General Information of Drug Combination (ID: DC04PH7)

Drug Combination Name
Crizotinib Plicamycin
Indication
Disease Entry Status REF
Plasma cell myeloma Investigative [1]
Component Drugs Crizotinib   DM4F29C Plicamycin   DM7C8YV
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL is unavailable
High-throughput Screening Result Testing Cell Line: RPMI-8226
Zero Interaction Potency (ZIP) Score: 37.1
Bliss Independence Score: 35.83
Loewe Additivity Score: 32.38
LHighest Single Agent (HSA) Score: 29.75

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Crizotinib
Disease Entry ICD 11 Status REF
Non-small-cell lung cancer 2C25.Y Approved [2]
Crizotinib Interacts with 4 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Proto-oncogene c-Met (MET) TTNDSF4 MET_HUMAN Modulator [3]
ALK tyrosine kinase receptor (ALK) TTPMQSO ALK_HUMAN Modulator [3]
Proto-oncogene c-Ros (ROS1) TTSZ6Y3 ROS1_HUMAN Modulator [3]
HGF/Met signaling pathway (HGF/Met pathway) TTKA5LP NOUNIPROTAC Inhibitor [9]
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Crizotinib Interacts with 3 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [10]
Organic anion transporting polypeptide 1B1 (SLCO1B1) DT3D8F0 SO1B1_HUMAN Substrate [11]
Organic anion transporting polypeptide 1B3 (SLCO1B3) DT9C1TS SO1B3_HUMAN Substrate [11]
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Crizotinib Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [12]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Metabolism [12]
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Crizotinib Interacts with 45 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Increases Expression [13]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Decreases Activity [14]
Hepatocyte growth factor receptor (MET) OT7K55MU MET_HUMAN Increases Response To Substance [7]
ALK tyrosine kinase receptor (ALK) OTV3P4V8 ALK_HUMAN Decreases Response To Substance [15]
Prominin-1 (PROM1) OTBHV8NX PROM1_HUMAN Decreases Expression [6]
CD44 antigen (CD44) OT9TTJ41 CD44_HUMAN Decreases Expression [6]
Epithelial cell adhesion molecule (EPCAM) OTHBZK5X EPCAM_HUMAN Decreases Expression [6]
Cytidine deaminase (CDA) OT3HXP6N CDD_HUMAN Decreases Expression [6]
Insulin-induced gene 1 protein (INSIG1) OTZF5X1D INSI1_HUMAN Increases Expression [16]
Acyl-CoA 6-desaturase (FADS2) OTUX531P FADS2_HUMAN Increases Expression [16]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) OTRT3F3U HMDH_HUMAN Increases Expression [16]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Activity [16]
Fatty acid synthase (FASN) OTFII9KG FAS_HUMAN Increases Expression [16]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Increases Activity [16]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1) OTCO26FV HMCS1_HUMAN Increases Expression [16]
Sterol regulatory element-binding protein 2 (SREBF2) OTBXUNPL SRBP2_HUMAN Increases Expression [16]
Potassium voltage-gated channel subfamily H member 2 (KCNH2) OTZX881H KCNH2_HUMAN Decreases Activity [16]
Acetyl-CoA carboxylase 1 (ACACA) OT5CQPZY ACACA_HUMAN Increases Phosphorylation [16]
Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C) OT6KFNMS CAC1C_HUMAN Decreases Activity [16]
Sodium channel protein type 5 subunit alpha (SCN5A) OTGYZWR6 SCN5A_HUMAN Decreases Activity [16]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [7]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Increases Expression [7]
Follitropin subunit beta (FSHB) OTGLS283 FSHB_HUMAN Decreases Secretion [17]
Lutropin subunit beta (LHB) OT5GBOVJ LSHB_HUMAN Decreases Secretion [17]
Tyrosine-protein kinase Lck (LCK) OT883FG9 LCK_HUMAN Decreases Activity [18]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [19]
Tissue factor (F3) OT3MSU3B TF_HUMAN Increases Expression [20]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Increases Phosphorylation [19]
Alanine aminotransferase 1 (GPT) OTOXOA0Q ALAT1_HUMAN Increases Secretion [21]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Phosphorylation [22]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Decreases Phosphorylation [22]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Decreases Phosphorylation [23]
Signal transducer and activator of transcription 3 (STAT3) OTAAGKYZ STAT3_HUMAN Decreases Phosphorylation [24]
Ras GTPase-activating-like protein IQGAP1 (IQGAP1) OTZRWTGA IQGA1_HUMAN Decreases Phosphorylation [25]
Small ribosomal subunit protein eS6 (RPS6) OTT4D1LN RS6_HUMAN Decreases Phosphorylation [24]
Baculoviral IAP repeat-containing protein 2 (BIRC2) OTFXFREP BIRC2_HUMAN Decreases Expression [7]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Increases Cleavage [26]
Echinoderm microtubule-associated protein-like 4 (EML4) OTJC45TA EMAL4_HUMAN Increases Mutagenesis [22]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Decreases Activity [14]
GTPase KRas (KRAS) OT78QCN8 RASK_HUMAN Decreases Response To Substance [27]
Pro-epidermal growth factor (EGF) OTANRJ0L EGF_HUMAN Decreases Response To Substance [23]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Decreases Response To Substance [27]
Mast/stem cell growth factor receptor Kit (KIT) OTHUY3VZ KIT_HUMAN Decreases Response To Substance [15]
Proheparin-binding EGF-like growth factor (HBEGF) OTLU00JS HBEGF_HUMAN Decreases Response To Substance [23]
Protransforming growth factor alpha (TGFA) OTPD1LL9 TGFA_HUMAN Decreases Response To Substance [23]
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⏷ Show the Full List of 45 DOT(s)
Indication(s) of Plicamycin
Disease Entry ICD 11 Status REF
Hypercalcaemia 5B91.0 Approved [3]
Testicular cancer 2C80 Approved [3]
Solid tumour/cancer 2A00-2F9Z Withdrawn from market [4]
Lung cancer 2C25.0 Investigative [5]
Ovarian cancer 2C73 Investigative [5]
Plicamycin Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
RNA synthesis (hRNA synth) TTX2AYW NOUNIPROTAC Modulator [29]
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Plicamycin Interacts with 16 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
17-beta-hydroxysteroid dehydrogenase type 2 (HSD17B2) OT3K7HY5 DHB2_HUMAN Decreases Expression [30]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Decreases Expression [31]
Aryl hydrocarbon receptor (AHR) OTFE4EYE AHR_HUMAN Decreases Expression [31]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Decreases Expression [31]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [32]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Activity [32]
Epoxide hydrolase 1 (EPHX1) OTBKWQER HYEP_HUMAN Decreases Expression [33]
Transcription factor Sp1 (SP1) OTISPT4X SP1_HUMAN Decreases Expression [28]
Proto-oncogene tyrosine-protein kinase Src (SRC) OTETYX40 SRC_HUMAN Decreases Expression [34]
Tissue factor (F3) OT3MSU3B TF_HUMAN Decreases Expression [35]
Tyrosine-protein kinase receptor UFO (AXL) OTKA2SUX UFO_HUMAN Decreases Expression [36]
Transcription factor Sp3 (SP3) OTYDQZ1T SP3_HUMAN Decreases Expression [28]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Decreases Expression [37]
Epidermal growth factor receptor kinase substrate 8 (EPS8) OTZ6ES6V EPS8_HUMAN Decreases Expression [34]
TNFAIP3-interacting protein 1 (TNIP1) OTRAOTEW TNIP1_HUMAN Decreases Expression [38]
Sphingomyelin phosphodiesterase 3 (SMPD3) OTHQBETH NSMA2_HUMAN Decreases Expression [39]
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⏷ Show the Full List of 16 DOT(s)

