Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHEMUB)

• Drug Name: KAEMPFEROL Drug Info
• Synonyms: kaempferol; 520-18-3; Kaempherol; Kempferol; Trifolitin; Populnetin; Robigenin; Rhamnolutein; Pelargidenolon; Rhamnolutin; Swartziol; Indigo Yellow; Kampherol; Nimbecetin; Kampferol; Campherol; Kaemferol; 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one; 5,7,4'-Trihydroxyflavonol; Pelargidenolon 1497; 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; C.I. 75640; CCRIS 41; NSC 407289; 3,5,7-trihydroxy-2-(4-hydroxyphenyl)chromen-4-one; 4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(4-hydroxyphe

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5280863
  ChEBI ID: CHEMBL150
  CAS Number: CAS 520-18-3
  TTD Drug ID: DMHEMUB
  VARIDT Drug ID: DR00616

Molecule-Related Drug Atlas

Drug(s) Targeting Arachidonate 15-lipoxygenase (15-LOX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indolizine derivative 1	DM4GZBI	N. A.	N. A.	Patented	[16]
Imidazole derivative 10	DMI7W3K	N. A.	N. A.	Patented	[17]
Indole and benzimidazole derivative 1	DMS0169	N. A.	N. A.	Patented	[17]
Triazole derivative 3	DMZR0TH	N. A.	N. A.	Patented	[17]
Isothiazolone derivative 1	DMHAJCM	N. A.	N. A.	Patented	[17]
PMID26560362-Compound-90	DM9V13U	N. A.	N. A.	Patented	[17]
Imidazole derivative 11	DMTJ0DP	N. A.	N. A.	Patented	[17]
Tri-substituted benzene derivative 1	DMEQ3RD	N. A.	N. A.	Patented	[17]
NSC-661755	DMDJT7U	N. A.	N. A.	Terminated	[18]
PUUPEHEDIONE	DMF28IU	Discovery agent	N.A.	Investigative	[19]

Drug(s) Targeting Aldose reductase (AKR1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epalrestat	DM5OGK0	Diabetic neuropathy	8C0Z	Approved	[20]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[21]
Fidarestat	DMZL1I8	Diabetic complication	5A2Y	Phase 3	[22]
Ranirestat	DMD5QRS	Diabetic neuropathy	8C0Z	Phase 3	[23]
CONTIGOSIDE B	DMX9V8K	Thrombosis	DB61-GB90	Phase 2/3	[24]
BNV-222	DMYFQJL	Diabetic neuropathy	8C0Z	Phase 2/3	[23]
BNV-222	DMYFQJL	Diabetic neuropathy	8C0Z	Phase 2/3	[25]
LIDORESTAT	DMA0RI9	Diabetic complication	5A2Y	Phase 2	[26]
QR-333	DMKVIWM	Diabetic neuropathy	8C0Z	Phase 2	[27]
ADMVA	DM819CO	Diabetic complication	5A2Y	Phase 2	[23]

Drug(s) Targeting Influenza Neuraminidase (Influ NA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Oseltamivir	DMGO72P	Influenza	1E30-1E32	Approved	[28]
Zanamivir	DMFMBZ4	Influenza	1E30-1E32	Approved	[28]
Peramivir	DMNXY5K	Influenza virus infection	1E30-1E32	Approved	[29]
UX-001	DMD2O0L	Hereditary inclusion body myositis	4A41.2	Phase 3	[30]
CS-8958	DM4CSDH	Influenza virus infection	1E30-1E32	Phase 3	[29]
DAS-181	DM0Y8JP	Influenza virus infection	1E30-1E32	Phase 2	[31]
Lactose	DMO4GPK	Discovery agent	N.A.	Phase 1	[30]
GS-3435	DMV7JC6	Influenza virus infection	1E30-1E32	Terminated	[32]
BCX-140	DMBJERO	Influenza virus infection	1E30-1E32	Terminated	[33]
Alpha-D-Mannose	DMF5DLW	Discovery agent	N.A.	Investigative	[30]

Drug(s) Targeting Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NARINGENIN	DMHAZLM	N. A.	N. A.	Phase 1	[5]
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[30]
2'-Monophosphoadenosine 5'-Diphosphoribose	DME9S8M	Discovery agent	N.A.	Investigative	[30]
APIGENIN	DMI3491	Discovery agent	N.A.	Investigative	[5]
4-ANDROSTENE-3-17-DIONE	DMSE8NU	Discovery agent	N.A.	Investigative	[30]
6-(3-Hydroxy-phenyl)-naphthalen-2-ol	DMH8WA2	Discovery agent	N.A.	Investigative	[34]
7-(3-Hydroxy-phenyl)-naphthalen-2-ol	DM2I91C	Discovery agent	N.A.	Investigative	[35]
NSC-94258	DM6VY3P	Discovery agent	N.A.	Investigative	[5]
4-[5-(3-Hydroxyphenyl)-3-thienyl]-2-methylphenol	DM7ERYJ	Discovery agent	N.A.	Investigative	[36]
6-(4-Hydroxy-phenyl)-naphthalen-1-ol	DM2V9XI	Discovery agent	N.A.	Investigative	[35]

