Details of the Drug Combination

General Information of Drug Combination (ID: DCG3XGK)

• Drug Combination Name: Crizotinib + Fulvestrant
• Indication: Astrocytoma; Status: Investigative [1]
• Component Drugs:
  Crizotinib (DM4F29C): Small molecular drug
  Fulvestrant (DM0YZC6): Small molecular drug
• High-throughput Screening Result:
  Testing Cell Line: U251
  Zero Interaction Potency (ZIP) Score: 5.54
  Bliss Independence Score: 0.89
  Loewe Additivity Score: 1
  LHighest Single Agent (HSA) Score: 0.72

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Crizotinib

Disease Entry	ICD 11	Status	REF
Non-small-cell lung cancer	2C25.Y	Approved	[2]

Crizotinib Interacts with 4 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Proto-oncogene c-Met (MET)	TTNDSF4	MET_HUMAN	Modulator	[7]
ALK tyrosine kinase receptor (ALK)	TTPMQSO	ALK_HUMAN	Modulator	[7]
Proto-oncogene c-Ros (ROS1)	TTSZ6Y3	ROS1_HUMAN	Modulator	[7]
HGF/Met signaling pathway (HGF/Met pathway)	TTKA5LP	NOUNIPROTAC	Inhibitor	[8]

Crizotinib Interacts with 3 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[9]
Organic anion transporting polypeptide 1B1 (SLCO1B1)	DT3D8F0	SO1B1_HUMAN	Substrate	[10]
Organic anion transporting polypeptide 1B3 (SLCO1B3)	DT9C1TS	SO1B3_HUMAN	Substrate	[10]

Crizotinib Interacts with 2 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[11]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Metabolism	[11]

Crizotinib Interacts with 45 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Increases Expression	[12]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Decreases Activity	[13]
Hepatocyte growth factor receptor (MET)	OT7K55MU	MET_HUMAN	Increases Response To Substance	[5]
ALK tyrosine kinase receptor (ALK)	OTV3P4V8	ALK_HUMAN	Decreases Response To Substance	[14]
Prominin-1 (PROM1)	OTBHV8NX	PROM1_HUMAN	Decreases Expression	[4]
CD44 antigen (CD44)	OT9TTJ41	CD44_HUMAN	Decreases Expression	[4]
Epithelial cell adhesion molecule (EPCAM)	OTHBZK5X	EPCAM_HUMAN	Decreases Expression	[4]
Cytidine deaminase (CDA)	OT3HXP6N	CDD_HUMAN	Decreases Expression	[4]
Insulin-induced gene 1 protein (INSIG1)	OTZF5X1D	INSI1_HUMAN	Increases Expression	[15]
Acyl-CoA 6-desaturase (FADS2)	OTUX531P	FADS2_HUMAN	Increases Expression	[15]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)	OTRT3F3U	HMDH_HUMAN	Increases Expression	[15]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Increases Activity	[15]
Fatty acid synthase (FASN)	OTFII9KG	FAS_HUMAN	Increases Expression	[15]
Caspase-7 (CASP7)	OTAPJ040	CASP7_HUMAN	Increases Activity	[15]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)	OTCO26FV	HMCS1_HUMAN	Increases Expression	[15]
Sterol regulatory element-binding protein 2 (SREBF2)	OTBXUNPL	SRBP2_HUMAN	Increases Expression	[15]
Potassium voltage-gated channel subfamily H member 2 (KCNH2)	OTZX881H	KCNH2_HUMAN	Decreases Activity	[15]
Acetyl-CoA carboxylase 1 (ACACA)	OT5CQPZY	ACACA_HUMAN	Increases Phosphorylation	[15]
Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C)	OT6KFNMS	CAC1C_HUMAN	Decreases Activity	[15]
Sodium channel protein type 5 subunit alpha (SCN5A)	OTGYZWR6	SCN5A_HUMAN	Decreases Activity	[15]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Decreases Expression	[5]
Bcl-2-like protein 11 (BCL2L11)	OTNQQWFJ	B2L11_HUMAN	Increases Expression	[5]
Follitropin subunit beta (FSHB)	OTGLS283	FSHB_HUMAN	Decreases Secretion	[16]
Lutropin subunit beta (LHB)	OT5GBOVJ	LSHB_HUMAN	Decreases Secretion	[16]
Tyrosine-protein kinase Lck (LCK)	OT883FG9	LCK_HUMAN	Decreases Activity	[17]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Increases Cleavage	[18]
Tissue factor (F3)	OT3MSU3B	TF_HUMAN	Increases Expression	[19]
Histone H2AX (H2AX)	OT18UX57	H2AX_HUMAN	Increases Phosphorylation	[18]
Alanine aminotransferase 1 (GPT)	OTOXOA0Q	ALAT1_HUMAN	Increases Secretion	[20]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Decreases Phosphorylation	[21]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Decreases Phosphorylation	[21]
RAC-alpha serine/threonine-protein kinase (AKT1)	OT8H2YY7	AKT1_HUMAN	Decreases Phosphorylation	[22]
Signal transducer and activator of transcription 3 (STAT3)	OTAAGKYZ	STAT3_HUMAN	Decreases Phosphorylation	[23]
Ras GTPase-activating-like protein IQGAP1 (IQGAP1)	OTZRWTGA	IQGA1_HUMAN	Decreases Phosphorylation	[24]
Small ribosomal subunit protein eS6 (RPS6)	OTT4D1LN	RS6_HUMAN	Decreases Phosphorylation	[23]
Baculoviral IAP repeat-containing protein 2 (BIRC2)	OTFXFREP	BIRC2_HUMAN	Decreases Expression	[5]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Increases Cleavage	[25]
Echinoderm microtubule-associated protein-like 4 (EML4)	OTJC45TA	EMAL4_HUMAN	Increases Mutagenesis	[21]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)	OTW8V2V1	ABCG2_HUMAN	Decreases Activity	[13]
GTPase KRas (KRAS)	OT78QCN8	RASK_HUMAN	Decreases Response To Substance	[26]
Pro-epidermal growth factor (EGF)	OTANRJ0L	EGF_HUMAN	Decreases Response To Substance	[22]
Epidermal growth factor receptor (EGFR)	OTAPLO1S	EGFR_HUMAN	Decreases Response To Substance	[26]
Mast/stem cell growth factor receptor Kit (KIT)	OTHUY3VZ	KIT_HUMAN	Decreases Response To Substance	[14]
Proheparin-binding EGF-like growth factor (HBEGF)	OTLU00JS	HBEGF_HUMAN	Decreases Response To Substance	[22]
Protransforming growth factor alpha (TGFA)	OTPD1LL9	TGFA_HUMAN	Decreases Response To Substance	[22]

Indication(s) of Fulvestrant

Disease Entry	ICD 11	Status	REF
Breast cancer	2C60-2C65	Approved	[3]

Fulvestrant Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Estrogen receptor (ESR)	TTZAYWL	ESR1_HUMAN	Antagonist	[35]

Fulvestrant Interacts with 2 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[36]
UDP-glucuronosyltransferase 1A1 (UGT1A1)	DEYGVN4	UD11_HUMAN	Metabolism	[37]