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Adenocarcinoma DCXM143 DU-145 Investigative [1]
Adenocarcinoma DCKV3NM OVCAR3 Investigative [1]
Adenocarcinoma DCPVFAH HCT116 Investigative [1]
Adenocarcinoma DC55L55 HCC-2998 Investigative [1]
Adult T acute lymphoblastic leukemia DCHPEDV MOLT-4 Investigative [1]
Amelanotic melanoma DCOS0DF MDA-MB-435 Investigative [1]
Amelanotic melanoma DCR0DAO M14 Investigative [1]
Anaplastic large cell lymphoma DC9WV79 SR Investigative [1]
Astrocytoma DCUHW44 U251 Investigative [1]
Astrocytoma DCT9OYY SNB-19 Investigative [1]
Childhood T acute lymphoblastic leukemia DCG16DE CCRF-CEM Investigative [1]
Chronic myelogenous leukemia DCHQMJ6 K-562 Investigative [1]
Clear cell renal cell carcinoma DC1J8QM A498 Investigative [1]
Clear cell renal cell carcinoma DC8E6WP 786-0 Investigative [1]
Clear cell renal cell carcinoma DCJUB8I TK-10 Investigative [1]
Clear cell renal cell carcinoma DC8HPW1 CAKI-1 Investigative [1]
Cutaneous melanoma DCIZ3GN SK-MEL-28 Investigative [1]
Cutaneous melanoma DC1Y6RV SK-MEL-5 Investigative [1]
Glioblastoma DCVPUYT SNB-75 Investigative [1]
Glioma DC90BL6 SF-295 Investigative [1]
Glioma DC8VIJI SF-268 Investigative [1]
Glioma DCSUDOW SF-539 Investigative [1]
High grade ovarian serous adenocarcinoma DC55RQG OVCAR-8 Investigative [1]
High grade ovarian serous adenocarcinoma DCWC2L6 OVCAR-5 Investigative [1]
Large cell lung carcinoma DCNOP70 NCI-H460 Investigative [1]
Lung adenocarcinoma DCTCN6L HOP-62 Investigative [1]
Lung adenocarcinoma DCIUPRB EKVX Investigative [1]
Malignant melanoma DCLJEUD UACC62 Investigative [1]
Melanoma DCLS8EE MALME-3M Investigative [1]
Melanoma DCZUU50 UACC-257 Investigative [1]
Minimally invasive lung adenocarcinoma DC9MK6R NCI-H322M Investigative [1]
Mixed endometrioid and clear cell carcinoma DCEX8AR IGROV1 Investigative [1]
Ovarian serous cystadenocarcinoma DC3MRU4 SK-OV-3 Investigative [1]
Papillary renal cell carcinoma DC85ME0 ACHN Investigative [1]
Pleural epithelioid mesothelioma DCWMO3L NCI-H226 Investigative [1]
Renal cell carcinoma DCJ3GO6 UO-31 Investigative [1]
Renal cell carcinoma DC7JS5M SN12C Investigative [1]
Breast adenocarcinoma DCNAOT2 MDA-MB-468 Investigative [40]
Carcinoma DC8E6GH RXF 393 Investigative [40]
Carcinoma DCIGX4H MCF7 Investigative [40]
Colon adenocarcinoma DCZ73OY COLO 205 Investigative [40]
Colon carcinoma DCVCNVM KM12 Investigative [40]
Invasive ductal carcinoma DCQ3VUC HS 578T Investigative [40]
Invasive ductal carcinoma DCTE2BZ BT-549 Investigative [40]
Invasive ductal carcinoma DCBOZI7 T-47D Investigative [40]
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⏷ Show the Full List of 45 DrugCom(s)

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