Drug(s) Targeting Androgen receptor messenger RNA (AR mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[37]
BAY 86-5044	DMRZLU4	Breast cancer	2C60-2C65	Phase 2	[38]
TRC-253	DMXI8CD	Prostate cancer	2C82.0	Phase 1/2	[39]
IONIS-AR-2.5Rx	DMF2DMS	Prostate cancer	2C82.0	Phase 1/2	[40]
ISIS-AR	DM8P3N5	Prostate cancer	2C82.0	Phase 1	[41]
EZN-4176	DMNPS59	Prostate cancer	2C82.0	Phase 1	[42]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[43]
RU-58841	DMMEAZ2	Acne vulgaris	ED80	Discontinued in Phase 1	[44]
flavone	DMEQH6J	Discovery agent	N.A.	Investigative	[3]
APIGENIN	DMI3491	Discovery agent	N.A.	Investigative	[3]

Drug(s) Targeting Plasmodium Oxoacyl-[acyl-carrier protein] reductase (Malaria fabG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[8]
Chrysin	DM7V2LG	Discovery agent	N.A.	Investigative	[8]
MORIN	DM2OGZ5	Discovery agent	N.A.	Investigative	[8]
3,7,3',4'-TETRAHYDROXYFLAVONE	DMES906	Discovery agent	N.A.	Investigative	[8]
(-)-CATECHINGALLATE	DMZOGSK	Discovery agent	N.A.	Investigative	[8]
2-Hexadecynoic acid	DMTFIPZ	Discovery agent	N.A.	Investigative	[45]
GALLOCATECHIN GALLATE	DMX2084	Discovery agent	N.A.	Investigative	[8]
ISORHAMNETIN	DMQ4Z6E	Discovery agent	N.A.	Investigative	[8]
NADPH	DM75Q34	Discovery agent	N.A.	Investigative	[46]

Drug(s) Targeting Lactoylglutathione lyase (GLO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BAICALEIN	DM4C7E6	Influenza virus infection	1E30-1E32	Phase 2	[7]
NARINGENIN	DMHAZLM	N. A.	N. A.	Phase 1	[7]
2-Sulfhydryl-Ethanol	DMJBO3D	Discovery agent	N.A.	Investigative	[47]
S-(N-butyl-N-hydroxycarbamoyl)glutathione	DMU7EQV	Discovery agent	N.A.	Investigative	[48]
S-(N-heptyl-N-hydroxycarbamoyl)glutathione	DMV6T1Q	Discovery agent	N.A.	Investigative	[48]
S-(N-propyl-N-hydroxycarbamoyl)glutathione	DMRFKZ6	Discovery agent	N.A.	Investigative	[48]
S-(N-Hydroxy-N-Iodophenylcarbamoyl)Glutathione	DM1AHIW	Discovery agent	N.A.	Investigative	[47]
S-(N-pentyl-N-hydroxycarbamoyl)glutathione	DM4E9J2	Discovery agent	N.A.	Investigative	[48]
S-(N-methyl-N-hydroxycarbamoyl)glutathione	DM1C9W3	Discovery agent	N.A.	Investigative	[48]
S-(N-4bromophenyl-N-hydroxycarbamoyl)glutathione	DM3FXPV	Discovery agent	N.A.	Investigative	[48]

Drug(s) Targeting Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PINOCEMBRIN	DM96VWD	N. A.	N. A.	Phase 2	[4]
NARINGENIN	DMHAZLM	N. A.	N. A.	Phase 1	[4]
Chrysin	DM7V2LG	Discovery agent	N.A.	Investigative	[4]
APIGENIN	DMI3491	Discovery agent	N.A.	Investigative	[4]
ISORHAMNETIN	DMQ4Z6E	Discovery agent	N.A.	Investigative	[4]
ACACETIN	DMQOB0X	Discovery agent	N.A.	Investigative	[4]
TRISMETHOXYRESVERATROL	DM6USPC	Discovery agent	N.A.	Investigative	[49]
Galangin	DM5TQ2O	Discovery agent	N.A.	Investigative	[4]
CHRYSOERIOL	DM96ECL	Discovery agent	N.A.	Investigative	[4]
DIOSMETIN	DM4KXIM	Discovery agent	N.A.	Investigative	[4]

