General Information of Disease (ID: DISWO58J)

Disease Name Neuralgia
Synonyms pain, nerve; paroxysmal nerve pains; paroxysmal nerve pain; pain, neuropathic; neuralgia
Definition A pain disorder characterize by pain in the distribution of a nerve or nerves
Disease Hierarchy
DIS7KN5G: Peripheral neuropathy
DIS4RWOW: Pain
DISWO58J: Neuralgia
Disease Identifiers
MONDO ID
MONDO_0021667
MESH ID
D009437
UMLS CUI
C0027796
MedGen ID
18010
HPO ID
HP:0033345
SNOMED CT ID
16269008

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 3 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Capsaicin DMGMF6V Approved Small molecular drug [1]
Lidocaine DML4ZOT Approved Small molecular drug [2]
Pregabalin DMDVP3B Approved Small molecular drug [3]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 184 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
AAK1 TT0Z32T Limited Biomarker [4]
ATF3 TTCE793 Limited Biomarker [5]
CREB1 TTH4AN3 Limited Biomarker [6]
CRHR1 TT7EFHR Limited Altered Expression [7]
CX3CL1 TT1OFBQ Limited Biomarker [8]
CXCR4 TTBID49 Limited Biomarker [9]
CYP17A1 TTRA5BZ Limited Biomarker [10]
GAD2 TT7UY6K Limited Biomarker [11]
GFAP TTI6FFX Limited Altered Expression [12]
HDAC2 TTSHTOI Limited Biomarker [13]
JUN TTS7IR5 Limited Biomarker [14]
MGLL TTZ963I Limited Biomarker [15]
MTNR1B TT32JK8 Limited Biomarker [16]
MYD88 TTB6Q2O Limited Biomarker [17]
NLRP1 TTQX29T Limited Biomarker [18]
OPRD1 TT27RFC Limited Biomarker [19]
P2RX1 TTJW7B3 Limited Biomarker [20]
P2RY1 TTA93TL Limited Biomarker [20]
P2RY6 TTNVSKA Limited Biomarker [21]
S1PR1 TT9JZCK Limited Biomarker [22]
SCN9A TT4G2JS Limited Biomarker [23]
SLC6A5 TTI0138 Limited Biomarker [24]
SNAP25 TTYQWA0 Limited Biomarker [25]
TMPRSS6 TTL9KE7 Limited Biomarker [16]
WAS TTE8T73 Limited Biomarker [26]
KCNK18 TTHT87J Disputed Biomarker [27]
ADCYAP1 TTW4LYC moderate Altered Expression [28]
ADORA1 TTK25J1 moderate Biomarker [29]
AIMP2 TTXWHGF moderate Altered Expression [30]
AKT3 TTO6SGY moderate Biomarker [31]
ANO1 TTOJI4S moderate Biomarker [32]
ANXA10 TT0NL6U moderate Biomarker [33]
CCL21 TTLZK1U moderate Genetic Variation [34]
CCL3 TT8I4WB moderate Biomarker [35]
CCR2 TTFZYTO moderate Biomarker [36]
CHRNA4 TT4H1MQ moderate Biomarker [37]
CRK TTFEUYR moderate Altered Expression [30]
CSF1 TT0IQER moderate Biomarker [38]
CXCL13 TT0NIZ1 moderate Biomarker [39]
CXCR5 TTIW59R moderate Biomarker [39]
EBI3 TTJF68X moderate Biomarker [40]
FKBP4 TTHY0FT moderate Biomarker [41]
FKBP5 TT0J5KQ moderate Biomarker [41]
GAD1 TTKGEP3 moderate Biomarker [42]
GAL TTXZAJ5 moderate Biomarker [43]
GALR1 TTX3HNZ moderate Biomarker [43]
GAP43 TTSGLN5 moderate Biomarker [44]
GCH1 TTLSWP6 moderate Genetic Variation [45]
GJD2 TTOZAFI moderate Altered Expression [46]
GPR35 TT254XD moderate Biomarker [47]
GPR55 TTNET8J moderate Biomarker [48]
GRIA2 TTWM461 moderate Biomarker [49]
GRIN2B TTN9D8E moderate Altered Expression [50]
GRM1 TTVBPDM moderate Altered Expression [51]
GRM2 TTXJ47W moderate Biomarker [52]
HCN2 TT9EUT4 moderate Biomarker [53]
HCRT TTU5HJP moderate Biomarker [54]
HDAC1 TT6R7JZ moderate Altered Expression [13]
HTR2C TTWJBZ5 moderate Biomarker [55]
IRAK1 TTXAJWN moderate Altered Expression [56]
KCNA2 TTVFB0O moderate Altered Expression [57]
KCNMA1 TTE87WJ moderate Biomarker [58]
KCNQ2 TTPXI3S moderate Altered Expression [59]
KMO TTIY56R moderate Biomarker [60]
LAMP2 TTULDG7 moderate Altered Expression [61]
LPAR1 TTQ6S1K moderate Biomarker [62]
MAPK14 TTQBR95 moderate Altered Expression [30]
NGF TTDN3LF moderate Genetic Variation [63]
OPRK1 TTQW87Y moderate Biomarker [64]
OPRL1 TTNT7K8 moderate Biomarker [65]
P2RX4 TT1NLOA moderate Biomarker [66]
PRKCG TTRFOXJ moderate Altered Expression [67]
PTK2B TTTEFBV moderate Biomarker [68]
SCN10A TT90XZ8 moderate Genetic Variation [69]
SCN11A TTN9VTF moderate Biomarker [69]
SLC1A2 TT2F078 moderate Altered Expression [70]
SORT1 TTRX9AV moderate Biomarker [71]
TACR1 TTZPO1L moderate Biomarker [72]
TLR5 TTCXP8J moderate Altered Expression [73]
TLR8 TT8CWFK moderate Biomarker [74]
TRAF6 TTCDR6M moderate Biomarker [75]
TRPA1 TTELV3W moderate Biomarker [76]
ADCYAP1R1 TT5OREU Strong Biomarker [77]
ADRA2A TTWG9A4 Strong Biomarker [78]
ADRA2C TT2NUT5 Strong Biomarker [78]
AGER TTMO9HF Strong Biomarker [79]
AGRP TT4DE1O Strong Biomarker [80]
AGTR2 TTQVOEI Strong Biomarker [81]
AIF1 TT12MEP Strong Altered Expression [82]
AQP9 TTQEI32 Strong Biomarker [83]
ATAT1 TTWUHQ1 Strong Biomarker [84]
BACE1 TTJUNZF Strong Altered Expression [85]
C1QB TT8A9DM Strong Biomarker [86]
C3AR1 TTI6B3F Strong Altered Expression [87]
CA7 TTJC376 Strong Genetic Variation [88]
CACNA1B TT4FDG6 Strong Altered Expression [89]
CACNA2D1 TTFK1JQ Strong Biomarker [90]
CALCA TTVSFJW Strong Biomarker [91]
CAPN2 TTG5QB7 Strong Biomarker [92]
CARM1 TTIZQFJ Strong Biomarker [93]
CASP6 TTKW4ML Strong Biomarker [94]
CLCN3 TT8XNZ7 Strong Biomarker [95]
CMKLR1 TT4UGZL Strong Biomarker [96]
CNR2 TTMSFAW Strong Biomarker [97]
CPS1 TT42M75 Strong Biomarker [98]
CTSE TTLXC4Q Strong Biomarker [99]
CTSS TTUMQVO Strong Biomarker [100]
CX3CR1 TT2T98G Strong Biomarker [101]
CXCR3 TT1UCIJ Strong Biomarker [102]
DAGLB TTXZDEN Strong Altered Expression [103]
DAO TT7Y3EJ Strong Biomarker [104]
DNMT3A TTJUALD Strong Biomarker [105]
DPP10 TTOVUPC Strong Biomarker [106]
DRD1 TTZFYLI Strong Biomarker [107]
DRD2 TTEX248 Strong Altered Expression [108]
DUSP5 TTZN92A Strong Altered Expression [109]
ENPP2 TTSCIM2 Strong Biomarker [110]
FCER1G TTDGEC0 Strong Biomarker [111]
FCGR1A TTZK4I3 Strong Biomarker [112]
FFAR1 TTB8FUC Strong Biomarker [113]
FURIN TTH9WF6 Strong Biomarker [114]
GDNF TTF23ML Strong Biomarker [115]
GLA TTIS03D Strong Altered Expression [116]
GPR132 TTNBW4F Strong Biomarker [117]
GPR3 TTHZVSK Strong Biomarker [118]
GPR34 TTVXSTQ Strong Biomarker [119]
GPR84 TTG0MQD Strong Biomarker [120]
GRIA1 TTVPQTF Strong Posttranslational Modification [25]
GRIN1 TTLD29N Strong Biomarker [121]
GRK2 TTAZ3MN Strong Biomarker [122]
GRM5 TTHS256 Strong Biomarker [123]
GRM7 TT0I76D Strong Biomarker [124]
GRM8 TT0IFKL Strong Biomarker [124]
HCAR2 TTWNV8U Strong Biomarker [125]
HCN1 TTNB6UQ Strong Biomarker [126]
HMGB1 TTWQYB7 Strong Altered Expression [127]
HTR1A TTSQIFT Strong Altered Expression [128]
HTR2B TT0K1SC Strong Biomarker [55]
IDO2 TTALN9W Strong Biomarker [60]
IRF8 TTHUBNK Strong Biomarker [18]
ITGAM TTB69FJ Strong Biomarker [129]
KCNK3 TTGR91N Strong Biomarker [130]
KCNK9 TTL4FMB Strong Biomarker [130]
KDM4A TTZHPB8 Strong Altered Expression [131]
KDR TTUTJGQ Strong Biomarker [132]
LY96 TT8S9AV Strong Biomarker [133]
LYZ TTAOZBW Strong Biomarker [134]
MAP2K2 TT8H9GB Strong Biomarker [135]
MAP3K4 TT1RSX7 Strong Altered Expression [136]
MAPKAP1 TTWDKCL Strong Biomarker [35]
MC4R TTD0CIQ Strong Biomarker [137]
MELTF TT8OBT3 Strong Biomarker [138]
MGAT1 TTYJRN5 Strong Biomarker [139]
MKNK1 TTEZAUX Strong Biomarker [140]
NOS1 TTZUFI5 Strong Therapeutic [141]
NTN1 TT0AH4L Strong Altered Expression [142]
NTRK1 TTTDVOJ Strong Altered Expression [143]
OAT TTTSCQ2 Strong Biomarker [144]
OPRM1 TTKWM86 Strong Biomarker [145]
P2RX3 TT2THBD Strong Altered Expression [146]
P2RY12 TTZ1DT0 Strong Biomarker [147]
P2RY13 TT1FE3L Strong Biomarker [148]
P2RY2 TTOZHQC Strong Biomarker [20]
PDXP TT9UYG4 Strong Biomarker [149]
PRKG1 TT7IZSA Strong Biomarker [150]
RGMA TTURJV4 Strong Biomarker [151]
RIPK2 TTCQ2E5 Strong Biomarker [152]
RNF34 TTEWDK1 Strong Altered Expression [153]
S1PR2 TTVSMOH Strong Biomarker [154]
SETD7 TTJ0FSU Strong Biomarker [155]
SLC11A2 TT2IS7P Strong Biomarker [156]
SLC12A5 TTH6UZY Strong Altered Expression [157]
SLC6A9 TTHJTF7 Strong Biomarker [139]
SSTR2 TTZ6T9E Strong Altered Expression [158]
