General Information of Drug Off-Target (DOT) (ID: OT626PBA)

DOT Name Fermitin family homolog 1 (FERMT1)
Synonyms Kindlerin; Kindlin syndrome protein; Kindlin-1; Unc-112-related protein 1
Gene Name FERMT1
Related Disease
Kindler syndrome ( )
Advanced cancer ( )
Bladder cancer ( )
Breast cancer ( )
Breast carcinoma ( )
Breast neoplasm ( )
Carcinoma ( )
Carcinoma of esophagus ( )
Colitis ( )
Colon adenoma ( )
Colon cancer ( )
Colon carcinoma ( )
Colonic neoplasm ( )
Colorectal carcinoma ( )
Epidermolysis bullosa ( )
Esophageal cancer ( )
Hepatocellular carcinoma ( )
Inflammatory bowel disease ( )
Lung adenocarcinoma ( )
Lung cancer ( )
Lung carcinoma ( )
Lung neoplasm ( )
Neoplasm ( )
Neoplasm of esophagus ( )
Pancreatic cancer ( )
Photosensitivity disease ( )
Skin cancer ( )
Skin disease ( )
Squamous cell carcinoma ( )
Ulcerative colitis ( )
Urinary bladder cancer ( )
Urinary bladder neoplasm ( )
Neuralgia ( )
Bone osteosarcoma ( )
Crohn disease ( )
Kaposi sarcoma ( )
Osteosarcoma ( )
Type-1/2 diabetes ( )
UniProt ID
FERM1_HUMAN
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Pfam ID
PF00373 ; PF18124 ; PF00169
Sequence
MLSSTDFTFASWELVVRVDHPNEEQQKDVTLRVSGDLHVGGVMLKLVEQINISQDWSDFA
LWWEQKHCWLLKTHWTLDKYGVQADAKLLFTPQHKMLRLRLPNLKMVRLRVSFSAVVFKA
VSDICKILNIRRSEELSLLKPSGDYFKKKKKKDKNNKEPIIEDILNLESSPTASGSSVSP
GLYSKTMTPIYDPINGTPASSTMTWFSDSPLTEQNCSILAFSQPPQSPEALADMYQPRSL
VDKAKLNAGWLDSSRSLMEQGIQEDEQLLLRFKYYSFFDLNPKYDAVRINQLYEQARWAI
LLEEIDCTEEEMLIFAALQYHISKLSLSAETQDFAGESEVDEIEAALSNLEVTLEGGKAD
SLLEDITDIPKLADNLKLFRPKKLLPKAFKQYWFIFKDTSIAYFKNKELEQGEPLEKLNL
RGCEVVPDVNVAGRKFGIKLLIPVADGMNEMYLRCDHENQYAQWMAACMLASKGKTMADS
SYQPEVLNILSFLRMKNRNSASQVASSLENMDMNPECFVSPRCAKRHKSKQLAARILEAH
QNVAQMPLVEAKLRFIQAWQSLPEFGLTYYLVRFKGSKKDDILGVSYNRLIKIDAATGIP
VTTWRFTNIKQWNVNWETRQVVIEFDQNVFTAFTCLSADCKIVHEYIGGYIFLSTRSKDQ
NETLDEDLFHKLTGGQD
Function
Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression.
Tissue Specificity
Expressed in brain, skeletal muscle, kidney, colon, adrenal gland, prostate, and placenta. Weakly or not expressed in heart, thymus, spleen, liver, small intestine, bone marrow, lung and peripheral blood leukocytes. Overexpressed in some colon and lung tumors. In skin, it is localized within the epidermis and particularly in basal keratocytes. Not detected in epidermal melanocytes and dermal fibroblasts.