Fulvestrant Interacts with 985 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Superoxide dismutase (SOD1)	OT39TA1L	SODC_HUMAN	Increases Expression	[28]
Transferrin receptor protein 1 (TFRC)	OT8ZPBDL	TFR1_HUMAN	Increases Expression	[28]
Transcription factor Jun (JUN)	OTCYBO6X	JUN_HUMAN	Increases Expression	[28]
Integrin beta-1 (ITGB1)	OT6G1IAR	ITB1_HUMAN	Increases Expression	[28]
Macrophage colony-stimulating factor 1 (CSF1)	OT68M7RD	CSF1_HUMAN	Increases Expression	[28]
DNA topoisomerase 2-alpha (TOP2A)	OT6LPS08	TOP2A_HUMAN	Increases Expression	[28]
C-C motif chemokine 5 (CCL5)	OTSCA5CK	CCL5_HUMAN	Increases Expression	[28]
G2/mitotic-specific cyclin-B1 (CCNB1)	OT19S7E5	CCNB1_HUMAN	Increases Expression	[28]
Ephrin type-A receptor 1 (EPHA1)	OTGJMRZ0	EPHA1_HUMAN	Increases Expression	[28]
Proteinase-activated receptor 1 (F2R)	OT4WVWBO	PAR1_HUMAN	Increases Expression	[28]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Increases Expression	[28]
Caspase-4 (CASP4)	OTVQTV1L	CASP4_HUMAN	Increases Expression	[28]
Dual specificity protein kinase CLK1 (CLK1)	OTG1LACW	CLK1_HUMAN	Increases Expression	[28]
Ras-related protein Rab-2A (RAB2A)	OT6SK83U	RAB2A_HUMAN	Increases Expression	[28]
CCHC-type zinc finger nucleic acid binding protein (CNBP)	OTTGM9NK	CNBP_HUMAN	Increases Expression	[28]
Dynein light chain 1, cytoplasmic (DYNLL1)	OTR69LHT	DYL1_HUMAN	Increases Expression	[28]
Paired box protein Pax-5 (PAX5)	OTYBJJWX	PAX5_HUMAN	Increases Expression	[28]
GA-binding protein alpha chain (GABPA)	OT9YB2SA	GABPA_HUMAN	Increases Expression	[28]
Mitogen-activated protein kinase kinase kinase 11 (MAP3K11)	OT0EYZAY	M3K11_HUMAN	Increases Expression	[28]
ATP-binding cassette sub-family C member 3 (ABCC3)	OTC3IJV4	MRP3_HUMAN	Increases Expression	[27]
ATP-binding cassette sub-family C member 5 (ABCC5)	OT34G4US	MRP5_HUMAN	Decreases Expression	[27]
Transforming acidic coiled-coil-containing protein 1 (TACC1)	OTGX20TE	TACC1_HUMAN	Increases Expression	[27]
Cystatin-A (CSTA)	OT1K68KE	CYTA_HUMAN	Decreases Expression	[27]
Protein c-Fos (FOS)	OTJBUVWS	FOS_HUMAN	Decreases Expression	[27]
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Decreases Expression	[27]
Receptor tyrosine-protein kinase erbB-2 (ERBB2)	OTOAUNCK	ERBB2_HUMAN	Increases Expression	[27]
Proliferating cell nuclear antigen (PCNA)	OTHZ1RIA	PCNA_HUMAN	Decreases Expression	[27]
Cyclin-A2 (CCNA2)	OTPHHYZJ	CCNA2_HUMAN	Decreases Expression	[27]
Ephrin-A1 (EFNA1)	OTU2NUA2	EFNA1_HUMAN	Increases Expression	[27]
Insulin-like growth factor-binding protein 4 (IGFBP4)	OT2HZRBD	IBP4_HUMAN	Decreases Expression	[27]
Insulin receptor substrate 1 (IRS1)	OTNO82CU	IRS1_HUMAN	Decreases Expression	[27]
CCN family member 3 (CCN3)	OTOW5YL4	CCN3_HUMAN	Increases Expression	[27]
Matrix metalloproteinase-15 (MMP15)	OT1XF517	MMP15_HUMAN	Increases Expression	[27]
Neprilysin (MME)	OT5Q39P8	NEP_HUMAN	Increases Expression	[38]
Interferon alpha-inducible protein 6 (IFI6)	OTWOOAM4	IFI6_HUMAN	Increases Expression	[38]
Amphiregulin (AREG)	OTJFOR67	AREG_HUMAN	Decreases Expression	[38]
Trefoil factor 3 (TFF3)	OTJJDRTU	TFF3_HUMAN	Decreases Expression	[38]
Interferon-related developmental regulator 1 (IFRD1)	OT4SQMLQ	IFRD1_HUMAN	Decreases Expression	[29]
26S proteasome non-ATPase regulatory subunit 14 (PSMD14)	OTJWHMZ5	PSDE_HUMAN	Decreases Expression	[29]
Aurora kinase A (AURKA)	OTMX0HYT	AURKA_HUMAN	Decreases Expression	[29]
Protein phosphatase 1D (PPM1D)	OT8NLZ9D	PPM1D_HUMAN	Decreases Expression	[29]
ATP-dependent RNA helicase DDX3Y (DDX3Y)	OTKL1FNX	DDX3Y_HUMAN	Decreases Expression	[29]
Asparagine--tRNA ligase, cytoplasmic (NARS1)	OTFS4J1W	SYNC_HUMAN	Decreases Expression	[29]
Trafficking kinesin-binding protein 2 (TRAK2)	OTXVA7FN	TRAK2_HUMAN	Decreases Expression	[29]
Calsyntenin-1 (CLSTN1)	OTQN35G2	CSTN1_HUMAN	Decreases Expression	[29]
Kinesin-like protein KIF20A (KIF20A)	OTXOQHE0	KI20A_HUMAN	Decreases Expression	[29]
Apolipoprotein D (APOD)	OTT77XW8	APOD_HUMAN	Increases Expression	[29]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)	OTM0GDTP	IF2A_HUMAN	Decreases Expression	[29]
Nucleophosmin (NPM1)	OTTBYYT0	NPM_HUMAN	Decreases Expression	[29]
Heat shock protein HSP 90-beta (HSP90AB1)	OTR69EG7	HS90B_HUMAN	Decreases Expression	[29]
Asparagine synthetase (ASNS)	OT8R922G	ASNS_HUMAN	Decreases Expression	[29]
Matrix Gla protein (MGP)	OTZWU3FU	MGP_HUMAN	Decreases Expression	[29]
High mobility group protein B1 (HMGB1)	OT4B7CPF	HMGB1_HUMAN	Decreases Expression	[29]
Pro-cathepsin H (CTSH)	OTLFL0DG	CATH_HUMAN	Increases Expression	[29]
60 kDa heat shock protein, mitochondrial (HSPD1)	OTTO1Y11	CH60_HUMAN	Decreases Expression	[29]
Heat shock cognate 71 kDa protein (HSPA8)	OTJI2RCI	HSP7C_HUMAN	Decreases Expression	[29]
DNA topoisomerase 1 (TOP1)	OT51O0CF	TOP1_HUMAN	Decreases Expression	[29]
Endoplasmin (HSP90B1)	OT02XLBR	ENPL_HUMAN	Decreases Expression	[29]
Stathmin (STMN1)	OTDJ4RV0	STMN1_HUMAN	Decreases Expression	[29]
Protein SON (SON)	OT9VWV18	SON_HUMAN	Decreases Expression	[29]
Nucleolin (NCL)	OTBXPKMP	NUCL_HUMAN	Decreases Expression	[29]
Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1)	OTBZKX4P	ROA2_HUMAN	Decreases Expression	[29]
Nuclear receptor subfamily 4immunitygroup A member 1 (NR4A1)	OTGP6GA4	NR4A1_HUMAN	Increases Expression	[29]
Splicing factor, proline- and glutamine-rich (SFPQ)	OTLCIAPJ	SFPQ_HUMAN	Decreases Expression	[29]
Ribonucleoside-diphosphate reductase large subunit (RRM1)	OTXGQOR9	RIR1_HUMAN	Decreases Expression	[29]
Signal transducer CD24 (CD24)	OT7CODJ4	CD24_HUMAN	Increases Expression	[29]
Threonine--tRNA ligase 1, cytoplasmic (TARS1)	OT0PWST5	SYTC_HUMAN	Decreases Expression	[29]
DNA-directed RNA polymerase II subunit RPB2 (POLR2B)	OTS3F0H2	RPB2_HUMAN	Decreases Expression	[29]
Heterogeneous nuclear ribonucleoprotein H (HNRNPH1)	OTFRWOLM	HNRH1_HUMAN	Decreases Expression	[29]
Heat shock 70 kDa protein 4 (HSPA4)	OT5HR0AR	HSP74_HUMAN	Decreases Expression	[29]
Thrombospondin-2 (THBS2)	OTXET551	TSP2_HUMAN	Decreases Expression	[29]
Coatomer subunit beta' (COPB2)	OT82JIGC	COPB2_HUMAN	Decreases Expression	[29]
Lamina-associated polypeptide 2, isoform alpha (TMPO)	OTL68EL4	LAP2A_HUMAN	Decreases Expression	[29]
Signal transducer and activator of transcription 1-alpha/beta (STAT1)	OTLMBUZ6	STAT1_HUMAN	Decreases Expression	[29]
Matrin-3 (MATR3)	OTESJ5S7	MATR3_HUMAN	Decreases Expression	[29]
Ras GTPase-activating-like protein IQGAP1 (IQGAP1)	OTZRWTGA	IQGA1_HUMAN	Decreases Expression	[29]
Histone H3-like centromeric protein A (CENPA)	OT0NEJ4X	CENPA_HUMAN	Decreases Expression	[29]
Sulfate transporter (SLC26A2)	OTJNHNTO	S26A2_HUMAN	Decreases Expression	[29]
Importin subunit alpha-1 (KPNA2)	OTU7FOE6	IMA1_HUMAN	Decreases Expression	[29]
Eukaryotic translation initiation factor 5 (EIF5)	OT79PQUN	IF5_HUMAN	Decreases Expression	[29]
Ras-related protein Rap-1A (RAP1A)	OT5RH6TI	RAP1A_HUMAN	Decreases Expression	[29]
DNA-dependent protein kinase catalytic subunit (PRKDC)	OTJVS4EG	PRKDC_HUMAN	Decreases Expression	[29]
Chromobox protein homolog 1 (CBX1)	OT2L4XZX	CBX1_HUMAN	Decreases Expression	[29]
Heterogeneous nuclear ribonucleoprotein U (HNRNPU)	OTLQN1E2	HNRPU_HUMAN	Decreases Expression	[29]
Large ribosomal subunit protein eL6 (RPL6)	OTRU71O4	RL6_HUMAN	Decreases Expression	[29]
DNA topoisomerase 2-beta (TOP2B)	OTDHKQZ8	TOP2B_HUMAN	Decreases Expression	[29]
Serine/arginine-rich splicing factor 1 (SRSF1)	OTF61HOV	SRSF1_HUMAN	Decreases Expression	[29]
ATP-dependent RNA helicase A (DHX9)	OT5AAOQI	DHX9_HUMAN	Decreases Expression	[29]
Neuroblast differentiation-associated protein AHNAK (AHNAK)	OT6KH1WG	AHNK_HUMAN	Decreases Expression	[29]
Zinc transporter ZIP6 (SLC39A6)	OTCYF466	S39A6_HUMAN	Decreases Expression	[29]
Importin subunit beta-1 (KPNB1)	OTBT2HFL	IMB1_HUMAN	Decreases Expression	[29]
Proteasome activator complex subunit 4 (PSME4)	OTDGF53O	PSME4_HUMAN	Decreases Expression	[29]
Condensin complex subunit 2 (NCAPH)	OTXOS97C	CND2_HUMAN	Decreases Expression	[29]
PCNA-associated factor (PCLAF)	OTMVIOUU	PAF15_HUMAN	Decreases Expression	[29]
26S proteasome non-ATPase regulatory subunit 6 (PSMD6)	OTX59EGK	PSMD6_HUMAN	Decreases Expression	[29]
Elongin-B (ELOB)	OTZ3X84T	ELOB_HUMAN	Decreases Expression	[29]
Histone-binding protein RBBP7 (RBBP7)	OTLB56HX	RBBP7_HUMAN	Decreases Expression	[29]
Transcription initiation factor TFIID subunit 9 (TAF9)	OTCTH3C6	TAF9_HUMAN	Decreases Expression	[29]
Golgin subfamily A member 5 (GOLGA5)	OTG6HB6U	GOGA5_HUMAN	Decreases Expression	[29]
Transportin-1 (TNPO1)	OT7W2CM8	TNPO1_HUMAN	Decreases Expression	[29]
Dehydrodolichyl diphosphate synthase complex subunit NUS1 (NUS1)	OT4DQ82L	NGBR_HUMAN	Decreases Expression	[29]
UAP56-interacting factor (FYTTD1)	OTXXKQJR	UIF_HUMAN	Decreases Expression	[29]
Rac GTPase-activating protein 1 (RACGAP1)	OTQE8IEH	RGAP1_HUMAN	Decreases Expression	[29]
Protein ILRUN (ILRUN)	OTE8FHQD	ILRUN_HUMAN	Decreases Expression	[29]
Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2)	OTAQD3YV	ARNT2_HUMAN	Increases Expression	[29]
Nucleolar RNA helicase 2 (DDX21)	OTV73GMZ	DDX21_HUMAN	Decreases Expression	[29]
Very long chain fatty acid elongase 5 (ELOVL5)	OT375W1Z	ELOV5_HUMAN	Decreases Expression	[29]
Serine/threonine-protein kinase 26 (STK26)	OTW4QE0D	STK26_HUMAN	Decreases Expression	[29]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Increases Expression	[39]
Serine/threonine-protein kinase Sgk1 (SGK1)	OT301T1U	SGK1_HUMAN	Decreases Expression	[30]
Prostaglandin E synthase (PTGES)	OTB7YQFU	PTGES_HUMAN	Decreases Expression	[30]
E3 ubiquitin-protein ligase SIAH2 (SIAH2)	OTKED2XN	SIAH2_HUMAN	Decreases Expression	[30]
Carbonic anhydrase 12 (CA12)	OT6WNFU8	CAH12_HUMAN	Decreases Expression	[30]
Tyrosine-protein kinase JAK2 (JAK2)	OTBIDOOR	JAK2_HUMAN	Decreases Expression	[30]
monooxygenase MICAL2 (MICAL2)	OT04OQQJ	MICA2_HUMAN	Decreases Expression	[30]
Transcription factor AP-2-alpha (TFAP2A)	OTMYT3NK	AP2A_HUMAN	Increases Expression	[30]
Proto-oncogene tyrosine-protein kinase receptor Ret (RET)	OTLU040A	RET_HUMAN	Decreases Expression	[30]
Monoacylglycerol lipase ABHD2 (ABHD2)	OTCRUOCS	ABHD2_HUMAN	Decreases Expression	[30]
Transcriptional activator Myb (MYB)	OTJH64IV	MYB_HUMAN	Decreases Expression	[30]
Myb-related protein A (MYBL1)	OTBJMC2P	MYBA_HUMAN	Decreases Expression	[30]
Tissue factor pathway inhibitor (TFPI)	OTA0FX16	TFPI1_HUMAN	Increases Expression	[30]
Delta-aminolevulinic acid dehydratase (ALAD)	OTHM9GSH	HEM2_HUMAN	Increases Expression	[30]
CD44 antigen (CD44)	OT9TTJ41	CD44_HUMAN	Decreases Expression	[30]
Stromal cell-derived factor 1 (CXCL12)	OT2QX5LL	SDF1_HUMAN	Decreases Expression	[30]
Ephrin type-A receptor 4 (EPHA4)	OT3AMK0C	EPHA4_HUMAN	Increases Expression	[30]
Single-stranded DNA-binding protein 2 (SSBP2)	OTYG1G80	SSBP2_HUMAN	Increases Expression	[30]
Large neutral amino acids transporter small subunit 1 (SLC7A5)	OT2WPVXD	LAT1_HUMAN	Decreases Expression	[30]
DNA-binding protein inhibitor ID-3 (ID3)	OTUULW5Z	ID3_HUMAN	Increases Expression	[30]
Urokinase plasminogen activator surface receptor (PLAUR)	OTIRKKEQ	UPAR_HUMAN	Decreases Expression	[30]
Early growth response protein 3 (EGR3)	OTGPJIRA	EGR3_HUMAN	Decreases Expression	[30]
Forkhead box protein C1 (FOXC1)	OTOWZGYO	FOXC1_HUMAN	Decreases Expression	[30]
Cyclin-G2 (CCNG2)	OTII38K2	CCNG2_HUMAN	Increases Expression	[30]
Kynureninase (KYNU)	OTINL2RE	KYNU_HUMAN	Increases Expression	[30]
Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (PDZK1)	OTGFK4MH	NHRF3_HUMAN	Decreases Expression	[30]
Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3)	OTXGJ8N1	P55G_HUMAN	Increases Expression	[30]
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2)	OTMDVWPS	DYRK2_HUMAN	Increases Expression	[30]
Transcription factor AP-2 gamma (TFAP2C)	OTUDIW05	AP2C_HUMAN	Decreases Expression	[30]
Serine/threonine-protein kinase Sgk3 (SGK3)	OTQ6QO99	SGK3_HUMAN	Decreases Expression	[30]
Inactive rhomboid protein 1 (RHBDF1)	OTCQ7UDS	RHDF1_HUMAN	Increases Expression	[30]
Calmin (CLMN)	OT7U5J3T	CLMN_HUMAN	Increases Expression	[30]
DNA endonuclease RBBP8 (RBBP8)	OTRHJ3GI	CTIP_HUMAN	Decreases Expression	[30]
Noelin (OLFM1)	OTOYPEWW	NOE1_HUMAN	Decreases Expression	[30]
Pleckstrin homology domain-containing family F member 2 (PLEKHF2)	OTBGDG8C	PKHF2_HUMAN	Increases Expression	[30]
Spermine oxidase (SMOX)	OT11E62Y	SMOX_HUMAN	Decreases Expression	[30]
Nicotinamide riboside kinase 1 (NMRK1)	OT0STQLV	NRK1_HUMAN	Decreases Expression	[30]
Rap guanine nucleotide exchange factor-like 1 (RAPGEFL1)	OTYKE9ZM	RPGFL_HUMAN	Decreases Expression	[30]
RNA 3'-terminal phosphate cyclase-like protein (RCL1)	OT7O00YX	RCL1_HUMAN	Decreases Expression	[30]
Cytochrome P450 1B1 (CYP1B1)	OTYXFLSD	CP1B1_HUMAN	Increases Expression	[40]
Extended synaptotagmin-3 (ESYT3)	OTG5H3YF	ESYT3_HUMAN	Increases Methylation	[31]
FERM domain-containing protein 3 (FRMD3)	OT0CD2GG	FRMD3_HUMAN	Increases Methylation	[31]
Dystrotelin (DYTN)	OTC5QZ6R	DYTN_HUMAN	Increases Methylation	[31]
Coiled-coil domain-containing protein 144A (CCDC144A)	OTN9UZHR	C144A_HUMAN	Decreases Methylation	[31]
Transmembrane protein 89 (TMEM89)	OTZLX09R	TMM89_HUMAN	Increases Methylation	[31]
Delphilin (GRID2IP)	OTNDNC0W	GRD2I_HUMAN	Increases Methylation	[31]
Paralemmin-3 (PALM3)	OTB83R61	PALM3_HUMAN	Increases Methylation	[31]
Rho GTPase-activating protein 42 (ARHGAP42)	OTIDSJMK	RHG42_HUMAN	Increases Methylation	[31]
Ciliary microtubule inner protein 2C (CIMIP2C)	OTKXQKQ4	CMI2C_HUMAN	Increases Methylation	[31]
Fidgetin-like protein 2 (FIGNL2)	OT0GD7S6	FIGL2_HUMAN	Increases Methylation	[31]
Dorsal root ganglia homeobox protein (DRGX)	OTDLEGNE	DRGX_HUMAN	Increases Methylation	[31]
Uncharacterized protein C12orf71 (C12ORF71)	OTUFA24U	CL071_HUMAN	Increases Methylation	[31]
Uncharacterized protein C16orf90 (C16ORF90)	OTAYN87M	CP090_HUMAN	Increases Methylation	[31]
Isthmin-1 (ISM1)	OTZTK2TV	ISM1_HUMAN	Increases Methylation	[31]
Rab GTPase-activating protein 1-like, isoform 10 (RABGAP1L)	OT7QO47I	RBG10_HUMAN	Increases Methylation	[31]
Uncharacterized protein C19orf84 (C19ORF84)	OT4MVCU6	CS084_HUMAN	Increases Methylation	[31]
Golgi-associated olfactory signaling regulator (GFY)	OTM64CSN	GFY_HUMAN	Increases Methylation	[31]
ATP-dependent RNA helicase DDX39A (DDX39A)	OT0Z6E1K	DX39A_HUMAN	Increases Methylation	[31]
Cytosolic acyl coenzyme A thioester hydrolase (ACOT7)	OT7C68YV	BACH_HUMAN	Increases Methylation	[31]
Synaptosomal-associated protein 23 (SNAP23)	OTY2MYBX	SNP23_HUMAN	Increases Methylation	[31]
Splicing regulator ARVCF (ARVCF)	OT78DKOU	ARVC_HUMAN	Increases Methylation	[31]
AP-3 complex subunit beta-1 (AP3B1)	OTYTIH5Q	AP3B1_HUMAN	Decreases Expression	[33]
E3 ubiquitin-protein ligase RNF103 (RNF103)	OT9DOB4H	RN103_HUMAN	Increases Methylation	[31]
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B)	OTQ4W7MT	TR11B_HUMAN	Increases Expression	[33]
Importin-5 (IPO5)	OTAK40ED	IPO5_HUMAN	Increases Methylation	[31]
Histone deacetylase complex subunit SAP18 (SAP18)	OTJAZWOL	SAP18_HUMAN	Increases Methylation	[31]
Nuclear receptor subfamily 5 group A member 2 (NR5A2)	OTXAUJAS	NR5A2_HUMAN	Increases Expression	[33]
Serine/threonine-protein kinase 25 (STK25)	OT4YPNTF	STK25_HUMAN	Increases Methylation	[31]
Receptor-binding cancer antigen expressed on SiSo cells (EBAG9)	OTTQLQCP	RCAS1_HUMAN	Decreases Expression	[33]
Pro-neuregulin-2, membrane-bound isoform (NRG2)	OTMDE844	NRG2_HUMAN	Increases Methylation	[31]
Homeobox protein cut-like 2 (CUX2)	OTDJTQAJ	CUX2_HUMAN	Increases Methylation	[31]
Suppressor of cytokine signaling 3 (SOCS3)	OTY183WJ	SOCS3_HUMAN	Decreases Expression	[33]
Olfactory receptor 7A17 (OR7A17)	OTFYB5NE	OR7AH_HUMAN	Increases Methylation	[31]
Telomerase reverse transcriptase (TERT)	OT085VVA	TERT_HUMAN	Decreases Expression	[41]
Guanine nucleotide-binding protein subunit beta-5 (GNB5)	OT3ZSAXH	GNB5_HUMAN	Increases Methylation	[31]
Kinetochore protein NDC80 homolog (NDC80)	OTS7D306	NDC80_HUMAN	Decreases Expression	[32]
Neuropilin-1 (NRP1)	OTCGULYV	NRP1_HUMAN	Decreases Expression	[33]
Ras-specific guanine nucleotide-releasing factor 2 (RASGRF2)	OT67DAGF	RGRF2_HUMAN	Decreases Methylation	[31]
Protocadherin-17 (PCDH17)	OTRK0M05	PCD17_HUMAN	Decreases Methylation	[31]
Regulator of G-protein signaling 12 (RGS12)	OTNCIQTH	RGS12_HUMAN	Increases Methylation	[31]
Microtubule-associated serine/threonine-protein kinase 4 (MAST4)	OT3LOE2J	MAST4_HUMAN	Increases Methylation	[31]
Guanine nucleotide exchange factor DBS (MCF2L)	OTEURA8N	MCF2L_HUMAN	Affects Methylation	[31]
Ephrin type-B receptor 6 (EPHB6)	OTKNN6GC	EPHB6_HUMAN	Increases Methylation	[31]
Laminin subunit alpha-5 (LAMA5)	OTIIXE4M	LAMA5_HUMAN	Increases Methylation	[31]
Ataxin-7 (ATXN7)	OTL3YF1H	ATX7_HUMAN	Decreases Methylation	[31]
Tumor protein p73 (TP73)	OT0LUO47	P73_HUMAN	Increases Methylation	[31]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Decreases Expression	[32]
Trinucleotide repeat-containing gene 18 protein (TNRC18)	OTREUWWG	TNC18_HUMAN	Decreases Methylation	[31]
Tapasin (TAPBP)	OTL81AVZ	TPSN_HUMAN	Increases Methylation	[31]
Rho guanine nucleotide exchange factor 9 (ARHGEF9)	OTB1FLIW	ARHG9_HUMAN	Increases Methylation	[31]
ERI1 exoribonuclease 3 (ERI3)	OT0HIU61	ERI3_HUMAN	Increases Methylation	[31]
Histone-lysine N-methyltransferase SUV39H1 (SUV39H1)	OTDTF5BU	SUV91_HUMAN	Increases Methylation	[31]
Forkhead box protein O3 (FOXO3)	OTHXQG4P	FOXO3_HUMAN	Affects Localization	[42]
