Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXJB4N)

• Drug Name: BMS-536924 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 135440466
  ChEBI ID: CHEBI:91454
  CAS Number: CAS 468740-43-4
  TTD Drug ID: DMXJB4N

Molecule-Related Drug Atlas

Drug(s) Targeting G1/S-specific cyclin-E1 (CCNE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PD-0183812	DMWYP86	Retinoblastoma	2D02.2	Terminated	[4]
4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol	DMSKJ1X	Discovery agent	N.A.	Investigative	[5]
3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione	DMDO175	Discovery agent	N.A.	Investigative	[6]
3,4-diphenyl-1H-pyrrole-2,5-dione	DMPK6YT	Discovery agent	N.A.	Investigative	[6]
3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione	DMGC7RY	Discovery agent	N.A.	Investigative	[6]
3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione	DM3EV9N	Discovery agent	N.A.	Investigative	[6]
aloisine A	DM5U1LN	Discovery agent	N.A.	Investigative	[7]
3-((3,5-diamino-1H-pyrazol-4-yl)diazenyl)phenol	DMJZK40	Discovery agent	N.A.	Investigative	[5]
(2'Z,3'E)-5-Chloro-5'-chloro-indirubin-3'-oxime	DMGXRSZ	Discovery agent	N.A.	Investigative	[8]
(2'Z,3'E)-5-Chloro-5'-methyl-indirubin-3'-oxime	DMZ0V6G	Discovery agent	N.A.	Investigative	[8]

Drug(s) Targeting LCK tyrosine protein kinase (LCK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[9]
VX-680	DM93YKJ	Solid tumour/cancer	2A00-2F9Z	Phase 2	[9]
JNJ-26483327	DMSQ3AZ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[10]
ISIS-CRP	DMQDUG4	Cardiovascular disease	BA00-BE2Z	Phase 1	[11]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[12]
Bisindolylmaleimide-I	DMOQJZC	Discovery agent	N.A.	Investigative	[12]
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole	DMN9YOB	Discovery agent	N.A.	Investigative	[13]
CI-1040	DMF3DZX	Discovery agent	N.A.	Investigative	[12]
AMP-PNP	DMTOK1D	Discovery agent	N.A.	Investigative	[14]
KN-62	DMLZ89P	Discovery agent	N.A.	Investigative	[12]

Drug(s) Targeting Focal adhesion kinase 1 (FAK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
VS-6063	DMGBLI3	Mesothelioma	2C51.2	Phase 2	[15]
BI-853520	DMNOSYW	Solid tumour/cancer	2A00-2F9Z	Phase 1	[16]
PF-562271	DMSLE03	Solid tumour/cancer	2A00-2F9Z	Phase 1	[17]
VS-4718	DMN9JCD	Solid tumour/cancer	2A00-2F9Z	Phase 1	[18]
GSK-2256098	DMR24MI	Pulmonary arterial hypertension	BB01.0	Phase 1	[19]
CEP-37440	DMV632P	Solid tumour/cancer	2A00-2F9Z	Phase 1	[16]
IN10018	DMPXOVA	Metastatic melanoma	2E2Z	Phase 1	[20]
1,2,4-triazolo[1,5a]pyridine derivative 1	DMIUPSA	N. A.	N. A.	Patented	[21]
PF-228	DM32FKD	Discovery agent	N.A.	Investigative	[22]
PMID23414845C30	DMNVQ29	Discovery agent	N.A.	Investigative	[23]

Drug(s) Targeting Albendazole monooxygenase (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[24]
PMX-53	DMZUAJ4	Atopic dermatitis	EA80	Phase 2	[25]
Heme	DMGC287	Discovery agent	N.A.	Investigative	[14]
ML-3163	DM3S5UC	Discovery agent	N.A.	Investigative	[26]
6-(3-Hydroxy-phenyl)-naphthalen-2-ol	DMH8WA2	Discovery agent	N.A.	Investigative	[27]
2-(2-(4-tert-Butylphenylthio)ethyl)-1H-imidazole	DMZVBPG	Discovery agent	N.A.	Investigative	[28]
ML-3375	DMXJY6W	Discovery agent	N.A.	Investigative	[26]
ML-3403	DMTQWI8	Discovery agent	N.A.	Investigative	[26]
4-[5-(3-Hydroxyphenyl)-3-thienyl]-2-methylphenol	DM7ERYJ	Discovery agent	N.A.	Investigative	[29]
2-Fluoro-4-[5-(3-hydroxyphenyl)-2-thienyl]phenol	DMUGAT8	Discovery agent	N.A.	Investigative	[29]