TDO2 TTXNCBV Strong Biomarker [60]
TKTL1 TTNQ1J3 Strong Genetic Variation [159]
TLR4 TTISGCA Strong Altered Expression [50]
TRPM8 TTXDKTO Strong Biomarker [160]
USP5 TTGYTMA Strong Altered Expression [161]
VEGFB TTPJQHE Strong Biomarker [162]
ZWINT TTWY768 Strong Altered Expression [163]
DLG4 TT9PB26 Definitive Biomarker [164]
SLC5A1 TT2UE56 Definitive Genetic Variation [4]
UTS2 TTERU0T Definitive Biomarker [165]
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⏷ Show the Full List of 184 DTT(s)
This Disease Is Related to 4 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
SLC17A6 DT5LHCR moderate Altered Expression [166]
SLC35A1 DTVZIRG moderate Biomarker [167]
SLC52A1 DT7NOKR moderate Altered Expression [168]
KCNK2 DTENHUP Strong Altered Expression [169]
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This Disease Is Related to 5 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
MT2A DEFKGT7 Limited Biomarker [16]
FAAH DEUM1EX moderate Biomarker [170]
FXYD2 DEULQ45 Strong Biomarker [171]
HINT1 DEWJATF Strong Biomarker [172]
PGPEP1 DEVDR46 Strong Biomarker [173]
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This Disease Is Related to 137 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
AMBRA1 OTY0YGT9 Limited Biomarker [174]
ARTN OTWIWGL6 Limited Biomarker [80]
ATP2B2 OT1NPZ9T Limited Biomarker [175]
CNTN3 OTC1274J Limited Biomarker [176]
DECR1 OTCDIR6X Limited Biomarker [177]
ELAVL2 OT6EJ8MQ Limited Genetic Variation [14]
P2RX5 OTLBR20R Limited Biomarker [20]
P2RX6 OT1FNTXA Limited Biomarker [20]
PNOC OTJEAADN Limited Biomarker [65]
AHSA1 OTC7AFHT moderate Altered Expression [30]
CASZ1 OTWJ2OR8 moderate Biomarker [167]
CHGA OTXYX5JH moderate Biomarker [167]
CNTNAP2 OT48T2ZP moderate Genetic Variation [178]
DUSP6 OT4H6RKW moderate Biomarker [179]
ERVW-1 OTWV8DXJ moderate Biomarker [180]
FERMT1 OT626PBA moderate Altered Expression [181]
GAL3ST1 OTSFFZRD moderate Biomarker [167]
GPR151 OT7EACU6 moderate Genetic Variation [182]
GRAP2 OTS5NIZ3 moderate Altered Expression [30]
ITIH4 OT460OO1 moderate Biomarker [183]
JMJD6 OTILR7E4 moderate Biomarker [184]
MZB1 OT071TET moderate Altered Expression [185]
NOL3 OT1K0L0D moderate Biomarker [65]
NOS1AP OTDFOBRU moderate Biomarker [186]
PAX2 OTKP1N8F moderate Altered Expression [187]
PINK1 OT50NR57 moderate Biomarker [188]
POLDIP2 OT8SZSJ6 moderate Altered Expression [30]
PRRT2 OTCJUBDO moderate Altered Expression [189]
RNF19A OTKWCV80 moderate Altered Expression [30]
TAT OT2CJ91O moderate Biomarker [190]
ADARB1 OTGKSZEV Strong Biomarker [191]
ANXA3 OTDD8OI7 Strong Biomarker [192]
APOC1 OTA58CED Strong Altered Expression [110]
ATP5F1E OTMPLAIS Strong Biomarker [104]
ATPSCKMT OTMPVCHS Strong Biomarker [193]
AVIL OTUK67IT Strong Biomarker [194]
BRAP OTB7BAFQ Strong Biomarker [195]
CALB2 OTSNMCG9 Strong Biomarker [196]
CAPS2 OT45M743 Strong Biomarker [197]
CAV3 OTWSFDB4 Strong Biomarker [198]
CCL1 OT23NON8 Strong Biomarker [199]
CDK5RAP1 OTDEJXD0 Strong Biomarker [200]
CFL1 OTT6D5MH Strong Therapeutic [201]
CLEC4E OT7P8ICY Strong Biomarker [202]
CREB3L4 OTSGQGT2 Strong Biomarker [6]
CTNND2 OTYKE30Y Strong Biomarker [203]
CTSZ OTSCX2LL Strong Biomarker [100]
CXCL17 OTRCEVIZ Strong Biomarker [47]
CXCL3 OTSL94KH Strong Biomarker [204]
DLX5 OTEEFBEU Strong Biomarker [19]
DNAH8 OTGES2OU Strong Biomarker [205]
EHD2 OTTX391J Strong Biomarker [206]
FBXO45 OTD4D2OP Strong Biomarker [207]
FLRT3 OT3XMZU3 Strong Biomarker [208]
FRS2 OTDMD800 Strong Biomarker [209]
FZR1 OT0WGWZS Strong Biomarker [104]
GABPA OT9YB2SA Strong Biomarker [210]
GDF10 OTEVXGJ7 Strong Biomarker [211]
GFRA1 OT3WBVYB Strong Biomarker [212]
GFRA2 OT34CXNN Strong Biomarker [213]
GRK1 OT7MPSG7 Strong Biomarker [214]
HCCS OTQE88BE Strong Biomarker [215]
HCN3 OTMO1ZYQ Strong Biomarker [216]
IKBKE OT5VYOSM Strong Biomarker [217]
IMPA1 OTBUVW1Z Strong Biomarker [195]
INPP5F OTPKUY50 Strong Biomarker [218]
KCNIP2 OTY4BLOJ Strong Biomarker [106]
KCNK10 OT93GC7V Strong Biomarker [219]
KCNK13 OTMOT2KX Strong Biomarker [220]
KCNMB3 OT2SRKQE Strong Biomarker [58]
KCNS1 OTD8GEO0 Strong Biomarker [221]
KIF2A OT2WQ6QD Strong Altered Expression [222]
KLF15 OTGMQMVR Strong Biomarker [108]
LPCAT2 OT6NTBAA Strong Biomarker [223]
LPIN1 OTQ75KF2 Strong Biomarker [173]
LRPAP1 OT6DVD2Q Strong Biomarker [224]
MAFB OTH2N3T8 Strong Altered Expression [225]
MAPK6 OTDDNF3Q Strong Biomarker [226]
MATN1 OTBRTCTQ Strong Genetic Variation [227]
MBD1 OTD19VO6 Strong Biomarker [228]
MCC OTQVI1EM Strong Biomarker [229]
MDH2 OT7364GY Strong Altered Expression [230]
MEF2A OTV2SF6E Strong Biomarker [5]
METTL9 OT3YR9B2 Strong Biomarker [173]
MOS OTNMQPFJ Strong Biomarker [231]
MPG OTAHW80B Strong Biomarker [232]
MRGPRD OTTMOJ8U Strong Biomarker [233]
MZF1 OTMVZCPW Strong Biomarker [234]
NEO1 OTGJ1997 Strong Biomarker [151]
NFAT5 OTKIE59S Strong Biomarker [235]
NLN OTFRITPU Strong Biomarker [236]
NOC2L OTNT7R33 Strong Biomarker [215]
NPAS4 OTA3HH6W Strong Biomarker [237]
NPBWR1 OTN8NRXK Strong Altered Expression [238]
OPN1MW OTPJ7LX4 Strong Biomarker [239]
OPN4 OT1LZ7TS Strong Biomarker [236]
P2RX2 OT0LF34A Strong Biomarker [20]
PANX1 OTXPEDOK Strong Biomarker [240]
PCP2 OT3LUE9M Strong Genetic Variation [241]
PDAP1 OTJSWMOD Strong Biomarker [173]
PDYN OTEJ6430 Strong Biomarker [64]
PENK OT8P3HMP Strong Biomarker [242]
PGP OT6QQ7OR Strong Genetic Variation [44]
PHEX OTG7N3J7 Strong Biomarker [243]
PLCB3 OT0OMDEM Strong Biomarker [244]
PLP1 OT8CM9CX Strong Biomarker [149]
PLXND1 OTNK9ALK Strong Biomarker [245]
PROK2 OT70IFEZ Strong Biomarker [246]
PSMG1 OTZ5I6UM Strong Biomarker [77]
PVALB OTZW1WVQ Strong Biomarker [247]
RAB8A OTPB54Y3 Strong Biomarker [248]
REST OTLL92LQ Strong Altered Expression [249]
RGS10 OTQ8N1QH Strong Altered Expression [250]
RGS7 OTDQA90X Strong Altered Expression [251]
RGS9 OTRA1LOC Strong Altered Expression [252]
RGS9BP OTE0U1OQ Strong Genetic Variation [252]
RP9 OTGQY66H Strong Biomarker [173]
RPTOR OT4TQZ9F Strong Biomarker [35]
RTL1 OTOT33IM Strong Biomarker [253]
RYK OTZ3WWZH Strong Biomarker [254]
SETMAR OTE2MIMZ Strong Biomarker [253]
SGK3 OTQ6QO99 Strong Biomarker [255]
SNX8 OTMG63Z6 Strong Genetic Variation [241]
SPX OTY3G4AR Strong Biomarker [256]
SRI OT4R3EAC Strong Biomarker [257]
SRL OT7IEBWZ Strong Biomarker [258]
ST3GAL4 OTNENJZQ Strong Biomarker [259]
SYNM OTOI8TRJ Strong Biomarker [260]
TBCA OTCCWMGK Strong Biomarker [261]
TCF12 OTZVONNU Strong Biomarker [262]
TET1 OTZDHT1D Strong Biomarker [263]
THBS4 OTA1T9KK Strong Biomarker [264]
TNFAIP1 OT37EWR0 Strong Biomarker [265]
TNFSF8 OTDYGDJ3 Strong Altered Expression [214]
TNPO1 OT7W2CM8 Strong Biomarker [35]
TRAM1 OT3I0H8E Strong Biomarker [266]
PRX OT34Z10B Definitive Biomarker [267]
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⏷ Show the Full List of 137 DOT(s)

References

1 Capsaicin FDA Label
2 Lidocaine FDA Label
3 Pregabalin FDA Label
4 Predicting human disease mutations and identifying drug targets from mouse gene knockout phenotyping campaigns.Dis Model Mech. 2019 May 7;12(5):dmm038224. doi: 10.1242/dmm.038224.
5 Identification of key candidate genes in neuropathic pain by integrated bioinformatic analysis.J Cell Biochem. 2020 Feb;121(2):1635-1648. doi: 10.1002/jcb.29398. Epub 2019 Sep 18.
6 Modulating cAMP responsive element binding protein 1 attenuates functional and behavioural deficits in rat model of neuropathic pain.Eur Rev Med Pharmacol Sci. 2019 Mar;23(6):2602-2611. doi: 10.26355/eurrev_201903_17410.
7 Contribution of Corticotropin-Releasing Factor Receptor 1 (CRF1) to Serotonin Receptor 5-HT(2C)R Function in Amygdala Neurons in a Neuropathic Pain Model.Int J Mol Sci. 2019 Sep 6;20(18):4380. doi: 10.3390/ijms20184380.
