMAN Increases Expression [7]
C-X-C chemokine receptor type 4 (CXCR4) OTUFSBX2 CXCR4_HUMAN Decreases Expression [7]
Large ribosomal subunit protein uL24 (RPL26) OTFNRC27 RL26_HUMAN Increases Expression [7]
Somatostatin (SST) OTY75GQH SMS_HUMAN Decreases Expression [7]
10 kDa heat shock protein, mitochondrial (HSPE1) OT7JSZLB CH10_HUMAN Increases Expression [7]
Syntaxin-binding protein 1 (STXBP1) OTRYA8C3 STXB1_HUMAN Decreases Expression [7]
Beta-2-microglobulin (B2M) OTDWN6NX B2MG_HUMAN Increases Expression [7]
Small ribosomal subunit protein eS7 (RPS7) OTIK25WI RS7_HUMAN Increases Expression [7]
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PPP1CB) OTYFTYFR PP1B_HUMAN Increases Expression [7]
Small ribosomal subunit protein uS13 (RPS18) OTFO45UM RS18_HUMAN Increases Expression [7]
Small ribosomal subunit protein uS15 (RPS13) OTOMDIJ2 RS13_HUMAN Increases Expression [7]
TATA box-binding protein-like 1 (TBPL1) OT4I143E TBPL1_HUMAN Increases Expression [7]
Eukaryotic peptide chain release factor subunit 1 (ETF1) OTH8C5U5 ERF1_HUMAN Increases Expression [7]
Rho-related GTP-binding protein RhoB (RHOB) OTHQFQF7 RHOB_HUMAN Decreases Expression [7]
Small ribosomal subunit protein eS6 (RPS6) OTT4D1LN RS6_HUMAN Decreases Expression [15]
Small ribosomal subunit protein eS25 (RPS25) OTKLWED2 RS25_HUMAN Increases Expression [7]
E3 ubiquitin-protein ligase RBX1 (RBX1) OTYA1UIO RBX1_HUMAN Decreases Expression [7]
Large ribosomal subunit protein uL5 (RPL11) OT3VZ6OE RL11_HUMAN Increases Expression [7]
Large ribosomal subunit protein uL2 (RPL8) OTHMZ1R9 RL8_HUMAN Increases Expression [7]
Ras-related C3 botulinum toxin substrate 1 (RAC1) OTKRO61U RAC1_HUMAN Decreases Expression [19]
S-phase kinase-associated protein 1 (SKP1) OT5BPAZ4 SKP1_HUMAN Decreases Expression [7]
Histone H3.1 (H3C1) OTGBGOZW H31_HUMAN Increases Expression [7]
Hemoglobin subunit alpha (HBA1) OTW2BQF4 HBA_HUMAN Increases Expression [7]
Disintegrin and metalloproteinase domain-containing protein 8 (ADAM8) OT24S8YN ADAM8_HUMAN Decreases Expression [7]
RNA-binding protein 6 (RBM6) OTI99KAZ RBM6_HUMAN Increases Expression [7]
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (PIP4K2B) OTF1VGJ9 PI42B_HUMAN Decreases Expression [7]
Reelin (RELN) OTLKMW1O RELN_HUMAN Decreases Expression [7]
DNA-dependent protein kinase catalytic subunit (PRKDC) OTJVS4EG PRKDC_HUMAN Decreases Expression [16]
Small ribosomal subunit protein bS6m (MRPS6) OTKFY73U RT06_HUMAN Decreases Expression [7]
Mothers against decapentaplegic homolog 3 (SMAD3) OTNA96MR SMAD3_HUMAN Decreases Phosphorylation [17]
Rho GTPase-activating protein 8 (ARHGAP8) OT19H5Q9 RHG08_HUMAN Increases Expression [7]
Forkhead box protein O4 (FOXO4) OT90X9LN FOXO4_HUMAN Decreases Expression [7]
Cytochrome c (CYCS) OTBFALJD CYC_HUMAN Decreases Expression [7]
Phosphatidylinositol transfer protein alpha isoform (PITPNA) OTTWC00K PIPNA_HUMAN Decreases Expression [7]
Cyclin-dependent kinase 6 (CDK6) OTR95N0X CDK6_HUMAN Increases Expression [7]
Cyclin-dependent kinase 5 (CDK5) OT1YAK9F CDK5_HUMAN Decreases Expression [7]
Clathrin heavy chain 1 (CLTC) OTBFASMA CLH1_HUMAN Increases Expression [7]
E3 ubiquitin-protein ligase Mdm2 (MDM2) OTOVXARF MDM2_HUMAN Increases Expression [7]
Transcription factor E2F1 (E2F1) OTLKYBBC E2F1_HUMAN Decreases Expression [7]
Interferon-induced transmembrane protein 3 (IFITM3) OT2QP8D3 IFM3_HUMAN Decreases Expression [7]
Interferon-induced transmembrane protein 2 (IFITM2) OTAT6TI6 IFM2_HUMAN Decreases Expression [7]
Large neutral amino acids transporter small subunit 1 (SLC7A5) OT2WPVXD LAT1_HUMAN Increases Expression [7]
ATP-dependent 6-phosphofructokinase, platelet type (PFKP) OTFP7AA8 PFKAP_HUMAN Increases Expression [22]
DNA-binding protein SATB1 (SATB1) OTT7SUVW SATB1_HUMAN Decreases Expression [7]
POU domain, class 4, transcription factor 1 (POU4F1) OTMHYGWQ PO4F1_HUMAN Decreases Expression [7]
Sodium-dependent dopamine transporter (SLC6A3) OT39XG28 SC6A3_HUMAN Decreases Expression [7]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (PLCB3) OT0OMDEM PLCB3_HUMAN Decreases Expression [7]
Transgelin (TAGLN) OTAEZ0KP TAGL_HUMAN Increases Expression [7]
Kinesin-like protein KIF23 (KIF23) OTY850JC KIF23_HUMAN Increases Expression [7]
Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1) OT4Y9NQI MP2K1_HUMAN Decreases Expression [15]