Protein sprouty homolog 2 (SPRY2)	OTH0CRCZ	SPY2_HUMAN	Affects Methylation	[31]
Pleiotropic regulator 1 (PLRG1)	OTIVZ5LL	PLRG1_HUMAN	Increases Methylation	[31]
Protein regulator of cytokinesis 1 (PRC1)	OTHD0XS0	PRC1_HUMAN	Decreases Expression	[33]
Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1)	OT80DZMT	BUB1_HUMAN	Decreases Expression	[32]
Sialic acid-binding Ig-like lectin 6 (SIGLEC6)	OTO4F5C9	SIGL6_HUMAN	Increases Methylation	[31]
Tolloid-like protein 1 (TLL1)	OTK9NM7G	TLL1_HUMAN	Decreases Methylation	[31]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L)	OTJKOMXE	BNI3L_HUMAN	Increases Methylation	[31]
NUAK family SNF1-like kinase 1 (NUAK1)	OTLLHJJQ	NUAK1_HUMAN	Increases Methylation	[31]
Phospholipid-transporting ATPase VA (ATP10A)	OTYF5A7X	AT10A_HUMAN	Decreases Methylation	[31]
Protein ENTREP2 (ENTREP2)	OTEUHFKS	EREP2_HUMAN	Increases Methylation	[31]
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (PIP5K1C)	OT3LPG1R	PI51C_HUMAN	Decreases Methylation	[31]
Gasdermin-E (GSDME)	OT1ZWY32	GSDME_HUMAN	Increases Methylation	[31]
Docking protein 2 (DOK2)	OTIJ38UF	DOK2_HUMAN	Increases Methylation	[31]
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B)	OT8KME51	BUB1B_HUMAN	Decreases Expression	[32]
Musculin (MSC)	OTBRPZL5	MUSC_HUMAN	Increases Methylation	[31]
Catenin delta-1 (CTNND1)	OTUMPSHR	CTND1_HUMAN	Decreases Methylation	[31]
Low-density lipoprotein receptor-related protein 3 (LRP3)	OTXMLT8C	LRP3_HUMAN	Increases Methylation	[31]
Protein CBFA2T3 (CBFA2T3)	OTOJ10S1	MTG16_HUMAN	Increases Methylation	[31]
Multiple epidermal growth factor-like domains protein 6 (MEGF6)	OTEUYTP1	MEGF6_HUMAN	Increases Methylation	[31]
Rho-associated protein kinase 2 (ROCK2)	OTVYN14T	ROCK2_HUMAN	Increases Methylation	[31]
TSC22 domain family protein 2 (TSC22D2)	OTFXF349	T22D2_HUMAN	Increases Methylation	[31]
Cadherin-16 (CDH16)	OTR0GE9G	CAD16_HUMAN	Increases Methylation	[31]
Nuclear receptor corepressor 1 (NCOR1)	OT04XNOU	NCOR1_HUMAN	Increases Expression	[33]
Alpha-tectorin (TECTA)	OT5E0NE2	TECTA_HUMAN	Decreases Methylation	[31]
Nuclear receptor subfamily 1 group I member 2 (NR1I2)	OTC5U0N5	NR1I2_HUMAN	Increases Activity	[43]
PC4 and SFRS1-interacting protein (PSIP1)	OT4YAFUS	PSIP1_HUMAN	Increases Methylation	[31]
Carbonic anhydrase-related protein 11 (CA11)	OT8RX3AJ	CAH11_HUMAN	Decreases Methylation	[31]
Disabled homolog 1 (DAB1)	OTPL9MA3	DAB1_HUMAN	Increases Methylation	[31]
Serpin B7 (SERPINB7)	OTZ95LR2	SPB7_HUMAN	Increases Methylation	[31]
Cell cycle checkpoint protein RAD17 (RAD17)	OT1I93DT	RAD17_HUMAN	Increases Methylation	[31]
CCN family member 5 (CCN5)	OTADU8JJ	CCN5_HUMAN	Increases Expression	[33]
Regulator of G-protein signaling 20 (RGS20)	OT6CGYHW	RGS20_HUMAN	Increases Methylation	[31]
Serine/threonine-protein kinase 17B (STK17B)	OT4NYNO8	ST17B_HUMAN	Increases Methylation	[31]
Slit homolog 2 protein (SLIT2)	OTLS2RJ4	SLIT2_HUMAN	Increases Methylation	[31]
Dendrin (DDN)	OTM52ZF5	DEND_HUMAN	Increases Methylation	[31]
Protein FAM13A (FAM13A)	OTZ6GN0Q	FA13A_HUMAN	Decreases Methylation	[31]
G2/mitotic-specific cyclin-B2 (CCNB2)	OTIEXTDK	CCNB2_HUMAN	Decreases Expression	[32]
Serine protease 23 (PRSS23)	OT6DQAM1	PRS23_HUMAN	Increases Methylation	[31]
NADH dehydrogenase 1 beta subcomplex subunit 2, mitochondrial (NDUFB2)	OT4717TF	NDUB2_HUMAN	Increases Methylation	[31]
Potassium voltage-gated channel subfamily H member 1 (KCNH1)	OTZZXWER	KCNH1_HUMAN	Decreases Expression	[44]
NADH dehydrogenase 1 alpha subcomplex subunit 10, mitochondrial (NDUFA10)	OTBURQ3A	NDUAA_HUMAN	Decreases Methylation	[31]
CUGBP Elav-like family member 2 (CELF2)	OTLJJ4VT	CELF2_HUMAN	Increases Methylation	[31]
Homeobox protein SIX3 (SIX3)	OTP5E3VU	SIX3_HUMAN	Decreases Methylation	[31]
Transforming acidic coiled-coil-containing protein 2 (TACC2)	OTW4M7HI	TACC2_HUMAN	Increases Methylation	[31]
Supervillin (SVIL)	OTWQQ1WK	SVIL_HUMAN	Increases Methylation	[31]
Sodium-dependent phosphate transport protein 2B (SLC34A2)	OTLFMBB0	NPT2B_HUMAN	Increases Methylation	[31]
Adhesion G protein-coupled receptor L2 (ADGRL2)	OTCXD2YR	AGRL2_HUMAN	Decreases Methylation	[31]
Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10)	OTL32QH7	GTR10_HUMAN	Decreases Methylation	[31]
Apoptosis-inducing factor 1, mitochondrial (AIFM1)	OTKPWB7Q	AIFM1_HUMAN	Decreases Methylation	[31]
Zinc finger protein SNAI1 (SNAI1)	OTDPYAMC	SNAI1_HUMAN	Increases Expression	[33]
Phosphatidylserine lipase ABHD16A (ABHD16A)	OTDS9K1Z	ABHGA_HUMAN	Increases Methylation	[31]
Uncharacterized protein C6orf47 (C6ORF47)	OTMKBNDD	CF047_HUMAN	Increases Methylation	[31]
One cut domain family member 2 (ONECUT2)	OTHUE5YY	ONEC2_HUMAN	Increases Methylation	[31]
Cholesterol 25-hydroxylase (CH25H)	OT9S2BSW	CH25H_HUMAN	Increases Methylation	[31]
Securin (PTTG1)	OTIMYS4W	PTTG1_HUMAN	Decreases Expression	[45]
G1/S-specific cyclin-E2 (CCNE2)	OTBBUKQQ	CCNE2_HUMAN	Decreases Expression	[32]
Aspartate aminotransferase, mitochondrial (GOT2)	OT6XBWN0	AATM_HUMAN	Increases Methylation	[31]
Adenosine deaminase (ADA)	OTOX2872	ADA_HUMAN	Decreases Methylation	[31]
Complement C3 (C3)	OTCH5GS0	CO3_HUMAN	Decreases Expression	[33]
Pro-epidermal growth factor (EGF)	OTANRJ0L	EGF_HUMAN	Affects Activity	[46]
Protransforming growth factor alpha (TGFA)	OTPD1LL9	TGFA_HUMAN	Increases Expression	[33]
Transforming growth factor beta-1 proprotein (TGFB1)	OTV5XHVH	TGFB1_HUMAN	Increases Expression	[47]
Prolactin (PRL)	OTWFQGX7	PRL_HUMAN	Decreases Secretion	[48]
Interleukin-1 beta (IL1B)	OT0DWXXB	IL1B_HUMAN	Increases Expression	[49]
Complement component C9 (C9)	OT7I5FDX	CO9_HUMAN	Increases Methylation	[31]
Lactotransferrin (LTF)	OT8JWCZ0	TRFL_HUMAN	Increases Expression	[33]
Estrogen receptor (ESR1)	OTKLU61J	ESR1_HUMAN	Decreases Expression	[50]
Glucocorticoid receptor (NR3C1)	OTCI2YDI	GCR_HUMAN	Increases Expression	[33]
Trefoil factor 1 (TFF1)	OTCYQH4F	TFF1_HUMAN	Decreases Expression	[51]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Decreases Expression	[52]
Non-histone chromosomal protein HMG-14 (HMGN1)	OTSMGH99	HMGN1_HUMAN	Decreases Methylation	[31]
Plasminogen activator inhibitor 2 (SERPINB2)	OT72QLZB	PAI2_HUMAN	Increases Expression	[49]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Increases Expression	[49]
Keratin, type I cytoskeletal 18 (KRT18)	OTVLQFIP	K1C18_HUMAN	Increases Methylation	[31]
Tyrosine-protein kinase Lck (LCK)	OT883FG9	LCK_HUMAN	Increases Methylation	[31]
Retinoblastoma-associated protein (RB1)	OTQJUJMZ	RB_HUMAN	Decreases Phosphorylation	[53]
Progesterone receptor (PGR)	OT0FZ3QE	PRGR_HUMAN	Decreases Expression	[54]
Cyclin-dependent kinase 1 (CDK1)	OTW1SC2N	CDK1_HUMAN	Decreases Expression	[32]
ATP synthase subunit beta, mitochondrial (ATP5F1B)	OTLFZUQK	ATPB_HUMAN	Increases Expression	[55]
Complement C2 (C2)	OTHMF4YM	CO2_HUMAN	Increases Methylation	[31]
Lipoprotein lipase (LPL)	OTTW0267	LIPL_HUMAN	Decreases Expression	[33]
Neurofilament medium polypeptide (NEFM)	OT8VCBNF	NFM_HUMAN	Increases Methylation	[31]
Thyroid peroxidase (TPO)	OTJJLL20	PERT_HUMAN	Increases Methylation	[31]
Prostate-specific antigen (KLK3)	OTFGSBFJ	KLK3_HUMAN	Decreases Expression	[33]
Cathepsin D (CTSD)	OTQZ36F3	CATD_HUMAN	Decreases Expression	[51]
Heat shock protein HSP 90-alpha (HSP90AA1)	OTLG1WPK	HS90A_HUMAN	Increases Expression	[33]
Tyrosine-protein kinase Lyn (LYN)	OTP686K2	LYN_HUMAN	Increases Methylation	[31]
Thrombospondin-1 (THBS1)	OT0ECWK3	TSP1_HUMAN	Increases Expression	[33]
Insulin-like growth factor 1 receptor (IGF1R)	OTXJIF13	IGF1R_HUMAN	Increases Phosphorylation	[56]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Increases Expression	[57]
Insulin-like growth factor-binding protein 1 (IGFBP1)	OT6UQV2K	IBP1_HUMAN	Increases Expression	[33]
Galectin-1 (LGALS1)	OT8LDFWR	LEG1_HUMAN	Increases Expression	[33]
Heme oxygenase 1 (HMOX1)	OTC1W6UX	HMOX1_HUMAN	Decreases Expression	[49]
Granulocyte colony-stimulating factor (CSF3)	OT9GC6TP	CSF3_HUMAN	Decreases Expression	[49]
Histone H2A.Z (H2AZ1)	OT3KJJNQ	H2AZ_HUMAN	Decreases Expression	[58]
Protein RD3-like (RD3L)	OTLV3BU0	RD3L_HUMAN	Increases Methylation	[31]
Granzyme B (GZMB)	OTPPVIRS	GRAB_HUMAN	Decreases Expression	[47]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Increases Expression	[49]
Lysosomal alpha-glucosidase (GAA)	OT03PU29	LYAG_HUMAN	Increases Methylation	[31]
Androgen receptor (AR)	OTUBKAZZ	ANDR_HUMAN	Decreases Expression	[54]
Retinoic acid receptor alpha (RARA)	OT192V9V	RARA_HUMAN	Decreases Expression	[33]
Osteopontin (SPP1)	OTJGC23Y	OSTP_HUMAN	Increases Expression	[33]
Nuclear receptor subfamily 2 group F member 6 (NR2F6)	OTNVO2B6	NR2F6_HUMAN	Increases Expression	[33]
Transforming growth factor beta-3 proprotein (TGFB3)	OT2LOUQ1	TGFB3_HUMAN	Decreases Expression	[33]
Microtubule-associated protein tau (MAPT)	OTMTP2Z7	TAU_HUMAN	Decreases Expression	[59]
Mast/stem cell growth factor receptor Kit (KIT)	OTHUY3VZ	KIT_HUMAN	Increases Methylation	[31]
Ras-related protein Ral-A (RALA)	OT734R7X	RALA_HUMAN	Increases Expression	[33]
Spectrin beta chain, erythrocytic (SPTB)	OT1Q9ABM	SPTB1_HUMAN	Increases Methylation	[31]
Serine/threonine-protein kinase pim-1 (PIM1)	OTWEKXTU	PIM1_HUMAN	Increases Expression	[49]
Glucose-6-phosphate 1-dehydrogenase (G6PD)	OT300SMK	G6PD_HUMAN	Increases Expression	[33]
Steroid hormone receptor ERR1 (ESRRA)	OTTDTUSP	ERR1_HUMAN	Increases Expression	[55]
Aromatase (CYP19A1)	OTZ6XF74	CP19A_HUMAN	Increases Expression	[33]
Dystrophin (DMD)	OTD21T5J	DMD_HUMAN	Decreases Methylation	[31]
Collagen alpha-2(VI) chain (COL6A2)	OTQC6PPO	CO6A2_HUMAN	Increases Methylation	[31]
Creatine kinase B-type (CKB)	OTUCKOTT	KCRB_HUMAN	Increases Expression	[33]
Bone morphogenetic protein 4 (BMP4)	OTPZMDFH	BMP4_HUMAN	Increases Expression	[33]
Nuclear receptor subfamily 2 group C member 1 (NR2C1)	OTJEL7WT	NR2C1_HUMAN	Increases Methylation	[31]
Gamma-interferon-inducible lysosomal thiol reductase (IFI30)	OT9DERT1	GILT_HUMAN	Decreases Methylation	[31]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Increases Expression	[33]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1)	OTNAZVKB	3BHS1_HUMAN	Increases Methylation	[31]
Perforin-1 (PRF1)	OTFVXD7H	PERF_HUMAN	Decreases Expression	[47]
Interleukin-1 receptor type 1 (IL1R1)	OTTU8959	IL1R1_HUMAN	Increases Methylation	[31]
Matrix metalloproteinase-9 (MMP9)	OTB2QDAV	MMP9_HUMAN	Increases Expression	[33]
Junction plakoglobin (JUP)	OTUH7VMO	PLAK_HUMAN	Increases Methylation	[31]
Nucleoside diphosphate kinase A (NME1)	OT0NELQ1	NDKA_HUMAN	Decreases Expression	[32]
Transcription factor 4 (TCF4)	OTB9ASTK	ITF2_HUMAN	Increases Methylation	[31]
Platelet-derived growth factor receptor alpha (PDGFRA)	OTDJXUCN	PGFRA_HUMAN	Decreases Methylation	[31]
Carboxypeptidase E (CPE)	OTXNTV79	CBPE_HUMAN	Increases Methylation	[31]
Transcription factor JunB (JUNB)	OTG2JXV5	JUNB_HUMAN	Increases Expression	[33]
Gap junction alpha-1 protein (GJA1)	OTT94MKL	CXA1_HUMAN	Decreases Expression	[60]
Creatine kinase S-type, mitochondrial (CKMT2)	OT1KNPI1	KCRS_HUMAN	Increases Methylation	[31]
Insulin-like growth factor-binding protein 3 (IGFBP3)	OTIX63TX	IBP3_HUMAN	Increases Methylation	[31]
Bone morphogenetic protein 7 (BMP7)	OTYATP2K	BMP7_HUMAN	Increases Expression	[33]
Inter-alpha-trypsin inhibitor heavy chain H1 (ITIH1)	OTSXJGQF	ITIH1_HUMAN	Increases Methylation	[31]
C-X-C motif chemokine 3 (CXCL3)	OTSL94KH	CXCL3_HUMAN	Increases Expression	[49]
Follistatin (FST)	OTRIVK9Y	FST_HUMAN	Increases Expression	[49]
Gastricsin (PGC)	OTQRITKI	PEPC_HUMAN	Increases Methylation	[31]
B-cell receptor CD22 (CD22)	OTXDJR9T	CD22_HUMAN	Increases Methylation	[31]
T-cell surface glycoprotein CD3 zeta chain (CD247)	OT45FGUX	CD3Z_HUMAN	Increases Methylation	[31]
Cytoplasmic aconitate hydratase (ACO1)	OT2VUR7L	ACOHC_HUMAN	Increases Methylation	[31]
Receptor tyrosine-protein kinase erbB-3 (ERBB3)	OTRSST0A	ERBB3_HUMAN	Decreases Expression	[33]
Catechol O-methyltransferase (COMT)	OTPWKTQG	COMT_HUMAN	Increases Expression	[33]
Tenascin-X (TNXB)	OTVBWAV5	TENX_HUMAN	Increases Methylation	[31]
Fibulin-1 (FBLN1)	OT5MHHOP	FBLN1_HUMAN	Increases Methylation	[31]
Transcription elongation factor A protein 1 (TCEA1)	OTBFO594	TCEA1_HUMAN	Decreases Methylation	[31]
Cerebellin-1 (CBLN1)	OTIXFRAG	CBLN1_HUMAN	Increases Methylation	[31]
Brain-derived neurotrophic factor (BDNF)	OTLGH7EW	BDNF_HUMAN	Increases Expression	[33]
G1/S-specific cyclin-D1 (CCND1)	OT8HPTKJ	CCND1_HUMAN	Decreases Expression	[50]
Insulin-like growth factor-binding protein 5 (IGFBP5)	OTRE5V0C	IBP5_HUMAN	Increases Expression	[33]
G1/S-specific cyclin-E1 (CCNE1)	OTLD7UID	CCNE1_HUMAN	Decreases Expression	[61]
Cyclin-dependent kinase 2 (CDK2)	OTB5DYYZ	CDK2_HUMAN	Increases Expression	[61]
Endothelin-1 receptor (EDNRA)	OTK9T5O3	EDNRA_HUMAN	Increases Methylation	[31]
Atypical chemokine receptor 3 (ACKR3)	OTA6GA4F	ACKR3_HUMAN	Decreases Methylation	[31]
NF-kappa-B inhibitor alpha (NFKBIA)	OTFT924M	IKBA_HUMAN	Decreases Expression	[49]
Integrin beta-7 (ITGB7)	OT33UUKU	ITB7_HUMAN	Increases Methylation	[31]
DNA cytosine-5)-methyltransferase 1 (DNMT1)	OTM2DGTK	DNMT1_HUMAN	Decreases Expression	[32]
NKG2-C type II integral membrane protein (KLRC2)	OTT4N86S	NKG2C_HUMAN	Increases Methylation	[31]
Beta-crystallin B3 (CRYBB3)	OTTGTQIQ	CRBB3_HUMAN	Decreases Methylation	[31]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Increases Phosphorylation	[62]
Proteasome subunit beta type-8 (PSMB8)	OTW5XGMF	PSB8_HUMAN	Increases Methylation	[31]
Choline O-acetyltransferase (CHAT)	OTEJWQ45	CLAT_HUMAN	Increases Methylation	[31]
Gamma-aminobutyric acid receptor subunit rho-2 (GABRR2)	OTLDLU1S	GBRR2_HUMAN	Increases Methylation	[31]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Increases Phosphorylation	[62]
CCN family member 2 (CCN2)	OTC39NSU	CCN2_HUMAN	Increases Expression	[33]
Lysine-specific demethylase 5A (KDM5A)	OTLYFX8A	KDM5A_HUMAN	Increases Methylation	[31]
Leukocyte tyrosine kinase receptor (LTK)	OT4GPX7K	LTK_HUMAN	Decreases Methylation	[31]
Transmembrane 4 L6 family member 1 (TM4SF1)	OTY0ECQN	T4S1_HUMAN	Increases Methylation	[31]
Adenosine receptor A1 (ADORA1)	OTI7X39E	AA1R_HUMAN	Decreases Expression	[33]
Fibroblast growth factor 9 (FGF9)	OT2SKDGM	FGF9_HUMAN	Decreases Expression	[63]
Sodium- and chloride-dependent taurine transporter (SLC6A6)	OT67U7G3	SC6A6_HUMAN	Increases Methylation	[31]
Gamma-aminobutyric acid receptor subunit alpha-5 (GABRA5)	OTBIKWQT	GBRA5_HUMAN	Decreases Methylation	[31]
DnaJ homolog subfamily A member 1 (DNAJA1)	OT38BZQQ	DNJA1_HUMAN	Increases Methylation	[31]
3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH)	OTCMMMIZ	3HIDH_HUMAN	Increases Methylation	[31]
Neural cell adhesion molecule L1 (L1CAM)	OTNWAQ4Y	L1CAM_HUMAN	Increases Expression	[33]
CD70 antigen (CD70)	OTHB2AL1	CD70_HUMAN	Increases Methylation	[31]
Long-chain-fatty-acid--CoA ligase 1 (ACSL1)	OTB06ESI	ACSL1_HUMAN	Increases Methylation	[31]
Cytochrome P450 2C18 (CYP2C18)	OTY687L9	CP2CI_HUMAN	Increases Methylation	[31]
Protein S100-A5 (S100A5)	OTCGGL6K	S10A5_HUMAN	Increases Expression	[33]
Protein S100-A3 (S100A3)	OTVIZJ2R	S10A3_HUMAN	Increases Methylation	[31]
Dual specificity protein kinase TTK (TTK)	OTBY1Z5H	TTK_HUMAN	Decreases Expression	[32]
Prostaglandin G/H synthase 2 (PTGS2)	OT75U9M4	PGH2_HUMAN	Increases Expression	[33]
Nuclear receptor ROR-alpha (RORA)	OTGQT12P	RORA_HUMAN	Increases Methylation	[31]
Sodium channel protein type 1 subunit alpha (SCN1A)	OTJ9ZTYI	SCN1A_HUMAN	Increases Methylation	[31]
Hepatocyte nuclear factor 1-beta (HNF1B)	OTSYIC3T	HNF1B_HUMAN	Decreases Expression	[64]
Transcription factor SOX-6 (SOX6)	OTT0W0LE	SOX6_HUMAN	Increases Methylation	[31]
Aryl hydrocarbon receptor (AHR)	OTFE4EYE	AHR_HUMAN	Increases Expression	[33]
Receptor-type tyrosine-protein kinase FLT3 (FLT3)	OTMSRYMK	FLT3_HUMAN	Increases Methylation	[31]
Breast cancer type 1 susceptibility protein (BRCA1)	OT5BN6VH	BRCA1_HUMAN	Decreases Expression	[50]
Collagen alpha-1(XVIII) chain (COL18A1)	OTJFUH6O	COIA1_HUMAN	Increases Methylation	[31]
Pre-B-cell leukemia transcription factor 3 (PBX3)	OT8WMVM4	PBX3_HUMAN	Increases Methylation	[31]
Glutamate receptor 3 (GRIA3)	OT34CNBR	GRIA3_HUMAN	Decreases Methylation	[31]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PIK3CB)	OTO8JQJA	PK3CB_HUMAN	Increases Methylation	[31]
Phosphatidylinositol 4-kinase alpha (PI4KA)	OT2L2G6C	PI4KA_HUMAN	Increases Methylation	[31]
Dipeptidyl aminopeptidase-like protein 6 (DPP6)	OTWW3H0K	DPP6_HUMAN	Decreases Methylation	[31]
Tyrosine-protein kinase Tec (TEC)	OTU6QJAJ	TEC_HUMAN	Increases Methylation	[31]
Condensin-2 complex subunit D3 (NCAPD3)	OTOZY2UL	CNDD3_HUMAN	Increases Methylation	[31]
Cathepsin O (CTSO)	OTFL6VRO	CATO_HUMAN	Increases Expression	[33]
Aldehyde dehydrogenase family 3 member B1 (ALDH3B1)	OT5NEUQE	AL3B1_HUMAN	Increases Methylation	[31]
Tumor necrosis factor receptor superfamily member 4 (TNFRSF4)	OTDK74C0	TNR4_HUMAN	Decreases Methylation	[31]
Neuronal acetylcholine receptor subunit alpha-4 (CHRNA4)	OT1H0ZXC	ACHA4_HUMAN	Increases Methylation	[31]
Cyclin-dependent kinase inhibitor 1B (CDKN1B)	OTNY5LLZ	CDN1B_HUMAN	Increases Expression	[53]
5-hydroxytryptamine receptor 5A (HTR5A)	OTRKPCQV	5HT5A_HUMAN	Increases Methylation	[31]
Tumor necrosis factor ligand superfamily member 6 (FASLG)	OTZARCHH	TNFL6_HUMAN	Decreases Methylation	[31]
G protein-activated inward rectifier potassium channel 2 (KCNJ6)	OTDE1FT0	KCNJ6_HUMAN	Increases Methylation	[31]