8 (-)-Epigallocatechin-3-Gallate Antihyperalgesic Effect Associates With Reduced CX3CL1 Chemokine Expression in Spinal Cord.Phytother Res. 2017 Feb;31(2):340-344. doi: 10.1002/ptr.5753. Epub 2016 Nov 29.
9 CXCL12/CXCR4 signaling contributes to neuropathic pain via central sensitization mechanisms in a rat spinal nerve ligation model.CNS Neurosci Ther. 2019 Sep;25(9):922-936. doi: 10.1111/cns.13128. Epub 2019 Apr 7.
10 Spinal cytochrome P450c17 plays a key role in the development of neuropathic mechanical allodynia: Involvement of astrocyte sigma-1 receptors.Neuropharmacology. 2019 May 1;149:169-180. doi: 10.1016/j.neuropharm.2019.02.013. Epub 2019 Feb 20.
11 Normalizing HDAC2 Levels in the Spinal Cord Alleviates Thermal and Mechanical Hyperalgesia After Peripheral Nerve Injury and Promotes GAD65 and KCC2 Expression.Front Neurosci. 2019 Apr 10;13:346. doi: 10.3389/fnins.2019.00346. eCollection 2019.
12 Picroside II Attenuates CCI-Induced Neuropathic Pain in Rats by Inhibiting Spinal Reactive Astrocyte-Mediated Neuroinflammation Through the NF-B Pathway.Neurochem Res. 2018 May;43(5):1058-1066. doi: 10.1007/s11064-018-2518-7. Epub 2018 Apr 18.
13 HDAC2, but not HDAC1, regulates Kv1.2 expression to mediate neuropathic pain in CCI rats.Neuroscience. 2019 Jun 1;408:339-348. doi: 10.1016/j.neuroscience.2019.03.033. Epub 2019 Apr 23.
14 Identification of Key Pathways and Genes in L4 Dorsal Root Ganglion (DRG) After Sciatic Nerve Injury via Microarray Analysis.J Invest Surg. 2020 Feb;33(2):172-180. doi: 10.1080/08941939.2018.1452996. Epub 2018 Apr 19.
15 Inhibition of 2-arachydonoylgycerol degradation attenuates orofacial neuropathic pain in trigeminal nerve-injured mice.J Oral Sci. 2018 Mar 24;60(1):37-44. doi: 10.2334/josnusd.17-0005. Epub 2018 Mar 2.
16 Melatonin MT2 receptor agonist IIK-7 produces antinociception by modulation of ROS and suppression of spinal microglial activation in neuropathic pain rats.J Pain Res. 2019 Aug 8;12:2473-2485. doi: 10.2147/JPR.S214671. eCollection 2019.
17 Effect of Toll-Like Receptor 4/Myeloid Differentiation Factor 88 Inhibition by Salvianolic Acid B on Neuropathic Pain After Spinal Cord Injury in Mice.World Neurosurg. 2019 Dec;132:e529-e534. doi: 10.1016/j.wneu.2019.08.086. Epub 2019 Aug 23.
18 Downregulated spinal IRF8 and BDNF in NAC are involved in neuropathic pain-induced depression relief via pulsed radiofrequency on dorsal root ganglion in rat SNI model.Brain Res Bull. 2019 Mar;146:192-200. doi: 10.1016/j.brainresbull.2019.01.008. Epub 2019 Jan 9.
19 Mu and delta opioid receptors play opposite nociceptive and behavioural roles on nerve-injured mice.Br J Pharmacol. 2020 Mar;177(5):1187-1205. doi: 10.1111/bph.14911. Epub 2020 Feb 10.
20 P2Y(12) deficiency in mouse impairs noradrenergic system in brain, and alters anxiety-like neurobehavior and memory.Genes Brain Behav. 2019 Feb;18(2):e12458. doi: 10.1111/gbb.12458. Epub 2018 Feb 9.
21 The role of P2Y6 receptors in the maintenance of neuropathic pain and its improvement of oxidative stress in rats.J Cell Biochem. 2019 Oct;120(10):17123-17130. doi: 10.1002/jcb.28972. Epub 2019 May 20.
22 Sphingosine-1-phosphate receptor 1 activation in astrocytes contributes to neuropathic pain.Proc Natl Acad Sci U S A. 2019 May 21;116(21):10557-10562. doi: 10.1073/pnas.1820466116. Epub 2019 May 8.
23 MicroRNA-182 Alleviates Neuropathic Pain by Regulating Nav1.7 Following Spared Nerve Injury in Rats.Sci Rep. 2018 Nov 13;8(1):16750. doi: 10.1038/s41598-018-34755-3.
24 Glycine transporter inhibitors: A new avenue for managing neuropathic pain.Brain Res Bull. 2019 Oct;152:143-158. doi: 10.1016/j.brainresbull.2019.07.008. Epub 2019 Jul 11.
25 Spinal SNAP-25 regulates membrane trafficking of GluA1-containing AMPA receptors in spinal injury-induced neuropathic pain in rats.Neurosci Lett. 2020 Jan 10;715:134616. doi: 10.1016/j.neulet.2019.134616. Epub 2019 Nov 6.
26 c-Jun N terminal kinase signaling pathways mediate cannabinoid tolerance in an agonist-specific manner.Neuropharmacology. 2020 Mar 1;164:107847. doi: 10.1016/j.neuropharm.2019.107847. Epub 2019 Nov 20.
27 Chemically Modified Derivatives of the Activator Compound Cloxyquin Exert Inhibitory Effect on TRESK (K(2P)18.1) Background Potassium Channel.Mol Pharmacol. 2019 Jun;95(6):652-660. doi: 10.1124/mol.118.115626. Epub 2019 Apr 12.
28 PACAP and VIP expression in the periaqueductal grey of the rat following sciatic nerve constriction injury.Neuropeptides. 2019 Apr;74:60-69. doi: 10.1016/j.npep.2018.12.002. Epub 2018 Dec 15.
29 Downregulation of adenosine and adenosine A1 receptor contributes to neuropathic pain in resiniferatoxin neuropathy.Pain. 2018 Aug;159(8):1580-1591. doi: 10.1097/j.pain.0000000000001246.
30 Astrocyte activation in the periaqueductal gray promotes descending facilitation to cancer-induced bone pain through the JNK MAPK signaling pathway.Mol Pain. 2019 Jan-Dec;15:1744806919831909. doi: 10.1177/1744806919831909.
31 Effects of miR-150 on neuropathic pain process via targeting AKT3.Biochem Biophys Res Commun. 2019 Sep 24;517(3):532-537. doi: 10.1016/j.bbrc.2019.07.061. Epub 2019 Jul 31.
32 Mechanism of persistent hyperalgesia in neuropathic pain caused by chronic constriction injury.Neural Regen Res. 2019 Jun;14(6):1091-1098. doi: 10.4103/1673-5374.250631.
33 The involvement of spinal annexin A10/NF-B/MMP-9 pathway in the development of neuropathic pain in rats.BMC Neurosci. 2019 Jun 17;20(1):28. doi: 10.1186/s12868-019-0513-9.
34 Relationship of Inflammatory Cytokines From M1-Type Microglia/Macrophages at the Injured Site and Lumbar Enlargement With Neuropathic Pain After Spinal Cord Injury in the CCL21 Knockout (plt) Mouse.Front Cell Neurosci. 2019 Nov 21;13:525. doi: 10.3389/fncel.2019.00525. eCollection 2019.
35 Involvement of Macrophage Inflammatory Protein-1 Family Members in the Development of Diabetic Neuropathy and Their Contribution to Effectiveness of Morphine.Front Immunol. 2018 Mar 12;9:494. doi: 10.3389/fimmu.2018.00494. eCollection 2018.
36 Chemokines CCL2 and CCL7, but not CCL12, play a significant role in the development of pain-related behavior and opioid-induced analgesia.Cytokine. 2019 Jul;119:202-213. doi: 10.1016/j.cyto.2019.03.007. Epub 2019 Apr 16.
37 Allosteric modulation of 42* nicotinic acetylcholine receptors: Desformylflustrabromine potentiates antiallodynic response of nicotine in a mouse model of neuropathic pain.Eur J Pain. 2018 Jan;22(1):84-93. doi: 10.1002/ejp.1092. Epub 2017 Aug 14.
38 Epigenetic reduction of miR-214-3p upregulates astrocytic colony-stimulating factor-1 and contributes to neuropathic pain induced by nerve injury.Pain. 2020 Jan;161(1):96-108. doi: 10.1097/j.pain.0000000000001681.
39 Increased CXCL13 and CXCR5 in Anterior Cingulate Cortex Contributes to Neuropathic Pain-Related Conditioned Place Aversion.Neurosci Bull. 2019 Aug;35(4):613-623. doi: 10.1007/s12264-019-00377-6. Epub 2019 Apr 30.
40 SP1, MYC, CTNNB1, CREB1, JUN genes as potential therapy targets for neuropathic pain of brain.J Cell Physiol. 2019 May;234(5):6688-6695. doi: 10.1002/jcp.27413. Epub 2018 Nov 27.
41 The stress regulator FKBP51: a novel and promising druggable target for the treatment of persistent pain states across sexes.Pain. 2018 Jul;159(7):1224-1234. doi: 10.1097/j.pain.0000000000001204.
42 A single GABA neuron receives contacts from myelinated primary afferents of two adjacent peripheral nerves. A possible role in neuropathic pain.J Comp Neurol. 2018 Dec 15;526(18):2984-2999. doi: 10.1002/cne.24509. Epub 2018 Nov 19.
43 Galanin receptor 1 plays an antinociceptive effect via inhibiting PKA activation in the nucleus accumbens of rats with neuropathic pain.Physiol Res. 2019 Jun 30;68(3):511-518. doi: 10.33549/physiolres.933941. Epub 2019 Mar 22.
44 A pain in the skin. Regenerating nerve sprouts are distinctly associated with ongoing burning pain in patients with diabetes.Eur J Pain. 2018 Nov;22(10):1727-1734. doi: 10.1002/ejp.1259. Epub 2018 Jul 9.
45 Association of rs3783641 single-nucleotide polymorphism in GTP cyclohydrolase 1 gene with post-herpetic neuralgia.J Dermatol. 2019 Nov;46(11):993-997. doi: 10.1111/1346-8138.15067. Epub 2019 Sep 4.
46 Neurons and satellite glial cells in adult rat lumbar dorsal root ganglia express connexin 36.Acta Histochem. 2018 Apr;120(3):168-178. doi: 10.1016/j.acthis.2017.11.005. Epub 2017 Dec 8.
47 Kynurenic acid and zaprinast diminished CXCL17-evoked pain-related behaviour and enhanced morphine analgesia in a mouse neuropathic pain model.Pharmacol Rep. 2019 Feb;71(1):139-148. doi: 10.1016/j.pharep.2018.10.002. Epub 2018 Oct 6.
48 Inflammatory and Neuropathic Nociception is Preserved in GPR55 Knockout Mice.Sci Rep. 2017 Apr 20;7(1):944. doi: 10.1038/s41598-017-01062-2.
