Details of Disease

General Information of Disease (ID: DISKH221)

Disease Name	Dengue
Synonyms	classical dengue; Singapore hemorrhagic fever; Thai hemorrhagic fever; hemorrhagic dengue; Philippine hemorrhagic fever; Dengue fever; Dengue virus caused disease or disorder; DF; classic dengue; Dengue virus infection; Dengue virus disease or disorder; Dengue; Dengue virus infectious disease; break bone fever; breakbone fever
Disease Class	1D2Z: Dengue fever
Definition	Dengue fever (DF), caused by dengue virus, is an arboviral disease characterized by an initial non-specific febrile illness that can sometimes progress to more severe forms manifesting capillary leakage and hemorrhage (dengue hemorrhagic fever, or DHF) and shock (dengue shock syndrome, or DSS).
Disease Hierarchy	DISGFCIX: Vector-borne disease DISUDW4N: Flaviviridae infectious disease DISEM33Q: Infectious disease DISKH221: Dengue
ICD Code	ICD-11 ICD-11: 1D20-1D2Z ICD-10 ICD-10: A90, R50 Expand ICD-9 61780.6
Disease Identifiers	MONDO ID MONDO_0005502 MESH ID D003715 UMLS CUI C0011311 MedGen ID 3721 Orphanet ID 99828 SNOMED CT ID 38362002

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 5 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
60P002	DMHBN8X	Phase 2	Small molecular drug	[1]
GBV-006	DMAV32G	Phase 2	NA	[2]
JNJ-64281802	DMNMSVX	Phase 2	Small molecule	[3]
AT-752	DMQV2HD	Phase 1	NA	[4]
AV-1 mAb	DMUF27W	Phase 1	Antibody	[5]
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This Disease is Treated as An Indication in 1 Preclinical Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
VIS513	DMJDT5O	Preclinical	Antibody	[6]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 41 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ADAMTS13	TTUREBK	Limited	Altered Expression	[7]
CD209	TTBXIM9	Limited	Genetic Variation	[8]
EIF2AK3	TT79U1M	Limited	Biomarker	[9]
GEM	TTAZF9M	Limited	Biomarker	[10]
IFNAR2	TTMQB37	Limited	Biomarker	[11]
IFNL1	TTM624L	Limited	Altered Expression	[12]
MBTPS1	TTNSM2I	Limited	Biomarker	[13]
NR0B1	TTTK36V	Limited	Biomarker	[14]
PADI4	TTQHAXM	Limited	Biomarker	[15]
PF4	TTSG7Q5	Limited	Biomarker	[16]
RNASEL	TT7V0K4	Limited	Altered Expression	[17]
SLC17A5	TTFSUIA	Limited	Biomarker	[18]
THPO	TTCG5PE	Limited	Genetic Variation	[19]
TLR8	TT8CWFK	Limited	Biomarker	[20]
CDK9	TT1LVF2	moderate	Biomarker	[21]
AGPAT1	TTPL1TK	Strong	Biomarker	[22]
APOL1	TTDB8PW	Strong	Genetic Variation	[23]
BST2	TT90BJT	Strong	Altered Expression	[24]
DDX58	TTVB0O3	Strong	Biomarker	[25]
FCGR1A	TTZK4I3	Strong	Biomarker	[26]
FCGR2A	TTXT21W	Strong	Genetic Variation	[27]
GP1BA	TTVB0Q9	Strong	Biomarker	[28]
IL3RA	TTENHJ0	Strong	Altered Expression	[29]
KIR2DS2	TTV3CFI	Strong	Biomarker	[30]
KLRC1	TTC4IMS	Strong	Altered Expression	[31]
KPNB1	TTHOJ5F	Strong	Biomarker	[32]
MAPKAP1	TTWDKCL	Strong	Biomarker	[33]
MGAM	TTXWASR	Strong	Biomarker	[34]
MKNK1	TTEZAUX	Strong	Posttranslational Modification	[35]
NAAA	TTMN4HY	Strong	Biomarker	[36]
NPC1L1	TTPD1CN	Strong	Biomarker	[37]
OLFM4	TTK1CX7	Strong	Biomarker	[38]
P2RX1	TTJW7B3	Strong	Biomarker	[39]
PRDX4	TTPBL9I	Strong	Altered Expression	[40]
REL	TT1ZCTH	Strong	Biomarker	[41]
RHD	TTLCKI8	Strong	Biomarker	[42]
S1PR2	TTVSMOH	Strong	Biomarker	[43]
SENP8	TTMBUHI	Strong	Genetic Variation	[44]
TAP1	TT7JZI8	Strong	Genetic Variation	[45]
THBD	TTAPV67	Strong	Altered Expression	[46]
TIRAP	TTKU0LS	Strong	Genetic Variation	[47]
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⏷ Show the Full List of 41 DTT(s)