Retinoic acid receptor RXR-gamma (RXRG)	OT254B09	RXRG_HUMAN	Decreases Methylation	[31]
Nuclear receptor-interacting protein 1 (NRIP1)	OTIZOJQV	NRIP1_HUMAN	Decreases Expression	[33]
Protein PRRC2A (PRRC2A)	OTBX6FM5	PRC2A_HUMAN	Increases Methylation	[31]
Protein farnesyltransferase subunit beta (CHURC1-FNTB)	OT34M7E3	FNTB_HUMAN	Increases Methylation	[31]
Protein phosphatase 1F (PPM1F)	OTU0MVR7	PPM1F_HUMAN	Increases Methylation	[31]
Casein kinase I isoform epsilon (CSNK1E)	OTF0UXX6	KC1E_HUMAN	Increases Methylation	[31]
CCAAT/enhancer-binding protein delta (CEBPD)	OTNBIPMY	CEBPD_HUMAN	Increases Methylation	[31]
Nuclear pore complex protein Nup153 (NUP153)	OTCAS0AR	NU153_HUMAN	Increases Methylation	[31]
Protein Tob1 (TOB1)	OTNW949D	TOB1_HUMAN	Increases Methylation	[31]
Lipopolysaccharide-responsive and beige-like anchor protein (LRBA)	OTOUZN9G	LRBA_HUMAN	Increases Methylation	[31]
Transcription activator BRG1 (SMARCA4)	OT68WOPQ	SMCA4_HUMAN	Decreases Expression	[52]
Nuclear receptor subfamily 0 group B member 1 (NR0B1)	OTC8P9GN	NR0B1_HUMAN	Increases Expression	[33]
Serine/threonine-protein kinase Nek2 (NEK2)	OT1H27HO	NEK2_HUMAN	Decreases Expression	[32]
Beta-chimaerin (CHN2)	OTSSDPWN	CHIO_HUMAN	Increases Methylation	[31]
Ephrin-A5 (EFNA5)	OTOH4DRR	EFNA5_HUMAN	Increases Expression	[33]
Stanniocalcin-1 (STC1)	OTGVVXYF	STC1_HUMAN	Decreases Methylation	[31]
Ataxin-1 (ATXN1)	OTQF0HNR	ATX1_HUMAN	Increases Methylation	[31]
Huntingtin-associated protein 1 (HAP1)	OT6SG0JQ	HAP1_HUMAN	Increases Methylation	[31]
Myomesin-2 (MYOM2)	OTD2UOXW	MYOM2_HUMAN	Increases Methylation	[31]
Tyrosine-protein phosphatase non-receptor type 5 (PTPN5)	OT2H1KDK	PTN5_HUMAN	Increases Methylation	[31]
Protein AF-10 (MLLT10)	OTURMDV7	AF10_HUMAN	Increases Methylation	[31]
Adenosine kinase (ADK)	OTXR6VDI	ADK_HUMAN	Increases Methylation	[31]
Hepatocyte nuclear factor 3-alpha (FOXA1)	OTEBY0TD	FOXA1_HUMAN	Increases Expression	[33]
Galectin-4 (LGALS4)	OTKQCG0H	LEG4_HUMAN	Increases Methylation	[31]
Histone deacetylase 4 (HDAC4)	OTQNGD32	HDAC4_HUMAN	Increases Methylation	[31]
Claudin-17 (CLDN17)	OTQCEYBY	CLD17_HUMAN	Decreases Methylation	[31]
Breast cancer anti-estrogen resistance protein 1 (BCAR1)	OTKT2C2N	BCAR1_HUMAN	Increases Expression	[33]
Pro-neuregulin-3, membrane-bound isoform (NRG3)	OTIFZ5CT	NRG3_HUMAN	Increases Methylation	[31]
Claudin-2 (CLDN2)	OTRF3D6Y	CLD2_HUMAN	Decreases Methylation	[31]
Neurexin-1-beta (NRXN1)	OTJN1JQA	NRX1B_HUMAN	Decreases Methylation	[31]
CD81 antigen (CD81)	OTQFXNAZ	CD81_HUMAN	Increases Methylation	[31]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)	OTOWDUNT	PTEN_HUMAN	Increases Methylation	[31]
26S proteasome complex subunit SEM1 (SEM1)	OTASLBM1	SEM1_HUMAN	Decreases Methylation	[31]
Protein max (MAX)	OTKZ0YKM	MAX_HUMAN	Increases Methylation	[31]
Small ribosomal subunit protein eS7 (RPS7)	OTIK25WI	RS7_HUMAN	Increases Methylation	[31]
Small nuclear ribonucleoprotein G (SNRPG)	OTWX4XK1	RUXG_HUMAN	Increases Methylation	[31]
DNA-directed RNA polymerases I, II, and III subunit RPABC5 (POLR2L)	OTSSOMUP	RPAB5_HUMAN	Decreases Methylation	[31]
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PPP2R2A)	OT9297OG	2ABA_HUMAN	Increases Methylation	[31]
Inward rectifier potassium channel 2 (KCNJ2)	OT2OQEZS	KCNJ2_HUMAN	Decreases Methylation	[31]
Tropomyosin alpha-4 chain (TPM4)	OTN4YLYR	TPM4_HUMAN	Increases Methylation	[31]
Actin, alpha skeletal muscle (ACTA1)	OTOVGLPG	ACTS_HUMAN	Increases Methylation	[31]
Reelin (RELN)	OTLKMW1O	RELN_HUMAN	Increases Methylation	[31]
C-C motif chemokine 20 (CCL20)	OTUCJY4N	CCL20_HUMAN	Increases Expression	[49]
Small ribosomal subunit protein uS9m (MRPS9)	OTD4XOHS	RT09_HUMAN	Decreases Methylation	[31]
Mothers against decapentaplegic homolog 3 (SMAD3)	OTNA96MR	SMAD3_HUMAN	Increases Methylation	[31]
Calcium-transporting ATPase type 2C member 1 (ATP2C1)	OTQN51T3	AT2C1_HUMAN	Affects Methylation	[31]
Phospholipid-transporting ATPase IH (ATP11A)	OT7M9ZDK	AT11A_HUMAN	Increases Methylation	[31]
Cytochrome c (CYCS)	OTBFALJD	CYC_HUMAN	Increases Expression	[55]
Cyclin-dependent kinase 6 (CDK6)	OTR95N0X	CDK6_HUMAN	Increases Expression	[52]
Transcription factor E2F1 (E2F1)	OTLKYBBC	E2F1_HUMAN	Decreases Expression	[61]
Runt-related transcription factor 1 (RUNX1)	OTU7J84H	RUNX1_HUMAN	Decreases Methylation	[31]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)	OTCO26FV	HMCS1_HUMAN	Increases Methylation	[31]
ATP-dependent 6-phosphofructokinase, platelet type (PFKP)	OTFP7AA8	PFKAP_HUMAN	Increases Methylation	[31]
DNA-binding protein SATB1 (SATB1)	OTT7SUVW	SATB1_HUMAN	Decreases Methylation	[31]
Zinc finger protein basonuclin-1 (BNC1)	OTGJ5WUF	BNC1_HUMAN	Decreases Methylation	[31]
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)	OTEUYEW6	ROR1_HUMAN	Increases Methylation	[31]
2-oxoglutarate dehydrogenase complex component E1 (OGDH)	OTHGTQWF	ODO1_HUMAN	Increases Methylation	[31]
Pro-neuregulin-1, membrane-bound isoform (NRG1)	OTZO6F1X	NRG1_HUMAN	Increases Methylation	[31]
Dystonin (DST)	OTHZBM4X	DYST_HUMAN	Increases Methylation	[31]
Caveolin-1 (CAV1)	OTEZUR1L	CAV1_HUMAN	Decreases Expression	[33]
Trefoil factor 2 (TFF2)	OTRXB19X	TFF2_HUMAN	Decreases Expression	[65]
Early growth response protein 4 (EGR4)	OT4R3ECK	EGR4_HUMAN	Increases Methylation	[31]
Focal adhesion kinase 1 (PTK2)	OT3Q1JDY	FAK1_HUMAN	Increases Degradation	[62]
Homeobox protein engrailed-1 (EN1)	OT2DKIDK	HME1_HUMAN	Decreases Methylation	[31]
Recombining binding protein suppressor of hairless (RBPJ)	OTD7CUG0	SUH_HUMAN	Increases Methylation	[31]
DNA repair protein RAD51 homolog 1 (RAD51)	OTNVWGC1	RAD51_HUMAN	Decreases Expression	[32]
Collagen alpha-1(XVI) chain (COL16A1)	OTOWKUO2	COGA1_HUMAN	Increases Methylation	[31]
Trichohyalin (TCHH)	OT4J7EFT	TRHY_HUMAN	Decreases Methylation	[31]
Forkhead box protein M1 (FOXM1)	OT5887KR	FOXM1_HUMAN	Decreases Expression	[32]
3',5'-cyclic-AMP phosphodiesterase 4D (PDE4D)	OT1RWFV0	PDE4D_HUMAN	Decreases Methylation	[31]
Transmembrane protein 62 (TMEM62)	OTJ4SPCM	TMM62_HUMAN	Increases Methylation	[31]
General transcription factor 3C polypeptide 1 (GTF3C1)	OT7JK0RG	TF3C1_HUMAN	Increases Methylation	[31]
Calcium-activated potassium channel subunit alpha-1 (KCNMA1)	OTNYXOZO	KCMA1_HUMAN	Increases Methylation	[31]
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1)	OT2LP7LJ	SNF5_HUMAN	Increases Expression	[52]
Cell division cycle protein 20 homolog (CDC20)	OTCOEZRV	CDC20_HUMAN	Decreases Expression	[32]
Follistatin-related protein 1 (FSTL1)	OT6KEZUD	FSTL1_HUMAN	Increases Methylation	[31]
Splicing factor, suppressor of white-apricot homolog (SFSWAP)	OT7H3ETA	SFSWA_HUMAN	Increases Methylation	[31]
Heat shock protein 75 kDa, mitochondrial (TRAP1)	OTNG0L8J	TRAP1_HUMAN	Increases Methylation	[31]
Ankyrin-3 (ANK3)	OTJ3IRBP	ANK3_HUMAN	Increases Methylation	[31]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 (BNIP2)	OTVZD4H6	BNIP2_HUMAN	Increases Methylation	[31]
Interleukin-24 (IL24)	OT4VUWH1	IL24_HUMAN	Increases Expression	[49]
Semaphorin-3B (SEMA3B)	OTCZCPMS	SEM3B_HUMAN	Increases Methylation	[31]
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1)	OTXNGZCG	MD2L1_HUMAN	Decreases Expression	[32]
Growth factor receptor-bound protein 10 (GRB10)	OTCKXGRC	GRB10_HUMAN	Increases Methylation	[31]
Metastasis-associated protein MTA1 (MTA1)	OTBHW3S9	MTA1_HUMAN	Decreases Expression	[33]
C-terminal-binding protein 1 (CTBP1)	OTVYH2DH	CTBP1_HUMAN	Decreases Expression	[33]
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)	OT70Z4II	ADAM9_HUMAN	Increases Methylation	[31]
snRNA-activating protein complex subunit 2 (SNAPC2)	OTN0EL6L	SNPC2_HUMAN	Increases Methylation	[31]
Baculoviral IAP repeat-containing protein 3 (BIRC3)	OT3E95KB	BIRC3_HUMAN	Increases Methylation	[31]
Phosphatidylinositol-binding clathrin assembly protein (PICALM)	OTQVRPMQ	PICAL_HUMAN	Increases Methylation	[31]
Mastermind-like domain-containing protein 1 (MAMLD1)	OT9EVMQY	MAMD1_HUMAN	Decreases Methylation	[31]
Solute carrier family 12 member 1 (SLC12A1)	OT6YSX0G	S12A1_HUMAN	Decreases Methylation	[31]
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A)	OTPLXCDN	DYR1A_HUMAN	Decreases Methylation	[31]
Protein patched homolog 1 (PTCH1)	OTMG07H5	PTC1_HUMAN	Increases Expression	[33]
Nuclear receptor coactivator 4 (NCOA4)	OTRVU0UA	NCOA4_HUMAN	Increases Methylation	[31]
ADP-ribosylation factor-related protein 1 (ARFRP1)	OTP1OV78	ARFRP_HUMAN	Increases Methylation	[31]
Protein Shroom2 (SHROOM2)	OTZ2FJ7Q	SHRM2_HUMAN	Increases Methylation	[31]
Beta-1-syntrophin (SNTB1)	OTSRBECI	SNTB1_HUMAN	Decreases Methylation	[31]
Nuclear nucleic acid-binding protein C1D (C1D)	OTI9PMN1	C1D_HUMAN	Decreases Methylation	[31]
Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C)	OT6KFNMS	CAC1C_HUMAN	Increases Methylation	[31]
Nidogen-2 (NID2)	OTHC33FF	NID2_HUMAN	Increases Methylation	[31]
Protein FAM53B (FAM53B)	OTVD7OU6	FA53B_HUMAN	Decreases Methylation	[31]
Four and a half LIM domains protein 2 (FHL2)	OT0OAYWT	FHL2_HUMAN	Increases Methylation	[31]
Dihydropyrimidinase-related protein 3 (DPYSL3)	OTINJV20	DPYL3_HUMAN	Increases Methylation	[31]
Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1)	OTD1KRKO	DYHC1_HUMAN	Increases Methylation	[31]
Elongin-A (ELOA)	OTOQTF5K	ELOA1_HUMAN	Increases Methylation	[31]
Filamin-C (FLNC)	OT3F8J6Y	FLNC_HUMAN	Decreases Methylation	[31]
Histone RNA hairpin-binding protein (SLBP)	OTVYYQRT	SLBP_HUMAN	Decreases Methylation	[31]
Inositol 1,4,5-trisphosphate receptor type 2 (ITPR2)	OTPHGZ19	ITPR2_HUMAN	Increases Methylation	[31]
Indian hedgehog protein (IHH)	OT1DWGXC	IHH_HUMAN	Decreases Methylation	[31]
Separin (ESPL1)	OTMGEVOK	ESPL1_HUMAN	Decreases Expression	[32]
Disco-interacting protein 2 homolog A (DIP2A)	OTXPTR8R	DIP2A_HUMAN	Decreases Methylation	[31]
Latent-transforming growth factor beta-binding protein 1 (LTBP1)	OTR7Q75L	LTBP1_HUMAN	Decreases Expression	[33]
LIM and SH3 domain protein 1 (LASP1)	OT2QIDCL	LASP1_HUMAN	Increases Methylation	[31]
Sodium/hydrogen exchanger 5 (SLC9A5)	OTM70CXN	SL9A5_HUMAN	Decreases Methylation	[31]
Protein disulfide-isomerase A6 (PDIA6)	OT8YBR17	PDIA6_HUMAN	Increases Methylation	[31]
Inactive phospholipase C-like protein 1 (PLCL1)	OTJL2C79	PLCL1_HUMAN	Decreases Methylation	[31]
Cyclin-dependent kinase 10 (CDK10)	OTKP7TTR	CDK10_HUMAN	Increases Methylation	[31]
Plectin (PLEC)	OTU4XDEG	PLEC_HUMAN	Increases Methylation	[31]
Serine/threonine-protein kinase 38 (STK38)	OTKMYCYR	STK38_HUMAN	Increases Methylation	[31]
RalA-binding protein 1 (RALBP1)	OTBIGB1D	RBP1_HUMAN	Increases Methylation	[31]
Ribosomal protein S6 kinase alpha-2 (RPS6KA2)	OTIOYUSU	KS6A2_HUMAN	Decreases Methylation	[31]
Scaffold attachment factor B1 (SAFB)	OTGRV2LW	SAFB1_HUMAN	Increases Methylation	[31]
Nuclear receptor subfamily 0 group B member 2 (NR0B2)	OT7UVICX	NR0B2_HUMAN	Decreases Expression	[33]
Nuclear receptor coactivator 2 (NCOA2)	OTMQFPBB	NCOA2_HUMAN	Increases Expression	[33]
Olfactory receptor 1C1 (OR1C1)	OT9WTEX5	OR1C1_HUMAN	Decreases Methylation	[31]
Mediator of RNA polymerase II transcription subunit 1 (MED1)	OTOO24C4	MED1_HUMAN	Decreases Expression	[33]
ETS-related transcription factor Elf-2 (ELF2)	OTEI347F	ELF2_HUMAN	Increases Methylation	[31]
NGFI-A-binding protein 2 (NAB2)	OTG4BDF3	NAB2_HUMAN	Increases Expression	[33]
Nuclear receptor coactivator 1 (NCOA1)	OTLIUJQD	NCOA1_HUMAN	Increases Expression	[33]
Glutamate receptor ionotropic, kainate 4 (GRIK4)	OTL5EIPA	GRIK4_HUMAN	Decreases Methylation	[31]
NT-3 growth factor receptor (NTRK3)	OTII30MY	NTRK3_HUMAN	Increases Methylation	[31]
Meprin A subunit alpha (MEP1A)	OTY2Z48T	MEP1A_HUMAN	Increases Methylation	[31]
Receptor-type tyrosine-protein phosphatase O (PTPRO)	OTFLKWOY	PTPRO_HUMAN	Increases Methylation	[31]
Cysteine dioxygenase type 1 (CDO1)	OTLG1P77	CDO1_HUMAN	Decreases Methylation	[31]
Protein inscuteable homolog (INSC)	OTP16ERR	INSC_HUMAN	Increases Methylation	[31]
Inverted formin-2 (INF2)	OT8ZM13C	INF2_HUMAN	Increases Methylation	[31]
Transmembrane protein 266 (TMEM266)	OTM17VHD	TM266_HUMAN	Increases Methylation	[31]
ATP-binding cassette sub-family B member 5 (ABCB5)	OT8AKP1J	ABCB5_HUMAN	Increases Methylation	[31]
CST complex subunit CTC1 (CTC1)	OTRJY7QD	CTC1_HUMAN	Decreases Methylation	[31]
FH1/FH2 domain-containing protein 3 (FHOD3)	OT1WUBQX	FHOD3_HUMAN	Decreases Methylation	[31]
Carcinoembryonic antigen-related cell adhesion molecule 16 (CEACAM16)	OTUMUSY0	CEA16_HUMAN	Increases Methylation	[31]
Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1)	OTN7XAUD	LRRF1_HUMAN	Decreases Methylation	[31]
Polycomb group RING finger protein 3 (PCGF3)	OTY7TPPZ	PCGF3_HUMAN	Increases Methylation	[31]
MAP7 domain-containing protein 1 (MAP7D1)	OTMGC8N9	MA7D1_HUMAN	Decreases Methylation	[31]
Mucin-like protein 3 (MUCL3)	OTGAD3I0	MUCL3_HUMAN	Increases Methylation	[31]
Cilia- and flagella-associated protein 100 (CFAP100)	OTHHFM2Z	CP100_HUMAN	Increases Methylation	[31]
Spermatogenesis-associated serine-rich protein 1 (SPATS1)	OTPUXCSA	SPAS1_HUMAN	Decreases Methylation	[31]
Cryptochrome-2 (CRY2)	OTERZ93T	CRY2_HUMAN	Increases Methylation	[31]
Ceramide kinase-like protein (CERKL)	OTG4YGBR	CERKL_HUMAN	Decreases Methylation	[31]
NAD kinase 2, mitochondrial (NADK2)	OT1I8GDE	NAKD2_HUMAN	Decreases Methylation	[31]
Glucoside xylosyltransferase 1 (GXYLT1)	OTI5MDYW	GXLT1_HUMAN	Increases Methylation	[31]
Protein GREB1 (GREB1)	OTU6ZA26	GREB1_HUMAN	Decreases Expression	[33]
PAN2-PAN3 deadenylation complex catalytic subunit PAN2 (PAN2)	OTB65N2I	PAN2_HUMAN	Increases Methylation	[31]
Acylglycerol kinase, mitochondrial (AGK)	OTJGWBYT	AGK_HUMAN	Increases Methylation	[31]
Fibulin-7 (FBLN7)	OT1XRDP6	FBLN7_HUMAN	Increases Methylation	[31]
FRAS1-related extracellular matrix protein 1 (FREM1)	OTMHRV87	FREM1_HUMAN	Increases Methylation	[31]
SH3 domain-containing protein 19 (SH3D19)	OTVU3VS2	SH319_HUMAN	Increases Methylation	[31]
Protein crumbs homolog 2 (CRB2)	OTG0L2CE	CRUM2_HUMAN	Increases Expression	[33]
NHL repeat-containing protein 3 (NHLRC3)	OTBI6YSN	NHLC3_HUMAN	Increases Methylation	[31]
Dedicator of cytokinesis protein 11 (DOCK11)	OTFSTN6A	DOC11_HUMAN	Increases Methylation	[31]
Protein FAM78A (FAM78A)	OTDZ36V8	FA78A_HUMAN	Decreases Methylation	[31]
EF-hand domain-containing protein 1 (EFHC1)	OTS9IBNE	EFHC1_HUMAN	Increases Methylation	[31]
Calcium homeostasis modulator protein 4 (CALHM4)	OTUDL2HG	CAHM4_HUMAN	Increases Methylation	[31]
Tubulin-specific chaperone cofactor E-like protein (TBCEL)	OT2PZLLL	TBCEL_HUMAN	Increases Methylation	[31]
Mucin-21 (MUC21)	OTQ8GP5L	MUC21_HUMAN	Increases Methylation	[31]
Uncharacterized protein C6orf132 (C6ORF132)	OTMH4S7O	CF132_HUMAN	Increases Methylation	[31]
Calmodulin-regulated spectrin-associated protein 1 (CAMSAP1)	OT1N2182	CAMP1_HUMAN	Increases Methylation	[31]
Uncharacterized protein C1orf185 (C1ORF185)	OT32C5NW	CA185_HUMAN	Increases Methylation	[31]
Coiled-coil domain-containing protein 18 (CCDC18)	OT0S9DA2	CCD18_HUMAN	Decreases Methylation	[31]
Growth hormone-regulated TBC protein 1 (GRTP1)	OT8HORRZ	GRTP1_HUMAN	Increases Methylation	[31]
Protein sel-1 homolog 2 (SEL1L2)	OTSBDWIG	SE1L2_HUMAN	Increases Methylation	[31]
E3 ubiquitin-protein ligase RNF220 (RNF220)	OT2FIEXO	RN220_HUMAN	Increases Methylation	[31]
Forkhead box protein B2 (FOXB2)	OTJE3RRR	FOXB2_HUMAN	Increases Methylation	[31]
Armadillo repeat-containing protein 3 (ARMC3)	OTF6M9MM	ARMC3_HUMAN	Increases Methylation	[31]
Anoctamin-1 (ANO1)	OTSREUNI	ANO1_HUMAN	Increases Methylation	[31]
Meteorin-like protein (METRNL)	OTB0DDL0	METRL_HUMAN	Increases Methylation	[31]
DDB1- and CUL4-associated factor 15 (DCAF15)	OTWBXZ0E	DCA15_HUMAN	Increases Methylation	[31]
Autophagy-related protein 16-1 (ATG16L1)	OTEOYC5D	A16L1_HUMAN	Increases Methylation	[31]
Tensin-3 (TNS3)	OTPG2D8Z	TENS3_HUMAN	Increases Methylation	[31]
Coiled-coil domain-containing protein 102B (CCDC102B)	OTVDZVD0	C102B_HUMAN	Decreases Methylation	[31]
Cytosolic phospholipase A2 zeta (PLA2G4F)	OT8MUO5U	PA24F_HUMAN	Increases Methylation	[31]
NADH-cytochrome b5 reductase 2 (CYB5R2)	OTTLM7XN	NB5R2_HUMAN	Increases Methylation	[31]
Bridge-like lipid transfer protein family member 3A (BLTP3A)	OTRLMP17	BLT3A_HUMAN	Increases Methylation	[31]
Capping protein, Arp2/3 and myosin-I linker protein 2 (CARMIL2)	OTV5S1J2	CARL2_HUMAN	Increases Methylation	[31]
Fatty-acid amide hydrolase 2 (FAAH2)	OTS6LX01	FAAH2_HUMAN	Decreases Methylation	[31]
GRAM domain-containing protein 4 (GRAMD4)	OT1HXEPM	GRAM4_HUMAN	Decreases Methylation	[31]
Pleckstrin homology domain-containing family A member 7 (PLEKHA7)	OTNUMAZ0	PKHA7_HUMAN	Increases Methylation	[31]
Beta-1,4-N-acetylgalactosaminyltransferase 3 (B4GALNT3)	OT6BFB22	B4GN3_HUMAN	Decreases Methylation	[31]
Teneurin-4 (TENM4)	OT91K3FC	TEN4_HUMAN	Increases Methylation	[31]
SANT and BTB domain regulator of class switch recombination (SANBR)	OTY7ZODH	SANBR_HUMAN	Decreases Methylation	[31]
Homeobox-containing protein 1 (HMBOX1)	OTPKTBVI	HMBX1_HUMAN	Increases Methylation	[31]
TELO2-interacting protein 2 (TTI2)	OTU7TQCO	TTI2_HUMAN	Decreases Methylation	[31]
Phostensin (PPP1R18)	OT0JVGOZ	PPR18_HUMAN	Decreases Methylation	[31]
Phospholipase B1, membrane-associated (PLB1)	OTZ6TTYV	PLB1_HUMAN	Increases Methylation	[31]
Enhancer of mRNA-decapping protein 4 (EDC4)	OTBBNIUJ	EDC4_HUMAN	Increases Methylation	[31]
Uncharacterized protein C16orf46 (C16ORF46)	OT8FDG3A	CP046_HUMAN	Increases Methylation	[31]