Molecular Interaction Atlas (MIA) of This DOT

38 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Kindler syndrome DIS8AP9J Definitive Autosomal recessive [1]
Advanced cancer DISAT1Z9 Strong Biomarker [2]
Bladder cancer DISUHNM0 Strong Altered Expression [3]
Breast cancer DIS7DPX1 Strong Biomarker [2]
Breast carcinoma DIS2UE88 Strong Biomarker [2]
Breast neoplasm DISNGJLM Strong Biomarker [3]
Carcinoma DISH9F1N Strong Altered Expression [4]
Carcinoma of esophagus DISS6G4D Strong Biomarker [5]
Colitis DISAF7DD Strong Biomarker [6]
Colon adenoma DISPMZ3U Strong Altered Expression [7]
Colon cancer DISVC52G Strong Altered Expression [8]
Colon carcinoma DISJYKUO Strong Altered Expression [8]
Colonic neoplasm DISSZ04P Strong Altered Expression [4]
Colorectal carcinoma DIS5PYL0 Strong Biomarker [9]
Epidermolysis bullosa DISVOTZQ Strong Genetic Variation [10]
Esophageal cancer DISGB2VN Strong Biomarker [5]
Hepatocellular carcinoma DIS0J828 Strong Altered Expression [11]
Inflammatory bowel disease DISGN23E Strong Genetic Variation [12]
Lung adenocarcinoma DISD51WR Strong Altered Expression [3]
Lung cancer DISCM4YA Strong Altered Expression [3]
Lung carcinoma DISTR26C Strong Altered Expression [3]
Lung neoplasm DISVARNB Strong Altered Expression [4]
Neoplasm DISZKGEW Strong Altered Expression [5]
Neoplasm of esophagus DISOLKAQ Strong Biomarker [5]
Pancreatic cancer DISJC981 Strong Altered Expression [13]
Photosensitivity disease DISTB3ML Strong Genetic Variation [14]
Skin cancer DISTM18U Strong Biomarker [15]
Skin disease DISDW8R6 Strong Genetic Variation [16]
Squamous cell carcinoma DISQVIFL Strong Biomarker [17]
Ulcerative colitis DIS8K27O Strong Biomarker [18]
Urinary bladder cancer DISDV4T7 Strong Altered Expression [3]
Urinary bladder neoplasm DIS7HACE Strong Altered Expression [3]
Neuralgia DISWO58J moderate Altered Expression [19]
Bone osteosarcoma DIST1004 Limited Biomarker [20]
Crohn disease DIS2C5Q8 Limited Genetic Variation [12]
Kaposi sarcoma DISC1H1Z Limited Genetic Variation [21]
Osteosarcoma DISLQ7E2 Limited Biomarker [20]
Type-1/2 diabetes DISIUHAP Limited Biomarker [22]
------------------------------------------------------------------------------------
⏷ Show the Full List of 38 Disease(s)
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
This DOT Affected the Drug Response of 1 Drug(s)
Drug Name Drug ID Highest Status Interaction REF
Arsenic trioxide DM61TA4 Approved Fermitin family homolog 1 (FERMT1) decreases the response to substance of Arsenic trioxide. [44]
------------------------------------------------------------------------------------
21 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate increases the expression of Fermitin family homolog 1 (FERMT1). [23]
Tretinoin DM49DUI Approved Tretinoin decreases the expression of Fermitin family homolog 1 (FERMT1). [24]
Doxorubicin DMVP5YE Approved Doxorubicin increases the expression of Fermitin family homolog 1 (FERMT1). [25]
Cupric Sulfate DMP0NFQ Approved Cupric Sulfate increases the expression of Fermitin family homolog 1 (FERMT1). [26]
Cisplatin DMRHGI9 Approved Cisplatin increases the expression of Fermitin family homolog 1 (FERMT1). [27]
Quercetin DM3NC4M Approved Quercetin decreases the expression of Fermitin family homolog 1 (FERMT1). [28]
Temozolomide DMKECZD Approved Temozolomide increases the expression of Fermitin family homolog 1 (FERMT1). [29]
Decitabine DMQL8XJ Approved Decitabine affects the expression of Fermitin family homolog 1 (FERMT1). [30]
Selenium DM25CGV Approved Selenium decreases the expression of Fermitin family homolog 1 (FERMT1). [31]