49 Translocation of AMPA Receptors in the Dorsal Horn of the Spinal Cord Corresponding to Long-term Depression Following Pulsed Radiofrequency Stimulation at the Dorsal Root Ganglion.Pain Med. 2020 Sep 1;21(9):1913-1920. doi: 10.1093/pm/pnz307.
50 Cav-1 participates in the development of diabetic neuropathy pain through the TLR4 signaling pathway.J Cell Physiol. 2020 Mar;235(3):2060-2070. doi: 10.1002/jcp.29106. Epub 2019 Jul 18.
51 The etiological changes of acetylation in peripheral nerve injury-induced neuropathic hypersensitivity.Mol Pain. 2018 Jan-Dec;14:1744806918798408. doi: 10.1177/1744806918798408. Epub 2018 Aug 14.
52 Riluzole induces LTD of spinal nociceptive signaling via postsynaptic GluR2 receptors.J Pain Res. 2018 Oct 26;11:2577-2586. doi: 10.2147/JPR.S169686. eCollection 2018.
53 A randomised, double-blind, placebo-controlled crossover trial of the influence of the HCN channel blocker ivabradine in a healthy volunteer pain model: an enriched population trial.Pain. 2019 Nov;160(11):2554-2565. doi: 10.1097/j.pain.0000000000001638.
54 A review of the role of orexin system in pain modulation.Biomed Pharmacother. 2017 Jun;90:187-193. doi: 10.1016/j.biopha.2017.03.053. Epub 2017 Mar 27.
55 Involvement of 5-HT2A, 5-HT2B and 5-HT2C receptors in mediating the ventrolateral orbital cortex-induced antiallodynia in a rat model of neuropathic pain.Neuroreport. 2020 Jan 27;31(2):167-173. doi: 10.1097/WNR.0000000000001377.
56 Interleukin-1 Receptor Associated Kinase 1 Mediates the Maintenance of Neuropathic Pain after Chronic Constriction Injury in Rats.Neurochem Res. 2019 May;44(5):1214-1227. doi: 10.1007/s11064-019-02767-8. Epub 2019 Mar 11.
57 DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons.Nat Commun. 2017 Mar 8;8:14712. doi: 10.1038/ncomms14712.
58 KCNMB3 in spinal microglia contributes to the generation and maintenance of neuropathic pain in mice.Int J Mol Med. 2019 Oct;44(4):1585-1593. doi: 10.3892/ijmm.2019.4279. Epub 2019 Jul 19.
59 Orofacial neuropathic pain induced by oxaliplatin: downregulation of KCNQ2 channels in V2 trigeminal ganglion neurons and treatment by the KCNQ2 channel potentiator retigabine.Mol Pain. 2017 Jan-Dec;13:1744806917724715. doi: 10.1177/1744806917724715.
60 Pharmacological Inhibition of Indoleamine 2,3-Dioxygenase-2 and Kynurenine 3-Monooxygenase, Enzymes of the Kynurenine Pathway, Significantly Diminishes Neuropathic Pain in a Rat Model.Front Pharmacol. 2018 Jul 11;9:724. doi: 10.3389/fphar.2018.00724. eCollection 2018.
61 Effect of autophagy on allodynia, hyperalgesia and astrocyte activation in a rat model of neuropathic pain.Int J Mol Med. 2018 Oct;42(4):2009-2019. doi: 10.3892/ijmm.2018.3763. Epub 2018 Jul 6.
62 LPA5 signaling is involved in multiple sclerosis-mediated neuropathic pain in the cuprizone mouse model.J Pharmacol Sci. 2018 Feb;136(2):93-96. doi: 10.1016/j.jphs.2018.01.001. Epub 2018 Feb 2.
63 A C-terminal cysteine residue is required for peptide-based inhibition of the NGF/TrkA interaction at nM concentrations: implications for peptide-based analgesics.Sci Rep. 2019 Jan 30;9(1):930. doi: 10.1038/s41598-018-37585-5.
64 Dynorphinergic system alterations in the corticostriatal circuitry of neuropathic mice support its role in the negative affective component of pain.Genes Brain Behav. 2019 Jul;18(6):e12467. doi: 10.1111/gbb.12467. Epub 2018 Mar 15.
65 Analysis of the distribution of spinal NOP receptors in a chronic pain model using NOP-eGFP knock-in mice.Br J Pharmacol. 2018 Jul;175(13):2662-2675. doi: 10.1111/bph.14225. Epub 2018 May 6.
66 Role of the P2X4 receptor in neuropathic pain.Curr Opin Pharmacol. 2019 Aug;47:33-39. doi: 10.1016/j.coph.2019.02.001. Epub 2019 Mar 14.
67 Downregulation of adult and neonatal Nav1.5 in the dorsal root ganglia and axon of peripheral sensory neurons of rats with spared nerve injury.Int J Mol Med. 2018 Apr;41(4):2225-2232. doi: 10.3892/ijmm.2018.3446. Epub 2018 Jan 30.
68 Treatment With the Delta Opioid Agonist UFP-512 Alleviates Chronic Inflammatory and Neuropathic Pain: Mechanisms Implicated.Front Pharmacol. 2019 Mar 26;10:283. doi: 10.3389/fphar.2019.00283. eCollection 2019.
69 A gain-of-function sodium channel 2-subunit mutation in painful diabetic neuropathy.Mol Pain. 2019 Jan-Dec;15:1744806919849802. doi: 10.1177/1744806919849802.
70 Region-specific deletions of the glutamate transporter GLT1 differentially affect nerve injury-induced neuropathic pain in mice.Glia. 2018 Sep;66(9):1988-1998. doi: 10.1002/glia.23452. Epub 2018 May 3.
71 Sortilin gates neurotensin and BDNF signaling to control peripheral neuropathic pain.Sci Adv. 2019 Jun 19;5(6):eaav9946. doi: 10.1126/sciadv.aav9946. eCollection 2019 Jun.
72 Neurokinin 1 receptor gene polymorphism might be correlated with recurrence rates in endometriosis.Gynecol Endocrinol. 2009 Nov;25(11):726-33. doi: 10.3109/09513590903159631.
73 MicroRNA-217 relieved neuropathic pain through targeting toll-like receptor 5 expression.J Cell Biochem. 2019 Mar;120(3):3009-3017. doi: 10.1002/jcb.27269. Epub 2018 Dec 11.
74 TLR8 and its endogenous ligand miR-21 contribute to neuropathic pain in murine DRG.J Exp Med. 2018 Dec 3;215(12):3019-3037. doi: 10.1084/jem.20180800. Epub 2018 Nov 19.
75 Roles of TRAF6 in Central Nervous System.Curr Neuropharmacol. 2018;16(9):1306-1313. doi: 10.2174/1570159X16666180412094655.
76 Identification and characterization of saikosaponins as antagonists of transient receptor potential A1 channel.Phytother Res. 2020 Apr;34(4):788-795. doi: 10.1002/ptr.6559. Epub 2019 Nov 28.
77 Synthesis of a novel and potent small-molecule antagonist of PAC1 receptor for the treatment of neuropathic pain.Eur J Med Chem. 2020 Jan 15;186:111902. doi: 10.1016/j.ejmech.2019.111902. Epub 2019 Nov 19.
78 Decreased spinal alpha2a- and alpha2c-adrenergic receptor subtype mRNA in a rat model of neuropathic pain.Neurosci Lett. 2003 Sep 25;349(1):5-8. doi: 10.1016/s0304-3940(03)00610-4.
79 Identification of a functional interaction of HMGB1 with Receptor for Advanced Glycation End-products in a model of neuropathic pain.Brain Behav Immun. 2014 Nov;42:169-77. doi: 10.1016/j.bbi.2014.06.199. Epub 2014 Jul 8.
80 Neuropathic pain in HIV patients receiving ART without stavudine in an Indonesia Referral Hospital.J Neurol Sci. 2019 Feb 15;397:146-149. doi: 10.1016/j.jns.2018.12.041. Epub 2019 Jan 2.
81 Attenuation of Unevoked Mechanical and Cold Pain Hypersensitivities Associated With Experimental Neuropathy in Mice by Angiotensin II Type-2 Receptor Antagonism.Anesth Analg. 2019 Jun;128(6):e84-e87. doi: 10.1213/ANE.0000000000003857.
82 Dynamic expression of glial fibrillary acidic protein and ionized calcium binding adaptor molecule 1 in the mouse spinal cord dorsal horn under pathological pain states.Neurol Res. 2019 Jul;41(7):633-643. doi: 10.1080/01616412.2019.1603804. Epub 2019 Apr 19.
83 LncRNA MALAT1 promotes neuropathic pain progression through the miR?54?p/AQP9 axis in CCI rat models.Mol Med Rep. 2020 Jan;21(1):291-303. doi: 10.3892/mmr.2019.10829. Epub 2019 Nov 20.
84 Sustained relief of neuropathic pain by AAV-targeted expression of CBD3 peptide in rat dorsal root ganglion.Gene Ther. 2014 Jan;21(1):44-51. doi: 10.1038/gt.2013.56. Epub 2013 Oct 24.
85 miR-15b mediates oxaliplatin-induced chronic neuropathic pain through BACE1 down-regulation.Br J Pharmacol. 2017 Mar;174(5):386-395. doi: 10.1111/bph.13698. Epub 2017 Jan 23.
86 Jun, Gal, Cd74, and C1qb as potential indicator for neuropathic pain.J Cell Biochem. 2018 Jun;119(6):4792-4798. doi: 10.1002/jcb.26673. Epub 2018 Mar 7.
87 Complement 3a receptor in dorsal horn microglia mediates pronociceptive neuropeptide signaling.Glia. 2017 Dec;65(12):1976-1989. doi: 10.1002/glia.23208. Epub 2017 Aug 29.
88 N-aryl-N'-ureido-O-sulfamates: Potent and selective inhibitors of the human Carbonic Anhydrase VII isoform with neuropathic pain relieving properties.Bioorg Chem. 2019 Aug;89:103033. doi: 10.1016/j.bioorg.2019.103033. Epub 2019 Jun 6.
89 CACNA1B (Ca(v)2.2) Overexpression and Its Association with Clinicopathologic Characteristics and Unfavorable Prognosis in Non-Small Cell Lung Cancer.Dis Markers. 2017;2017:6136401. doi: 10.1155/2017/6136401. Epub 2017 Jan 3.
90 2-1 gene deletion affects somatosensory neuron function and delays mechanical hypersensitivity in response to peripheral nerve damage.J Neurosci. 2013 Oct 16;33(42):16412-26. doi: 10.1523/JNEUROSCI.1026-13.2013.
91 Impaired AMPKCGRP signaling in the central nervous system contributes to enhanced neuropathic pain in highfat dietinduced obese rats, with or without nerve injury.Mol Med Rep. 2019 Aug;20(2):1279-1287. doi: 10.3892/mmr.2019.10368. Epub 2019 Jun 6.
92 Calpain-2 Regulates TNF- Expression Associated with Neuropathic Pain Following Motor Nerve Injury.Neuroscience. 2018 Apr 15;376:142-151. doi: 10.1016/j.neuroscience.2018.02.023. Epub 2018 Feb 23.
93 Dorsal Root Ganglia Coactivator-associated Arginine Methyltransferase 1 Contributes to Peripheral Nerve Injury-induced Pain Hypersensitivities.Neuroscience. 2018 Dec 1;394:232-242. doi: 10.1016/j.neuroscience.2018.10.038. Epub 2018 Nov 1.