Peptidyl-prolyl cis-trans isomerase FKBP4 (FKBP4) OTPV1D60 FKBP4_HUMAN Increases Expression [7]
Peroxisome proliferator-activated receptor delta (PPARD) OTI4WTOP PPARD_HUMAN Decreases Expression [7]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Decreases Expression [20]
Keratin, type I cytoskeletal 17 (KRT17) OT6Y1DPK K1C17_HUMAN Increases Expression [7]
Neurogenic locus notch homolog protein 2 (NOTCH2) OTQ3Y9PA NOTC2_HUMAN Increases Expression [7]
Proteolipid protein 2 (PLP2) OTEZ4LOV PLP2_HUMAN Increases Expression [7]
Dynamin-1 (DNM1) OTI8X2WQ DYN1_HUMAN Decreases Expression [7]
Focal adhesion kinase 1 (PTK2) OT3Q1JDY FAK1_HUMAN Increases Expression [7]
GA-binding protein subunit beta-1 (GABPB1) OTEXDEJN GABP1_HUMAN Increases Expression [7]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Increases Expression [23]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [20]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Decreases Expression [26]
Lysyl oxidase homolog 1 (LOXL1) OTA0NEJU LOXL1_HUMAN Decreases Expression [7]
Histone acetyltransferase p300 (EP300) OTL8QJDX EP300_HUMAN Decreases Expression [7]
Secernin-1 (SCRN1) OTELM5C2 SCRN1_HUMAN Decreases Expression [7]
POU domain, class 4, transcription factor 2 (POU4F2) OT6SW5H0 PO4F2_HUMAN Decreases Expression [7]
Follistatin-related protein 1 (FSTL1) OT6KEZUD FSTL1_HUMAN Decreases Expression [7]
Contactin-1 (CNTN1) OT7RNPEY CNTN1_HUMAN Decreases Expression [7]
Interferon-related developmental regulator 2 (IFRD2) OT2URF18 IFRD2_HUMAN Increases Expression [7]
Ral guanine nucleotide dissociation stimulator (RALGDS) OTG36NI7 GNDS_HUMAN Decreases Expression [7]
Protein AF1q (MLLT11) OTG5RVHC AF1Q_HUMAN Decreases Expression [7]
Dual specificity protein phosphatase 4 (DUSP4) OT6WAO12 DUS4_HUMAN Increases Expression [7]
E3 ubiquitin-protein ligase CBL-B (CBLB) OTPLRER9 CBLB_HUMAN Decreases Expression [7]
Steroidogenic factor 1 (NR5A1) OTOULYR4 STF1_HUMAN Decreases Expression [7]
Serine-protein kinase ATM (ATM) OTQVOHLT ATM_HUMAN Decreases Expression [16]
Growth factor receptor-bound protein 10 (GRB10) OTCKXGRC GRB10_HUMAN Increases Expression [7]
DNA-binding protein Ikaros (IKZF1) OTCW1FKL IKZF1_HUMAN Decreases Expression [7]
Sequestosome-1 (SQSTM1) OTGY5D5J SQSTM_HUMAN Increases Expression [7]
Serine/threonine-protein kinase ATR (ATR) OTH0OP1J ATR_HUMAN Decreases Expression [16]
Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1) OTHBQVD5 4EBP1_HUMAN Increases Expression [7]
Calcium/calmodulin-dependent protein kinase type II subunit beta (CAMK2B) OTS9YK3E KCC2B_HUMAN Decreases Expression [7]
Neurogenic differentiation factor 1 (NEUROD1) OTZQ7QJ2 NDF1_HUMAN Increases Expression [7]
Ras-related protein Rab-31 (RAB31) OTMLXQZ0 RAB31_HUMAN Decreases Expression [7]
Laminin subunit gamma-2 (LAMC2) OTJMTM72 LAMC2_HUMAN Decreases Expression [7]
Calcyphosin (CAPS) OTC9GZ2M CAYP1_HUMAN Decreases Expression [7]
Kelch-like ECH-associated protein 1 (KEAP1) OTFHOD0C KEAP1_HUMAN Increases Expression [7]
Transcription factor Dp-1 (TFDP1) OT6RZ7VT TFDP1_HUMAN Decreases Expression [7]
Large ribosomal subunit protein mL62 (MRPL58) OTPTWLZY ICT1_HUMAN Increases Expression [7]
Protein BTG3 (BTG3) OT9ANHVT BTG3_HUMAN Increases Expression [7]
Src substrate cortactin (CTTN) OTJRG4ES SRC8_HUMAN Decreases Expression [7]
Endonuclease G, mitochondrial (ENDOG) OT5IM7B3 NUCG_HUMAN Decreases Expression [7]
UDP-glucose 4-epimerase (GALE) OTVFS16E GALE_HUMAN Decreases Expression [7]
Polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3) OT7M67WT GALT3_HUMAN Decreases Expression [7]
Growth factor receptor-bound protein 14 (GRB14) OTFET2YM GRB14_HUMAN Increases Expression [7]
Transcription factor HES-1 (HES1) OT8P19W2 HES1_HUMAN Increases Expression [7]
Histone RNA hairpin-binding protein (SLBP) OTVYYQRT SLBP_HUMAN Increases Expression [7]
Endoplasmic reticulum membrane sensor NFE2L1 (NFE2L1) OT1QHOS2 NF2L1_HUMAN Increases Expression [7]
Inositol 1,4,5-trisphosphate receptor type 2 (ITPR2) OTPHGZ19 ITPR2_HUMAN Decreases Expression [7]
Indian hedgehog protein (IHH) OT1DWGXC IHH_HUMAN Increases Expression [8]
Plastin-1 (PLS1) OTWURB8U PLSI_HUMAN Decreases Expression [7]
Structural maintenance of chromosomes protein 1A (SMC1A) OT9ZMRK9 SMC1A_HUMAN Decreases Expression [7]