Serine/threonine-protein kinase Nek5 (NEK5)	OTHDXCYZ	NEK5_HUMAN	Increases Methylation	[31]
Neuroblastoma breakpoint family member 10 (NBPF10)	OTGOCELY	NBPFA_HUMAN	Affects Methylation	[31]
NIPA-like protein 3 (NIPAL3)	OTI858LL	NPAL3_HUMAN	Increases Methylation	[31]
Cytochrome b5 domain-containing protein 1 (CYB5D1)	OTSZWTPT	CB5D1_HUMAN	Increases Methylation	[31]
E3 ubiquitin-protein ligase RFWD3 (RFWD3)	OTDUULBQ	RFWD3_HUMAN	Decreases Methylation	[31]
tRNA methyltransferase 10 homolog B (TRMT10B)	OT3EJP6J	TM10B_HUMAN	Increases Methylation	[31]
Kv channel-interacting protein 4 (KCNIP4)	OTB1BS0X	KCIP4_HUMAN	Decreases Methylation	[31]
Docking protein 6 (DOK6)	OTX55OIF	DOK6_HUMAN	Affects Methylation	[31]
Solute carrier family 25 member 47 (SLC25A47)	OT5NGRWC	S2547_HUMAN	Increases Methylation	[31]
SCAN domain-containing protein 3 (SCAND3)	OTIIMBQL	SCND3_HUMAN	Decreases Methylation	[31]
Opsin-5 (OPN5)	OTCYGHDA	OPN5_HUMAN	Decreases Methylation	[31]
CREB-regulated transcription coactivator 3 (CRTC3)	OTVIGVUW	CRTC3_HUMAN	Increases Methylation	[31]
Golgi-associated kinase 1B (GASK1B)	OT2HPHEI	GAK1B_HUMAN	Decreases Methylation	[31]
Transmembrane and coiled-coil domain-containing protein 3 (TMCO3)	OTYW1KP2	TMCO3_HUMAN	Increases Methylation	[31]
Protein SNORC (SNORC)	OTY3IJK5	SNORC_HUMAN	Increases Methylation	[31]
Inactive serine protease PAMR1 (PAMR1)	OT83ZH5U	PAMR1_HUMAN	Increases Methylation	[31]
Serine/threonine-protein kinase LMTK1 (AATK)	OTVHAX5N	LMTK1_HUMAN	Decreases Methylation	[31]
Metastasis-associated in colon cancer protein 1 (MACC1)	OTV3DLX0	MACC1_HUMAN	Decreases Methylation	[31]
Ferric-chelate reductase 1 (FRRS1)	OTQDEGEB	FRRS1_HUMAN	Increases Methylation	[31]
Neurobeachin-like protein 2 (NBEAL2)	OTMCAXWR	NBEL2_HUMAN	Increases Methylation	[31]
Transmembrane protein 182 (TMEM182)	OTVDIS2V	TM182_HUMAN	Increases Methylation	[31]
RING finger protein 207 (RNF207)	OT9AYVGV	RN207_HUMAN	Increases Methylation	[31]
Protein ITPRID1 (ITPRID1)	OT9MH0BX	ITPI1_HUMAN	Increases Methylation	[31]
Colorectal cancer-associated protein 1 (COLCA1)	OT8BP6UD	COLC1_HUMAN	Decreases Methylation	[31]
Protein shisa-6 (SHISA6)	OTWBCJ8O	SHSA6_HUMAN	Decreases Methylation	[31]
Major facilitator superfamily domain-containing protein 6 (MFSD6)	OTQ6KAV1	MFSD6_HUMAN	Increases Methylation	[31]
BEN domain-containing protein 4 (BEND4)	OT7Z1422	BEND4_HUMAN	Increases Methylation	[31]
Tumor protein p63-regulated gene 1 protein (TPRG1)	OTS48DQM	TPRG1_HUMAN	Increases Methylation	[31]
Phosphoinositide 3-kinase adapter protein 1 (PIK3AP1)	OTMW1B47	BCAP_HUMAN	Increases Methylation	[31]
Coiled-coil domain-containing protein 149 (CCDC149)	OT7S7MU9	CC149_HUMAN	Decreases Methylation	[31]
Cytochrome P450 4V2 (CYP4V2)	OTQKNK0D	CP4V2_HUMAN	Decreases Methylation	[31]
MOB kinase activator 2 (MOB2)	OTMBE0NS	MOB2_HUMAN	Affects Methylation	[31]
RING finger protein 44 (RNF44)	OTGWL4U4	RNF44_HUMAN	Increases Methylation	[31]
DET1 homolog (DET1)	OTHYSDX3	DET1_HUMAN	Increases Methylation	[31]
MOB kinase activator 1B (MOB1B)	OTRE19ZS	MOB1B_HUMAN	Increases Methylation	[31]
Keratin, type I cytoskeletal 26 (KRT26)	OTLAXIN0	K1C26_HUMAN	Increases Methylation	[31]
CUB and sushi domain-containing protein 2 (CSMD2)	OT541Z3W	CSMD2_HUMAN	Increases Methylation	[31]
Protein lifeguard 1 (GRINA)	OTMC1O66	LFG1_HUMAN	Increases Methylation	[31]
Podocan (PODN)	OTV3P7P5	PODN_HUMAN	Increases Methylation	[31]
Protein sidekick-1 (SDK1)	OTX26906	SDK1_HUMAN	Increases Methylation	[31]
Ankyrin repeat and sterile alpha motif domain-containing protein 1B (ANKS1B)	OT26DGM9	ANS1B_HUMAN	Increases Methylation	[31]
Transcription factor AP-2-delta (TFAP2D)	OT71O6YN	AP2D_HUMAN	Decreases Methylation	[31]
Pleckstrin homology domain-containing family H member 3 (PLEKHH3)	OTREOQBO	PKHH3_HUMAN	Increases Methylation	[31]
Cytokine-dependent hematopoietic cell linker (CLNK)	OTOWK51S	CLNK_HUMAN	Decreases Methylation	[31]
Calcium/calmodulin-dependent protein kinase II inhibitor 1 (CAMK2N1)	OTKCR5XL	CK2N1_HUMAN	Increases Methylation	[31]
Uncharacterized protein C11orf96 (C11ORF96)	OTEQU0V7	CK096_HUMAN	Increases Methylation	[31]
Polypeptide N-acetylgalactosaminyltransferase 5 (GALNT5)	OTCV61V1	GALT5_HUMAN	Increases Methylation	[31]
Pleckstrin homology-like domain family B member 2 (PHLDB2)	OTDKMB2G	PHLB2_HUMAN	Increases Methylation	[31]
Protein hinderin (KIAA1328)	OT2RMGGB	K1328_HUMAN	Increases Methylation	[31]
TBC1 domain family member 1 (TBC1D1)	OTI9V7B0	TBCD1_HUMAN	Increases Methylation	[31]
Store-operated calcium entry regulator STIMATE (STIMATE)	OTEDLKEW	STIMA_HUMAN	Increases Methylation	[31]
Armadillo-like helical domain-containing protein 4 (ARMH4)	OT25GBJM	ARMD4_HUMAN	Increases Methylation	[31]
Protein polybromo-1 (PBRM1)	OT39WUR9	PB1_HUMAN	Decreases Methylation	[31]
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (MAGI2)	OTXDDKZS	MAGI2_HUMAN	Decreases Methylation	[31]
Reticulon-4 receptor-like 1 (RTN4RL1)	OTDKKOE7	R4RL1_HUMAN	Increases Methylation	[31]
Telomerase-binding protein EST1A (SMG6)	OTRCEJQL	EST1A_HUMAN	Increases Methylation	[31]
Leucine zipper protein 1 (LUZP1)	OTQV3VZM	LUZP1_HUMAN	Increases Methylation	[31]
Serine incorporator 5 (SERINC5)	OT3COPVF	SERC5_HUMAN	Increases Methylation	[31]
Myotubularin-related protein 13 (SBF2)	OTBB8NO8	MTMRD_HUMAN	Increases Methylation	[31]
Histone-arginine methyltransferase CARM1 (CARM1)	OT0IPRVR	CARM1_HUMAN	Increases Expression	[33]
Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2)	OTHCYR6Y	ANKL2_HUMAN	Increases Methylation	[31]
Angiopoietin-related protein 5 (ANGPTL5)	OTC6AFVO	ANGL5_HUMAN	Increases Methylation	[31]
Cilium assembly protein DZIP1 (DZIP1)	OTBVPO66	DZIP1_HUMAN	Increases Methylation	[31]
Probable guanine nucleotide exchange factor MCF2L2 (MCF2L2)	OTOGFMIH	MF2L2_HUMAN	Increases Methylation	[31]
Protein O-mannosyl-transferase TMTC1 (TMTC1)	OTZ7NW96	TMTC1_HUMAN	Increases Methylation	[31]
Neuron navigator 3 (NAV3)	OT97M1TR	NAV3_HUMAN	Decreases Methylation	[31]
Glycerate kinase (GLYCTK)	OTVTBNSM	GLCTK_HUMAN	Increases Methylation	[31]
Aprataxin and PNK-like factor (APLF)	OTYUR3AH	APLF_HUMAN	Increases Expression	[33]
Adhesion G protein-coupled receptor A3 (ADGRA3)	OTPJEV0S	AGRA3_HUMAN	Increases Methylation	[31]
Proton-coupled zinc antiporter SLC30A8 (SLC30A8)	OTF0FG5K	ZNT8_HUMAN	Increases Methylation	[31]
Sphingosine-1-phosphate phosphatase 2 (SGPP2)	OTIDIJCR	SGPP2_HUMAN	Increases Methylation	[31]
Neuronal PAS domain-containing protein 3 (NPAS3)	OT8D1ILB	NPAS3_HUMAN	Increases Methylation	[31]
POU domain class 2-associating factor 2 (POU2AF2)	OTPBW3NC	OCAT1_HUMAN	Increases Methylation	[31]
Lamin tail domain-containing protein 2 (LMNTD2)	OTKGJ1ST	LMTD2_HUMAN	Increases Methylation	[31]
Nucleotidyltransferase MB21D2 (MB21D2)	OT5C4VVU	M21D2_HUMAN	Increases Methylation	[31]
PEX5-related protein (PEX5L)	OTLR4HSR	PEX5R_HUMAN	Decreases Methylation	[31]
Proline-, glutamic acid- and leucine-rich protein 1 (PELP1)	OTVXQNOT	PELP1_HUMAN	Decreases Expression	[33]
Voltage-dependent calcium channel subunit alpha-2/delta-3 (CACNA2D3)	OTEH9HGE	CA2D3_HUMAN	Increases Methylation	[31]
Transcription initiation factor TFIID subunit 1-like (TAF1L)	OT9Z7EVA	TAF1L_HUMAN	Increases Methylation	[31]
Leucine-rich repeat LGI family member 2 (LGI2)	OTFJ2ZSG	LGI2_HUMAN	Decreases Methylation	[31]
Regulatory-associated protein of mTOR (RPTOR)	OT4TQZ9F	RPTOR_HUMAN	Increases Methylation	[31]
UPF0462 protein C4orf33 (C4ORF33)	OT3O3FC3	CD033_HUMAN	Decreases Methylation	[31]
Mesoderm induction early response protein 2 (MIER2)	OTYURSWD	MIER2_HUMAN	Increases Methylation	[31]
Xylosyl- and glucuronyltransferase LARGE2 (LARGE2)	OT5BZS3J	LARG2_HUMAN	Increases Methylation	[31]
Putative transporter SVOPL (SVOPL)	OTJ4G2ND	SVOPL_HUMAN	Increases Methylation	[31]
Follistatin-related protein 5 (FSTL5)	OT18C29S	FSTL5_HUMAN	Decreases Methylation	[31]
ADAMTS-like protein 1 (ADAMTSL1)	OTBNYF3F	ATL1_HUMAN	Increases Methylation	[31]
EF-hand domain-containing family member B (EFHB)	OT83HFEP	EFHB_HUMAN	Increases Methylation	[31]
Protein BANP (BANP)	OT1JMTBD	BANP_HUMAN	Increases Methylation	[31]
Sodium-dependent lysophosphatidylcholine symporter 1 (MFSD2A)	OTVG1VG0	NLS1_HUMAN	Increases Methylation	[31]
Kyphoscoliosis peptidase (KY)	OTK1L8VX	KY_HUMAN	Increases Methylation	[31]
Clarin-3 (CLRN3)	OTZDNL65	CLRN3_HUMAN	Increases Methylation	[31]
Exophilin-5 (EXPH5)	OTOMXDUO	EXPH5_HUMAN	Decreases Methylation	[31]
Nesprin-1 (SYNE1)	OTSBSLUH	SYNE1_HUMAN	Increases Methylation	[31]
Metalloreductase STEAP2 (STEAP2)	OTGE9ETG	STEA2_HUMAN	Decreases Methylation	[31]
Kelch repeat and BTB domain-containing protein 8 (KBTBD8)	OTO8X1UF	KBTB8_HUMAN	Decreases Methylation	[31]
Neuroligin-2 (NLGN2)	OTHDYL3H	NLGN2_HUMAN	Increases Methylation	[31]
Serine/threonine-protein kinase Nek11 (NEK11)	OTMYENTC	NEK11_HUMAN	Decreases Methylation	[31]
Olfactory receptor 5T1 (OR5T1)	OTJT8C6S	OR5T1_HUMAN	Decreases Methylation	[31]
Olfactory receptor 2AK2 (OR2AK2)	OTNG4ZS1	O2AK2_HUMAN	Increases Methylation	[31]
Olfactory receptor 8J3 (OR8J3)	OTLQYWZG	OR8J3_HUMAN	Decreases Methylation	[31]
Olfactory receptor 8J1 (OR8J1)	OTWWGQW0	OR8J1_HUMAN	Decreases Methylation	[31]
Olfactory receptor 4S2 (OR4S2)	OTHEO86H	OR4S2_HUMAN	Decreases Methylation	[31]
LHFPL tetraspan subfamily member 5 protein (LHFPL5)	OTNDTO5B	LHPL5_HUMAN	Decreases Methylation	[31]
SWI/SNF complex subunit SMARCC2 (SMARCC2)	OTC5SNMZ	SMRC2_HUMAN	Decreases Expression	[52]
Iron-sulfur cluster transfer protein NUBPL (NUBPL)	OTQMCSXT	NUBPL_HUMAN	Increases Methylation	[31]
DEP domain-containing mTOR-interacting protein (DEPTOR)	OTCBP1BT	DPTOR_HUMAN	Increases Methylation	[31]
T-cell immunomodulatory protein (ITFG1)	OTX0PCR3	TIP_HUMAN	Decreases Methylation	[31]
Glutamate receptor ionotropic, NMDA 3A (GRIN3A)	OTQS9GYY	NMD3A_HUMAN	Increases Methylation	[31]
Transmembrane channel-like protein 1 (TMC1)	OTHYH8MU	TMC1_HUMAN	Increases Methylation	[31]
Polycystin-1-like protein 1 (PKD1L1)	OTLAARJ1	PK1L1_HUMAN	Increases Methylation	[31]
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 (ASAP3)	OTQB4H1J	ASAP3_HUMAN	Increases Methylation	[31]
Epidermal growth factor receptor kinase substrate 8-like protein 3 (EPS8L3)	OT7XYA2T	ES8L3_HUMAN	Increases Methylation	[31]
Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8L1)	OT83O8WI	ES8L1_HUMAN	Decreases Methylation	[31]
Importin-4 (IPO4)	OT2N5020	IPO4_HUMAN	Increases Methylation	[31]
Membrane progestin receptor beta (PAQR8)	OTGZ8W9F	PAQR8_HUMAN	Decreases Methylation	[31]
Dual specificity protein phosphatase 19 (DUSP19)	OT0RRSG9	DUS19_HUMAN	Decreases Methylation	[31]
Splicing factor Cactin (CACTIN)	OTO7UVK7	CATIN_HUMAN	Increases Methylation	[31]
AFG1-like ATPase (AFG1L)	OTQ9VV5T	AFG1L_HUMAN	Increases Methylation	[31]
Ankyrin repeat and SOCS box protein 10 (ASB10)	OTYSZ9V6	ASB10_HUMAN	Increases Methylation	[31]
Autism susceptibility gene 2 protein (AUTS2)	OTAEXHSC	AUTS2_HUMAN	Increases Methylation	[31]
Cysteine/serine-rich nuclear protein 3 (CSRNP3)	OTOANEHZ	CSRN3_HUMAN	Increases Methylation	[31]
Phosphoinositide 3-kinase regulatory subunit 5 (PIK3R5)	OT4LNXJU	PI3R5_HUMAN	Decreases Methylation	[31]
Piezo-type mechanosensitive ion channel component 1 (PIEZO1)	OTBG1FU4	PIEZ1_HUMAN	Increases Methylation	[31]
Phosphatidate phosphatase LPIN2 (LPIN2)	OTRRTMXX	LPIN2_HUMAN	Increases Methylation	[31]
Sorting nexin-19 (SNX19)	OTGNS3HG	SNX19_HUMAN	Decreases Methylation	[31]
Engulfment and cell motility protein 1 (ELMO1)	OTY2ORXK	ELMO1_HUMAN	Decreases Methylation	[31]
Delta-sarcoglycan (SGCD)	OTRBL3NQ	SGCD_HUMAN	Increases Methylation	[31]
A-kinase anchor protein 1, mitochondrial (AKAP1)	OTIIB2JB	AKAP1_HUMAN	Increases Expression	[33]
Estrogen receptor beta (ESR2)	OTXNR2WQ	ESR2_HUMAN	Increases Expression	[33]
Transcription initiation factor TFIID subunit 4B (TAF4B)	OTCICY31	TAF4B_HUMAN	Increases Methylation	[31]
General transcription factor IIH subunit 4 (GTF2H4)	OTPD1DIU	TF2H4_HUMAN	Decreases Methylation	[31]
Histone acetyltransferase KAT6A (KAT6A)	OT4TSQLG	KAT6A_HUMAN	Decreases Methylation	[31]
Neuronal cell adhesion molecule (NRCAM)	OT80HHQ2	NRCAM_HUMAN	Increases Methylation	[31]
Bcl-2-like protein 2 (BCL2L2)	OTMKVO0J	B2CL2_HUMAN	Increases Expression	[33]
Caspase-10 (CASP10)	OTE6J88E	CASPA_HUMAN	Increases Methylation	[31]
ATP-binding cassette sub-family C member 2 (ABCC2)	OTJSIGV5	MRP2_HUMAN	Increases Expression	[57]
Fibroblast growth factor 13 (FGF13)	OTHNNVSG	FGF13_HUMAN	Increases Methylation	[31]
SWI/SNF complex subunit SMARCC1 (SMARCC1)	OTUOMBE7	SMRC1_HUMAN	Increases Expression	[52]
Receptor-type tyrosine-protein phosphatase N2 (PTPRN2)	OTL6SH28	PTPR2_HUMAN	Increases Methylation	[31]
Lipoma-preferred partner (LPP)	OT6TU8SE	LPP_HUMAN	Increases Methylation	[31]
Mediator of RNA polymerase II transcription subunit 12 (MED12)	OTQZ4D2X	MED12_HUMAN	Increases Methylation	[31]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (ATP2A3)	OTFYDEES	AT2A3_HUMAN	Increases Methylation	[31]
Secretory carrier-associated membrane protein 4 (SCAMP4)	OTSCZTJ5	SCAM4_HUMAN	Increases Methylation	[31]
Endoplasmic reticulum-Golgi intermediate compartment protein 1 (ERGIC1)	OT351FKB	ERGI1_HUMAN	Decreases Methylation	[31]
Terminal nucleotidyltransferase 5B (TENT5B)	OTO2P28B	TET5B_HUMAN	Increases Methylation	[31]
Collagen alpha-1(XXVI) chain (COL26A1)	OTMS7RNF	COQA1_HUMAN	Decreases Methylation	[31]
Isochorismatase domain-containing protein 2 (ISOC2)	OT69N6MB	ISOC2_HUMAN	Increases Methylation	[31]
Repulsive guidance molecule A (RGMA)	OTZAMDO2	RGMA_HUMAN	Increases Methylation	[31]
Dedicator of cytokinesis protein 10 (DOCK10)	OTI3MBLV	DOC10_HUMAN	Increases Methylation	[31]
EF-hand domain-containing protein D2 (EFHD2)	OTM9VMN3	EFHD2_HUMAN	Increases Methylation	[31]
Netrin-G2 (NTNG2)	OTTY88DL	NTNG2_HUMAN	Increases Methylation	[31]
Anaphase-promoting complex subunit 16 (ANAPC16)	OTG9MUYS	APC16_HUMAN	Increases Methylation	[31]
Rho guanine nucleotide exchange factor 26 (ARHGEF26)	OTX0U8PX	ARHGQ_HUMAN	Increases Methylation	[31]
PHD finger protein 21B (PHF21B)	OTU5GLCQ	PF21B_HUMAN	Increases Methylation	[31]
Polypeptide N-acetylgalactosaminyltransferase 14 (GALNT14)	OT9BSDDQ	GLT14_HUMAN	Increases Methylation	[31]
CKLF-like MARVEL transmembrane domain-containing protein 7 (CMTM7)	OTI7Q2JW	CKLF7_HUMAN	Decreases Methylation	[31]
Aurora kinase B (AURKB)	OTIY4VHU	AURKB_HUMAN	Decreases Expression	[32]
Protein FAM163A (FAM163A)	OT0MYZ0F	F163A_HUMAN	Increases Methylation	[31]
SH3 domain-containing YSC84-like protein 1 (SH3YL1)	OTVXOONW	SH3Y1_HUMAN	Increases Methylation	[31]
ATP-binding cassette sub-family C member 11 (ABCC11)	OTVHL7OR	MRP8_HUMAN	Increases Methylation	[31]
Cadherin-related family member 1 (CDHR1)	OT1ORXCM	CDHR1_HUMAN	Decreases Methylation	[31]
Membrane-spanning 4-domains subfamily A member 4A (MS4A4A)	OTWV82RP	M4A4A_HUMAN	Decreases Methylation	[31]
Protein maelstrom homolog (MAEL)	OTZ2VU30	MAEL_HUMAN	Decreases Methylation	[31]
MAP/microtubule affinity-regulating kinase 4 (MARK4)	OT6Z2TGV	MARK4_HUMAN	Increases Methylation	[31]
Zeta-sarcoglycan (SGCZ)	OTVGTEOD	SGCZ_HUMAN	Decreases Methylation	[31]
Adenylate kinase 8 (AK8)	OT2UF6YM	KAD8_HUMAN	Decreases Methylation	[31]
bMERB domain-containing protein 1 (BMERB1)	OT1IH086	MERB1_HUMAN	Increases Methylation	[31]
Junctional sarcoplasmic reticulum protein 1 (JSRP1)	OT1AAYWO	JSPR1_HUMAN	Increases Methylation	[31]
Cytosolic carboxypeptidase 4 (AGBL1)	OT8NQLH0	CBPC4_HUMAN	Decreases Methylation	[31]
Nucleolar protein 4-like (NOL4L)	OT14W6UW	NOL4L_HUMAN	Increases Methylation	[31]
Retinol dehydrogenase 12 (RDH12)	OTELFRRJ	RDH12_HUMAN	Increases Methylation	[31]
N-terminal EF-hand calcium-binding protein 3 (NECAB3)	OTRASC9G	NECA3_HUMAN	Increases Methylation	[31]
Noelin-3 (OLFM3)	OTBHPDTL	NOE3_HUMAN	Decreases Methylation	[31]
Erythroid membrane-associated protein (ERMAP)	OTKXBB52	ERMAP_HUMAN	Decreases Methylation	[31]
CUB and sushi domain-containing protein 1 (CSMD1)	OTIVDSC4	CSMD1_HUMAN	Decreases Methylation	[31]
PHD finger protein 12 (PHF12)	OTECRO7N	PHF12_HUMAN	Increases Methylation	[31]
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (MAGI1)	OTMV4ASV	MAGI1_HUMAN	Decreases Methylation	[31]
Olfactory receptor 8B4 (OR8B4)	OTT4T35X	OR8B4_HUMAN	Decreases Methylation	[31]
Galactose-3-O-sulfotransferase 4 (GAL3ST4)	OTCXGJGO	G3ST4_HUMAN	Increases Methylation	[31]
Erbin (ERBIN)	OTNWTUA8	ERBIN_HUMAN	Increases Methylation	[31]
Intraflagellar transport protein 140 homolog (IFT140)	OT6KO5FH	IF140_HUMAN	Increases Methylation	[31]
GPI transamidase component PIG-S (PIGS)	OTCC4CEN	PIGS_HUMAN	Increases Methylation	[31]
Tetraspanin-18 (TSPAN18)	OTHSGPVB	TSN18_HUMAN	Decreases Methylation	[31]
2-aminoethanethiol dioxygenase (ADO)	OTRLGQ7V	AEDO_HUMAN	Increases Methylation	[31]
Eyes absent homolog 1 (EYA1)	OTHU807A	EYA1_HUMAN	Decreases Methylation	[31]
G-protein coupled estrogen receptor 1 (GPER1)	OTUK0TDC	GPER1_HUMAN	Increases Expression	[66]
Prohibitin-2 (PHB2)	OTCAX3AW	PHB2_HUMAN	Decreases Expression	[33]
Ataxin-2 (ATXN2)	OT465IGT	ATX2_HUMAN	Increases Methylation	[31]
Tumor susceptibility gene 101 protein (TSG101)	OT97UIXC	TS101_HUMAN	Increases Methylation	[31]
Calcium and integrin-binding protein 1 (CIB1)	OT4BVCRU	CIB1_HUMAN	Increases Methylation	[31]
Histone H2B type 1-M (H2BC14)	OTSDZZZY	H2B1M_HUMAN	Increases Methylation	[31]
Cbp/p300-interacting transactivator 2 (CITED2)	OT812TV7	CITE2_HUMAN	Increases Expression	[33]