94 Gene Expression Profiling of Cutaneous Injured and Non-Injured Nociceptors in SNI Animal Model of Neuropathic Pain.Sci Rep. 2017 Aug 24;7(1):9367. doi: 10.1038/s41598-017-08865-3.
95 17-Estradiol Attenuates Neuropathic Pain Caused by Spared Nerve Injury by Upregulating CIC-3 in the Dorsal Root Ganglion of Ovariectomized Rats.Front Neurosci. 2019 Nov 8;13:1205. doi: 10.3389/fnins.2019.01205. eCollection 2019.
96 Development of a membrane-anchored chemerin receptor agonist as a novel modulator of allergic airway inflammation and neuropathic pain.J Biol Chem. 2014 May 9;289(19):13385-96. doi: 10.1074/jbc.M113.522680. Epub 2014 Mar 21.
97 Indomethacin plus minocycline coadministration relieves chemotherapy and antiretroviral drug-induced neuropathic pain in a cannabinoid receptors-dependent manner.J Pharmacol Sci. 2019 Apr;139(4):325-332. doi: 10.1016/j.jphs.2019.02.007. Epub 2019 Feb 27.
98 Clinical efficacy of transforaminal epidural injection for management of zoster-associated pain: a retrospective analysis.Skeletal Radiol. 2018 Feb;47(2):253-260. doi: 10.1007/s00256-017-2795-2. Epub 2017 Oct 19.
99 Cathepsin E in neutrophils contributes to the generation of neuropathic pain in experimental autoimmune encephalomyelitis.Pain. 2019 Sep;160(9):2050-2062. doi: 10.1097/j.pain.0000000000001596.
100 Differential expression of Cathepsin S and X in the spinal cord of a rat neuropathic pain model.BMC Neurosci. 2008 Aug 12;9:80. doi: 10.1186/1471-2202-9-80.
101 Involvement of NF-B and the CX3CR1 Signaling Network in Mechanical Allodynia Induced by Tetanic Sciatic Stimulation.Neurosci Bull. 2018 Feb;34(1):64-73. doi: 10.1007/s12264-017-0149-7. Epub 2017 Jun 13.
102 Chemokine CXCL10/CXCR3 signaling contributes to neuropathic pain in spinal cord and dorsal root ganglia after chronic constriction injury in rats.Neurosci Lett. 2019 Feb 16;694:20-28. doi: 10.1016/j.neulet.2018.11.021. Epub 2018 Nov 15.
103 Liposomal Delivery of Diacylglycerol Lipase-Beta Inhibitors to Macrophages Dramatically Enhances Selectivity and Efficacy in Vivo.Mol Pharm. 2018 Mar 5;15(3):721-728. doi: 10.1021/acs.molpharmaceut.7b00657. Epub 2017 Sep 13.
104 An integrated review on new targets in the treatment of neuropathic pain.Korean J Physiol Pharmacol. 2019 Jan;23(1):1-20. doi: 10.4196/kjpp.2019.23.1.1. Epub 2018 Dec 26.
105 Contribution of dorsal root ganglion octamer transcription factor 1 to neuropathic pain after peripheral nerve injury.Pain. 2019 Feb;160(2):375-384. doi: 10.1097/j.pain.0000000000001405.
106 K(+) Channel Modulatory Subunits KChIP and DPP Participate in Kv4-Mediated Mechanical Pain Control.J Neurosci. 2017 Apr 19;37(16):4391-4404. doi: 10.1523/JNEUROSCI.1619-16.2017. Epub 2017 Mar 22.
107 Expression of the dopaminergic D1 and D2 receptors in the anterior cingulate cortex in a model of neuropathic pain.Mol Pain. 2011 Dec 15;7:97. doi: 10.1186/1744-8069-7-97.
108 KLF15 regulates dopamine D2 receptor and participates in mouse models of neuropathic pain.Biochem Biophys Res Commun. 2017 Oct 14;492(2):269-274. doi: 10.1016/j.bbrc.2017.08.066. Epub 2017 Aug 19.
109 miR-32-5p-mediated Dusp5 downregulation contributes to neuropathic pain.Biochem Biophys Res Commun. 2018 Jan 1;495(1):506-511. doi: 10.1016/j.bbrc.2017.11.013. Epub 2017 Nov 3.
110 CSF levels of apolipoprotein C1 and autotaxin found to associate with neuropathic pain and fibromyalgia.J Pain Res. 2019 Oct 15;12:2875-2889. doi: 10.2147/JPR.S215348. eCollection 2019.
111 Gene expression profile changes in rat dorsal horn after sciatic nerve injury.Neurol Res. 2017 Feb;39(2):176-182. doi: 10.1080/01616412.2016.1273590. Epub 2016 Dec 30.
112 The high-affinity IgG receptor FcRI modulates peripheral nerve injury-induced neuropathic pain in rats.Mol Brain. 2019 Oct 22;12(1):83. doi: 10.1186/s13041-019-0499-3.
113 Activation of GPR40 produces mechanical antiallodynia via the spinal glial interleukin-10/-endorphin pathway.J Neuroinflammation. 2019 Apr 13;16(1):84. doi: 10.1186/s12974-019-1457-9.
114 Effect of recombinant adenovirus coding for endomorphin-2 on neuropathic pain in rats.Int J Clin Exp Pathol. 2012;5(9):914-23. Epub 2012 Oct 20.
115 The impact of N-cadherin--catenin signaling on the analgesic effects of glial cell-derived neurotrophic factor in neuropathic pain.Biochem Biophys Res Commun. 2020 Feb 5;522(2):463-470. doi: 10.1016/j.bbrc.2019.11.076. Epub 2019 Nov 25.
116 Signatures of Altered Gene Expression in Dorsal Root Ganglia of a Fabry Disease Mouse Model.Front Mol Neurosci. 2018 Jan 25;10:449. doi: 10.3389/fnmol.2017.00449. eCollection 2017.
117 The G2A receptor (GPR132) contributes to oxaliplatin-induced mechanical pain hypersensitivity.Sci Rep. 2017 Mar 27;7(1):446. doi: 10.1038/s41598-017-00591-0.
118 Methods for the Development of In Silico GPCR Models.Methods Enzymol. 2017;593:405-448. doi: 10.1016/bs.mie.2017.05.005. Epub 2017 Jul 14.
119 GPR34 in spinal microglia exacerbates neuropathic pain in mice.J Neuroinflammation. 2019 Apr 11;16(1):82. doi: 10.1186/s12974-019-1458-8.
120 Agonists for G-protein-coupled receptor 84 (GPR84) alter cellular morphology and motility but do not induce pro-inflammatory responses in microglia.J Neuroinflammation. 2017 Oct 3;14(1):198. doi: 10.1186/s12974-017-0970-y.
121 Spinal D-Serine Increases PKC-Dependent GluN1 Phosphorylation Contributing to the Sigma-1 Receptor-Induced Development of Mechanical Allodynia in a Mouse Model of Neuropathic Pain.J Pain. 2017 Apr;18(4):415-427. doi: 10.1016/j.jpain.2016.12.002. Epub 2016 Dec 14.
122 Inhibition of MicroRNA-15a/16 Expression Alleviates Neuropathic Pain Development through Upregulation of G Protein-Coupled Receptor Kinase 2.Biomol Ther (Seoul). 2019 Jul 1;27(4):414-422. doi: 10.4062/biomolther.2018.073.
123 Metabotropic Glutamate Receptor 5 and 8 Modulate the Ameliorative Effect of Ultramicronized Palmitoylethanolamide on Cognitive Decline Associated with Neuropathic Pain.Int J Mol Sci. 2019 Apr 9;20(7):1757. doi: 10.3390/ijms20071757.
124 The Modulation of Pain by Metabotropic Glutamate Receptors 7 and 8 in the Dorsal Striatum.Curr Neuropharmacol. 2020;18(1):34-50. doi: 10.2174/1570159X17666190618121859.
125 Ketones and pain: unexplored role of hydroxyl carboxylic acid receptor type 2 in the pathophysiology of neuropathic pain.FASEB J. 2019 Jan;33(1):1062-1073. doi: 10.1096/fj.201801033R. Epub 2018 Aug 7.
126 HCN1 channels as targets for anesthetic and nonanesthetic propofol analogs in the amelioration of mechanical and thermal hyperalgesia in a mouse model of neuropathic pain.J Pharmacol Exp Ther. 2013 Jun;345(3):363-73. doi: 10.1124/jpet.113.203620. Epub 2013 Apr 2.
127 miR-129-5p Alleviates Neuropathic Pain Through Regulating HMGB1 Expression in CCI Rat Models.J Mol Neurosci. 2020 Jan;70(1):84-93. doi: 10.1007/s12031-019-01403-y. Epub 2019 Sep 5.
128 5-HT1A autoreceptor in dorsal raphe nucleus mediates sensitization of conditioned place preference to cocaine in mice experienced with chronic pain.Neuroreport. 2019 Jun 12;30(9):681-687. doi: 10.1097/WNR.0000000000001260.
129 Involvement of 7nAChR in electroacupuncture relieving neuropathic pain in the spinal cord of rat with spared nerve injury.Brain Res Bull. 2018 Mar;137:257-264. doi: 10.1016/j.brainresbull.2018.01.002. Epub 2018 Jan 4.
130 Spinal TASK-1 and TASK-3 modulate inflammatory and neuropathic pain.Eur J Pharmacol. 2019 Nov 5;862:172631. doi: 10.1016/j.ejphar.2019.172631. Epub 2019 Aug 28.
131 The histone demethylase JMJD2A regulates the expression of BDNF and mediates neuropathic pain in mice.Exp Cell Res. 2017 Dec 1;361(1):155-162. doi: 10.1016/j.yexcr.2017.10.014. Epub 2017 Oct 18.
132 VEGF and its receptor-2 involved in neuropathic pain transmission mediated by P2X?/)?receptor of primary sensory neurons.Brain Res Bull. 2010 Oct 30;83(5):284-91. doi: 10.1016/j.brainresbull.2010.08.002. Epub 2010 Aug 10.
133 Lovastatin inhibits Toll-like receptor 4 signaling in microglia by targeting its co-receptor myeloid differentiation protein 2 and attenuates neuropathic pain.Brain Behav Immun. 2019 Nov;82:432-444. doi: 10.1016/j.bbi.2019.09.013. Epub 2019 Sep 19.
134 Lysozyme elicits pain during nerve injury by neuronal Toll-like receptor 4 activation and has therapeutic potential in neuropathic pain.Sci Transl Med. 2019 Aug 7;11(504):eaav4176. doi: 10.1126/scitranslmed.aav4176.
135 Identification of Biomarkers Related to Neuropathic Pain Induced by Peripheral Nerve Injury.J Mol Neurosci. 2019 Dec;69(4):505-515. doi: 10.1007/s12031-019-01322-y. Epub 2019 Jul 27.
136 Upregulation of miR-183 represses neuropathic pain through inhibiton of MAP3K4 in CCI rat models.J Cell Physiol. 2020 Apr;235(4):3815-3822. doi: 10.1002/jcp.29276. Epub 2019 Oct 10.