Ribosomal RNA processing protein 1 homolog B (RRP1B) OTHDRVML RRP1B_HUMAN Increases Expression [7]
Membrane-bound transcription factor site-1 protease (MBTPS1) OTV0FQMT MBTP1_HUMAN Decreases Expression [7]
Major facilitator superfamily domain-containing protein 10 (MFSD10) OTG2EXFP MFS10_HUMAN Decreases Expression [7]
Signal transducer and activator of transcription 4 (STAT4) OTAK3VFR STAT4_HUMAN Decreases Expression [7]
Metabotropic glutamate receptor 4 (GRM4) OT5ID1DZ GRM4_HUMAN Decreases Expression [7]
Nucleolar and coiled-body phosphoprotein 1 (NOLC1) OTKDZU0D NOLC1_HUMAN Decreases Expression [7]
HUWE1-associated protein modifying stress responses 1 (HAPSTR1) OTWCI7ZA HAPR1_HUMAN Increases Expression [7]
Condensin complex subunit 2 (NCAPH) OTXOS97C CND2_HUMAN Increases Expression [7]
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (HERPUD1) OT9EROL6 HERP1_HUMAN Increases Expression [7]
Translocating chain-associated membrane protein 2 (TRAM2) OTSFG0ST TRAM2_HUMAN Increases Expression [7]
Ribosome biogenesis regulatory protein homolog (RRS1) OTTNCZN6 RRS1_HUMAN Increases Expression [7]
Bromodomain-containing protein 3 (BRD3) OTRT44ZG BRD3_HUMAN Decreases Expression [7]
Mitochondrial inner membrane protein OXA1L (OXA1L) OTS0BFRD OXA1L_HUMAN Increases Expression [7]
Early endosome antigen 1 (EEA1) OTIBXC1B EEA1_HUMAN Increases Expression [7]
Cyclin-dependent kinase 5 activator 1 (CDK5R1) OTJELWK0 CD5R1_HUMAN Decreases Expression [7]
Platelet-activating factor acetylhydrolase IB subunit alpha1 (PAFAH1B3) OT6A9JT8 PA1B3_HUMAN Decreases Expression [7]
kinase isozyme 1, mitochondrial (PDK1) OTMABK9Z PDK1_HUMAN Decreases Expression [15]
Mitochondrial import receptor subunit TOM20 homolog (TOMM20) OT76TPR2 TOM20_HUMAN Increases Expression [7]
Disks large-associated protein 5 (DLGAP5) OTWCN39U DLGP5_HUMAN Increases Expression [7]
Transcription initiation factor TFIID subunit 7 (TAF7) OT43QHS3 TAF7_HUMAN Increases Expression [7]
ELAV-like protein 1 (ELAVL1) OTY55PLY ELAV1_HUMAN Decreases Expression [7]
Mitochondrial import receptor subunit TOM34 (TOMM34) OTH6MITE TOM34_HUMAN Decreases Expression [7]
Neuronal pentraxin-1 (NPTX1) OTKVHCV0 NPTX1_HUMAN Decreases Expression [7]
ATP-sensitive inward rectifier potassium channel 8 (KCNJ8) OTZ8G8FE KCNJ8_HUMAN Increases Expression [7]
Alpha-internexin (INA) OT1D33T4 AINX_HUMAN Decreases Expression [7]
Synaptophysin-like protein 1 (SYPL1) OTBX291E SYPL1_HUMAN Increases Expression [7]
Transcription initiation factor TFIID subunit 9 (TAF9) OTCTH3C6 TAF9_HUMAN Increases Expression [7]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Increases Expression [27]
C-C motif chemokine 15 (CCL15) OTOGZ85M CCL15_HUMAN Decreases Expression [7]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Increases Degradation [28]
Cyclin-dependent kinase inhibitor 3 (CDKN3) OTBE3H07 CDKN3_HUMAN Increases Expression [7]
Thiosulfate sulfurtransferase (TST) OTZ4F5LK THTR_HUMAN Decreases Expression [7]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) OTQYEXL2 F264_HUMAN Decreases Expression [7]
Tectonic-1 (TCTN1) OTG5KEV8 TECT1_HUMAN Decreases Expression [7]
MORN repeat-containing protein 2 (MORN2) OTL98XZO MORN2_HUMAN Decreases Expression [7]
Centrosomal protein of 55 kDa (CEP55) OTGSG2PA CEP55_HUMAN Increases Expression [7]
Interferon-induced protein 44-like (IFI44L) OTXKORJP IF44L_HUMAN Increases Expression [7]
Shugoshin 2 (SGO2) OTNGJDS8 SGO2_HUMAN Increases Expression [7]
Protein sidekick-2 (SDK2) OTTBK3MH SDK2_HUMAN Decreases Expression [7]
APC membrane recruitment protein 1 (AMER1) OT8EFJPM AMER1_HUMAN Decreases Expression [7]
Cytochrome c oxidase assembly factor 6 homolog (COA6) OTT52V2I COA6_HUMAN Increases Expression [7]
Breast cancer metastasis-suppressor 1-like protein (BRMS1L) OTJIW47U BRM1L_HUMAN Decreases Expression [7]
Protein FAM72A (FAM72A) OTBZYSR3 FA72A_HUMAN Increases Expression [7]
F-actin-uncapping protein LRRC16A (CARMIL1) OT1A5IX5 CARL1_HUMAN Decreases Expression [7]
TBC1 domain family member 9B (TBC1D9B) OTV5UGNC TBC9B_HUMAN Decreases Expression [7]
Olfactomedin-like protein 2B (OLFML2B) OTDNJFR4 OLM2B_HUMAN Decreases Expression [7]
Histone H2A type 2-A (H2AC18) OTCE5JC7 H2A2A_HUMAN Increases Expression [7]
Speckle-type POZ protein-like (SPOPL) OTS42VUL SPOPL_HUMAN Increases Expression [7]
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (JMJD6) OTILR7E4 JMJD6_HUMAN Increases Expression [7]
