Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0HPWY)

• Drug Name: biochanin A Drug Info
• Synonyms: Biochanin A; 491-80-5; Biochanin; 4'-Methylgenistein; 5,7-Dihydroxy-4'-methoxyisoflavone; 5,7-Dihydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one; Genistein 4-methyl ether; 5,7-Dihydrox -4'-methoxyisoflavone; Biochanine A; 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-methoxyphenyl)-; olmelin; Pratensol; NSC 123538; Biochanin-A; 5,7-dihydroxy-3-(4-methoxyphenyl)chromen-4-one; 4-Methylgenistein; C16H12O5; UNII-U13J6U390T; CCRIS 5449; 5,7-Dihydroxy-3-p-methoxyphenyl-4H-chromen-4-one; EINECS 207-744-7; NSC123538; Genistein 4'-methyl ether; 4'-methylgenistein; BIOCHANIN

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5280373
  ChEBI ID: CHEMBL131921
  CAS Number: CAS 491-80-5
  TTD Drug ID: DM0HPWY

Molecule-Related Drug Atlas

Drug(s) Targeting Plasmodium Beta-hydroxyacyl-ACP dehydratase (Malaria FabZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[4]
MORIN	DM2OGZ5	Discovery agent	N.A.	Investigative	[4]
3,7,3',4'-TETRAHYDROXYFLAVONE	DMES906	Discovery agent	N.A.	Investigative	[4]
(-)-CATECHINGALLATE	DMZOGSK	Discovery agent	N.A.	Investigative	[4]
2-Hexadecynoic acid	DMTFIPZ	Discovery agent	N.A.	Investigative	[9]
GALLOCATECHIN GALLATE	DMX2084	Discovery agent	N.A.	Investigative	[4]

Drug(s) Targeting Aromatase (CYP19A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Anastrozole	DMNP60F	Breast cancer	2C60-2C65	Approved	[10]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[11]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[11]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[12]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[13]
Testolactone	DMVY4GN	Breast cancer	2C60-2C65	Approved	[14]
LIAROZOLE	DM4OYXE	Dermatological disease	DA24.Y	Phase 2/3	[2]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[15]
BGS-649	DMO4MNQ	Endometriosis	GA10	Phase 2	[16]
NARINGENIN	DMHAZLM	N. A.	N. A.	Phase 1	[2]

Drug(s) Targeting Fatty acid synthase (FASN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cerulenin	DM6N4PR	Weight loss	MG43.5	Approved	[17]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[4]
TVB-2640	DM19GUH	Astrocytoma	2A00.0Y	Phase 2	[18]
TVB-2640	DM19GUH	Astrocytoma	2A00.0Y	Phase 2	[19]
FAS1	DMAX2EW	Fungal infection	1F29-1F2F	Preclinical	[20]
FSA2	DMLNRCI	Fungal infection	1F29-1F2F	Preclinical	[20]
MORIN	DM2OGZ5	Discovery agent	N.A.	Investigative	[4]
3,7,3',4'-TETRAHYDROXYFLAVONE	DMES906	Discovery agent	N.A.	Investigative	[4]
(-)-CATECHINGALLATE	DMZOGSK	Discovery agent	N.A.	Investigative	[4]
2-Hexadecynoic acid	DMTFIPZ	Discovery agent	N.A.	Investigative	[9]

Drug(s) Targeting Estrogen-related receptor-beta (ESRRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
daidzein	DMRFTJX	Discovery agent	N.A.	Investigative	[3]
DY131	DMFJ3VC	Discovery agent	N.A.	Investigative	[21]

Drug(s) Targeting Estrogen-related receptor-gamma (ESRRG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
daidzein	DMRFTJX	Discovery agent	N.A.	Investigative	[3]
DY131	DMFJ3VC	Discovery agent	N.A.	Investigative	[22]
GSK4716	DMHUMP9	Discovery agent	N.A.	Investigative	[22]

Drug(s) Targeting Estrogen-related receptor-alpha (ESRRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rimexolone	DMTAREC	Arthritis	FA20	Approved	[23]
Pregnenolone	DM6VFO1	Schizophrenia	6A20	Phase 4	[24]
D-5519	DM9FAJM	Asthma	CA23	Phase 3	[25]
Dexamethasone palmitate	DMCMT4V	Choroidal neovascularization	9B76	Phase 1/2	[26]
RPR-106541	DMRGC5B	Asthma	CA23	Discontinued in Phase 2	[27]
Rofleponide	DM6OSPQ	Allergic rhinitis	CA08.0	Discontinued in Phase 2	[28]
AD-121	DMB8XJM	Rheumatoid arthritis	FA20	Discontinued in Phase 1/2	[23]
GW-250495	DMWJZAP	Asthma	CA23	Discontinued in Phase 1	[23]
PLD-177	DMPHUBO	Allergic rhinitis	CA08.0	Terminated	[23]
Steroid hormone conjugates	DMOJM08	Cachexia	MG20	Terminated	[29]

Drug(s) Affected By Agrin (AGRN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[30]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[31]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[31]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[34]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[35]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[36]

Drug(s) Affected By Low-density lipoprotein receptor class A domain-containing protein 4 (LDLRAD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[30]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[40]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[34]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[36]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[41]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[42]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 21 (TNFRSF21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[47]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[48]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[49]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]

Drug(s) Affected By Guanine nucleotide-binding protein G(i) subunit alpha-3 (GNAI3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Bortezomib	DMNO38U	Leukemia		Approved	[54]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[41]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[55]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[57]

Drug(s) Affected By Cadherin-2 (CDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[58]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[61]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[62]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[63]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[64]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[65]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[66]