Drug(s) Targeting Proto-oncogene c-Met (MET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[30]
Cabozantinib	DMIYDT4	Medullary thyroid gland carcinoma		Approved	[31]
Amivantamab	DMZ7AMY	Non-small-cell lung cancer	2C25	Approved	[32]
Capmatinib	DMYCXKL	Non-small-cell lung cancer	2C25.Y	Approved	[33]
Tepotinib	DMUQ0E8	Non-small-cell lung cancer	2C25	Approved	[34]
RG3638	DMTQJE0	Gastric adenocarcinoma	2B72	Phase 3	[35]
Savolitinib	DMALFKX	Renal cell carcinoma	2C90	Phase 3	[36]
Beperminogene perplasmid	DM6RWBN	Critical limb ischemia	BD4Y	Phase 3	[37]
Tivantinib	DMNVP8Q	Hepatocellular carcinoma	2C12.02	Phase 3	[38]
MGCD516	DM752PU	Solid tumour/cancer	2A00-2F9Z	Phase 2/3	[35]

Drug(s) Targeting Insulin-like growth factor I receptor (IGF1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Teprotumumab	DM4L59B	Graves disease	5A02.0	Approved	[39]
Mecasermin	DM1O3BY	Growth failure	LD2F.1Y	Approved	[40]
Somatomedin-1	DMZ9FAO	Hormone deficiency	5A61.1	Approved	[41]
OSI-906	DMHKZLF	Solid tumour/cancer	2A00-2F9Z	Phase 3	[42]
Rinfabate	DML9FD4	Solid tumour/cancer	2A00-2F9Z	Phase 2/3	[43]
MM-141	DM2RJ4D	Pancreatic cancer	2C10	Phase 2	[44]
TT-100	DMZE6Y9	Non-small-cell lung cancer	2C25.Y	Phase 2	[45]
AMG 479	DM0DRAZ	Breast cancer	2C60-2C65	Phase 2	[46]
VPI-2690B	DMUQZT4	Diabetic nephropathy	GB61.Z	Phase 2	[47]
AXL-1717	DMTQ1Y3	Solid tumour/cancer	2A00-2F9Z	Phase 2	[48]

Drug(s) Targeting Platelet-derived growth factor receptor alpha (PDGFRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[49]
Ripretinib	DM958QB	Gastrointestinal stromal tumour	2B5B	Approved	[50]
Olaratumab	DMNYOIX	Soft tissue sarcoma	2B57	Approved	[51]
Avapritinib	DMK2GZX	Gastrointestinal stromal tumour	2B5B	Approved	[52]
E-3810	DM42PFT	Solid tumour/cancer	2A00-2F9Z	Phase 3	[53]
CP-868596	DMZIM37	Gastrointestinal cancer	2C11	Phase 3	[54]
Famitinib	DMSFWT7	Solid tumour/cancer	2A00-2F9Z	Phase 2	[55]
XL-820	DMMHX9K	Solid tumour/cancer	2A00-2F9Z	Phase 2	[56]
MP470	DMELUAK	Solid tumour/cancer	2A00-2F9Z	Phase 2	[57]
MEDI-575	DMI9WVM	Glioblastoma multiforme	2A00.0	Phase 2	[58]

Drug(s) Targeting Extracellular signal-regulated kinase 2 (ERK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BVD-523	DMNB4XK	Melanoma	2C30	Phase 2	[59]
HH2710	DM0C5MV	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[60]
ASTX029	DMVZXIA	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[61]
VAN-10-4-eluting stent	DM3ZW6A	Artery stenosis	BD52	Phase 1	[62]
GDC-0994	DMFC2OY	Solid tumour/cancer	2A00-2F9Z	Phase 1	[63]
JSI-1187	DMVJWBS	Solid tumour/cancer	2A00-2F9Z	Phase 1	[64]
LY3214996	DMFDAY7	Solid tumour/cancer	2A00-2F9Z	Phase 1	[36]
CHIR-99021	DMB8MNU	Allergic inflammation	4A80-4A85	Patented	[65]
COR-D	DMLXMCB	T-cell leukaemia	2A90	Preclinical	[66]
SB220025	DMSBUET	Arthritis	FA20	Terminated	[67]

Drug(s) Targeting Platelet-derived growth factor receptor beta (PDGFRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[68]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[49]
Becaplermin	DM1R5X4	Diabetic complication	5A2Y	Approved	[69]
E-3810	DM42PFT	Solid tumour/cancer	2A00-2F9Z	Phase 3	[53]
Famitinib	DMSFWT7	Solid tumour/cancer	2A00-2F9Z	Phase 2	[55]
XL-820	DMMHX9K	Solid tumour/cancer	2A00-2F9Z	Phase 2	[56]
MK-2461	DM21WBH	Alzheimer disease	8A20	Phase 1/2	[70]
SNN-0031	DM2X3BR	Brain injury	NA07.Z	Phase 1/2	[71]
TAK-593	DMNFZOT	Solid tumour/cancer	2A00-2F9Z	Phase 1	[72]
Pyridine derivative 18	DMBZMYT	N. A.	N. A.	Patented	[73]

Drug(s) Targeting RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[36]
Enzastaurin	DM5H0R9	Diffuse large B-cell lymphoma	2A81	Phase 3	[36]
GDC-0068	DMWBZJD	Breast cancer	2C60-2C65	Phase 3	[36]
CI-1033	DMSI8N3	Lymphoma	2A80-2A86	Phase 2	[9]
CMX-2043	DMPSCVY	Cardiac disease	BA00-BE2Z	Phase 2	[74]
ARQ 092	DM5WK0J	Proteus syndrome	LD2C	Phase 2	[75]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[76]
RX-0201	DMTBAV3	Pancreatic cancer	2C10	Phase 2	[77]
PTX-200	DM0ZIT2	Breast cancer	2C60-2C65	Phase 2	[36]
Triciribine prodrug	DMBN1XS	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[76]

