Details of Disease

General Information of Disease (ID: DISIU1JS)

• Disease Name: Insulinoma
• Synonyms: adenomas, beta-cell; beta cell tumor; Insulomas; tumors, beta-cell; beta-cell tumour; insulinoma tumour suppressor GENE locus; adenoma, beta cell; adenoma, beta-cell; insulin-producing tumour of islet cells; beta-cell adenoma; beta-cell tumor; beta-cell tumours; beta-cell adenomas; insulinoma tumor suppressor GENE locus; beta cell tumour; Insulinomas; beta-cell tumors; insuloma; islet cell adenoma; tumor, beta-cell; insulinoma; pancreatic insulinoma
• Disease Class: 2C10: Pancreatic cancer
• Definition: An insulin-producing neuroendocrine tumor arising from the beta cells of the pancreas. Patients exhibit symptoms related to hypoglycemia due to inappropriate secretion of insulin.|Editor note: NCIT definition core part identical to pancreatic insulin-producing neuroendocrine tumor. In mesh this is an adenoma. Obs reason: duplicate. This will be merged with MONDO:0005048 pancreatic insulin-producing neuroendocrine tumor
• Disease Hierarchy:
  DISEECV2: Functional pancreatic neuroendocrine tumor
  DIS6JE0J: Pancreatic insulin-producing neuroendocrine tumor
  DISIU1JS: Insulinoma
• ICD Code:
  ICD-11: ICD-11: 2C10.1
  Expand ICD-11: '2C10.1
• Disease Identifiers:
  MONDO ID: MONDO_0024677
  MESH ID: D007340
  UMLS CUI: C0021670
  MedGen ID: 43907
  HPO ID: HP:0012197
  SNOMED CT ID: 302822000

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 2 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Diazoxide	DML1538	Approved	Small molecular drug	[1]
Romidepsin	DMT5GNL	Approved	Small molecular drug	[2]

This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
EM-3106B	DMFUXMS	Investigative	NA	[3]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 36 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CACNA1D	TT7RGTM	Limited	Biomarker	[4]
CDKN1C	TTBSUAR	Limited	Genetic Variation	[5]
GAD2	TT7UY6K	Limited	Biomarker	[6]
GPR119	TT7QNVC	Limited	Altered Expression	[7]
SSTR5	TT2BC4G	Limited	Altered Expression	[8]
GLP1R	TTVIMDE	moderate	Biomarker	[9]
IAPP	TTHN8EM	moderate	Biomarker	[10]
PDX1	TT8SGZK	moderate	Altered Expression	[11]
ACO2	TTMTF2P	Strong	Altered Expression	[12]
CPE	TTXPWO6	Strong	Altered Expression	[13]
CR2	TT0HUN7	Strong	Biomarker	[14]
EHMT1	TTOFXD7	Strong	Biomarker	[9]
ELK3	TT5OJMV	Strong	Biomarker	[15]
EPHB1	TT8MDAC	Strong	Biomarker	[15]
G6PC	TTBQMJ8	Strong	Altered Expression	[16]
G6PC2	TT7EV4P	Strong	Altered Expression	[17]
GAD1	TTKGEP3	Strong	Biomarker	[18]
GCK	TTDLNGZ	Strong	Biomarker	[19]
GIP	TT40HS5	Strong	Biomarker	[20]
HCAR2	TTWNV8U	Strong	Altered Expression	[21]
KCNJ1	TTJ13ST	Strong	Biomarker	[22]
KCNJ6	TTTIBVP	Strong	Biomarker	[22]
LMO2	TTFX379	Strong	Altered Expression	[23]
MAPK8IP1	TTXKZ8Q	Strong	Altered Expression	[24]
MC2R	TTPWFDX	Strong	Biomarker	[25]
PRSS1	TT2WR1T	Strong	Altered Expression	[26]
PSEN2	TTWN3F4	Strong	Biomarker	[27]
RALBP1	TTVSRUA	Strong	Biomarker	[28]
RIPK1	TTVJHX8	Strong	Biomarker	[28]
SLC22A12	TTA592U	Strong	Biomarker	[29]
SLC30A8	TTXIGT7	Strong	Biomarker	[30]
SLC6A2	TTAWNKZ	Strong	Biomarker	[15]
SSTR2	TTZ6T9E	Strong	Altered Expression	[31]
SSTR3	TTJX3UE	Strong	Altered Expression	[32]
STAB1	TTJFEOC	Strong	Altered Expression	[33]
TSPAN7	TTMT6VE	Strong	Altered Expression	[34]

