Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMES906)

• Drug Name: 3,7,3',4'-TETRAHYDROXYFLAVONE Drug Info
• Synonyms: Fisetin; 528-48-3; 2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4H-chromen-4-one; 5-Desoxyquercetin; Fustel; Cotinin; Viset; 3,3',4',7-Tetrahydroxyflavone; Fisetholz; Superfustel; Fustet; Fietin; Junger fustik; 3,7,3',4'-Tetrahydroxyflavone; Ventin sumach; Zante fustic; Young fustic; Superfustel K; Ungarisches gelbholz; CI Natural Brown 1; Young fustic crystals; Bois bleu de Honqrie; BOIS bleude honqrie; CI 75620; NSC 407010; NSC 656275; 5-Deoxyquercetin; 2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4H-1-benzopyran-4-one; Natural Brown 1; FISETIN

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5281614
  ChEBI ID: CHEMBL31574
  CAS Number: CAS 528-48-3
  TTD Drug ID: DMES906

Molecule-Related Drug Atlas

Drug(s) Targeting Plasmodium Beta-hydroxyacyl-ACP dehydratase (Malaria FabZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[2]
MORIN	DM2OGZ5	Discovery agent	N.A.	Investigative	[2]
biochanin A	DM0HPWY	Discovery agent	N.A.	Investigative	[2]
(-)-CATECHINGALLATE	DMZOGSK	Discovery agent	N.A.	Investigative	[2]
2-Hexadecynoic acid	DMTFIPZ	Discovery agent	N.A.	Investigative	[7]
GALLOCATECHIN GALLATE	DMX2084	Discovery agent	N.A.	Investigative	[2]

Drug(s) Targeting Fatty acid synthase (FASN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cerulenin	DM6N4PR	Weight loss	MG43.5	Approved	[8]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[2]
TVB-2640	DM19GUH	Astrocytoma	2A00.0Y	Phase 2	[9]
TVB-2640	DM19GUH	Astrocytoma	2A00.0Y	Phase 2	[10]
FAS1	DMAX2EW	Fungal infection	1F29-1F2F	Preclinical	[11]
FSA2	DMLNRCI	Fungal infection	1F29-1F2F	Preclinical	[11]
MORIN	DM2OGZ5	Discovery agent	N.A.	Investigative	[2]
biochanin A	DM0HPWY	Discovery agent	N.A.	Investigative	[2]
(-)-CATECHINGALLATE	DMZOGSK	Discovery agent	N.A.	Investigative	[2]
2-Hexadecynoic acid	DMTFIPZ	Discovery agent	N.A.	Investigative	[7]

Drug(s) Targeting Plasmodium Enoyl-ACP reductase (Malaria fabI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[12]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[13]
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[14]
Beta-D-Glucose	DM5IHYP	Discovery agent	N.A.	Investigative	[14]
MORIN	DM2OGZ5	Discovery agent	N.A.	Investigative	[2]
(-)-CATECHINGALLATE	DMZOGSK	Discovery agent	N.A.	Investigative	[2]
Thiolactomycin	DMBAWDG	Malaria	1F40-1F45	Investigative	[12]
GALLOCATECHIN GALLATE	DMX2084	Discovery agent	N.A.	Investigative	[2]
Diazaborines	DM5UFZX	Discovery agent	N.A.	Investigative	[15]
ISORHAMNETIN	DMQ4Z6E	Discovery agent	N.A.	Investigative	[2]

Drug(s) Targeting Plasmodium Oxoacyl-[acyl-carrier protein] reductase (Malaria fabG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[2]
Chrysin	DM7V2LG	Discovery agent	N.A.	Investigative	[2]
KAEMPFEROL	DMHEMUB	Discovery agent	N.A.	Investigative	[2]
MORIN	DM2OGZ5	Discovery agent	N.A.	Investigative	[2]
(-)-CATECHINGALLATE	DMZOGSK	Discovery agent	N.A.	Investigative	[2]
2-Hexadecynoic acid	DMTFIPZ	Discovery agent	N.A.	Investigative	[7]
GALLOCATECHIN GALLATE	DMX2084	Discovery agent	N.A.	Investigative	[2]
ISORHAMNETIN	DMQ4Z6E	Discovery agent	N.A.	Investigative	[2]
NADPH	DM75Q34	Discovery agent	N.A.	Investigative	[16]

Drug(s) Targeting Cyclin-dependent kinase 6 (CDK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Apremilast	DMTWS9E	Psoriasis vulgaris	EA90	Approved	[17]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[18]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[19]
Ribociclib Succinate	DM9CIUW	Breast cancer	2C60-2C65	Approved	[20]
Trilaciclib	DMP5A4T	Small-cell lung cancer	2C25.Y	Approved	[21]
LEE011	DMMX75K	Breast cancer	2C60-2C65	Phase 3	[22]
G1T38	DMQO2IT	Breast cancer	2C60-2C65	Phase 2	[23]
GLR2007	DM7DWLY	Glioblastoma of brain	2A00.00	Phase 1/2	[24]
FCN-437	DMQ8VUW	Breast cancer	2C60-2C65	Phase 1/2	[25]
NUV-422	DMQJQNT	Malignant glioma	2A00.0	Phase 1/2	[26]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[27]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[27]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[28]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[29]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[30]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[27]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[27]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[27]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[31]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[32]

Drug(s) Affected By Serine/threonine-protein kinase Chk1 (CHEK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[33]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[35]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[37]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[38]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[41]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[42]

Drug(s) Affected By Apoptosis-inducing factor 1, mitochondrial (AIFM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[43]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[44]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[45]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[46]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[49]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[50]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]