Drug(s) Targeting LOX-5 messenger RNA (ALOX5 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TEBUFELONE	DMMUE8P	Pain	MG30-MG3Z	Discontinued in Phase 2	[50]
ZD-2138	DMVFCX7	Asthma	CA23	Discontinued in Phase 2	[51]
BW A4C	DMNUMDG	Arthritis	FA20	Terminated	[52]
2,4'-Dimethoxy-5,3'-di-(2-propenyl)-biphenyl	DMWNJ84	Discovery agent	N.A.	Investigative	[53]
METHYLHONOKIOL	DM9YE6K	Discovery agent	N.A.	Investigative	[53]
HONOKIOL	DMJWT3X	Discovery agent	N.A.	Investigative	[53]
PUUPEHEDIONE	DMF28IU	Discovery agent	N.A.	Investigative	[19]
PUUPEHENONE	DMF3BCK	Discovery agent	N.A.	Investigative	[19]
Isojaspic acid	DMHTBDN	Discovery agent	N.A.	Investigative	[19]
5,3'-Dipropyl-biphenyl-2,4'-diol	DMJRXLD	Discovery agent	N.A.	Investigative	[53]

Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[54]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[55]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[56]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[59]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[63]

Drug(s) Affected By C-reactive protein (CRP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[64]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[65]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[66]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[13]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[67]
Acalabrutinib	DM7GCVW	leukaemia	2A60-2B33	Approved	[68]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[69]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[70]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[71]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[73]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[75]
Artemether	DM48QOT	Malaria	1F40-1F45	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[78]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[79]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[80]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[83]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[83]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[84]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[85]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[86]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[83]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[83]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[83]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[73]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[87]

Drug(s) Affected By Tumor protein p73 (TP73)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[88]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[89]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[95]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[96]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[90]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[97]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[98]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[100]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[103]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[59]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[104]

Drug(s) Affected By CCN family member 5 (CCN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[105]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[106]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[107]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[107]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[107]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[109]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[110]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[111]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[112]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[113]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]
Fructose	DM43AN2	Vomiting	MD90	Approved	[64]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[115]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[116]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[98]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[117]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[118]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[119]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[120]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[121]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[122]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[123]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[124]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[125]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[126]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[127]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[128]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[129]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[127]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[97]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[130]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[131]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[132]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[133]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[134]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[133]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[135]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[136]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]

Drug(s) Affected By Myb-related protein A (MYBL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[138]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[139]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[56]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[140]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[138]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[141]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[143]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[145]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[146]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[147]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[148]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[151]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[152]

Drug(s) Affected By CD44 antigen (CD44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[153]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[138]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Selenium	DM25CGV	N. A.	N. A.	Approved	[155]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[156]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[159]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[102]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[160]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[161]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[162]
Selenium	DM25CGV	N. A.	N. A.	Approved	[163]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[164]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[165]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[167]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[168]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[169]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[170]

Drug(s) Affected By Polyunsaturated fatty acid lipoxygenase ALOX12 (ALOX12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[171]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[172]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[173]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[174]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[175]
Masoprocol	DMMVNZ0	Prostate cancer	2C82.0	Approved	[172]
Bortezomib	DMNO38U	Leukemia		Approved	[176]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[172]
BAICALEIN	DM4C7E6	Influenza virus infection	1E30-1E32	Phase 2	[172]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[177]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[178]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[179]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[180]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[181]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[182]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[183]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[184]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[185]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[186]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[188]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[179]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[189]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[190]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[191]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[178]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[64]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[153]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[181]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[182]

Drug(s) Affected By 14-3-3 protein sigma (SFN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[192]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[193]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[194]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[195]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[9]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[67]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[195]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[102]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[196]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[197]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[198]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[199]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[117]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[200]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[201]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[202]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[90]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[203]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[134]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[204]

Drug(s) Affected By Cyclin-dependent kinase 4 inhibitor C (CDKN2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[97]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[56]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[106]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[207]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[104]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[104]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[208]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[209]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[115]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[210]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[211]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[119]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[212]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[213]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[214]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[119]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[215]

Drug(s) Affected By Mitogen-activated protein kinase 9 (MAPK9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[115]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[216]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[119]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[217]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[218]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[219]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[220]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]

Drug(s) Affected By Laminin subunit beta-2 (LAMB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[221]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[222]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[223]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[224]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[225]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[226]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[154]

Drug(s) Affected By Cytochrome c (CYCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[153]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[227]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[130]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[228]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[229]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[230]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[171]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[56]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[231]
Pefloxacin	DM49IGF	Gonococcal urethritis	1A70.0Y	Approved	[232]

Drug(s) Affected By Transcription factor A, mitochondrial (TFAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[233]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[234]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[231]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[235]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[237]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[238]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[239]

Drug(s) Affected By POU domain, class 5, transcription factor 1 (POU5F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[156]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[240]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[241]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[102]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[160]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[243]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[62]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[244]

