Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMU8ANS)

• Drug Name: Ximelegatran Drug Info
• Synonyms: Cyclohexanecarboxamide, 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-, trans-; y-27632; 146986-50-7; Y-27632 dihydrochloride; Y27632; UNII-0X370ROP6H; Y 27632; cyclohexanecarboxamide, 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-, trans-; 0X370ROP6H; CHEBI:75393; 4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-1-carboxamide; (R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE; 4-[(1R)-1-aminoethyl]-N-(4-pyridyl)cyclohexanecarboxamide; 4-[(1R)-1-aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide; (R)-(+)-trans-N-(4-pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide; Y-27632

Indication

Disease Entry	ICD 11	Status	REF
Myocardial infarction	BA41-BA43	Approved	[1]
Asthma	CA23	Terminated	[2]

• Cross-matching ID:
  PubChem CID: 448042
  ChEBI ID: CHEMBL75393
  CAS Number: CAS 146986-50-7
  TTD Drug ID: DMU8ANS
  VARIDT Drug ID: DR00750

Molecule-Related Drug Atlas

Drug(s) Targeting Rho-associated protein kinase (ROCK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Netarsudil	DM0LPI9	Open-angle glaucoma	9C61	Approved	[9]
Roclatan	DMVQ5X1	Glaucoma/ocular hypertension	9C61	Phase 3	[10]
AR-12286	DM5TC43	Glaucoma/ocular hypertension	9C61	Phase 2	[11]
AMA-76	DMBWNX5	Glaucoma/ocular hypertension	9C61	Phase 2	[12]
Cethrin	DMD3XMW	Spinal cord injury	ND51.2	Phase 1/2	[13]
Y-39983	DMXSEHF	Glaucoma/ocular hypertension	9C61	Phase 1/2	[14]
STM 434	DMDF29A	Ovarian cancer	2C73	Phase 1	[15]
AT13148	DMYIPKJ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[16]
Hexahydro azepinone derivative 1	DMC1ZIX	N. A.	N. A.	Patented	[15]
Isoquinoline sulfonyl derivative 2	DMT5E7M	N. A.	N. A.	Patented	[15]

Drug(s) Targeting Coagulation factor IIa (F2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Argatroban	DMFI46A	Thrombosis	DB61-GB90	Approved	[17]
Pyridoxal Phosphate	DMO2K0J	Malnutrition	5B50-5B71	Approved	[18]
Bivalirudin	DMECRX1	Thrombocytopenia	3B64	Approved	[19]
Dabigatran	DMDI6R4	Stroke	8B20	Approved	[20]
Desirudin Recombinant	DM2BTFN	Coagulation defect	3B10.0	Approved	[21]
Human prothrombin complex concentrate	DMPHVQ1	Bleeding disorder	GA20-GA21	Approved	[22]
Lepirudin	DM1I3D5	Thrombocytopenia	3B64	Approved	[23]
Anisindione	DM2C48U	Coagulation defect	3B10.0	Approved	[24]
ATryn antithrombin	DM79Y2T	Multiple sclerosis	8A40	Approved	[25]
Hirudin	DMYOC29	N. A.	N. A.	Phase 4	[26]

Drug(s) Affected By Serine/threonine-protein kinase N2 (PKN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[27]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[31]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[36]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[37]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[39]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[40]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[42]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[45]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[46]

Drug(s) Affected By High affinity copper uptake protein 1 (SLC31A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[47]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[48]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
TRIENTINE	DMD2WPG	Inborn error of metabolism	5C50-5C59	Approved	[47]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[51]

Drug(s) Affected By Antileukoproteinase (SLPI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[52]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[52]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[52]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[52]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[52]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[52]

Drug(s) Affected By Thy-1 membrane glycoprotein (THY1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[56]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[57]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[58]
Bortezomib	DMNO38U	Leukemia		Approved	[59]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[60]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[61]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[62]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[63]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[64]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[65]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[66]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[68]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[69]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[70]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]

Drug(s) Affected By DNA excision repair protein ERCC-1 (ERCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[27]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[42]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[74]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[75]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[76]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[77]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[78]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[79]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[80]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[81]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[82]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[83]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[52]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[84]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[85]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[52]

Drug(s) Affected By Sodium/potassium-transporting ATPase subunit beta-2 (ATP1B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[87]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[88]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[46]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[89]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[90]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[91]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[92]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[93]

