Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMAOJBX)

• Drug Name: Tetrandrine Drug Info
• Synonyms: Tetrandrine, Millenia Hope; Tetrandrine, West Virginia University; Tranex-18

Indication

Disease Entry	ICD 11	Status	REF
Sarcoma	2A60-2C35	Phase 1	[1]
Colorectal cancer	2B91.Z	Discontinued in Phase 3	[2]

• Cross-matching ID:
  PubChem CID: 73078
  ChEBI ID: CHEMBL49
  CAS Number: CAS 518-34-3
  TTD Drug ID: DMAOJBX
  INTEDE Drug ID: DR1570

Molecule-Related Drug Atlas

Drug(s) Targeting Calcium channel unspecific (CaC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicardipine	DMCDYW7	High blood pressure	BA00	Approved	[12]
Clevidipine butyrate	DMW4M97	Hypertension	BA00-BA04	Approved	[13]
Nisoldipine	DM7ISKJ	Hypertension	BA00-BA04	Approved	[14]
Felodipine	DMOSW35	Hypertension	BA00-BA04	Approved	[15]
Nimodipine	DMQ0RKZ	Cerebral vasospasm	BA85.Z	Approved	[16]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[17]
Isradipine	DMA5XGH	Hypertension	BA00-BA04	Approved	[17]
DIPROTEVERINE HYDROCHLORIDE	DMG8U6M	Angina pectoris	BA40	Phase 3	[18]
ATI-2042	DMWP59B	Atrial fibrillation	BC81.3	Phase 2	[19]
HBI-3000	DM74ZKN	Heart arrhythmia	BC65	Phase 2	[20]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[21]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[22]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[23]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[24]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[25]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[26]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[27]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[28]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[22]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[29]

Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[30]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[31]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[32]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[34]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[35]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[36]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[37]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[38]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[33]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[39]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[40]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[42]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[43]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[44]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[45]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[46]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[48]

Drug(s) Affected By Ubiquitin-like protein ATG12 (ATG12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Selenium	DM25CGV	N. A.	N. A.	Approved	[50]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[52]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[53]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[54]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[56]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[58]

Drug(s) Affected By Ubiquitin-like modifier-activating enzyme ATG7 (ATG7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[59]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[52]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[63]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[65]

Drug(s) Affected By Apoptosis-inducing factor 1, mitochondrial (AIFM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[66]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[42]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[68]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[70]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[72]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]

Drug(s) Affected By Zinc finger protein SNAI1 (SNAI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[75]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[76]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[81]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[83]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[84]

Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[85]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[86]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[87]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[88]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[89]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[90]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[91]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[92]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[94]

Drug(s) Affected By Prelamin-A/C (LMNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[50]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[97]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[98]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[99]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[101]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[102]

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trastuzumab	DMZQOUX	Breast cancer	2C60-2C65	Approved	[85]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[103]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[104]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[105]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[106]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Selenium	DM25CGV	N. A.	N. A.	Approved	[50]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[110]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[111]
Fructose	DM43AN2	Vomiting	MD90	Approved	[85]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[112]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[113]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[114]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[115]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[116]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[117]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[118]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[119]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[120]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[121]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[122]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[123]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[124]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[125]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[126]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[127]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[125]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[128]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[129]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[130]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[42]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[131]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[132]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[131]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[133]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[134]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[135]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[88]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[76]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[136]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[137]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[138]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[139]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[142]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[143]

Drug(s) Affected By Cadherin-2 (CDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[139]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[145]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[143]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[146]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[147]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[148]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[149]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[150]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[151]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[152]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[153]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[154]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[155]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[157]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[158]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[159]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[160]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[161]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[152]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[162]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[163]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[164]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[151]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[85]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[165]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[154]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[155]

Drug(s) Affected By 14-3-3 protein sigma (SFN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[166]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[167]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[90]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[168]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[169]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[170]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[168]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[143]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[171]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[172]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[173]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[174]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[114]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[175]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[176]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[177]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[178]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[179]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[180]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[139]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[181]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[182]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[115]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[40]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[183]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[177]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[43]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[184]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[132]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[185]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[186]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[187]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[184]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[188]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[189]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[190]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[191]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[192]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[193]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[194]

Drug(s) Affected By BH3-interacting domain death agonist (BID)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[165]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[42]
Selenium	DM25CGV	N. A.	N. A.	Approved	[195]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[196]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[170]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[197]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[198]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]

Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[200]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[201]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[202]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[203]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[204]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[205]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[206]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[207]
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[208]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]

Drug(s) Affected By Growth factor receptor-bound protein 2 (GRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[209]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[210]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[211]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[150]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[212]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[213]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[102]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[214]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[165]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[215]
Selenium	DM25CGV	N. A.	N. A.	Approved	[50]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[216]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[217]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[139]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[218]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[219]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[220]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[221]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[222]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[42]
Selenium	DM25CGV	N. A.	N. A.	Approved	[50]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[223]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[224]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[225]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[196]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[226]

Drug(s) Affected By Son of sevenless homolog 1 (SOS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[116]
Selenium	DM25CGV	N. A.	N. A.	Approved	[50]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[227]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[139]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[98]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[150]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[228]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[229]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]

Drug(s) Affected By 5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[116]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[230]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[231]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[232]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[233]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[102]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[234]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[235]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[56]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[236]

Drug(s) Affected By Endonuclease G, mitochondrial (ENDOG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Selenium	DM25CGV	N. A.	N. A.	Approved	[50]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[68]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[196]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[237]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[56]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[238]

Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[239]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[240]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[241]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[242]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[243]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[244]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[64]

Drug(s) Affected By Inactive caspase-12 (CASP12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[245]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[246]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[247]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[248]
Methamphetamine	DMPM4SK	Anxiety		Approved	[249]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[250]
Thymoquinone	DMVDTR2	Polycystic ovarian syndrome	5A80.1	Phase 2/3	[251]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[252]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[246]
3,7,3',4'-TETRAHYDROXYFLAVONE	DMES906	Discovery agent	N.A.	Investigative	[253]

Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[254]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[139]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[256]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[62]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[257]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[52]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[53]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[54]

Drug(s) Affected By Autophagy protein 5 (ATG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[256]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[52]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[53]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[258]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[64]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[259]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[260]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[261]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[262]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Calcium channel unspecific (CaC)	TT5HONZ	NOUNIPROTAC	Antagonist	[3]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[4]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Substrate	[5]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
14-3-3 protein sigma (SFN)	OTLJCZ1U	1433S_HUMAN	Gene/Protein Processing	[6]
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)	OT7TNF0L	AAPK1_HUMAN	Post-Translational Modifications	[7]
Apoptosis-inducing factor 1, mitochondrial (AIFM1)	OTKPWB7Q	AIFM1_HUMAN	Gene/Protein Processing	[6]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Gene/Protein Processing	[8]
Autophagy protein 5 (ATG5)	OT4T5SMS	ATG5_HUMAN	Gene/Protein Processing	[9]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Gene/Protein Processing	[10]
Bcl-2 homologous antagonist/killer (BAK1)	OTDP6ILW	BAK_HUMAN	Gene/Protein Processing	[6]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Gene/Protein Processing	[6]
BH3-interacting domain death agonist (BID)	OTOSHSHU	BID_HUMAN	Gene/Protein Processing	[6]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Gene/Protein Processing	[11]

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