Drug(s) Affected By Histone-lysine N-methyltransferase 2A (KMT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[245]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[12]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[59]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[246]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[247]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[248]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[249]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[250]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[251]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[252]

Drug(s) Affected By Serine-protein kinase ATM (ATM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[253]
Paromomycin	DM1AGXN	Amoebiasis	1A36	Approved	[254]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[256]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[257]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[258]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[92]

Drug(s) Affected By Protein GREB1 (GREB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[105]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[139]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[259]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[247]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]
Nandrolone	DMFWKG1	Osteoporosis	FB83.0	Approved	[260]
Mestranol	DMG3F94	Contraception	QA21	Approved	[139]

Drug(s) Affected By Quinone oxidoreductase PIG3 (TP53I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[132]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[100]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[261]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[262]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[263]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[264]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[264]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[264]

Drug(s) Affected By Dehydrogenase/reductase SDR family member 11 (DHRS11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[265]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[265]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Flufenamic Acid	DMC8VNH	Dysmenorrhea	GA34.3	Approved	[265]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[222]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[267]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[268]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[224]

Drug(s) Affected By Type II iodothyronine deiodinase (DIO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[97]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[269]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[270]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[271]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[222]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[272]
Ergocalciferol	DMHO0AR	Hypoparathyroidism	5A50	Approved	[273]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[268]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[224]

Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[132]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[274]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[275]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[276]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[277]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[278]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[279]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[280]

Drug(s) Affected By Tumor protein 63 (TP63)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[89]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[9]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[281]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[282]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[283]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[284]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[285]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[251]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[286]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[226]

Drug(s) Affected By Homeobox protein NANOG (NANOG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[287]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[156]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[240]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[241]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[102]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[160]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[243]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[247]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[288]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[56]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[231]
Fructose	DM43AN2	Vomiting	MD90	Approved	[289]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[290]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[291]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[152]
Ketotifen	DM74XKS	Allergic conjunctivitis	9A60.02	Approved	[292]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[293]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[208]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[293]

Drug(s) Affected By Beta-1,3-galactosyltransferase 5 (B3GALT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[222]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[268]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[251]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[226]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[294]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[295]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[296]
APIGENIN	DMI3491	Discovery agent	N.A.	Investigative	[12]

Drug(s) Affected By Solute carrier organic anion transporter family member 1B1 (SLCO1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[297]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[298]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[299]
Repaglinide	DM5SXUV	Diabetic complication	5A2Y	Approved	[300]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[301]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[302]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[303]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[303]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[304]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[305]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Aldose reductase (AKR1B1)	TTFBNVI	ALDR_HUMAN	Inhibitor	[2]
Androgen receptor messenger RNA (AR mRNA)	TTKPW01	ANDR_HUMAN	Inhibitor	[3]
Arachidonate 15-lipoxygenase (15-LOX)	TTN9T81	LOX15_HUMAN	Inhibitor	[1]
Cytochrome P450 1B1 (CYP1B1)	TTI84H7	CP1B1_HUMAN	Inhibitor	[4]
Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1)	TTIWB6L	DHB1_HUMAN	Inhibitor	[5]
Influenza Neuraminidase (Influ NA)	TT50QJ3	NRAM_I33A0	Inhibitor	[6]
Lactoylglutathione lyase (GLO1)	TTV9A7R	LGUL_HUMAN	Inhibitor	[7]
LOX-5 messenger RNA (ALOX5 mRNA)	TTSJ6Q4	LOX5_HUMAN	Inhibitor	[1]
Plasmodium Oxoacyl-[acyl-carrier protein] reductase (Malaria fabG)	TTBE4IR	Q965D6_PLAFA	Inhibitor	[8]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
14-3-3 protein sigma (SFN)	OTLJCZ1U	1433S_HUMAN	Gene/Protein Processing	[9]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Gene/Protein Processing	[10]
Bcl-2-binding component 3, isoforms 3/4 (BBC3)	OTUAXDAY	BBC3B_HUMAN	Gene/Protein Processing	[11]
Beta-1,3-galactosyltransferase 5 (B3GALT5)	OTWXPEMU	B3GT5_HUMAN	Gene/Protein Processing	[12]
C-reactive protein (CRP)	OT0RFT8F	CRP_HUMAN	Gene/Protein Processing	[13]
CCN family member 5 (CCN5)	OTADU8JJ	CCN5_HUMAN	Gene/Protein Processing	[14]
CD44 antigen (CD44)	OT9TTJ41	CD44_HUMAN	Gene/Protein Processing	[10]
Cyclin-dependent kinase 4 inhibitor C (CDKN2C)	OTCLOV90	CDN2C_HUMAN	Gene/Protein Processing	[9]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Gene/Protein Processing	[15]
Cytochrome c (CYCS)	OTBFALJD	CYC_HUMAN	Protein Interaction/Cellular Processes	[11]

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