Drug(s) Affected By Fatty acid-binding protein, adipocyte (FABP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[94]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[95]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[97]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[98]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[99]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[100]

Drug(s) Affected By Endoglin (ENG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[27]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[101]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[103]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[104]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[105]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[106]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[107]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[108]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[109]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[110]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[111]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[112]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[113]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[114]

Drug(s) Affected By Cofilin-1 (CFL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[116]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[118]
Haloperidol	DM96SE0	Delirium		Approved	[119]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[121]

Drug(s) Affected By DNA excision repair protein ERCC-5 (ERCC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[122]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[42]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[122]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[123]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[125]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[126]

Drug(s) Affected By G1/S-specific cyclin-D3 (CCND3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[129]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[131]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[132]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[101]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[107]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[133]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[134]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[136]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[137]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[66]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[138]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[139]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[140]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[141]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[142]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[143]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[144]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[145]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[146]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[147]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[148]
Fructose	DM43AN2	Vomiting	MD90	Approved	[149]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[151]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[152]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[153]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[37]
Selenium	DM25CGV	N. A.	N. A.	Approved	[27]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[154]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[155]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[42]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[157]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[158]

Drug(s) Affected By Solute carrier family 12 member 2 (SLC12A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[42]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[159]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[160]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[161]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Furosemide	DMMQ8ZG	Congestive heart failure	BD10	Approved	[160]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[159]

Drug(s) Affected By Myosin regulatory light chain 2, atrial isoform (MYL7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[162]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[163]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[163]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[164]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[105]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[165]
Phenylephrine	DMZHUO5	Allergic rhinitis	CA08.0	Approved	[166]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[167]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[87]

Drug(s) Affected By Dystonin (DST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[169]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[170]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[171]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[33]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[54]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[172]
Selenium	DM25CGV	N. A.	N. A.	Approved	[27]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[173]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[113]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[174]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[42]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[175]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[176]

Drug(s) Affected By Bcl-2-interacting killer (BIK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[177]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[178]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[42]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[179]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[180]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[181]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[182]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[170]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[31]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[183]

Drug(s) Affected By CD166 antigen (ALCAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[54]
Selenium	DM25CGV	N. A.	N. A.	Approved	[27]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[48]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[46]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[184]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[170]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[31]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]

Drug(s) Affected By Laminin subunit alpha-3 (LAMA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[101]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[186]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[56]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[186]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[186]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[31]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[186]

Drug(s) Affected By Nuclear receptor subfamily 4 group A member 3 (NR4A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[187]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[188]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[188]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[189]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[104]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[188]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[190]

Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[191]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[192]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[54]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[193]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[194]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[195]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[196]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[197]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[198]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[199]

Drug(s) Affected By Collagen alpha-1(XVII) chain (COL17A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[185]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[56]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[185]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[200]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[201]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[203]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[204]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Coagulation factor IIa (F2)	TT6L509	THRB_HUMAN	Inhibitor	[1]
Rho-associated protein kinase (ROCK)	TTMQO60	NOUNIPROTAC	Modulator	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Antileukoproteinase (SLPI)	OTUNFUU8	SLPI_HUMAN	Gene/Protein Processing	[4]
Bcl-2-interacting killer (BIK)	OTTH1T3D	BIK_HUMAN	Gene/Protein Processing	[5]
Bcl2-associated agonist of cell death (BAD)	OT63ERYM	BAD_HUMAN	Gene/Protein Processing	[5]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Gene/Protein Processing	[6]
CD166 antigen (ALCAM)	OTCO4LP7	CD166_HUMAN	Gene/Protein Processing	[4]
Cofilin-1 (CFL1)	OTT6D5MH	COF1_HUMAN	Gene/Protein Processing	[7]
Collagen alpha-1(XVII) chain (COL17A1)	OTID5AH2	COHA1_HUMAN	Protein Interaction/Cellular Processes	[8]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Gene/Protein Processing	[5]
DNA excision repair protein ERCC-1 (ERCC1)	OTNPYQHI	ERCC1_HUMAN	Gene/Protein Processing	[5]
DNA excision repair protein ERCC-5 (ERCC5)	OTQAKFJM	ERCC5_HUMAN	Gene/Protein Processing	[5]

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