137 MC4R Is Involved in Neuropathic Pain by Regulating JNK Signaling Pathway After Chronic Constriction Injury.Front Neurosci. 2019 Sep 10;13:919. doi: 10.3389/fnins.2019.00919. eCollection 2019.
138 A peptide derived from melanotransferrin delivers a protein-based interleukin 1 receptor antagonist across the BBB and ameliorates neuropathic pain in a preclinical model.J Cereb Blood Flow Metab. 2019 Oct;39(10):2074-2088. doi: 10.1177/0271678X18772998. Epub 2018 May 30.
139 Glycine transporter inhibitors as a novel drug discovery strategy for neuropathic pain.Pharmacol Ther. 2009 Jul;123(1):54-79. doi: 10.1016/j.pharmthera.2009.03.018. Epub 2009 Apr 23.
140 Nociceptor Translational Profiling Reveals the Ragulator-Rag GTPase Complex as a Critical Generator of Neuropathic Pain.J Neurosci. 2019 Jan 16;39(3):393-411. doi: 10.1523/JNEUROSCI.2661-18.2018. Epub 2018 Nov 20.
141 [Effect of electroacupuncture on expression of spinal neuronal nitric oxide synthase protein and mRNA in rats with neuropathic pain].Zhen Ci Yan Jiu. 2012 Oct;37(5):345-50.
142 Electroacupuncture decreases Netrin-1-induced myelinated afferent fiber sprouting and neuropathic pain through -opioid receptors.J Pain Res. 2019 Apr 23;12:1259-1268. doi: 10.2147/JPR.S191900. eCollection 2019.
143 Activation of neurotrophins in lumbar dorsal root probably contributes to neuropathic pain after spinal nerve ligation.Iran J Basic Med Sci. 2017 Jan;20(1):29-35. doi: 10.22038/ijbms.2017.8089.
144 Gene expression profiles reveal key pathways and genes associated with neuropathic pain in patients with spinal cord injury.Mol Med Rep. 2017 Apr;15(4):2120-2128. doi: 10.3892/mmr.2017.6231. Epub 2017 Feb 22.
145 Why mu-opioid agonists have less analgesic efficacy in neuropathic pain?.Eur J Pain. 2019 Mar;23(3):435-454. doi: 10.1002/ejp.1328. Epub 2018 Nov 25.
146 Electroacupuncture downregulates P2X3 receptor expression in dorsal root ganglia of the spinal nerve-ligated rat.Mol Pain. 2019 Jan-Dec;15:1744806919847810. doi: 10.1177/1744806919847810.
147 P2Y12 regulates microglia activation and excitatory synaptic transmission in spinal lamina II neurons during neuropathic pain in rodents.Cell Death Dis. 2019 Feb 18;10(3):165. doi: 10.1038/s41419-019-1425-4.
148 P2Y receptors in neuropathic pain.Pharmacol Biochem Behav. 2019 Nov;186:172788. doi: 10.1016/j.pbb.2019.172788. Epub 2019 Sep 5.
149 Coping with Phantom Limb Pain.Mol Neurobiol. 2018 Jan;55(1):70-84. doi: 10.1007/s12035-017-0718-9.
150 Two isoforms of cyclic GMP-dependent kinase-I exhibit distinct expression patterns in the adult mouse dorsal root ganglion.Mol Pain. 2018 Jan-Dec;14:1744806918796409. doi: 10.1177/1744806918796409.
151 RGMa inhibition with human monoclonal antibodies promotes regeneration, plasticity and repair, and attenuates neuropathic pain after spinal cord injury.Sci Rep. 2017 Sep 5;7(1):10529. doi: 10.1038/s41598-017-10987-7.
152 The NOD2 signaling in peripheral macrophages contributes to neuropathic pain development.Pain. 2019 Jan;160(1):102-116. doi: 10.1097/j.pain.0000000000001383.
153 Altered Gene Expression of RNF34 and PACAP Possibly Involved in Mechanism of Exercise-Induced Analgesia for Neuropathic Pain in Rats.Int J Mol Sci. 2017 Sep 13;18(9):1962. doi: 10.3390/ijms18091962.
154 Sphingosine-1-phosphate receptor 2 modulates pain sensitivity by suppressing the ROS-RUNX3 pathway in a rat model of neuropathy.J Cell Physiol. 2020 Apr;235(4):3864-3873. doi: 10.1002/jcp.29280. Epub 2019 Oct 11.
155 SETD7 mediates spinal microgliosis and neuropathic pain in a rat model of peripheral nerve injury.Brain Behav Immun. 2019 Nov;82:382-395. doi: 10.1016/j.bbi.2019.09.007. Epub 2019 Sep 7.
156 The involvement of iron responsive element (-) divalent metal transporter 1-mediated the spinal iron overload via CXCL10/CXCR3 pathway in neuropathic pain in rats.Neurosci Lett. 2019 Feb 16;694:154-160. doi: 10.1016/j.neulet.2018.12.001. Epub 2018 Dec 3.
157 Role of the BDNF-TrkB pathway in KCC2 regulation and rehabilitation following neuronal injury: A mini review.Neurochem Int. 2019 Sep;128:32-38. doi: 10.1016/j.neuint.2019.04.003. Epub 2019 Apr 12.
158 Somatostatin Type 2 Receptor Antibody Enhances Mechanical Hyperalgesia in the Dorsal Root Ganglion Neurons after Sciatic Nerve-pinch Injury: Evidence of Behavioral Studies and Bax Protein Expression.CNS Neurol Disord Drug Targets. 2019;18(10):791-797. doi: 10.2174/1871527318666191101094412.
159 Preoperative Neuropathic Pain-like Symptoms and Central Pain Mechanisms in Knee Osteoarthritis Predicts Poor Outcome 6 Months After Total Knee Replacement Surgery.J Pain. 2018 Nov;19(11):1329-1341. doi: 10.1016/j.jpain.2018.05.011. Epub 2018 Jun 18.
160 Intrathecal TRPM8 blocking attenuates cold hyperalgesia via PKC and NF-B signaling in the dorsal root ganglion of rats with neuropathic pain.J Pain Res. 2019 Apr 18;12:1287-1296. doi: 10.2147/JPR.S197168. eCollection 2019.
161 SUMOylation regulates USP5-Cav3.2 calcium channel interactions.Mol Brain. 2019 Aug 27;12(1):73. doi: 10.1186/s13041-019-0493-9.
162 CircAnks1a in the spinal cord regulates hypersensitivity in a rodent model of neuropathic pain.Nat Commun. 2019 Sep 11;10(1):4119. doi: 10.1038/s41467-019-12049-0.
163 A genome-wide association study identifies candidate loci associated to syringomyelia secondary to Chiari-like malformation in Cavalier King Charles Spaniels.BMC Genet. 2018 Mar 22;19(1):16. doi: 10.1186/s12863-018-0605-z.
164 nNOS-PSD95 interactions activate the PKC- isoform leading to increased GluN1 phosphorylation and the development of neuropathic mechanical allodynia in mice.Neurosci Lett. 2019 Jun 11;703:156-161. doi: 10.1016/j.neulet.2019.03.043. Epub 2019 Mar 26.
165 Urotensin II inhibitor eases neuropathic pain by suppressing the JNK/NF-B pathway.J Endocrinol. 2017 Feb;232(2):165-174. doi: 10.1530/JOE-16-0255.
166 Wnt1/-catenin signaling upregulates spinal VGLUT2 expression to control neuropathic pain in mice.Neuropharmacology. 2020 Mar 1;164:107869. doi: 10.1016/j.neuropharm.2019.107869. Epub 2019 Nov 27.
167 Catestatin Enhances Neuropathic Pain Mediated by P2X4 Receptor of Dorsal Root Ganglia in a Rat Model of Chronic Constriction Injury.Cell Physiol Biochem. 2018;51(2):812-826. doi: 10.1159/000495334. Epub 2018 Nov 21.
168 The association between the expression of PAR2 and TMEM16A and neuropathic pain.Mol Med Rep. 2018 Mar;17(3):3744-3750. doi: 10.3892/mmr.2017.8295. Epub 2017 Dec 18.
169 MiR-183-5p Alleviates Chronic Constriction Injury-Induced Neuropathic Pain Through Inhibition of TREK-1.Neurochem Res. 2018 Jun;43(6):1143-1149. doi: 10.1007/s11064-018-2529-4. Epub 2018 May 7.
170 A Cocktail Interaction Study Evaluating the Drug-Drug Interaction Potential of the Perpetrator Drug ASP8477 at Multiple Ascending Dose Levels.Clin Pharmacol Drug Dev. 2019 May;8(4):529-540. doi: 10.1002/cpdd.660. Epub 2019 Feb 7.
171 Fxyd2 regulates A- and C-fiber mechanosensitivity and is required for the maintenance of neuropathic pain.Sci Rep. 2016 Nov 2;6:36407. doi: 10.1038/srep36407.
172 Switch-on fluorescent/FRET probes to study human histidine triad nucleotide binding protein 1 (hHint1), a novel target for opioid tolerance and neuropathic pain.Org Biomol Chem. 2017 Dec 13;15(48):10230-10237. doi: 10.1039/c7ob02472j.
173 Nerve Injury-Induced Neuronal PAP-I Maintains Neuropathic Pain by Activating Spinal Microglia.J Neurosci. 2020 Jan 8;40(2):297-310. doi: 10.1523/JNEUROSCI.1414-19.2019. Epub 2019 Nov 19.
174 Effects of caloric restriction on neuropathic pain, peripheral nerve degeneration and inflammation in normometabolic and autophagy defective prediabetic Ambra1 mice.PLoS One. 2018 Dec 10;13(12):e0208596. doi: 10.1371/journal.pone.0208596. eCollection 2018.
175 Pathological pain processing in mouse models of multiple sclerosis and spinal cord injury: contribution of plasma membrane calcium ATPase 2 (PMCA2).J Neuroinflammation. 2019 Nov 8;16(1):207. doi: 10.1186/s12974-019-1585-2.
176 Dysfunctional Coping Mechanisms Contribute to Dry Eye Symptoms.J Clin Med. 2019 Jun 24;8(6):901. doi: 10.3390/jcm8060901.
177 Inhibition of NOX2 signaling limits pain-related behavior and improves motor function in male mice after spinal cord injury: Participation of IL-10/miR-155 pathways.Brain Behav Immun. 2019 Aug;80:73-87. doi: 10.1016/j.bbi.2019.02.024. Epub 2019 Feb 23.
178 Immune or Genetic-Mediated Disruption of CASPR2 Causes Pain Hypersensitivity Due to Enhanced Primary Afferent Excitability.Neuron. 2018 Feb 21;97(4):806-822.e10. doi: 10.1016/j.neuron.2018.01.033. Epub 2018 Feb 8.
179 Intrathecal injection of dexmedetomidine ameliorates chronic neuropathic pain via the modulation of MPK3/ERK1/2 in a mouse model of chronic neuropathic pain.Neurol Res. 2019 Dec;41(12):1059-1068. doi: 10.1080/01616412.2019.1672391. Epub 2019 Oct 4.
180 P2Y(12) shRNA treatment relieved HIV gp120-induced neuropathic pain in rats.Neurochem Int. 2018 Jan;112:259-266. doi: 10.1016/j.neuint.2017.08.006. Epub 2017 Aug 18.