Semaphorin-3C (SEMA3C)	OTEGUY7F	SEM3C_HUMAN	Increases Methylation	[31]
Testican-3 (SPOCK3)	OTYSOOO7	TICN3_HUMAN	Decreases Methylation	[31]
SH3-containing GRB2-like protein 3-interacting protein 1 (SGIP1)	OTQW6R3Z	SGIP1_HUMAN	Increases Methylation	[31]
Uncharacterized protein C7orf50 (C7ORF50)	OTDHN459	CG050_HUMAN	Increases Methylation	[31]
Ferroptosis suppressor protein 1 (AIFM2)	OT57XWXO	FSP1_HUMAN	Increases Methylation	[31]
Phagosome assembly factor 1 (PHAF1)	OTF7ZOG6	PHAF1_HUMAN	Increases Methylation	[31]
NEDD4 family-interacting protein 1 (NDFIP1)	OTIORSWF	NFIP1_HUMAN	Increases Methylation	[31]
Death-inducer obliterator 1 (DIDO1)	OT9PB547	DIDO1_HUMAN	Increases Methylation	[31]
CDK5 and ABL1 enzyme substrate 2 (CABLES2)	OTGD9A2A	CABL2_HUMAN	Increases Methylation	[31]
Tubulin-specific chaperone D (TBCD)	OTS4JKNQ	TBCD_HUMAN	Increases Methylation	[31]
E3 ubiquitin-protein ligase TRIM62 (TRIM62)	OT15YO6N	TRI62_HUMAN	Decreases Methylation	[31]
PHD finger protein 20 (PHF20)	OTCBVH5P	PHF20_HUMAN	Increases Methylation	[31]
Protein TALPID3 (KIAA0586)	OTOZRC1U	TALD3_HUMAN	Increases Methylation	[31]
Katanin p60 ATPase-containing subunit A-like 1 (KATNAL1)	OTBUZ7KA	KATL1_HUMAN	Increases Methylation	[31]
Chitinase domain-containing protein 1 (CHID1)	OT4DIUKC	CHID1_HUMAN	Decreases Methylation	[31]
Brother of CDO (BOC)	OTXBCY9W	BOC_HUMAN	Decreases Methylation	[31]
Sal-like protein 3 (SALL3)	OTJ2LZKQ	SALL3_HUMAN	Affects Methylation	[31]
Leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4)	OTIMWEK5	LGR4_HUMAN	Increases Methylation	[31]
Hydroxycarboxylic acid receptor 1 (HCAR1)	OT5ZSESQ	HCAR1_HUMAN	Increases Methylation	[31]
Caspase recruitment domain-containing protein 11 (CARD11)	OTRCTLYC	CAR11_HUMAN	Increases Methylation	[31]
Calcium-binding protein 8 (CALN1)	OTN2XE4T	CABP8_HUMAN	Increases Methylation	[31]
R-spondin-3 (RSPO3)	OTZK8GDS	RSPO3_HUMAN	Increases Methylation	[31]
Histone deacetylase 8 (HDAC8)	OT5L4RYX	HDAC8_HUMAN	Increases Methylation	[31]
Dual specificity protein phosphatase 16 (DUSP16)	OTK7S078	DUS16_HUMAN	Decreases Methylation	[31]
Alpha-(1,6)-fucosyltransferase (FUT8)	OTJJCVG1	FUT8_HUMAN	Decreases Methylation	[31]
Hyccin (HYCC1)	OTO65AE3	HYCCI_HUMAN	Increases Methylation	[31]
Keratin-associated protein 2-1 (KRTAP2-1)	OTV1SGF2	KRA21_HUMAN	Increases Methylation	[31]
F-box-like/WD repeat-containing protein TBL1XR1 (TBL1XR1)	OTM3B3OA	TBL1R_HUMAN	Increases Methylation	[31]
Reticulon-4 receptor (RTN4R)	OT8J693X	RTN4R_HUMAN	Increases Methylation	[31]
Forkhead box protein P3 (FOXP3)	OTA9Z9OC	FOXP3_HUMAN	Increases Methylation	[31]
E3 ubiquitin-protein ligase TRIM4 (TRIM4)	OTLKQNKQ	TRIM4_HUMAN	Increases Methylation	[31]
Tripartite motif-containing protein 2 (TRIM2)	OT0V1YVC	TRIM2_HUMAN	Increases Methylation	[31]
Cilia- and flagella-associated protein 74 (CFAP74)	OTVW2BGR	CFA74_HUMAN	Increases Methylation	[31]
SRC kinase signaling inhibitor 1 (SRCIN1)	OTQZNQQ5	SRCN1_HUMAN	Decreases Methylation	[31]
Eukaryotic translation initiation factor 5A-2 (EIF5A2)	OT4SY4KY	IF5A2_HUMAN	Decreases Methylation	[31]
Hyaluronan and proteoglycan link protein 2 (HAPLN2)	OT0G3KEQ	HPLN2_HUMAN	Decreases Methylation	[31]
Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP)	OT9AGAIJ	LHPP_HUMAN	Increases Methylation	[31]
Transmembrane protein 168 (TMEM168)	OTJKZ6G9	TM168_HUMAN	Increases Methylation	[31]
B-cell lymphoma/leukemia 11A (BCL11A)	OTI6ZBP6	BC11A_HUMAN	Increases Methylation	[31]
EH domain-containing protein 4 (EHD4)	OT7G5JTT	EHD4_HUMAN	Increases Methylation	[31]
Enhancer of polycomb homolog 1 (EPC1)	OT3Q25ND	EPC1_HUMAN	Increases Methylation	[31]
Sodium-coupled neutral amino acid symporter 1 (SLC38A1)	OTO3VD5E	S38A1_HUMAN	Increases Methylation	[31]
Chordin (CHRD)	OTNM60Y1	CHRD_HUMAN	Increases Methylation	[31]
Cysteine-rich secretory protein LCCL domain-containing 1 (CRISPLD1)	OT38HXJP	CRLD1_HUMAN	Increases Methylation	[31]
Polyadenylate-binding protein 3 (PABPC3)	OTTR9DPT	PABP3_HUMAN	Increases Methylation	[31]
Tumor protein 63 (TP63)	OT0WOOKQ	P63_HUMAN	Increases Methylation	[31]
Thiamin pyrophosphokinase 1 (TPK1)	OTCHPUD0	TPK1_HUMAN	Increases Methylation	[31]
Homeodomain-interacting protein kinase 3 (HIPK3)	OT4WYQM2	HIPK3_HUMAN	Increases Methylation	[31]
Serine/threonine-protein kinase PLK3 (PLK3)	OT19CT2Z	PLK3_HUMAN	Increases Methylation	[31]
Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase (ST6GALNAC4)	OTJCJQI7	SIA7D_HUMAN	Increases Methylation	[31]
PR domain zinc finger protein 13 (PRDM13)	OTUNAFQW	PRD13_HUMAN	Increases Methylation	[31]
Dual specificity protein phosphatase 21 (DUSP21)	OTZAGY5R	DUS21_HUMAN	Decreases Methylation	[31]
Uncharacterized protein C19orf44 (C19ORF44)	OTES5EZZ	CS044_HUMAN	Increases Methylation	[31]
Histone-lysine N-methyltransferase SMYD3 (SMYD3)	OT9YR20G	SMYD3_HUMAN	Affects Methylation	[31]
Proton-activated chloride channel (PACC1)	OTKBS8CC	PACC1_HUMAN	Increases Methylation	[31]
Tetratricopeptide repeat protein 12 (TTC12)	OTDB24YV	TTC12_HUMAN	Increases Methylation	[31]
Probable ATP-dependent RNA helicase DDX31 (DDX31)	OTNWY581	DDX31_HUMAN	Increases Methylation	[31]
Protein argonaute-3 (AGO3)	OTNQGROH	AGO3_HUMAN	Affects Methylation	[31]
Akirin-1 (AKIRIN1)	OTINWTT9	AKIR1_HUMAN	Increases Methylation	[31]
Homeobox protein NANOG (NANOG)	OTUEY1FM	NANOG_HUMAN	Increases Expression	[67]
Adhesion G protein-coupled receptor L3 (ADGRL3)	OT81Q8LY	AGRL3_HUMAN	Decreases Methylation	[31]
Protein ERGIC-53-like (LMAN1L)	OT2CSBR3	LMA1L_HUMAN	Increases Methylation	[31]
Histone-lysine N-methyltransferase PRDM16 (PRDM16)	OT0BGA27	PRD16_HUMAN	Decreases Methylation	[31]
Solute carrier family 38 member 10 (SLC38A10)	OTXPUL6S	S38AA_HUMAN	Increases Methylation	[31]
Mucin-5B (MUC5B)	OTPW6K5C	MUC5B_HUMAN	Increases Methylation	[31]
Transcription factor HES-4 (HES4)	OTCGMQDT	HES4_HUMAN	Increases Methylation	[31]
Helicase MOV-10 (MOV10)	OT0KAY9G	MOV10_HUMAN	Increases Methylation	[31]
Synaptotagmin-like protein 2 (SYTL2)	OTUIOWKL	SYTL2_HUMAN	Increases Methylation	[31]
E3 ubiquitin-protein ligase MSL2 (MSL2)	OTVPQYBG	MSL2_HUMAN	Increases Methylation	[31]
Mineralization regulator ANKH (ANKH)	OTCN25R5	ANKH_HUMAN	Decreases Methylation	[31]
Roundabout homolog 2 (ROBO2)	OTFJ9FQW	ROBO2_HUMAN	Decreases Methylation	[31]
Fibrosin-1-like protein (FBRSL1)	OT4BPXGG	FBSL_HUMAN	Increases Methylation	[31]
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (PDE11A)	OT9X261C	PDE11_HUMAN	Increases Methylation	[31]
LYR motif-containing protein 4 (LYRM4)	OTK6JCKL	LYRM4_HUMAN	Increases Methylation	[31]
Regulation of nuclear pre-mRNA domain-containing protein 1B (RPRD1B)	OTB41D5K	RPR1B_HUMAN	Increases Methylation	[31]
Gephyrin (GPHN)	OTAKK1SV	GEPH_HUMAN	Increases Methylation	[31]
Transcriptional and immune response regulator (TCIM)	OTARUXQF	TCIM_HUMAN	Increases Expression	[33]
Matrix-remodeling-associated protein 5 (MXRA5)	OTXZBWCU	MXRA5_HUMAN	Decreases Methylation	[31]
CTP synthase 2 (CTPS2)	OT2X9YO1	PYRG2_HUMAN	Increases Methylation	[31]
Bromodomain adjacent to zinc finger domain protein 1A (BAZ1A)	OTWHOVZS	BAZ1A_HUMAN	Increases Methylation	[31]
Solute carrier family 2, facilitated glucose transporter member 9 (SLC2A9)	OTENU71Z	GTR9_HUMAN	Increases Methylation	[31]
Interleukin-17 receptor B (IL17RB)	OT0KDNSF	I17RB_HUMAN	Decreases Expression	[32]
Double-stranded RNA-specific editase B2 (ADARB2)	OTDJKS39	RED2_HUMAN	Increases Methylation	[31]
Protein DEPP1 (DEPP1)	OTB36PHJ	DEPP1_HUMAN	Decreases Expression	[49]
E3 ubiquitin-protein ligase RNF146 (RNF146)	OTE4CO7E	RN146_HUMAN	Decreases Methylation	[31]
Double-stranded RNA-binding protein Staufen homolog 2 (STAU2)	OTORNUIF	STAU2_HUMAN	Decreases Methylation	[31]
tRNA:m(4)X modification enzyme TRM13 homolog (TRMT13)	OT2H0MCE	TRM13_HUMAN	Increases Methylation	[31]
F-box only protein 28 (FBXO28)	OTKTMVC4	FBX28_HUMAN	Decreases Methylation	[31]
Transmembrane protein 51 (TMEM51)	OTZCW8XJ	TMM51_HUMAN	Increases Methylation	[31]
Solute carrier family 52, riboflavin transporter, member 1 (SLC52A1)	OTQ4D276	S52A1_HUMAN	Increases Methylation	[31]
CUE domain-containing protein 1 (CUEDC1)	OTQ7V4FF	CUED1_HUMAN	Increases Methylation	[31]
Membrane progestin receptor gamma (PAQR5)	OTGGWXQE	PAQR5_HUMAN	Increases Methylation	[31]
Rho guanine nucleotide exchange factor 38 (ARHGEF38)	OTA6K93F	ARH38_HUMAN	Increases Methylation	[31]
Odorant-binding protein 2a (OBP2A)	OTBIJ5TI	OBP2A_HUMAN	Increases Methylation	[31]
Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8)	OTPT2I7B	SL2A8_HUMAN	Increases Methylation	[31]
Sodium channel regulatory subunit beta-3 (SCN3B)	OTNTQT9O	SCN3B_HUMAN	Decreases Methylation	[31]
Probable ATP-dependent RNA helicase DDX56 (DDX56)	OTGURA53	DDX56_HUMAN	Increases Methylation	[31]
Cytochrome c oxidase assembly factor 4 homolog, mitochondrial (COA4)	OT8319UQ	COA4_HUMAN	Increases Methylation	[31]
24-hydroxycholesterol 7-alpha-hydroxylase (CYP39A1)	OTBAJT4I	CP39A_HUMAN	Increases Methylation	[31]
Cadherin EGF LAG seven-pass G-type receptor 1 (CELSR1)	OT7PS8O1	CELR1_HUMAN	Increases Methylation	[31]
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (SMARCAL1)	OTTKXLUZ	SMAL1_HUMAN	Decreases Methylation	[31]
Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)	OT9G360P	IF2B1_HUMAN	Increases Methylation	[31]
Ral guanine nucleotide dissociation stimulator-like 1 (RGL1)	OTY6ZHVA	RGL1_HUMAN	Increases Methylation	[31]
Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1)	OTW3T4B2	IRPL1_HUMAN	Decreases Methylation	[31]
CXXC-type zinc finger protein 1 (CXXC1)	OTO10D1N	CXXC1_HUMAN	Decreases Methylation	[31]
Neurotrimin (NTM)	OTHF0UQU	NTRI_HUMAN	Decreases Methylation	[31]
Costars family protein ABRACL (ABRACL)	OT95T48Q	ABRAL_HUMAN	Increases Methylation	[31]
Coiled-coil domain-containing protein 180 (CCDC180)	OT4AL3LW	CC180_HUMAN	Increases Methylation	[31]
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 (NYAP2)	OT80PO4Q	NYAP2_HUMAN	Increases Methylation	[31]
Rho GTPase-activating protein 20 (ARHGAP20)	OTG1STV8	RHG20_HUMAN	Increases Methylation	[31]
KAT8 regulatory NSL complex subunit 3 (KANSL3)	OTWXDTLY	KANL3_HUMAN	Decreases Methylation	[31]
Arginine-glutamic acid dipeptide repeats protein (RERE)	OT3G4GBZ	RERE_HUMAN	Increases Methylation	[31]
Sperm microtubule associated protein 2 (SPMAP2)	OTLJPJ39	SPMA2_HUMAN	Increases Methylation	[31]
Protein IMPACT (IMPACT)	OTQ923OB	IMPCT_HUMAN	Increases Methylation	[31]
Copine-7 (CPNE7)	OTR0FJ8A	CPNE7_HUMAN	Increases Methylation	[31]
Dickkopf-related protein 3 (DKK3)	OTDU94EY	DKK3_HUMAN	Increases Methylation	[31]
PTB domain-containing engulfment adapter protein 1 (GULP1)	OT1WMVDH	GULP1_HUMAN	Increases Methylation	[31]
Gamma-aminobutyric acid type B receptor subunit 1 (GABBR1)	OTU5A52J	GABR1_HUMAN	Increases Methylation	[31]
Alpha-catulin (CTNNAL1)	OTESJ6JD	CTNL1_HUMAN	Increases Methylation	[31]
Protein CLN8 (CLN8)	OT0D4CB5	CLN8_HUMAN	Decreases Methylation	[31]
Tripartite motif-containing protein 10 (TRIM10)	OTEO4UCZ	TRI10_HUMAN	Increases Methylation	[31]
Death domain-associated protein 6 (DAXX)	OTX6O7PL	DAXX_HUMAN	Increases Methylation	[31]
tRNA (FTSJ1)	OTNE7W96	TRM7_HUMAN	Increases Methylation	[31]
Dynein axonemal heavy chain 17 (DNAH17)	OT4G6E70	DYH17_HUMAN	Increases Methylation	[31]
Regulator of G-protein signaling 17 (RGS17)	OT5RVUDS	RGS17_HUMAN	Decreases Methylation	[31]
Olfactory receptor 12D3 (OR12D3)	OTQ9XNBB	O12D3_HUMAN	Increases Methylation	[31]
Deleted in malignant brain tumors 1 protein (DMBT1)	OTVNU9D9	DMBT1_HUMAN	Increases Expression	[68]
Switch-associated protein 70 (SWAP70)	OTPHT2QD	SWP70_HUMAN	Decreases Methylation	[31]
Contactin-associated protein-like 2 (CNTNAP2)	OT48T2ZP	CNTP2_HUMAN	Increases Methylation	[31]
Interleukin-17B (IL17B)	OTS86H50	IL17B_HUMAN	Decreases Methylation	[31]
Sodium channel protein type 11 subunit alpha (SCN11A)	OTY0HJJZ	SCNBA_HUMAN	Increases Methylation	[31]
Cardiolipin synthase (CRLS1)	OT7XNL0K	CRLS1_HUMAN	Decreases Methylation	[31]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 (ENPP5)	OTY807N5	ENPP5_HUMAN	Decreases Methylation	[31]
Anaphase-promoting complex subunit 2 (ANAPC2)	OTAGLIAO	ANC2_HUMAN	Increases Methylation	[31]
ADP-ribosylation factor-binding protein GGA1 (GGA1)	OTSEV0JU	GGA1_HUMAN	Increases Methylation	[31]
Serine/threonine-protein kinase tousled-like 1 (TLK1)	OTICTXI8	TLK1_HUMAN	Increases Methylation	[31]
POU domain, class 2, transcription factor 3 (POU2F3)	OTIOOJWD	PO2F3_HUMAN	Increases Methylation	[31]
Mucin-12 (MUC12)	OTYDC13T	MUC12_HUMAN	Increases Methylation	[31]
F-box only protein 5 (FBXO5)	OTTR957W	FBX5_HUMAN	Decreases Expression	[32]
Histone deacetylase 9 (HDAC9)	OTO8O0LF	HDAC9_HUMAN	Decreases Methylation	[31]
Protein argonaute-2 (AGO2)	OT4JY32Q	AGO2_HUMAN	Increases Methylation	[31]
Bromodomain and PHD finger-containing protein 3 (BRPF3)	OTRNO4PR	BRPF3_HUMAN	Increases Methylation	[31]
DENN domain-containing protein 2A (DENND2A)	OT01E1PL	DEN2A_HUMAN	Increases Methylation	[31]
Cell cycle progression protein 1 (CCPG1)	OT0IHDKL	CCPG1_HUMAN	Increases Methylation	[31]
Myocardin-related transcription factor B (MRTFB)	OT9OXGS9	MRTFB_HUMAN	Decreases Methylation	[31]
Protein HEG homolog 1 (HEG1)	OT3CUXA7	HEG1_HUMAN	Increases Methylation	[31]
Glutamate receptor ionotropic, delta-1 (GRID1)	OTJ3WIKC	GRID1_HUMAN	Increases Methylation	[31]
Transcription factor MafF (MAFF)	OT9B7MX0	MAFF_HUMAN	Increases Expression	[33]
Protein ATP1B4 (ATP1B4)	OT2YC9GZ	AT1B4_HUMAN	Decreases Methylation	[31]
Dual specificity protein phosphatase CDC14A (CDC14A)	OTL10OY6	CC14A_HUMAN	Increases Methylation	[31]
FAS-associated factor 1 (FAF1)	OTGAMLM4	FAF1_HUMAN	Increases Methylation	[31]
Protein timeless homolog (TIMELESS)	OTD8DCBJ	TIM_HUMAN	Decreases Expression	[32]
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (MACF1)	OTVIHD77	MACF1_HUMAN	Increases Methylation	[31]
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 (AGAP1)	OTVX8835	AGAP1_HUMAN	Affects Methylation	[31]
Trinucleotide repeat-containing gene 6B protein (TNRC6B)	OTGVT0SH	TNR6B_HUMAN	Increases Methylation	[31]
Transcription factor 19 (TCF19)	OT7NKLF9	TCF19_HUMAN	Decreases Expression	[32]
Type 2 lactosamine alpha-2,3-sialyltransferase (ST3GAL6)	OTB17Q43	SIA10_HUMAN	Increases Methylation	[31]
UDP-N-acetylglucosamine transporter (SLC35A3)	OTG92DK5	S35A3_HUMAN	Increases Methylation	[31]
Protein strawberry notch homolog 2 (SBNO2)	OT1C6J3K	SBNO2_HUMAN	Increases Methylation	[31]
Angiomotin-like protein 2 (AMOTL2)	OTRCTKV9	AMOL2_HUMAN	Increases Methylation	[31]
Serine/threonine-protein kinase SIK3 (SIK3)	OTH0V1L5	SIK3_HUMAN	Increases Methylation	[31]
Peptidyl-prolyl cis-trans isomerase-like 1 (PPIL1)	OTS5S837	PPIL1_HUMAN	Increases Methylation	[31]
Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)	OT8M52QY	LMBL1_HUMAN	Decreases Methylation	[31]
Transformation/transcription domain-associated protein (TRRAP)	OT68OI2Y	TRRAP_HUMAN	Increases Methylation	[31]
FERM, ARHGEF and pleckstrin domain-containing protein 1 (FARP1)	OTL1EBTM	FARP1_HUMAN	Increases Methylation	[31]
Centrosomal protein of 170 kDa protein B (CEP170B)	OTYB0VGH	C170B_HUMAN	Increases Methylation	[31]
Protein PRRC2C (PRRC2C)	OTBX3MXM	PRC2C_HUMAN	Increases Methylation	[31]
Ankyrin repeat and SOCS box protein 4 (ASB4)	OTI4AFZL	ASB4_HUMAN	Increases Methylation	[31]
Ankyrin repeat and SOCS box protein 3 (ASB3)	OTI3TK38	ASB3_HUMAN	Decreases Methylation	[31]
AP-4 complex subunit sigma-1 (AP4S1)	OTM3QBU8	AP4S1_HUMAN	Decreases Methylation	[31]
Protocadherin gamma-A1 (PCDHGA1)	OTR1U1LI	PCDG1_HUMAN	Increases Methylation	[31]
Methyltransferase N6AMT1 (N6AMT1)	OTOK0NYQ	N6MT1_HUMAN	Increases Methylation	[31]
Sorting nexin-8 (SNX8)	OTMG63Z6	SNX8_HUMAN	Increases Methylation	[31]
Nuclear receptor corepressor 2 (NCOR2)	OTY917X0	NCOR2_HUMAN	Increases Methylation	[31]
Junctional adhesion molecule A (F11R)	OTGHPAV6	JAM1_HUMAN	Decreases Methylation	[31]
Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (ARFGEF1)	OTPAU0L4	BIG1_HUMAN	Increases Methylation	[31]
Synphilin-1 (SNCAIP)	OTH8VNOK	SNCAP_HUMAN	Increases Methylation	[31]
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (TAF6L)	OTQLO30U	TAF6L_HUMAN	Increases Methylation	[31]
Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)	OT4ZSEEE	IF2B2_HUMAN	Increases Methylation	[31]
Nuclear receptor coactivator 3 (NCOA3)	OTBX300Z	NCOA3_HUMAN	Increases Expression	[33]
Calmodulin-binding transcription activator 1 (CAMTA1)	OTAN1S5B	CMTA1_HUMAN	Increases Methylation	[31]
Ras-related and estrogen-regulated growth inhibitor (RERG)	OTF6MMLV	RERG_HUMAN	Affects Response To Substance	[52]
Serine/threonine-protein kinase mTOR (MTOR)	OTHH8KU7	MTOR_HUMAN	Decreases Response To Substance	[32]
Breast cancer anti-estrogen resistance protein 3 (BCAR3)	OTPJ17M8	BCAR3_HUMAN	Affects Response To Substance	[52]
FK506-binding protein-like (FKBPL)	OTR9ND6K	FKBPL_HUMAN	Increases Response To Substance	[69]
Anterior gradient protein 2 homolog (AGR2)	OTRRZT7W	AGR2_HUMAN	Affects Response To Substance	[70]
AT-rich interactive domain-containing protein 1A (ARID1A)	OTRWDV3P	ARI1A_HUMAN	Decreases Response To Substance	[71]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)	OTW8V2V1	ABCG2_HUMAN	Affects Response To Substance	[52]
Artemin (ARTN)	OTWIWGL6	ARTN_HUMAN	Decreases Response To Substance	[72]
Cyclin-dependent kinase 12 (CDK12)	OTZUDGNU	CDK12_HUMAN	Affects Response To Substance	[73]

Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
Adenocarcinoma	DCB5QBZ	DU-145	Investigative	[1]
Adenocarcinoma	DCPHGWL	OVCAR3	Investigative	[1]
Adenocarcinoma	DCB5W68	NCIH23	Investigative	[1]
Amelanotic melanoma	DC2HHR3	M14	Investigative	[1]
Chronic myelogenous leukemia	DC7UOWK	K-562	Investigative	[1]
Clear cell renal cell carcinoma	DCWXSRL	TK-10	Investigative	[1]
Clear cell renal cell carcinoma	DCK2EUS	786-0	Investigative	[1]
Cutaneous melanoma	DC8PGMC	SK-MEL-5	Investigative	[1]
High grade ovarian serous adenocarcinoma	DCAK25M	OVCAR-4	Investigative	[1]
High grade ovarian serous adenocarcinoma	DC21XTR	OVCAR-8	Investigative	[1]
Lung adenocarcinoma	DCGSS9M	HOP-62	Investigative	[1]
Lung adenocarcinoma	DCZ9KV1	NCI-H522	Investigative	[1]
Melanoma	DC0VGDC	UACC-257	Investigative	[1]
Minimally invasive lung adenocarcinoma	DC4F8LB	NCI-H322M	Investigative	[1]
Carcinoma	DC3OYU6	MCF7	Investigative	[74]
Invasive ductal carcinoma	DCFEHTU	HS 578T	Investigative	[74]
Invasive ductal carcinoma	DCRWNED	BT-549	Investigative	[74]

