Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMZYX6)

• Drug Name: OXYBENZONE Drug Info
• Synonyms: oxybenzone; 131-57-7; 2-HYDROXY-4-METHOXYBENZOPHENONE; Benzophenone-3; Oxybenzon; 4-Methoxy-2-hydroxybenzophenone; 2-Benzoyl-5-methoxyphenol; (2-hydroxy-4-methoxyphenyl)(phenyl)methanone; Oxybenzonum; Oxibenzona; Anuvex; Methanone, (2-hydroxy-4-methoxyphenyl)phenyl-; Chimassorb 90; Uvinul 9; Advastab 45; Sunscreen UV-15; Syntase 62; Uvistat 24; Cyasorb UV 9; Usaf cy-9; Spectra-sorb UV 9; Escalol 567; Ongrostab HMB; Oxybenzonum [INN-Latin]; Uvinul M40; Oxibenzonum; Oxibenzona [INN-Spanish]; HMBP; Cyasorb UV 9 Light Absorber

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 4632
  ChEBI ID: CHEMBL34283
  CAS Number: CAS 131-57-7
  TTD Drug ID: DMMZYX6

Molecule-Related Drug Atlas

Drug(s) Targeting Hormone sensitive lipase (LIPE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BENZYL BENZOATE	DMDPYI5	Infestations of lice and scabies	1G00.Z	Approved	[4]
PMID15026062C41	DMJGFLD	Pancreatitis	DC31-DC34	Clinical trial	[5]
ETHIOFENCARB	DMQTEDP	Discovery agent	N.A.	Investigative	[1]
NCI-58425	DM9C7GP	Discovery agent	N.A.	Investigative	[1]
2-(3-methoxybenzylthio)-2-phenylacetic acid	DM21MAU	Discovery agent	N.A.	Investigative	[1]
BIFENOX	DM4MUXT	Discovery agent	N.A.	Investigative	[1]
NCI-159878	DMTCBLS	Discovery agent	N.A.	Investigative	[1]
PMI-008	DMHX704	Obesity	5B81	Investigative	[6]

Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[7]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[8]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[9]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[10]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[11]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[12]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[13]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]

Drug(s) Affected By Nibrin (NBN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[18]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[19]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[22]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[24]

Drug(s) Affected By E3 SUMO-protein ligase PIAS1 (PIAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[25]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[26]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[25]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[29]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[30]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[31]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[32]

Drug(s) Affected By Cell cycle checkpoint protein RAD17 (RAD17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[34]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[36]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[37]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[38]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[39]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[40]

Drug(s) Affected By Nuclear factor of activated T-cells 5 (NFAT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[9]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[46]
Sodium chloride	DMM3950	Skin burns	ME65.0	Approved	[47]

Drug(s) Affected By Tyrosine-protein kinase Lck (LCK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[49]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[18]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[50]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[31]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[52]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[53]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[54]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[55]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[56]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[57]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[58]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[59]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[60]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[61]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]

Drug(s) Affected By Eukaryotic translation initiation factor 4E (EIF4E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[18]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[66]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[67]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[68]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Momelotinib	DMF98Q0	Myelofibrosis	2A20.2	Approved	[69]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[68]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]

Drug(s) Affected By Heat shock protein HSP 90-alpha (HSP90AA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[70]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[71]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[72]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[73]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[74]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[75]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]

Drug(s) Affected By Dihydrolipoyl dehydrogenase, mitochondrial (DLD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[9]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[18]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[77]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[30]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[78]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[79]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[80]

Drug(s) Affected By Ras-related protein Rap-2a (RAP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[77]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[83]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[30]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[78]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[84]

Drug(s) Affected By Myb-related protein A (MYBL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[85]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[86]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[9]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[87]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[85]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[88]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[86]

Drug(s) Affected By Nucleoprotein TPR (TPR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[43]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[93]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[93]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-2 (ATF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[94]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[97]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[99]
Bortezomib	DMNO38U	Leukemia		Approved	[100]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[101]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[103]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[104]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[105]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[106]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[107]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[108]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]

Drug(s) Affected By Neurofibromin (NF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[25]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[111]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[12]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[112]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[25]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[113]

Drug(s) Affected By cAMP-dependent protein kinase catalytic subunit beta (PRKACB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[25]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[25]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[100]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[114]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[115]

Drug(s) Affected By Adenomatous polyposis coli protein (APC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[58]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[12]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[118]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[119]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[99]

Drug(s) Affected By Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[121]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[122]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[124]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[125]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[67]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]

Drug(s) Affected By Retinoblastoma-like protein 1 (RBL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[130]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[26]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]

Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 4 (PTPN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[78]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[133]
Crocin	DM5F24X	N. A.	N. A.	Phase 3	[134]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[9]

Drug(s) Affected By Replication factor C subunit 1 (RFC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[135]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[136]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[137]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[135]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[135]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[138]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[113]

Drug(s) Affected By Breast cancer type 1 susceptibility protein (BRCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[139]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[140]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[142]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[145]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[34]

Drug(s) Affected By Nuclear receptor-interacting protein 1 (NRIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[111]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[149]
Teniposide	DMLW57T	Acute lymphoblastic leukaemia	2A85	Approved	[150]

Drug(s) Affected By Double-strand break repair protein MRE11 (MRE11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[151]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[9]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[22]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[24]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[152]

Drug(s) Affected By RecQ-like DNA helicase BLM (BLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[151]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[135]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[9]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[26]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]