181 Kindlin-1 Regulates Astrocyte Activation and Pain Sensitivity in Rats With Neuropathic Pain.Reg Anesth Pain Med. 2018 Jul;43(5):547-553. doi: 10.1097/AAP.0000000000000780.
182 Frailty Index associates with GRIN2B in two representative samples from the United States and the United Kingdom.PLoS One. 2018 Nov 26;13(11):e0207824. doi: 10.1371/journal.pone.0207824. eCollection 2018.
183 Sex Differences in a Rodent Model of HIV-1-Associated Neuropathic Pain.Int J Mol Sci. 2019 Mar 9;20(5):1196. doi: 10.3390/ijms20051196.
184 JMJD6 exerts function in neuropathic pain by regulating NFB following peripheral nerve injury in rats.Int J Mol Med. 2018 Jul;42(1):633-642. doi: 10.3892/ijmm.2018.3613. Epub 2018 Apr 3.
185 Parabrachial Pituitary Adenylate Cyclase-Activating Polypeptide Activation of Amygdala Endosomal Extracellular Signal-Regulated Kinase Signaling Regulates the Emotional Component of Pain.Biol Psychiatry. 2017 Apr 15;81(8):671-682. doi: 10.1016/j.biopsych.2016.08.025. Epub 2016 Aug 29.
186 ZLc002, a putative small-molecule inhibitor of nNOS interaction with NOS1AP, suppresses inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with paclitaxel to reduce tumor cell viability.Mol Pain. 2018 Jan-Dec;14:1744806918801224. doi: 10.1177/1744806918801224. Epub 2018 Aug 29.
187 MicroRNA-362-3p attenuates motor deficit following spinal cord injury via targeting paired box gene 2.J Integr Neurosci. 2019 Mar 30;18(1):57-64. doi: 10.31083/j.jin.2019.01.12.
188 Erratum: PINK1 mediates spinal cord mitophagy in neuropathic pain [Corrigendum].J Pain Res. 2019 Aug 27;12:2627. doi: 10.2147/JPR.S227509. eCollection 2019.
189 Activation of enkephalinergic (Enk) interneurons in the central amygdala (CeA) buffers the behavioral effects of persistent pain.Neurobiol Dis. 2019 Apr;124:364-372. doi: 10.1016/j.nbd.2018.12.005. Epub 2018 Dec 17.
190 Increasing spinal 5-HT(2A) receptor responsiveness mediates anti-allodynic effect and potentiates fluoxetine efficacy in neuropathic rats. Evidence for GABA release.Pharmacol Res. 2017 Apr;118:93-103. doi: 10.1016/j.phrs.2016.09.021. Epub 2016 Sep 20.
191 RNA editing enzyme ADAR2 is a mediator of neuropathic pain after peripheral nerve injury.FASEB J. 2017 May;31(5):1847-1855. doi: 10.1096/fj.201600950R. Epub 2017 Jan 26.
192 Proteomic Identification of an Upregulated Isoform of Annexin A3 in the Spinal Cords of Rats in a Neuropathic Pain Model.Front Neurosci. 2017 Sep 5;11:484. doi: 10.3389/fnins.2017.00484. eCollection 2017.
193 Identification of FAM173B as a protein methyltransferase promoting chronic pain.PLoS Biol. 2018 Feb 14;16(2):e2003452. doi: 10.1371/journal.pbio.2003452. eCollection 2018 Feb.
194 Involvement of advillin in somatosensory neuron subtype-specific axon regeneration and neuropathic pain.Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):E8557-E8566. doi: 10.1073/pnas.1716470115. Epub 2018 Aug 20.
195 Altered cerebral blood flow in the anterior cingulate cortex is associated with neuropathic pain.J Neurol Neurosurg Psychiatry. 2018 Oct;89(10):1082-1087. doi: 10.1136/jnnp-2017-316601. Epub 2018 Apr 7.
196 Expression of Calretinin Among Different Neurochemical Classes of Interneuron in the Superficial Dorsal Horn of the Mouse Spinal Cord.Neuroscience. 2019 Feb 1;398:171-181. doi: 10.1016/j.neuroscience.2018.12.009. Epub 2018 Dec 13.
197 Paralogs of the Calcium-Dependent Activator Protein for Secretion Differentially Regulate Synaptic Transmission and Peptide Secretion in Sensory Neurons.Front Cell Neurosci. 2018 Sep 11;12:304. doi: 10.3389/fncel.2018.00304. eCollection 2018.
198 Cdk5-Dependent Phosphorylation of Ca(V)3.2 T-Type Channels: Possible Role in Nerve Ligation-Induced Neuropathic Allodynia and the Compound Action Potential in Primary Afferent C Fibers.J Neurosci. 2020 Jan 8;40(2):283-296. doi: 10.1523/JNEUROSCI.0181-19.2019. Epub 2019 Nov 19.
199 miR-21-5p inhibits neuropathic pain development via directly targeting C-C motif ligand 1 and tissue inhibitor of metalloproteinase-3.J Cell Biochem. 2019 Oct;120(10):16614-16623. doi: 10.1002/jcb.28920. Epub 2019 Jun 3.
200 PiRNA-DQ541777 Contributes to Neuropathic Pain via Targeting Cdk5rap1.J Neurosci. 2019 Nov 6;39(45):9028-9039. doi: 10.1523/JNEUROSCI.1602-19.2019. Epub 2019 Sep 13.
201 Simvastatin Attenuates Neuropathic Pain by Inhibiting the RhoA/LIMK/Cofilin Pathway.Neurochem Res. 2016 Sep;41(9):2457-69. doi: 10.1007/s11064-016-1958-1. Epub 2016 May 23.
202 Essential roles of C-type lectin Mincle in induction of neuropathic pain in mice.Sci Rep. 2019 Jan 29;9(1):872. doi: 10.1038/s41598-018-37318-8.
203 Palmitoylation of -catenin promotes kinesin-mediated membrane trafficking of Na(v)1.6 in sensory neurons to promote neuropathic pain.Sci Signal. 2018 Mar 27;11(523):eaar4394. doi: 10.1126/scisignal.aar4394.
204 Pharmacological Blockade of Spinal CXCL3/CXCR2 Signaling by NVP CXCR2 20, a Selective CXCR2 Antagonist, Reduces Neuropathic Pain Following Peripheral Nerve Injury.Front Immunol. 2019 Sep 26;10:2198. doi: 10.3389/fimmu.2019.02198. eCollection 2019.
205 Schekwanglupaside C, a new lupane saponin from Schefflera kwangsiensis, is a potent activator of sarcoplasmic reticulum Ca(2+)-ATPase.Fitoterapia. 2019 Sep;137:104150. doi: 10.1016/j.fitote.2019.04.005. Epub 2019 Apr 14.
206 TNFR2 promotes Treg-mediated recovery from neuropathic pain across sexes.Proc Natl Acad Sci U S A. 2019 Aug 20;116(34):17045-17050. doi: 10.1073/pnas.1902091116. Epub 2019 Aug 7.
207 Spinal TNF- impedes Fbxo45-dependent Munc13-1 ubiquitination to mediate neuropathic allodynia in rats.Cell Death Dis. 2018 Jul 24;9(8):811. doi: 10.1038/s41419-018-0859-4.
208 Increased Expression of Fibronectin Leucine-Rich Transmembrane Protein 3 in the Dorsal Root Ganglion Induces Neuropathic Pain in Rats.J Neurosci. 2019 Sep 18;39(38):7615-7627. doi: 10.1523/JNEUROSCI.0295-19.2019. Epub 2019 Jul 25.
209 Blockade of anoctamin-1 in injured and uninjured nerves reduces neuropathic pain.Brain Res. 2018 Oct 1;1696:38-48. doi: 10.1016/j.brainres.2018.06.001. Epub 2018 Jun 2.
210 Levo-corydalmine Attenuates Vincristine-Induced Neuropathic Pain in Mice by Upregulating the Nrf2/HO-1/CO Pathway to Inhibit Connexin 43 Expression.Neurotherapeutics. 2020 Jan;17(1):340-355. doi: 10.1007/s13311-019-00784-7.
211 Decrease of growth and differentiation factor 10 contributes to neuropathic pain through N-methyl-D-aspartate receptor activation.Neuroreport. 2017 May 24;28(8):444-450. doi: 10.1097/WNR.0000000000000785.
212 Pharmacological characterization and gene expression profiling of an L5/L6 spinal nerve ligation model for neuropathic pain in mice.Neuroscience. 2008 May 2;153(2):492-500. doi: 10.1016/j.neuroscience.2008.02.031. Epub 2008 Feb 29.
213 A genome-wide association study suggests an association of Chr8p21.3 (GFRA2) with diabetic neuropathic pain.Eur J Pain. 2015 Mar;19(3):392-9. doi: 10.1002/ejp.560.
214 Identification of candidate genes and miRNAs associated with neuropathic pain induced by spared nerve injury.Int J Mol Med. 2019 Oct;44(4):1205-1218. doi: 10.3892/ijmm.2019.4305. Epub 2019 Aug 6.
215 Effect of NIR laser therapy by MLS-MiS source against neuropathic pain in rats: in vivo and ex vivo analysis.Sci Rep. 2019 Jun 26;9(1):9297. doi: 10.1038/s41598-019-45469-5.
216 HCN3 ion channels: roles in sensory neuronal excitability and pain.J Physiol. 2019 Sep;597(17):4661-4675. doi: 10.1113/JP278211. Epub 2019 Jul 27.
217 Inhibition of the protein kinase IKKepsilon attenuates neuropathic pain in mice.Neuropharmacology. 2019 Mar 1;146:198-211. doi: 10.1016/j.neuropharm.2018.12.004. Epub 2018 Dec 6.
218 Pregabalin on Hdac2 and Inpp5f levels in rats with CCI-induced neuropathic pain.Exp Ther Med. 2019 Feb;17(2):1300-1305. doi: 10.3892/etm.2018.7037. Epub 2018 Nov 30.
219 Recent advance and possible future in TREK-2: a two-pore potassium channel may involved in the process of NPP, brain ischemia and memory impairment.Med Hypotheses. 2008;70(3):618-24. doi: 10.1016/j.mehy.2007.06.016. Epub 2007 Aug 6.
220 Amygdaloid administration of tetrapentylammonium attenuates development of pain and anxiety-like behavior following peripheral nerve injury.Pharmacol Rep. 2019 Feb;71(1):54-60. doi: 10.1016/j.pharep.2018.08.005. Epub 2018 Aug 17.
221 Mice lacking Kcns1 in peripheral neurons show increased basal and neuropathic pain sensitivity.Pain. 2018 Aug;159(8):1641-1651. doi: 10.1097/j.pain.0000000000001255.
222 KIF2A characterization after spinal cord injury.Cell Mol Life Sci. 2019 Nov;76(21):4355-4368. doi: 10.1007/s00018-019-03116-2. Epub 2019 Apr 30.
223 Relief from neuropathic pain by blocking of the platelet-activating factor-pain loop.FASEB J. 2017 Jul;31(7):2973-2980. doi: 10.1096/fj.201601183R. Epub 2017 Mar 24.
224 Neuropathic pain inhibitor, RAP-103, is a potent inhibitor of microglial CCL1/CCR8.Neurochem Int. 2018 Oct;119:184-189. doi: 10.1016/j.neuint.2017.12.005. Epub 2017 Dec 14.