Transmembrane protein 65 (TMEM65) OT2JUZ7Q TMM65_HUMAN Decreases Expression [7]
Biogenesis of lysosome-related organelles complex 1 subunit 2 (BLOC1S2) OTUR3E76 BL1S2_HUMAN Increases Expression [7]
Kelch-like protein 24 (KLHL24) OTWZSX5C KLH24_HUMAN Increases Expression [22]
All-trans retinoic acid-induced differentiation factor (ATRAID) OTOHZG1O ARAID_HUMAN Increases Expression [7]
Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) OTVFQEPA IKIP_HUMAN Increases Expression [7]
Centromere protein U (CENPU) OTQ4TZRS CENPU_HUMAN Increases Expression [7]
Histone H2A.V (H2AZ2) OT0I5H2P H2AV_HUMAN Decreases Expression [7]
eIF5-mimic protein 2 (BZW1) OT4GUFIG 5MP2_HUMAN Decreases Expression [7]
BTB/POZ domain-containing protein KCTD9 (KCTD9) OTBN6ZUC KCTD9_HUMAN Increases Expression [7]
FAST kinase domain-containing protein 5, mitochondrial (FASTKD5) OTBNBGVI FAKD5_HUMAN Decreases Expression [7]
Sprouty-related, EVH1 domain-containing protein 2 (SPRED2) OTUX685J SPRE2_HUMAN Increases Expression [7]
Dehydrodolichyl diphosphate synthase complex subunit DHDDS (DHDDS) OTVLYBUS DHDDS_HUMAN Decreases Expression [7]
Retrotransposon-derived protein PEG10 (PEG10) OTWD2278 PEG10_HUMAN Decreases Expression [7]
Kinectin (KTN1) OTQAV541 KTN1_HUMAN Increases Expression [7]
Poly(ADP-ribose) glycohydrolase (PARG) OT10JTIO PARG_HUMAN Decreases Expression [7]
C2 domain-containing protein 5 (C2CD5) OTI495RD C2CD5_HUMAN Decreases Expression [7]
CREB3 regulatory factor (CREBRF) OT2GK1HI CRERF_HUMAN Increases Expression [7]
NudC domain-containing protein 3 (NUDCD3) OT2WYBNC NUDC3_HUMAN Decreases Expression [7]
Extracellular sulfatase Sulf-1 (SULF1) OTJCNCO0 SULF1_HUMAN Decreases Expression [7]
RNA-binding protein 12B (RBM12B) OT3C1W1U RB12B_HUMAN Decreases Expression [7]
Solute carrier family 35 member F2 (SLC35F2) OTSAD4EQ S35F2_HUMAN Increases Expression [7]
ATP-dependent RNA helicase SUPV3L1, mitochondrial (SUPV3L1) OT416O2G SUV3_HUMAN Increases Expression [7]
Synaptotagmin-like protein 1 (SYTL1) OTP0R3S5 SYTL1_HUMAN Increases Expression [7]
ELMO domain-containing protein 1 (ELMOD1) OT0WRVJC ELMD1_HUMAN Decreases Expression [7]
Activating signal cointegrator 1 complex subunit 3 (ASCC3) OTF6DCYB ASCC3_HUMAN Increases Expression [7]
GTP-binding protein 8 (GTPBP8) OTI8X03A GTPB8_HUMAN Increases Expression [7]
Inactive dipeptidyl peptidase 10 (DPP10) OTZTXB50 DPP10_HUMAN Increases Expression [7]
Phospholipid-transporting ATPase IG (ATP11C) OTKMV2K5 AT11C_HUMAN Decreases Expression [7]
Estradiol 17-beta-dehydrogenase 11 (HSD17B11) OT3VIM3B DHB11_HUMAN Increases Expression [7]
Arrestin domain-containing protein 4 (ARRDC4) OTINJ0FX ARRD4_HUMAN Decreases Expression [7]
MAPK-interacting and spindle-stabilizing protein-like (MAPK1IP1L) OTG5B19W MISSL_HUMAN Increases Expression [7]
ATP-binding cassette sub-family F member 1 (ABCF1) OT6Q079J ABCF1_HUMAN Decreases Expression [7]
Transient receptor potential cation channel subfamily V member 1 (TRPV1) OTHHDR03 TRPV1_HUMAN Decreases Expression [7]
Neuron navigator 1 (NAV1) OT667KTL NAV1_HUMAN Decreases Expression [7]
Transmembrane protein 185A (TMEM185A) OTX1JIEM T185A_HUMAN Decreases Expression [7]
Kinetochore scaffold 1 (KNL1) OT4Q3LHV KNL1_HUMAN Increases Expression [7]
Fin bud initiation factor homolog (FIBIN) OTTP8DRJ FIBIN_HUMAN Increases Expression [7]
Endonuclease 8-like 3 (NEIL3) OTBCI2NS NEIL3_HUMAN Increases Expression [7]
Gasdermin-B (GSDMB) OTWA7P10 GSDMB_HUMAN Decreases Expression [7]
Proline-rich protein 7 (PRR7) OT56XAQK PRR7_HUMAN Decreases Expression [7]
Membrane protein FAM174A (FAM174A) OT62F9KA F174A_HUMAN Decreases Expression [7]
Protein kish-A (TMEM167A) OT47KUOO KISHA_HUMAN Decreases Expression [7]
Interferon-induced protein 44 (IFI44) OTOKSZVA IFI44_HUMAN Decreases Expression [7]
Apoptosis-enhancing nuclease (AEN) OTUL3PSA AEN_HUMAN Increases Expression [7]
DEP domain-containing protein 1B (DEPDC1B) OTMVFOT1 DEP1B_HUMAN Increases Expression [7]
Pleckstrin homology-like domain family A member 1 (PHLDA1) OTFTWMIQ PHLA1_HUMAN Decreases Expression [7]
Soluble calcium-activated nucleotidase 1 (CANT1) OT1TPWQR CANT1_HUMAN Decreases Expression [7]
Reticulon-4-interacting protein 1, mitochondrial (RTN4IP1) OTHUZANE RT4I1_HUMAN Decreases Expression [7]