Drug(s) Affected By Voltage-dependent calcium channel subunit alpha-2/delta-1 (CACNA2D1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[34]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[153]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[133]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[133]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[154]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[40]

Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[155]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[33]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[156]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[157]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[159]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]

Drug(s) Affected By Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PPP1CB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[7]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[160]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[161]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[26]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]

Drug(s) Affected By Transcription factor A, mitochondrial (TFAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[162]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[163]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[164]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[165]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[166]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[167]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[168]

Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[93]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[33]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[151]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[169]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[169]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[170]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[169]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[122]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[171]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]

Drug(s) Affected By TP53-binding protein 1 (TP53BP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[172]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[173]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[174]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[175]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[176]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[177]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[78]

Drug(s) Affected By Serine-protein kinase ATM (ATM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[178]
Paromomycin	DM1AGXN	Amoebiasis	1A36	Approved	[179]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[180]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[181]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[182]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[25]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[183]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[184]

Drug(s) Affected By Helicase-like transcription factor (HLTF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[25]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[25]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[185]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[113]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[186]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[187]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[188]
Artemether	DM48QOT	Malaria	1F40-1F45	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[190]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[124]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[191]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[192]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[193]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]

Drug(s) Affected By Nuclear receptor coactivator 2 (NCOA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[72]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[194]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[30]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[72]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[78]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[133]

Drug(s) Affected By Mitogen-activated protein kinase 6 (MAPK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[9]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[195]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[77]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[196]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[197]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[40]

Drug(s) Affected By Protein GREB1 (GREB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[72]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[86]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[198]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[86]
Nandrolone	DMFWKG1	Osteoporosis	FB83.0	Approved	[199]
Mestranol	DMG3F94	Contraception	QA21	Approved	[86]

Drug(s) Affected By Rapamycin-insensitive companion of mTOR (RICTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[83]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[200]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[113]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[201]

Drug(s) Affected By Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[9]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[202]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[202]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[12]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[203]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[203]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]

Drug(s) Affected By Probable D-lactate dehydrogenase, mitochondrial (LDHD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[151]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[111]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[204]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[204]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[151]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[30]

Drug(s) Affected By RB1-inducible coiled-coil protein 1 (RB1CC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[205]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[195]
Bortezomib	DMNO38U	Leukemia		Approved	[100]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[206]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[207]

Drug(s) Affected By Cohesin subunit SA-1 (STAG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[151]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[9]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[204]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[153]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[208]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[2]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[82]

Drug(s) Affected By DNA topoisomerase 2-binding protein 1 (TOPBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[129]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[26]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[46]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[113]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[209]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[210]

Drug(s) Affected By DNA repair protein RAD50 (RAD50)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[211]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[212]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[44]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]

Drug(s) Affected By Autophagy-related protein 2 homolog B (ATG2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[83]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[113]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[213]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[78]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[214]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[215]

Drug(s) Affected By DNA endonuclease RBBP8 (RBBP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[85]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[85]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[26]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[133]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[46]
Mestranol	DMG3F94	Contraception	QA21	Approved	[85]

Drug(s) Affected By Transcription initiation factor TFIID subunit 9B (TAF9B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[100]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[115]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[38]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[78]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[133]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[115]

Drug(s) Affected By Death domain-associated protein 6 (DAXX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[217]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[112]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Bendamustine hydrochloride	DMFH15Z	leukaemia	2A60-2B33	Approved	[218]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[119]

Drug(s) Affected By Mediator of RNA polymerase II transcription subunit 13 (MED13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[219]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[115]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[78]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[133]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[115]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[220]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[92]

Drug(s) Affected By Structural maintenance of chromosomes protein 3 (SMC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[44]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Bortezomib	DMNO38U	Leukemia		Approved	[100]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[221]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[39]

Drug(s) Affected By Cyclin-D-binding Myb-like transcription factor 1 (DMTF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[222]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[223]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[138]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[214]

Drug(s) Affected By Filaggrin (FLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[224]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[225]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[225]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[226]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[224]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[227]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[228]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[77]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[226]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[225]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Hormone sensitive lipase (LIPE)	TTLUQ8E	LIPS_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Adenomatous polyposis coli protein (APC)	OTKV0TIK	APC_HUMAN	Gene/Protein Processing	[2]
Autophagy-related protein 2 homolog B (ATG2B)	OT7FGFJ1	ATG2B_HUMAN	Gene/Protein Processing	[2]
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	OT81JS6K	WRN_HUMAN	Gene/Protein Processing	[2]
Breast cancer type 1 susceptibility protein (BRCA1)	OT5BN6VH	BRCA1_HUMAN	Gene/Protein Processing	[2]
cAMP-dependent protein kinase catalytic subunit beta (PRKACB)	OT6RMDCE	KAPCB_HUMAN	Gene/Protein Processing	[2]
Cell cycle checkpoint protein RAD17 (RAD17)	OT1I93DT	RAD17_HUMAN	Gene/Protein Processing	[2]
Cohesin subunit SA-1 (STAG1)	OT564IX4	STAG1_HUMAN	Gene/Protein Processing	[2]
Cyclic AMP-dependent transcription factor ATF-2 (ATF2)	OTNIZPEA	ATF2_HUMAN	Gene/Protein Processing	[2]
Cyclin-D-binding Myb-like transcription factor 1 (DMTF1)	OTDKO9OO	DMTF1_HUMAN	Gene/Protein Processing	[2]
Death domain-associated protein 6 (DAXX)	OTX6O7PL	DAXX_HUMAN	Post-Translational Modifications	[3]

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