Drug(s) Targeting Cyclin-dependent kinase 2 (CDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
R-roscovitine	DMSH108	Non-small-cell lung cancer	2C25.Y	Phase 2	[78]
Ro 31-7453	DM83QCL	Solid tumour/cancer	2A00-2F9Z	Phase 2	[9]
PHA848125	DMS2Q9G	Thymic cancer	2C27	Phase 2	[79]
TG02	DMZFIGQ	Anaplastic astrocytoma	2A00.0	Phase 1/2	[80]
NUV-422	DMQJQNT	Malignant glioma	2A00.0	Phase 1/2	[81]
RGB-286638	DMEGOQP	Haematological malignancy	2B33.Y	Phase 1	[82]
FN-1501	DM7BMD6	Solid tumour/cancer	2A00-2F9Z	Phase 1	[83]
AG-024322	DMY4WVK	Solid tumour/cancer	2A00-2F9Z	Phase 1	[78]
PHA-793887	DM2Y4FG	Solid tumour/cancer	2A00-2F9Z	Phase 1	[84]
SNS-032	DMEITAS	Solid tumour/cancer	2A00-2F9Z	Phase 1	[85]

Drug(s) Targeting Vascular endothelial growth factor receptor 2 (KDR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[68]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[86]
Regorafenib	DMHSY1I	Gastrointestinal stromal tumour	2B5B	Approved	[30]
Sunitinib	DMCBJSR	Acute undifferentiated leukemia		Approved	[87]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[88]
Vandetanib	DMRICNP	Solid tumour/cancer	2A00-2F9Z	Approved	[9]
Pazopanib HCl	DM6U9CQ	Renal cell carcinoma	2C90	Approved	[89]
Fruquintinib	DMHOSCQ	Colorectal cancer	2B91.Z	Approved	[90]
Cabozantinib	DMIYDT4	Medullary thyroid gland carcinoma		Approved	[31]
Tivozanib	DMUKC5L	Renal cell carcinoma	2C90	Approved	[91]

Drug(s) Targeting ERBB2 messenger RNA (HER2 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
HKI-272	DM6QOVN	Breast cancer	2C60-2C65	Phase 3	[92]
BMS-690514	DMX302C	Chronic pain	MG30	Phase 2	[93]
3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione	DMDO175	Discovery agent	N.A.	Investigative	[6]
3,4-diphenyl-1H-pyrrole-2,5-dione	DMPK6YT	Discovery agent	N.A.	Investigative	[6]
3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione	DMGC7RY	Discovery agent	N.A.	Investigative	[6]
3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione	DM3EV9N	Discovery agent	N.A.	Investigative	[6]
PMID24915291C38	DMBXT9J	Discovery agent	N.A.	Investigative	[94]
Geldanamycin-estradiol hybrid	DMUSJ96	Discovery agent	N.A.	Investigative	[95]
CL-387785	DMLKFZC	Discovery agent	N.A.	Investigative	[96]
HDS-029	DMLRUVA	Discovery agent	N.A.	Investigative	[96]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Albendazole monooxygenase (CYP3A4)	TTXV4FI	CP3A4_HUMAN	Inhibitor	[2]
Cyclin-dependent kinase 2 (CDK2)	TT7HF4W	CDK2_HUMAN	Inhibitor	[1]
ERBB2 messenger RNA (HER2 mRNA)	TTR5TV4	ERBB2_HUMAN	Inhibitor	[1]
Extracellular signal-regulated kinase 2 (ERK2)	TT4TQBX	MK01_HUMAN	Inhibitor	[1]
Focal adhesion kinase 1 (FAK)	TTON5IT	FAK1_HUMAN	Inhibitor	[1]
G1/S-specific cyclin-E1 (CCNE1)	TTCEJ4F	CCNE1_HUMAN	Inhibitor	[1]
Insulin-like growth factor I receptor (IGF1R)	TTHRID2	IGF1R_HUMAN	Inhibitor	[3]
LCK tyrosine protein kinase (LCK)	TT860QF	LCK_HUMAN	Inhibitor	[1]
Platelet-derived growth factor receptor alpha (PDGFRA)	TT8FYO9	PGFRA_HUMAN	Inhibitor	[1]
Platelet-derived growth factor receptor beta (PDGFRB)	TTI7421	PGFRB_HUMAN	Inhibitor	[1]
Proto-oncogene c-Met (MET)	TTNDSF4	MET_HUMAN	Inhibitor	[1]
RAC-alpha serine/threonine-protein kinase (AKT1)	TTWTSCV	AKT1_HUMAN	Inhibitor	[1]
Vascular endothelial growth factor receptor 2 (KDR)	TTUTJGQ	VGFR2_HUMAN	Inhibitor	[1]

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