(3R)-3-hydroxyacyl-CoA dehydrogenase (HSD17B8) OTX1DWEF DHB8_HUMAN Decreases Expression [7]
Polyphosphoinositide phosphatase (FIG4) OT501PY9 FIG4_HUMAN Decreases Expression [7]
Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3) OTXGJ8N1 P55G_HUMAN Decreases Expression [7]
Protein NDRG1 (NDRG1) OTVO66BO NDRG1_HUMAN Decreases Expression [7]
Secreted frizzled-related protein 3 (FRZB) OTTO3DPY SFRP3_HUMAN Increases Expression [8]
Histone acetyltransferase KAT6A (KAT6A) OT4TSQLG KAT6A_HUMAN Increases Expression [7]
Neuronal cell adhesion molecule (NRCAM) OT80HHQ2 NRCAM_HUMAN Decreases Expression [7]
Bcl-2-like protein 2 (BCL2L2) OTMKVO0J B2CL2_HUMAN Decreases Expression [7]
COP9 signalosome complex subunit 5 (COPS5) OTQLBWJE CSN5_HUMAN Decreases Expression [7]
SWI/SNF complex subunit SMARCC1 (SMARCC1) OTUOMBE7 SMRC1_HUMAN Increases Expression [7]
Rho guanine nucleotide exchange factor 2 (ARHGEF2) OTBQTFRT ARHG2_HUMAN Increases Expression [7]
Histone H2A type 1-C (H2AC6) OTF3YK7V H2A1C_HUMAN Increases Expression [7]
Ribonuclease P/MRP protein subunit POP5 (POP5) OTCZTDJC POP5_HUMAN Decreases Expression [7]
Mitochondrial calcium uniporter regulator 1 (MCUR1) OTSL49SR MCUR1_HUMAN Increases Expression [7]
Exosome complex component RRP43 (EXOSC8) OT75ACNG EXOS8_HUMAN Increases Expression [7]
Spindle and kinetochore-associated protein 1 (SKA1) OTDYJ12A SKA1_HUMAN Increases Expression [7]
AP-2 complex subunit mu (AP2M1) OTQCOSFN AP2M1_HUMAN Decreases Expression [7]
RNA-binding protein Musashi homolog 2 (MSI2) OTUGOB7P MSI2H_HUMAN Decreases Expression [7]
Arylsulfatase G (ARSG) OTT7TDW7 ARSG_HUMAN Increases Expression [7]
ERO1-like protein alpha (ERO1A) OTVKOQWM ERO1A_HUMAN Increases Expression [7]
Proline-rich protein 11 (PRR11) OT2JJ08Z PRR11_HUMAN Increases Expression [7]
Secreted frizzled-related protein 2 (SFRP2) OT8GZ0CA SFRP2_HUMAN Decreases Expression [8]
Microtubule-associated protein 6 (MAP6) OTPUI00F MAP6_HUMAN Decreases Expression [7]
Lymphokine-activated killer T-cell-originated protein kinase (PBK) OT5Z27TW TOPK_HUMAN Increases Expression [7]
Beta-1,3-galactosyltransferase 6 (B3GALT6) OTF4HBAT B3GT6_HUMAN Decreases Expression [7]
Bcl-2-modifying factor (BMF) OT90NSLI BMF_HUMAN Decreases Expression [7]
RNA-binding region-containing protein 3 (RNPC3) OTW5MKC1 RNPC3_HUMAN Decreases Expression [7]
Hippocampus abundant transcript 1 protein (MFSD14A) OT7G17V5 MF14A_HUMAN Increases Expression [7]
SLIT and NTRK-like protein 1 (SLITRK1) OT1QQ7FR SLIK1_HUMAN Decreases Expression [7]
Hedgehog-interacting protein (HHIP) OT77RQYS HHIP_HUMAN Increases Expression [7]
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (MAGI1) OTMV4ASV MAGI1_HUMAN Decreases Expression [7]
Sperm-associated antigen 5 (SPAG5) OTCLJ56M SPAG5_HUMAN Increases Expression [7]
Tribbles homolog 3 (TRIB3) OTG5OS7X TRIB3_HUMAN Increases Expression [7]
Tribbles homolog 1 (TRIB1) OTPEO17G TRIB1_HUMAN Decreases Expression [7]
Protein cramped-like (CRAMP1) OT0X95YA CRML_HUMAN Decreases Expression [7]
Cysteine/serine-rich nuclear protein 1 (CSRNP1) OTDK1FPH CSRN1_HUMAN Increases Expression [7]
2-aminoethanethiol dioxygenase (ADO) OTRLGQ7V AEDO_HUMAN Increases Expression [7]
Legumain (LGMN) OTB323OZ LGMN_HUMAN Decreases Expression [7]
Perilipin-2 (PLIN2) OTRXJ9UN PLIN2_HUMAN Increases Expression [7]
Nuclear pore complex protein Nup88 (NUP88) OT647WOR NUP88_HUMAN Decreases Expression [7]
TSC22 domain family protein 3 (TSC22D3) OT03UM03 T22D3_HUMAN Increases Expression [7]
Selenide, water dikinase 2 (SEPHS2) OTTFXROR SPS2_HUMAN Increases Expression [7]
Cell cycle checkpoint control protein RAD9A (RAD9A) OTJ3AJQU RAD9A_HUMAN Decreases Expression [7]
Kinesin-like protein KIF2C (KIF2C) OTJ8G3NP KIF2C_HUMAN Increases Expression [7]
Mothers against decapentaplegic homolog 5 (SMAD5) OTQNSVCQ SMAD5_HUMAN Increases Expression [7]
Cell division control protein 6 homolog (CDC6) OTX93FE7 CDC6_HUMAN Decreases Expression [22]
Tumor susceptibility gene 101 protein (TSG101) OT97UIXC TS101_HUMAN Decreases Expression [7]
Probable rRNA-processing protein EBP2 (EBNA1BP2) OTBRVMZH EBP2_HUMAN Decreases Expression [7]
Histone H2B type 1-N (H2BC15) OTU39CFZ H2B1N_HUMAN Increases Expression [7]
Histone H2B type 1-M (H2BC14) OTSDZZZY H2B1M_HUMAN Increases Expression [7]
Growth/differentiation factor 15 (GDF15) OTWQN50N GDF15_HUMAN Increases Expression [7]