225 Transcription factor MafB contributes to the activation of spinal microglia underlying neuropathic pain development.Glia. 2019 Apr;67(4):729-740. doi: 10.1002/glia.23570. Epub 2018 Nov 28.
226 Effects of miR-26a-5p on neuropathic pain development by targeting MAPK6 in in CCI rat models.Biomed Pharmacother. 2018 Nov;107:644-649. doi: 10.1016/j.biopha.2018.08.005. Epub 2018 Aug 15.
227 A double-blind, randomized, comparative study of the use of a combination of uridine triphosphate trisodium, cytidine monophosphate disodium, and hydroxocobalamin, versus isolated treatment with hydroxocobalamin, in patients presenting with compressive neuralgias.J Pain Res. 2017 Feb 15;10:397-404. doi: 10.2147/JPR.S123045. eCollection 2017.
228 MBD1 Contributes to the Genesis of Acute Pain and Neuropathic Pain by Epigenetic Silencing of Oprm1 and Kcna2 Genes in Primary Sensory Neurons.J Neurosci. 2018 Nov 14;38(46):9883-9899. doi: 10.1523/JNEUROSCI.0880-18.2018. Epub 2018 Sep 28.
229 Activation of the Intrinsic Pain Inhibitory Circuit from the Midcingulate Cg2 to Zona Incerta Alleviates Neuropathic Pain.J Neurosci. 2019 Nov 13;39(46):9130-9144. doi: 10.1523/JNEUROSCI.1683-19.2019. Epub 2019 Oct 11.
230 Regulation of -opioid type 1 receptors by microRNA134 in dorsal root ganglion neurons following peripheral inflammation.Eur J Pain. 2013 Mar;17(3):313-23. doi: 10.1002/j.1532-2149.2012.00197.x. Epub 2012 Aug 3.
231 Mixed-methods development of a new patient-reported outcome instrument for chronic low back pain: part 1-the Patient Assessment for Low Back Pain - Symptoms (PAL-S).Pain. 2018 Jun;159(6):1045-1055. doi: 10.1097/j.pain.0000000000001187.
232 Heat-shock protein 90 (Hsp90) promotes opioid-induced anti-nociception by an ERK mitogen-activated protein kinase (MAPK) mechanism in mouse brain.J Biol Chem. 2017 Jun 23;292(25):10414-10428. doi: 10.1074/jbc.M116.769489. Epub 2017 Apr 27.
233 Identification of a G protein-coupled receptor specifically responsive to beta-alanine.J Biol Chem. 2004 May 28;279(22):23559-64. doi: 10.1074/jbc.M314240200. Epub 2004 Mar 22.
234 MZF1 in the Dorsal Root Ganglia Contributes to the Development and Maintenance of Neuropathic Pain via Regulation of TRPV1.Neural Plast. 2019 Sep 8;2019:2782417. doi: 10.1155/2019/2782417. eCollection 2019.
235 Suppression of Pax2 Attenuates Allodynia and Hyperalgesia through ET-1-ETAR-NFAT5 Signaling in a Rat Model of Neuropathic Pain.Neuroscience. 2018 Aug 1;384:139-151. doi: 10.1016/j.neuroscience.2018.05.024. Epub 2018 May 27.
236 Selectivity profiling of NOP, MOP, DOP and KOP receptor antagonists in the rat spinal nerve ligation model of mononeuropathic pain.Eur J Pharmacol. 2018 May 15;827:41-48. doi: 10.1016/j.ejphar.2018.03.008. Epub 2018 Mar 8.
237 Environmental enrichment improves pain sensitivity, depression-like phenotype, and memory deficit in mice with neuropathic pain: role of NPAS4.Psychopharmacology (Berl). 2019 Jul;236(7):1999-2014. doi: 10.1007/s00213-019-5187-6. Epub 2019 Feb 23.
238 Schwann cell overexpression of the GPR7 receptor in inflammatory and painful neuropathies.Mol Cell Neurosci. 2005 Jan;28(1):55-63. doi: 10.1016/j.mcn.2004.08.010.
239 Cannabinoids in Pain Management and Palliative Medicine.Dtsch Arztebl Int. 2017 Sep 22;114(38):627-634. doi: 10.3238/arztebl.2017.0627.
240 Hematopoietic pannexin 1 function is critical for neuropathic pain.Sci Rep. 2017 Feb 14;7:42550. doi: 10.1038/srep42550.
241 Genome-wide association study identifies genes associated with neuropathy in patients with head and neck cancer.Sci Rep. 2018 Jun 8;8(1):8789. doi: 10.1038/s41598-018-27070-4.
242 Overexpression of -Opioid Receptors in Peripheral Afferents, but Not in Combination with Enkephalin, Decreases Neuropathic Pain Behavior and Enhances Opioid Analgesia in Mouse.Anesthesiology. 2018 May;128(5):967-983. doi: 10.1097/ALN.0000000000002063.
243 HYP-17, a novel voltage-gated sodium channel blocker, relieves inflammatory and neuropathic pain in rats.Pharmacol Biochem Behav. 2017 Feb;153:116-129. doi: 10.1016/j.pbb.2016.12.013. Epub 2016 Dec 24.
244 Phospholipase C{beta}3 in mouse and human dorsal root ganglia and spinal cord is a possible target for treatment of neuropathic pain.Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):20004-8. doi: 10.1073/pnas.0810899105. Epub 2008 Dec 9.
245 A Novel Autoantibody against Plexin D1 in Patients with Neuropathic Pain.Ann Neurol. 2018 Aug;84(2):208-224. doi: 10.1002/ana.25279. Epub 2018 Sep 3.
246 The Prokineticins: Neuromodulators and Mediators of Inflammation and Myeloid Cell-Dependent Angiogenesis.Physiol Rev. 2018 Apr 1;98(2):1055-1082. doi: 10.1152/physrev.00012.2017.
247 Neuropathic Pain Creates an Enduring Prefrontal Cortex Dysfunction Corrected by the Type II Diabetic Drug Metformin But Not by Gabapentin.J Neurosci. 2018 Aug 15;38(33):7337-7350. doi: 10.1523/JNEUROSCI.0713-18.2018. Epub 2018 Jul 20.
248 Melatonin Suppresses Neuropathic Pain via MT2-Dependent and -Independent Pathways in Dorsal Root Ganglia Neurons of Mice.Theranostics. 2017 May 12;7(7):2015-2032. doi: 10.7150/thno.19500. eCollection 2017.
249 Sertraline, chlorprothixene, and chlorpromazine characteristically interact with the REST-binding site of the corepressor mSin3, showing medulloblastoma cell growth inhibitory activities.Sci Rep. 2018 Sep 13;8(1):13763. doi: 10.1038/s41598-018-31852-1.
250 Regulator of G Protein Signaling 10 (Rgs10) Expression Is Transcriptionally Silenced in Activated Microglia by Histone Deacetylase Activity.Mol Pharmacol. 2017 Mar;91(3):197-207. doi: 10.1124/mol.116.106963. Epub 2016 Dec 28.
251 Inflammation-associated regulation of RGS in astrocytes and putative implication in neuropathic pain.J Neuroinflammation. 2017 Oct 27;14(1):209. doi: 10.1186/s12974-017-0971-x.
252 RGS9-2 Modulates Responses to Oxycodone in Pain-Free and Chronic Pain States.Neuropsychopharmacology. 2017 Jun;42(7):1548-1556. doi: 10.1038/npp.2017.4. Epub 2017 Jan 11.
253 Pro-resolving mediator maresin 1 ameliorates pain hypersensitivity in a rat spinal nerve ligation model of neuropathic pain.J Pain Res. 2018 Aug 10;11:1511-1519. doi: 10.2147/JPR.S160779. eCollection 2018.
254 Ryk receptors on unmyelinated nerve fibers mediate excitatory synaptic transmission and CCL2 release during neuropathic pain induced by peripheral nerve injury.Mol Pain. 2017 Jan-Dec;13:1744806917709372. doi: 10.1177/1744806917709372.
255 Long non-coding RNA CCAT1 modulates neuropathic pain progression through sponging miR-155.Oncotarget. 2017 Sep 23;8(52):89949-89957. doi: 10.18632/oncotarget.21192. eCollection 2017 Oct 27.
256 LncRNA NONRATT021972 Was Associated with Neuropathic Pain Scoring in Patients with Type 2 Diabetes.Behav Neurol. 2017;2017:2941297. doi: 10.1155/2017/2941297. Epub 2017 Aug 8.
257 A Novel Mu-Delta Opioid Agonist Demonstrates Enhanced Efficacy With Reduced Tolerance and Dependence in Mouse Neuropathic Pain Models.J Pain. 2020 Jan-Feb;21(1-2):146-160. doi: 10.1016/j.jpain.2019.05.017. Epub 2019 Jun 12.
258 Pyrrolinone derivatives as a new class of P2X3 receptor antagonists Part 2: Discovery of orally bioavailable compounds.Bioorg Med Chem Lett. 2019 Mar 1;29(5):688-693. doi: 10.1016/j.bmcl.2019.01.039. Epub 2019 Feb 1.
259 Synthesis and biological evaluation of pyrrolidine-based T-type calcium channel inhibitors for the treatment of neuropathic pain.J Enzyme Inhib Med Chem. 2018 Dec;33(1):1460-1471. doi: 10.1080/14756366.2018.1513926.
260 Dynamic pain connectome functional connectivity and oscillations reflect multiple sclerosis pain.Pain. 2018 Nov;159(11):2267-2276. doi: 10.1097/j.pain.0000000000001332.
261 Involvement of substance P in the antinociceptive effect of botulinum toxin type A: Evidence from knockout mice.Neuroscience. 2017 Sep 1;358:137-145. doi: 10.1016/j.neuroscience.2017.06.040. Epub 2017 Jul 1.
262 Inhibition of miR-200b/miR-429 contributes to neuropathic pain development through targeting zinc finger E box binding protein-1.J Cell Physiol. 2018 Jun;233(6):4815-4824. doi: 10.1002/jcp.26284. Epub 2018 Jan 15.
263 TET1 Overexpression Mitigates Neuropathic Pain Through Rescuing the Expression of -Opioid Receptor and Kv1.2 in the Primary Sensory Neurons.Neurotherapeutics. 2019 Apr;16(2):491-504. doi: 10.1007/s13311-018-00689-x.
264 Direct, gabapentin-insensitive interaction of a soluble form of the calcium channel subunit (2)-1 with thrombospondin-4.Sci Rep. 2019 Nov 7;9(1):16272. doi: 10.1038/s41598-019-52655-y.
265 Effects of XIST/miR-137 axis on neuropathic pain by targeting TNFAIP1 in a rat model.J Cell Physiol. 2018 May;233(5):4307-4316. doi: 10.1002/jcp.26254. Epub 2017 Dec 26.
266 Translocation Associated Membrane Protein 1 Contributes to Chronic Constriction Injury-Induced Neuropathic Pain in the Dorsal Root Ganglion and Spinal Cord in Rats.J Mol Neurosci. 2018 Dec;66(4):535-546. doi: 10.1007/s12031-018-1187-y. Epub 2018 Oct 18.
267 Peripheral demyelination and neuropathic pain behavior in periaxin-deficient mice. Neuron. 2000 May;26(2):523-31. doi: 10.1016/s0896-6273(00)81184-8.