Progesterone DMUY35B Approved Progesterone decreases the expression of Fermitin family homolog 1 (FERMT1). [32]
Menadione DMSJDTY Approved Menadione affects the expression of Fermitin family homolog 1 (FERMT1). [33]
Panobinostat DM58WKG Approved Panobinostat increases the expression of Fermitin family homolog 1 (FERMT1). [34]
Urethane DM7NSI0 Phase 4 Urethane decreases the expression of Fermitin family homolog 1 (FERMT1). [35]
SNDX-275 DMH7W9X Phase 3 SNDX-275 increases the expression of Fermitin family homolog 1 (FERMT1). [34]
Tocopherol DMBIJZ6 Phase 2 Tocopherol decreases the expression of Fermitin family homolog 1 (FERMT1). [31]
(+)-JQ1 DM1CZSJ Phase 1 (+)-JQ1 decreases the expression of Fermitin family homolog 1 (FERMT1). [37]
PMID28460551-Compound-2 DM4DOUB Patented PMID28460551-Compound-2 decreases the expression of Fermitin family homolog 1 (FERMT1). [38]
Bisphenol A DM2ZLD7 Investigative Bisphenol A increases the expression of Fermitin family homolog 1 (FERMT1). [40]
Trichostatin A DM9C8NX Investigative Trichostatin A increases the expression of Fermitin family homolog 1 (FERMT1). [41]
Milchsaure DM462BT Investigative Milchsaure decreases the expression of Fermitin family homolog 1 (FERMT1). [42]
chloropicrin DMSGBQA Investigative chloropicrin decreases the expression of Fermitin family homolog 1 (FERMT1). [43]
------------------------------------------------------------------------------------
⏷ Show the Full List of 21 Drug(s)
2 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene decreases the methylation of Fermitin family homolog 1 (FERMT1). [36]
PMID28870136-Compound-52 DMFDERP Patented PMID28870136-Compound-52 affects the phosphorylation of Fermitin family homolog 1 (FERMT1). [39]
------------------------------------------------------------------------------------

References

1 Classification of Genes: Standardized Clinical Validity Assessment of Gene-Disease Associations Aids Diagnostic Exome Analysis and Reclassifications. Hum Mutat. 2017 May;38(5):600-608. doi: 10.1002/humu.23183. Epub 2017 Feb 13.
2 Kindlin-1 Promotes Pulmonary Breast Cancer Metastasis.Cancer Res. 2018 Mar 15;78(6):1484-1496. doi: 10.1158/0008-5472.CAN-17-1518. Epub 2018 Jan 12.
3 Role of the focal adhesion protein kindlin-1 in breast cancer growth and lung metastasis.J Natl Cancer Inst. 2011 Sep 7;103(17):1323-37. doi: 10.1093/jnci/djr290. Epub 2011 Aug 10.
4 URP1: a member of a novel family of PH and FERM domain-containing membrane-associated proteins is significantly over-expressed in lung and colon carcinomas.Biochim Biophys Acta. 2003 Apr 17;1637(3):207-16. doi: 10.1016/s0925-4439(03)00035-8.
5 The Effect of FERMT1 Regulated by miR-24 on the Growth and Radiation Resistance of Esophageal Cancer.J Biomed Nanotechnol. 2019 Mar 1;15(3):621-631. doi: 10.1166/jbn.2019.2711.
6 Chronic colitis due to an epithelial barrier defect: the role of kindlin-1 isoforms.J Pathol. 2007 Dec;213(4):462-70. doi: 10.1002/path.2253.
7 Digital transcript profile analysis with aRNA-LongSAGE validates FERMT1 as a potential novel prognostic marker for colon cancer.Clin Cancer Res. 2011 May 1;17(9):2908-18. doi: 10.1158/1078-0432.CCR-10-2552. Epub 2011 Jan 10.
8 FERMT1 mediates epithelial-mesenchymal transition to promote colon cancer metastasis via modulation of -catenin transcriptional activity.Oncogene. 2017 Mar 30;36(13):1779-1792. doi: 10.1038/onc.2016.339. Epub 2016 Sep 19.
9 Focal adhesion molecule Kindlin-1 mediates activation of TGF- signaling by interacting with TGF-RI, SARA and Smad3 in colorectal cancer cells.Oncotarget. 2016 Nov 15;7(46):76224-76237. doi: 10.18632/oncotarget.12779.