Protein CMSS1 (CMSS1) OTHASLWD CMS1_HUMAN Increases Expression [7]
Dysbindin domain-containing protein 2 (DBNDD2) OT9RI580 DBND2_HUMAN Decreases Expression [7]
Rho GTPase-activating protein 9 (ARHGAP9) OTJNHX96 RHG09_HUMAN Increases Expression [7]
DNA replication complex GINS protein PSF3 (GINS3) OT8NVXTD PSF3_HUMAN Decreases Expression [7]
Centromere protein K (CENPK) OTKPUF8K CENPK_HUMAN Decreases Expression [7]
UDP-sugar transporter protein SLC35A5 (SLC35A5) OTEL7K2R S35A5_HUMAN Decreases Expression [7]
Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1) OTJGE772 CHAC1_HUMAN Increases Expression [7]
Nuclear pore complex protein Nup85 (NUP85) OTB5ZHC8 NUP85_HUMAN Decreases Expression [7]
Tubulin polymerization-promoting protein family member 3 (TPPP3) OTU8VUIG TPPP3_HUMAN Decreases Expression [7]
ADP-ribose pyrophosphatase, mitochondrial (NUDT9) OTUYF0H3 NUDT9_HUMAN Increases Expression [7]
Meiotic nuclear division protein 1 homolog (MND1) OTS87F3H MND1_HUMAN Increases Expression [7]
TM2 domain-containing protein 2 (TM2D2) OTB51WEY TM2D2_HUMAN Decreases Expression [7]
Bcl-2-like protein 13 (BCL2L13) OT2VRFTM B2L13_HUMAN Decreases Expression [7]
Serine/threonine-protein kinase PINK1, mitochondrial (PINK1) OT50NR57 PINK1_HUMAN Decreases Expression [7]
Kinetochore protein Nuf2 (NUF2) OTOOQL35 NUF2_HUMAN Increases Expression [7]
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) OTUYHB84 MLP3B_HUMAN Increases Expression [7]
Sentrin-specific protease 6 (SENP6) OT05LLF4 SENP6_HUMAN Increases Expression [7]
Superkiller complex protein 8 (SKIC8) OTDSQYDN SKI8_HUMAN Decreases Expression [7]
Mucolipin-1 (MCOLN1) OTO8GJ70 MCLN1_HUMAN Decreases Expression [7]
Transmembrane protein 126A (TMEM126A) OTLP76WE T126A_HUMAN Increases Expression [7]
Polyadenylate-binding protein-interacting protein 1 (PAIP1) OTL2F5T5 PAIP1_HUMAN Decreases Expression [7]
DNA replication factor Cdt1 (CDT1) OTVY53VG CDT1_HUMAN Increases Expression [7]
SH3 domain-binding glutamic acid-rich-like protein 3 (SH3BGRL3) OTKMW34I SH3L3_HUMAN Decreases Expression [7]
2-aminomuconic semialdehyde dehydrogenase (ALDH8A1) OTINY3MW AL8A1_HUMAN Decreases Expression [7]
Sodium-coupled neutral amino acid symporter 1 (SLC38A1) OTO3VD5E S38A1_HUMAN Increases Expression [7]
Frizzled-8 (FZD8) OTZ9IRFL FZD8_HUMAN Increases Expression [8]
E3 ubiquitin ligase RNF121 (RNF121) OTA0YMLW RN121_HUMAN Decreases Expression [7]
Ethanolamine kinase 1 (ETNK1) OTDKB4DQ EKI1_HUMAN Decreases Expression [7]
Transmembrane 9 superfamily member 3 (TM9SF3) OTBISJZQ TM9S3_HUMAN Decreases Expression [7]
Exosome complex component RRP41 (EXOSC4) OTG4TICP EXOS4_HUMAN Decreases Expression [7]
Semaphorin-4B (SEMA4B) OT1Y3YZD SEM4B_HUMAN Decreases Expression [7]
Anillin (ANLN) OTXJY54C ANLN_HUMAN Increases Expression [7]
Neural proliferation differentiation and control protein 1 (NPDC1) OT788NC8 NPDC1_HUMAN Decreases Expression [7]
Delta-like protein 4 (DLL4) OTRA4K2V DLL4_HUMAN Decreases Expression [7]
Cytochrome P450 26B1 (CYP26B1) OT92XA92 CP26B_HUMAN Decreases Expression [7]
DNA polymerase epsilon subunit 3 (POLE3) OTOELRF6 DPOE3_HUMAN Increases Expression [7]
Lymphoid-specific helicase (HELLS) OTVVV668 HELLS_HUMAN Increases Expression [7]
Kinesin-like protein KIF15 (KIF15) OTJRJEXL KIF15_HUMAN Increases Expression [7]
Homer protein homolog 2 (HOMER2) OT4JGKJF HOME2_HUMAN Decreases Expression [7]
FIGNL1-interacting regulator of recombination and mitosis (FIRRM) OTALLHT1 FIRRM_HUMAN Decreases Expression [7]
Ubiquitin-like-conjugating enzyme ATG3 (ATG3) OT28VBVK ATG3_HUMAN Increases Expression [7]
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3) OTMEF544 SIR3_HUMAN Decreases Expression [7]
Structural maintenance of chromosomes protein 4 (SMC4) OTEJE6AG SMC4_HUMAN Increases Expression [7]
Histone chaperone ASF1B (ASF1B) OTKXX12I ASF1B_HUMAN Decreases Expression [7]
Anoctamin-10 (ANO10) OTG3BNOU ANO10_HUMAN Decreases Expression [7]
Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) OT55W5WC FKB14_HUMAN Decreases Expression [7]
Telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP) OT3M5P3G TE2IP_HUMAN Decreases Expression [7]
CDGSH iron-sulfur domain-containing protein 1 (CISD1) OT0MTVGF CISD1_HUMAN Increases Expression [7]
GEM-interacting protein (GMIP) OTRFXK76 GMIP_HUMAN Decreases Expression [7]