Drug(s) Affected By rRNA 2'-O-methyltransferase fibrillarin (FBL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[47]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[67]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[69]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[70]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[72]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[73]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[75]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[76]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[77]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[78]

Drug(s) Affected By Epidermal growth factor receptor substrate 15 (EPS15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[79]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[41]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[82]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[83]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]

Drug(s) Affected By Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[88]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[41]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[90]

Drug(s) Affected By Eukaryotic translation initiation factor 5 (EIF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[91]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[92]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[47]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[95]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]

Drug(s) Affected By Solute carrier family 25 member 3 (SLC25A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[92]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[97]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[98]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[99]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[100]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[101]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[102]
Selenium	DM25CGV	N. A.	N. A.	Approved	[30]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[103]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[104]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[105]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[106]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[108]

Drug(s) Affected By Serine/arginine-rich splicing factor 1 (SRSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[91]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[92]
Selenium	DM25CGV	N. A.	N. A.	Approved	[30]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[109]
Bortezomib	DMNO38U	Leukemia		Approved	[54]

Drug(s) Affected By AT-rich interactive domain-containing protein 5B (ARID5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[61]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[110]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[109]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[41]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Indomethacin	DMSC4A7	Bursitis		Approved	[111]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[112]

Drug(s) Affected By Non-POU domain-containing octamer-binding protein (NONO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[47]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[41]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[93]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[114]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[115]

Drug(s) Affected By NADH dehydrogenase 1 alpha subcomplex subunit 5 (NDUFA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[41]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[116]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[117]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[118]
Fenretinide	DMRD5SP	Macular degeneration	9B78.3	Phase 3	[119]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[120]

Drug(s) Affected By Rab-like protein 6 (RABL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[41]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[121]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[122]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[82]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[93]
MG-132	DMKA2YS	N. A.	N. A.	Preclinical	[123]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[93]

Drug(s) Affected By Telomere-associated protein RIF1 (RIF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[40]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[126]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[127]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[128]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[129]

Drug(s) Affected By Mitochondrial mRNA pseudouridine synthase RPUSD3 (RPUSD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[47]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[41]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[130]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[121]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[129]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[131]

Drug(s) Affected By Sushi domain-containing protein 6 (SUSD6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[47]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[125]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[92]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[117]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]

Drug(s) Affected By Prefoldin subunit 5 (PFDN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[133]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[134]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[135]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[136]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[121]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[127]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[30]

Drug(s) Affected By Latexin (LXN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[139]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[140]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[36]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[137]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[137]

Drug(s) Affected By BRISC and BRCA1-A complex member 2 (BABAM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[41]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[141]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[126]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[142]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[30]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[143]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[144]

Drug(s) Affected By Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 (ENPP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[145]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[146]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[127]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[122]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[122]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[147]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]

Drug(s) Affected By Deoxyribose-phosphate aldolase (DERA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[30]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[36]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[90]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[148]

Drug(s) Affected By 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (CYP27B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcidiol	DMN4CV5	Hypophosphatemia		Approved	[149]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[150]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[151]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[152]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[153]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[154]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[155]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[156]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[158]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[159]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[77]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[159]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[160]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[161]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[162]

Drug(s) Affected By Creatine kinase B-type (CKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[163]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[92]
Selenium	DM25CGV	N. A.	N. A.	Approved	[30]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[164]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[164]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[165]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[168]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[158]
Selenium	DM25CGV	N. A.	N. A.	Approved	[30]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[169]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[44]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[170]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[171]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[172]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[173]

Drug(s) Affected By Solute carrier organic anion transporter family member 1B1 (SLCO1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[174]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[175]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[176]
Repaglinide	DM5SXUV	Diabetic complication	5A2Y	Approved	[177]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[178]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[179]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[180]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[180]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[181]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[182]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Aromatase (CYP19A1)	TTSZLWK	CP19A_HUMAN	Inhibitor	[2]
Estrogen-related receptor-alpha (ESRRA)	TTPNQAC	ERR1_HUMAN	Agonist	[3]
Estrogen-related receptor-beta (ESRRB)	TTKF0XS	ERR2_HUMAN	Agonist	[3]
Estrogen-related receptor-gamma (ESRRG)	TT9ZRHB	ERR3_HUMAN	Agonist	[3]
Fatty acid synthase (FASN)	TT7AOUD	FAS_HUMAN	Inhibitor	[4]
Plasmodium Beta-hydroxyacyl-ACP dehydratase (Malaria FabZ)	TTHPFTS	Q965D7_PLAFA	Inhibitor	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (CYP27B1)	OTTK98BH	CP27B_HUMAN	Gene/Protein Processing	[5]
Agrin (AGRN)	OTWJENAZ	AGRIN_HUMAN	Gene/Protein Processing	[6]
Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1)	OTV57BZD	AL7A1_HUMAN	Gene/Protein Processing	[6]
AT-rich interactive domain-containing protein 5B (ARID5B)	OTUQ4CQY	ARI5B_HUMAN	Gene/Protein Processing	[6]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Gene/Protein Processing	[7]
BRISC and BRCA1-A complex member 2 (BABAM2)	OTOY7FNT	BABA2_HUMAN	Gene/Protein Processing	[6]
Cadherin-2 (CDH2)	OTH0Y56P	CADH2_HUMAN	Gene/Protein Processing	[6]
Creatine kinase B-type (CKB)	OTUCKOTT	KCRB_HUMAN	Gene/Protein Processing	[8]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Gene/Protein Processing	[6]
Deoxyribose-phosphate aldolase (DERA)	OT8SMO3N	DEOC_HUMAN	Gene/Protein Processing	[6]

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