10 Focal adhesions in the skin: lessons learned from skin fragility disorders.Eur J Dermatol. 2017 Jun 1;27(S1):8-11. doi: 10.1684/ejd.2017.3039.
11 Expression of Kindlin-1 in human hepatocellular carcinoma and its prognostic significance.Tumour Biol. 2015 Jun;36(6):4235-41. doi: 10.1007/s13277-015-3060-8. Epub 2015 Jan 16.
12 Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.Nat Genet. 2017 Feb;49(2):256-261. doi: 10.1038/ng.3760. Epub 2017 Jan 9.
13 Kindlin-1 expression is involved in migration and invasion of pancreatic cancer.Int J Oncol. 2013 Apr;42(4):1360-6. doi: 10.3892/ijo.2013.1838. Epub 2013 Feb 22.
14 Recurrent mutations in kindlin-1, a novel keratinocyte focal contact protein, in the autosomal recessive skin fragility and photosensitivity disorder, Kindler syndrome.J Invest Dermatol. 2004 Jan;122(1):78-83. doi: 10.1046/j.0022-202X.2003.22136.x.
15 FERMT1 promoter mutations in patients with Kindler syndrome.Clin Genet. 2015 Sep;88(3):248-54. doi: 10.1111/cge.12490. Epub 2014 Oct 7.
16 Kindlin-1 protects cells from oxidative damage through activation of ERK signalling.Free Radic Biol Med. 2017 Jul;108:896-903. doi: 10.1016/j.freeradbiomed.2017.05.013. Epub 2017 May 10.
17 KIND1 Loss Sensitizes Keratinocytes to UV-Induced Inflammatory Response and DNA Damage.J Invest Dermatol. 2017 Feb;137(2):475-483. doi: 10.1016/j.jid.2016.09.023. Epub 2016 Oct 7.
18 Loss of Kindlin-1 causes skin atrophy and lethal neonatal intestinal epithelial dysfunction.PLoS Genet. 2008 Dec;4(12):e1000289. doi: 10.1371/journal.pgen.1000289. Epub 2008 Dec 5.
19 Kindlin-1 Regulates Astrocyte Activation and Pain Sensitivity in Rats With Neuropathic Pain.Reg Anesth Pain Med. 2018 Jul;43(5):547-553. doi: 10.1097/AAP.0000000000000780.
20 Prognostic implications of Kindlin proteins in human osteosarcoma.Onco Targets Ther. 2017 Feb 7;10:657-665. doi: 10.2147/OTT.S125418. eCollection 2017.
21 A novel large deletion mutation of FERMT1 gene in a Chinese patient with Kindler syndrome.J Zhejiang Univ Sci B. 2015 Nov;16(11):957-62. doi: 10.1631/jzus.B1500080.
22 Evaluating KIND1 human embryonic stem cell-derived pancreatic progenitors to ameliorate streptozotocin-induced diabetes in mice.Indian J Med Res. 2017 Aug;146(2):244-254. doi: 10.4103/ijmr.IJMR_210_16.
23 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
24 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
25 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
26 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
27 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
28 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
29 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
30 Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003. doi: 10.1371/journal.pone.0053003. Epub 2012 Dec 27.
31 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
32 Progesterone regulation of implantation-related genes: new insights into the role of oestrogen. Cell Mol Life Sci. 2007 Apr;64(7-8):1009-32.
33 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
34 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
35 Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
36 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
37 CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
38 Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
39 Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
40 Bisphenol A and bisphenol S induce distinct transcriptional profiles in differentiating human primary preadipocytes. PLoS One. 2016 Sep 29;11(9):e0163318.
41 From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
42 Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
43 Transcriptomic analysis of human primary bronchial epithelial cells after chloropicrin treatment. Chem Res Toxicol. 2015 Oct 19;28(10):1926-35.
44 The NRF2-mediated oxidative stress response pathway is associated with tumor cell resistance to arsenic trioxide across the NCI-60 panel. BMC Med Genomics. 2010 Aug 13;3:37. doi: 10.1186/1755-8794-3-37.