Calcium-binding and coiled-coil domain-containing protein 1 (CALCOCO1) OT1PAIN0 CACO1_HUMAN Decreases Expression [7]
GMP reductase 2 (GMPR2) OTKZSZPE GMPR2_HUMAN Decreases Expression [7]
Vesicular glutamate transporter 2 (SLC17A6) OTP1MJGP VGLU2_HUMAN Decreases Expression [7]
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 (B3GAT1) OTXFP98E B3GA1_HUMAN Decreases Expression [7]
Hepatocyte nuclear factor 6 (ONECUT1) OTK1QUQT HNF6_HUMAN Decreases Expression [7]
Origin recognition complex subunit 3 (ORC3) OTYQWB6B ORC3_HUMAN Decreases Expression [7]
DnaJ homolog subfamily B member 9 (DNAJB9) OT38EQT6 DNJB9_HUMAN Increases Expression [7]
Dickkopf-related protein 4 (DKK4) OTWCCVF6 DKK4_HUMAN Increases Expression [8]
Alpha-catulin (CTNNAL1) OTESJ6JD CTNL1_HUMAN Increases Expression [7]
Dickkopf-related protein 2 (DKK2) OTKSZSUM DKK2_HUMAN Decreases Expression [8]
Protein DBF4 homolog A (DBF4) OTBL7JHQ DBF4A_HUMAN Increases Expression [7]
Death domain-associated protein 6 (DAXX) OTX6O7PL DAXX_HUMAN Decreases Expression [7]
Lysine-specific demethylase 5B (KDM5B) OT5DL94T KDM5B_HUMAN Decreases Expression [7]
Poly polymerase 2 (PARP2) OTYL81ZI PARP2_HUMAN Increases Expression [7]
Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6) OTVUZCLG GTR6_HUMAN Decreases Expression [7]
Transcription factor COE1 (EBF1) OTZ61YYH COE1_HUMAN Decreases Expression [7]
Probable ribosome biogenesis protein RLP24 (RSL24D1) OT6KI56F RLP24_HUMAN Increases Expression [7]
Inactive cell surface hyaluronidase CEMIP2 (CEMIP2) OT9I1XUO CEIP2_HUMAN Decreases Expression [7]
Ena/VASP-like protein (EVL) OTZ8ZDNY EVL_HUMAN Decreases Expression [7]
E3 ISG15--protein ligase HERC5 (HERC5) OTZ5PR39 HERC5_HUMAN Increases Expression [7]
Meteorin (METRN) OTI2645G METRN_HUMAN Decreases Expression [7]
Lymphoid enhancer-binding factor 1 (LEF1) OTWS5I5H LEF1_HUMAN Increases Expression [7]
ADP-sugar pyrophosphatase (NUDT5) OTHYCBA6 NUDT5_HUMAN Decreases Expression [7]
Angiopoietin-related protein 2 (ANGPTL2) OTB6JG41 ANGL2_HUMAN Decreases Expression [7]
Proteasome activator complex subunit 2 (PSME2) OTYPP33T PSME2_HUMAN Decreases Expression [7]
Cadherin-9 (CDH9) OTV9N5XK CADH9_HUMAN Increases Expression [8]
Cadherin-7 (CDH7) OTQEXCKU CADH7_HUMAN Increases Expression [8]
Frizzled-4 (FZD4) OTGLZIE0 FZD4_HUMAN Increases Expression [8]
Targeting protein for Xklp2 (TPX2) OTWLJYH0 TPX2_HUMAN Increases Expression [7]
Frizzled-10 (FZD10) OTSAENLT FZD10_HUMAN Increases Expression [8]
A-kinase anchor protein 8-like (AKAP8L) OTM3ZHGU AKP8L_HUMAN Increases Expression [7]
Neurogenic locus notch homolog protein 3 (NOTCH3) OTMVVA7F NOTC3_HUMAN Decreases Expression [7]
Ras GTPase-activating protein-binding protein 2 (G3BP2) OTAWW3KI G3BP2_HUMAN Decreases Expression [7]
Peptidyl-prolyl cis-trans isomerase E (PPIE) OTIE5OAD PPIE_HUMAN Increases Expression [7]
Forkhead box protein J3 (FOXJ3) OTXAUJ47 FOXJ3_HUMAN Increases Expression [7]
Microtubule-associated protein RP/EB family member 3 (MAPRE3) OTSCLETV MARE3_HUMAN Decreases Expression [7]
Structural maintenance of chromosomes protein 3 (SMC3) OTWGFRHD SMC3_HUMAN Increases Expression [7]
DNA replication complex GINS protein PSF2 (GINS2) OT974IYI PSF2_HUMAN Decreases Expression [7]
Ribitol-5-phosphate xylosyltransferase 1 (RXYLT1) OTQTO7VU RXLT1_HUMAN Increases Expression [7]
Cyclic AMP-dependent transcription factor ATF-5 (ATF5) OT03QCLM ATF5_HUMAN Increases Expression [7]
Phospholipid-transporting ATPase IF (ATP11B) OTQOXTH2 AT11B_HUMAN Decreases Expression [7]
Nischarin (NISCH) OTTMT8UD NISCH_HUMAN Decreases Expression [7]
AP-3 complex subunit mu-1 (AP3M1) OTOQYRSL AP3M1_HUMAN Decreases Expression [7]
Nucleolar protein 58 (NOP58) OTP536HD NOP58_HUMAN Increases Expression [7]
N-acetylglucosamine-6-phosphate deacetylase (AMDHD2) OTBV5PAI NAGA_HUMAN Decreases Expression [7]
U6 snRNA-associated Sm-like protein LSm2 (LSM2) OTHL77NY LSM2_HUMAN Increases Expression [7]
Endophilin-B1 (SH3GLB1) OTAZ5OP8 SHLB1_HUMAN Increases Expression [7]
Dehydrogenase/reductase SDR family member 7 (DHRS7) OTV729DT DHRS7_HUMAN Increases Expression [7]
PRELI domain containing protein 3B (PRELID3B) OT4TRT4K PLD3B_HUMAN Increases Expression [7]
Peptidyl-prolyl cis-trans isomerase-like 1 (PPIL1) OTS5S837 PPIL1_HUMAN Decreases Expression [7]
Large ribosomal subunit protein eL36 (RPL36) OT9R9LWG RL36_HUMAN Increases Expression [7]