Drug(s) Affected By Serine/threonine-protein kinase Chk2 (CHEK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[53]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[33]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[54]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[55]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[56]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[58]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[59]

Drug(s) Affected By Calpain-1 catalytic subunit (CAPN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[60]
Selenium	DM25CGV	N. A.	N. A.	Approved	[61]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[63]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[64]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[66]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[58]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[68]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[45]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[70]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[71]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[70]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[72]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[73]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[74]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[75]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[76]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[77]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[78]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[79]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[83]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]

Drug(s) Affected By CD44 antigen (CD44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[85]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[86]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[87]
Selenium	DM25CGV	N. A.	N. A.	Approved	[88]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[89]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[92]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[93]

Drug(s) Affected By Calpain-2 catalytic subunit (CAPN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[60]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[94]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[95]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[63]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[97]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Glibenclamide	DM8JXPZ	Diabetic complication	5A2Y	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[98]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[99]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[100]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[101]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[98]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[102]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[103]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[104]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[105]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[106]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[107]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[94]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[108]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[109]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[110]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[111]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-3 (ERBB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[112]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[113]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[115]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[116]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[117]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[118]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[120]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[122]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[123]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[124]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[125]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[126]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[127]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[129]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[120]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[130]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[131]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[132]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[133]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[85]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[122]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[123]

Drug(s) Affected By CCN family member 2 (CCN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[112]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[137]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[93]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[138]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[139]

Drug(s) Affected By M-phase inducer phosphatase 3 (CDC25C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[33]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[94]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[140]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[38]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[95]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[143]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[144]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[94]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[146]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[147]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[148]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[149]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[150]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[151]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[152]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[139]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[153]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[106]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[154]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[98]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[155]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[156]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[157]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[158]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[159]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[160]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[161]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[162]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[163]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[164]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[71]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[165]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[43]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[166]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[167]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[168]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[169]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[170]
Fructose	DM43AN2	Vomiting	MD90	Approved	[171]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[173]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[174]

Drug(s) Affected By BH3-interacting domain death agonist (BID)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[85]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[45]
Selenium	DM25CGV	N. A.	N. A.	Approved	[175]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[176]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[177]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[178]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[180]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[45]
Selenium	DM25CGV	N. A.	N. A.	Approved	[61]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[182]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[140]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[183]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[184]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[170]

Drug(s) Affected By Sterol regulatory element-binding protein 2 (SREBF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[133]
Selenium	DM25CGV	N. A.	N. A.	Approved	[61]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[185]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[176]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[186]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[187]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[188]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[190]

Drug(s) Affected By Endonuclease G, mitochondrial (ENDOG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[44]
Selenium	DM25CGV	N. A.	N. A.	Approved	[61]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[46]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[66]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[58]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[191]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[192]

Drug(s) Affected By Inactive caspase-12 (CASP12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[194]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[195]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[196]
Methamphetamine	DMPM4SK	Anxiety		Approved	[197]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[198]
Thymoquinone	DMVDTR2	Polycystic ovarian syndrome	5A80.1	Phase 2/3	[199]
Tetrandrine	DMAOJBX	Sarcoma	2A60-2C35	Phase 1	[200]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[201]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[194]

Drug(s) Affected By Type II iodothyronine deiodinase (DIO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[202]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[203]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[204]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[137]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[58]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[205]
Ergocalciferol	DMHO0AR	Hypoparathyroidism	5A50	Approved	[206]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[207]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[208]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-6 beta (ATF6B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[209]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[64]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[58]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[210]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[211]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[212]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[213]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[201]

Drug(s) Affected By Serine/threonine-protein kinase LATS2 (LATS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[214]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[215]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[190]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[216]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[191]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[217]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[218]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[87]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[219]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 20 (MAP3K20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[115]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[220]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[221]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[208]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[218]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[222]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[223]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cyclin-dependent kinase 6 (CDK6)	TTO0FDJ	CDK6_HUMAN	Inhibitor	[1]
Fatty acid synthase (FASN)	TT7AOUD	FAS_HUMAN	Inhibitor	[2]
Plasmodium Beta-hydroxyacyl-ACP dehydratase (Malaria FabZ)	TTHPFTS	Q965D7_PLAFA	Inhibitor	[2]
Plasmodium Enoyl-ACP reductase (Malaria fabI)	TTNX2CS	Q965D5_PLAFA	Inhibitor	[2]
Plasmodium Oxoacyl-[acyl-carrier protein] reductase (Malaria fabG)	TTBE4IR	Q965D6_PLAFA	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Apoptosis-inducing factor 1, mitochondrial (AIFM1)	OTKPWB7Q	AIFM1_HUMAN	Protein Interaction/Cellular Processes	[3]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Gene/Protein Processing	[4]
BH3-interacting domain death agonist (BID)	OTOSHSHU	BID_HUMAN	Protein Interaction/Cellular Processes	[5]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Gene/Protein Processing	[6]
Calpain-1 catalytic subunit (CAPN1)	OTK6OQZR	CAN1_HUMAN	Gene/Protein Processing	[3]
Calpain-2 catalytic subunit (CAPN2)	OTIAPE5J	CAN2_HUMAN	Gene/Protein Processing	[3]
Catenin beta-1 (CTNNB1)	OTZ932A3	CTNB1_HUMAN	Gene/Protein Processing	[6]
CCN family member 2 (CCN2)	OTC39NSU	CCN2_HUMAN	Gene/Protein Processing	[4]
CD44 antigen (CD44)	OT9TTJ41	CD44_HUMAN	Gene/Protein Processing	[6]
Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6)	OTAFHAVI	ATF6A_HUMAN	Gene/Protein Processing	[3]

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