This Disease Is Related to 2 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
GPT	DER5HFI	moderate	Altered Expression	[48]
SI	DE5EO4Y	Strong	Biomarker	[34]
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This Disease Is Related to 79 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ARHGEF5	OTUVGFT9	Limited	Biomarker	[49]
CCL4L2	OTDBSXOU	Limited	Altered Expression	[50]
CHST10	OTEDU5YC	Limited	Genetic Variation	[51]
CSPG5	OTXFEBWR	Limited	Biomarker	[52]
DHX9	OT5AAOQI	Limited	Biomarker	[53]
ERVW-1	OTWV8DXJ	Limited	Biomarker	[54]
GRIP1	OT958HK1	Limited	Genetic Variation	[51]
HAVCR1	OT184CRZ	Limited	Biomarker	[49]
LGALS9	OT7MF91K	Limited	Altered Expression	[55]
MAVS	OTTQ0J64	Limited	Altered Expression	[56]
MPZ	OTAR2YXH	Limited	Biomarker	[14]
PPP2R5E	OT8GPFT5	Limited	Genetic Variation	[51]
RNASE1	OTKZ7CO9	Limited	Biomarker	[57]
ROBO3	OTPVG40S	Limited	Biomarker	[25]
STING1	OTDAP4G0	Limited	Biomarker	[58]
TIMELESS	OTD8DCBJ	Limited	Biomarker	[49]
CLEC5A	OT19WV30	moderate	Genetic Variation	[59]
IFITM3	OT2QP8D3	moderate	Genetic Variation	[60]
IFNA1	OTPMKY0L	moderate	Biomarker	[61]
APEX2	OTJ22LIT	Strong	Biomarker	[62]
ARC	OTN2QQPG	Strong	Genetic Variation	[63]
CAPRIN1	OTEJAMS3	Strong	Biomarker	[64]
CEACAM8	OTLL9WWO	Strong	Altered Expression	[65]
CERS1	OT6EYRM3	Strong	Biomarker	[66]
CGAS	OTJYIXNB	Strong	Biomarker	[67]
CNBP	OTTGM9NK	Strong	Biomarker	[68]
CNOT2	OT98OJ42	Strong	Biomarker	[69]
DDX50	OTUXH147	Strong	Biomarker	[70]
DDX6	OTKWXVDY	Strong	Biomarker	[71]
DHX40	OTOL02QN	Strong	Biomarker	[15]
EGFLAM	OTACZZJ0	Strong	Biomarker	[72]
EXOC7	OT4YA137	Strong	Altered Expression	[73]
GDF1	OTZ1VRBH	Strong	Biomarker	[66]
HAP1	OT6SG0JQ	Strong	Biomarker	[74]
HELZ2	OTM6HVO6	Strong	Biomarker	[75]
HPSE2	OTGEPP8V	Strong	Biomarker	[76]
HSD17B6	OTSB55D2	Strong	Altered Expression	[62]
ICAM3	OTTZ5A5D	Strong	Biomarker	[76]
IFI6	OTWOOAM4	Strong	Biomarker	[77]
IFIH1	OTZA2AHA	Strong	Altered Expression	[78]
IKBKE	OT5VYOSM	Strong	Biomarker	[79]
ILF2	OTWWVM9X	Strong	Biomarker	[80]
ILF3	OTKMZ5K5	Strong	Biomarker	[80]
IVNS1ABP	OTYHL4I7	Strong	Biomarker	[81]
KIR2DS5	OTXLEN11	Strong	Biomarker	[82]
KPNA2	OTU7FOE6	Strong	Biomarker	[32]
LAMP3	OTN0XL3W	Strong	Biomarker	[83]
LSAMP	OTYXVQX2	Strong	Biomarker	[83]
MATK	OTVOJJLJ	Strong	Biomarker	[84]
MLXIP	OT30UNI7	Strong	Altered Expression	[85]
MNT	OTPC4ANL	Strong	Biomarker	[86]
MOGS	OT99MBGB	Strong	Biomarker	[34]
MYLIP	OTL0PFGV	Strong	Altered Expression	[85]
MYOM2	OTD2UOXW	Strong	Biomarker	[87]
NFYA	OTWFFOVH	Strong	Biomarker	[74]
NUP153	OTCAS0AR	Strong	Biomarker	[88]
OAS2	OT64CCTM	Strong	Genetic Variation	[89]
P2RX2	OT0LF34A	Strong	Biomarker	[39]
P2RX6	OT1FNTXA	Strong	Biomarker	[39]
PLAAT4	OTI66SAJ	Strong	Altered Expression	[25]
PRSS57	OTR6GDQM	Strong	Biomarker	[90]
RAB18	OTNMAQLS	Strong	Biomarker	[91]
RAB6A	OTLS86J5	Strong	Biomarker	[91]
RCL1	OT7O00YX	Strong	Genetic Variation	[19]
RETREG1	OTYOSLZX	Strong	Biomarker	[92]
RNF168	OT6AZXX8	Strong	Biomarker	[93]
RPTOR	OT4TQZ9F	Strong	Biomarker	[33]
RSAD2	OTCA9WCM	Strong	Biomarker	[94]
SARS1	OTFKXQ1O	Strong	Genetic Variation	[95]
SARS2	OTU4T99W	Strong	Genetic Variation	[95]
SMOC1	OTJG2JQY	Strong	Genetic Variation	[96]
SSB	OTCCTPBR	Strong	Biomarker	[97]
STAM	OT6X5RR1	Strong	Biomarker	[98]
STT3B	OTRLJTF0	Strong	Biomarker	[62]
TAP2	OTWSYFI7	Strong	Genetic Variation	[45]
TNPO1	OT7W2CM8	Strong	Biomarker	[33]
TPM4	OTN4YLYR	Strong	Biomarker	[99]
TRAT1	OTMPUNPD	Strong	Biomarker	[100]
TRIM69	OTTEGTRD	Strong	Biomarker	[100]
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⏷ Show the Full List of 79 DOT(s)

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