Metal-response element-binding transcription factor 2 (MTF2) OTNL1O2O MTF2_HUMAN Increases Expression [7]
Disheveled-associated activator of morphogenesis 1 (DAAM1) OT0VHIYZ DAAM1_HUMAN Decreases Expression [7]
Hypoxia up-regulated protein 1 (HYOU1) OTBGBSOV HYOU1_HUMAN Increases Expression [7]
Protocadherin alpha-9 (PCDHA9) OTMDYFZR PCDA9_HUMAN Decreases Expression [7]
Protocadherin alpha-1 (PCDHA1) OT65E2NU PCDA1_HUMAN Decreases Expression [7]
DnaJ homolog subfamily C member 15 (DNAJC15) OTNDUKAA DJC15_HUMAN Increases Expression [7]
Phosphoserine aminotransferase (PSAT1) OTVV1YV9 SERC_HUMAN Increases Expression [7]
Chloride intracellular channel protein 4 (CLIC4) OT6KTPKD CLIC4_HUMAN Increases Expression [7]
Transforming acidic coiled-coil-containing protein 3 (TACC3) OTRNEZTA TACC3_HUMAN Increases Expression [7]
Proton-coupled zinc antiporter SLC30A1 (SLC30A1) OTY8J0S4 ZNT1_HUMAN Increases Expression [7]
Cadherin-10 (CDH10) OTK3D5WP CAD10_HUMAN Decreases Expression [7]
Nuclear receptor coactivator 3 (NCOA3) OTBX300Z NCOA3_HUMAN Decreases Expression [20]
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⏷ Show the Full List of 717 DOT(s)
Indication(s) of Ibrutinib
Disease Entry ICD 11 Status REF
Mantle cell lymphoma 2A85.5 Approved [3]
Small lymphocytic lymphoma 2A82.0 Approved [4]
Waldenstrom macroglobulinemia 2A85.4 Approved [4]
B-cell non-hodgkin lymphoma 2B33.5 Phase 3 [5]
Diffuse large B-cell lymphoma 2A81 Phase 3 [5]
Follicular lymphoma 2A80 Phase 3 [5]
Non-hodgkin lymphoma 2B33.5 Phase 3 [5]
Pancreatic cancer 2C10 Phase 3 [5]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 2 [6]
Solid tumour/cancer 2A00-2F9Z Phase 2 [5]
Ibrutinib Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Tyrosine-protein kinase BTK (ATK) TTGM6VW BTK_HUMAN Inhibitor [29]
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Ibrutinib Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [30]
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Ibrutinib Interacts with 3 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [31]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Metabolism [31]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Metabolism [31]
------------------------------------------------------------------------------------
Ibrutinib Interacts with 21 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Tyrosine-protein kinase BTK (BTK) OTG3CDVK BTK_HUMAN Decreases Response To Substance [32]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Decreases Expression [33]
PR domain zinc finger protein 1 (PRDM1) OTQLSVBS PRDM1_HUMAN Decreases Expression [33]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Decreases Expression [33]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (PLCG2) OTGVC9MY PLCG2_HUMAN Decreases Phosphorylation [33]
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) OTVLI4DD TNAP3_HUMAN Decreases Expression [33]
Interleukin-10 (IL10) OTIRFRXC IL10_HUMAN Decreases Expression [33]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Decreases Expression [33]
Polycomb complex protein BMI-1 (BMI1) OTROVLJ0 BMI1_HUMAN Decreases Expression [33]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Affects Localization [33]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [33]
Baculoviral IAP repeat-containing protein 3 (BIRC3) OT3E95KB BIRC3_HUMAN Decreases Expression [33]
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) OT9RDS3H IKKB_HUMAN Decreases Activity [34]
Albumin (ALB) OTVMM513 ALBU_HUMAN Affects Binding [35]
Alanine aminotransferase 1 (GPT) OTOXOA0Q ALAT1_HUMAN Increases Secretion [36]
Hemoglobin subunit beta (HBB) OT514IKQ HBB_HUMAN Affects Binding [35]
TNF receptor-associated factor 2 (TRAF2) OT1MEZZN TRAF2_HUMAN Decreases Response To Substance [33]
TNF receptor-associated factor 3 (TRAF3) OT5TQBGV TRAF3_HUMAN Decreases Response To Substance [33]
CREB-binding protein (CREBBP) OTPA4QGM CBP_HUMAN Decreases Response To Substance [33]
Mitogen-activated protein kinase kinase kinase 14 (MAP3K14) OTT3DOOL M3K14_HUMAN Decreases Response To Substance [33]
Serine/threonine-protein kinase pim-1 (PIM1) OTWEKXTU PIM1_HUMAN Decreases Response To Substance [33]
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⏷ Show the Full List of 21 DOT(s)

References

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