This Disease Is Related to 3 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC2A2	DTUJPOL	Limited	Genetic Variation	[35]
SLC25A38	DTV8SWX	Strong	Altered Expression	[36]
SLC30A10	DTYBI73	Strong	Biomarker	[30]

This Disease Is Related to 46 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
BTC	OTW4B2O0	Limited	Biomarker	[37]
HMGN2	OTN20MEF	Limited	Biomarker	[38]
INSM1	OTG8RV8E	Limited	Altered Expression	[39]
LHX2	OTK61NP8	Limited	Biomarker	[40]
MNX1	OTXP9FH1	Limited	Biomarker	[41]
PDHX	OTG7O271	Limited	Altered Expression	[42]
CDKN2B	OTAG24N1	Disputed	Posttranslational Modification	[43]
RIT2	OTSNYG0D	moderate	Biomarker	[44]
ADSS2	OTW26XXB	Strong	Biomarker	[45]
APOC2	OTLINYIQ	Strong	Altered Expression	[46]
BANK1	OTXAAA11	Strong	Altered Expression	[47]
CCN5	OTADU8JJ	Strong	Biomarker	[48]
CCNC	OTMVK4K4	Strong	Altered Expression	[49]
CDKAL1	OTA0SGNE	Strong	Biomarker	[50]
CORO1A	OTVAZOHC	Strong	Genetic Variation	[5]
EIPR1	OTNQKNL3	Strong	Biomarker	[51]
ERP44	OT7ZI7AG	Strong	Altered Expression	[52]
FASTK	OTTHFZMP	Strong	Biomarker	[53]
GCKR	OTSIWXGG	Strong	Altered Expression	[19]
GCM2	OTSKNPTI	Strong	Biomarker	[54]
GOLGA6A	OTHU9MRX	Strong	Biomarker	[55]
GPD2	OTV232Y7	Strong	Biomarker	[56]
HES3	OTJ1J42N	Strong	Biomarker	[57]
IGSF9	OTNTKWS2	Strong	Altered Expression	[58]
INPPL1	OTCDAVBQ	Strong	Biomarker	[59]
INS-IGF2	OTZR74BO	Strong	Altered Expression	[60]
INSL5	OTLUI3PV	Strong	Biomarker	[61]
KCNH4	OTHJ8WTU	Strong	Altered Expression	[62]
KCNH8	OT3I5FLB	Strong	Altered Expression	[62]
KRT16	OTGA0EQN	Strong	Altered Expression	[63]
NFE2L1	OT1QHOS2	Strong	Biomarker	[64]
NIT1	OT1KHPKJ	Strong	Biomarker	[65]
PDIA2	OTC2WMXS	Strong	Altered Expression	[52]
PDIA5	OT76ZSX5	Strong	Altered Expression	[52]
PDZD2	OTPPVRGY	Strong	Biomarker	[66]
RAB3A	OT2GIUO5	Strong	Altered Expression	[67]
RAB8A	OTPB54Y3	Strong	Biomarker	[68]
RANBP2	OTFG5CVF	Strong	Altered Expression	[26]
RPS15	OT0WYZYG	Strong	Biomarker	[69]
SELENOS	OTUEWIU9	Strong	Biomarker	[70]
SNX1	OTXQSJ1J	Strong	Biomarker	[71]
STOML3	OTLQGALK	Strong	Biomarker	[72]
TCF19	OT7NKLF9	Strong	Biomarker	[73]
TPD52	OTPKSK43	Strong	Altered Expression	[63]
TRABD	OTCFGFJH	Strong	Altered Expression	[23]
PTPRN	OTAP7NOL	Definitive	Biomarker	[74]

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