References

• [1] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4903).
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1015).
• [4] Enhancement of the antiproliferative activity of gemcitabine by modulation of c-Met pathway in pancreatic cancer. Curr Pharm Des. 2013;19(5):940-50.
• [5] Antitumor action of the MET tyrosine kinase inhibitor crizotinib (PF-02341066) in gastric cancer positive for MET amplification. Mol Cancer Ther. 2012 Jul;11(7):1557-64. doi: 10.1158/1535-7163.MCT-11-0934. Epub 2012 Jun 22.
• [6] Aberrant expression of the transcriptional factor Twist1 promotes invasiveness in ALK-positive anaplastic large cell lymphoma. Cell Signal. 2012 Apr;24(4):852-8. doi: 10.1016/j.cellsig.2011.11.020. Epub 2011 Dec 8.
• [7] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [8] Met tyrosine kinase inhibitor, PF-2341066, suppresses growth and invasion of nasopharyngeal carcinoma.Drug Des Devel Ther. 2015 Aug 26;9:4897-907.
• [9] Increased oral availability and brain accumulation of the ALK inhibitor crizotinib by coadministration of the P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) inhibitor elacridar. Int J Cancer. 2014 Mar 15;134(6):1484-94.
• [10] Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66.
• [11] Crizotinib for the treatment of non-small-cell lung cancer. Am J Health Syst Pharm. 2013 Jun 1;70(11):943-7.
• [12] Prediction of crizotinib-midazolam interaction using the Simcyp population-based simulator: comparison of CYP3A time-dependent inhibition between human liver microsomes versus hepatocytes. Drug Metab Dispos. 2013 Feb;41(2):343-52.
• [13] Editor's Highlight: PlacentalDisposition and Effects of Crizotinib: An Ex Vivo Study in the Isolated Dual-Side Perfused Human Cotyledon. Toxicol Sci. 2017 Jun 1;157(2):500-509. doi: 10.1093/toxsci/kfx063.
• [14] Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers. Sci Transl Med. 2012 Feb 8;4(120):120ra17. doi: 10.1126/scitranslmed.3003316. Epub 2012 Jan 25.
• [15] Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):245-55.
• [16] Rapid-onset hypogonadism secondary to crizotinib use in men with metastatic nonsmall cell lung cancer. Cancer. 2012 Nov 1;118(21):5302-9. doi: 10.1002/cncr.27450. Epub 2012 Apr 4.
• [17] Structure based drug design of crizotinib (PF-02341066), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). J Med Chem. 2011 Sep 22;54(18):6342-63. doi: 10.1021/jm2007613. Epub 2011 Aug 18.
• [18] ROS-dependent DNA damage contributes to crizotinib-induced hepatotoxicity via the apoptotic pathway. Toxicol Appl Pharmacol. 2019 Nov 15;383:114768. doi: 10.1016/j.taap.2019.114768. Epub 2019 Oct 19.
• [19] Elucidating mechanisms of toxicity using phenotypic data from primary human cell systems--a chemical biology approach for thrombosis-related side effects. Int J Mol Sci. 2015 Jan 5;16(1):1008-29. doi: 10.3390/ijms16011008.
• [20] Cytotoxicity of 34 FDA approved small-molecule kinase inhibitors in primary rat and human hepatocytes. Toxicol Lett. 2018 Jul;291:138-148. doi: 10.1016/j.toxlet.2018.04.010. Epub 2018 Apr 12.
• [21] Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK. Proc Natl Acad Sci U S A. 2011 May 3;108(18):7535-40. doi: 10.1073/pnas.1019559108. Epub 2011 Apr 18.
• [22] Paracrine receptor activation by microenvironment triggers bypass survival signals and ALK inhibitor resistance in EML4-ALK lung cancer cells. Clin Cancer Res. 2012 Jul 1;18(13):3592-602. doi: 10.1158/1078-0432.CCR-11-2972. Epub 2012 May 2.
• [23] Crizotinib-resistant mutants of EML4-ALK identified through an accelerated mutagenesis screen. Chem Biol Drug Des. 2011 Dec;78(6):999-1005. doi: 10.1111/j.1747-0285.2011.01239.x. Epub 2011 Oct 31.
• [24] Tyrosine phosphorylation of the scaffold protein IQGAP1 in the MET pathway alters function. J Biol Chem. 2020 Dec 25;295(52):18105-18121. doi: 10.1074/jbc.RA120.015891. Epub 2020 Oct 21.
• [25] Keratinocytes apoptosis contributes to crizotinib induced-erythroderma. Toxicol Lett. 2020 Feb 1;319:102-110. doi: 10.1016/j.toxlet.2019.11.007. Epub 2019 Nov 7.
• [26] Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer. Clin Cancer Res. 2012 Mar 1;18(5):1472-82. doi: 10.1158/1078-0432.CCR-11-2906. Epub 2012 Jan 10.
• [27] Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
• [28] Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
• [29] Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells. J Cell Biochem. 2006 Aug 1;98(5):1163-84.
• [30] Moving toward integrating gene expression profiling into high-throughput testing: a gene expression biomarker accurately predicts estrogen receptor alpha modulation in a microarray compendium. Toxicol Sci. 2016 May;151(1):88-103.
• [31] DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
• [32] mTOR inhibition reverses acquired endocrine therapy resistance of breast cancer cells at the cell proliferation and gene-expression levels. Cancer Sci. 2008 Oct;99(10):1992-2003. doi: 10.1111/j.1349-7006.2008.00955.x.
• [33] Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
• [34] The Wilms' tumor suppressor WT1 induces estrogen-independent growth and anti-estrogen insensitivity in ER-positive breast cancer MCF7 cells. Oncol Rep. 2010 Apr;23(4):1109-17. doi: 10.3892/or_00000739.
• [35] Beta3-tubulin is induced by estradiol in human breast carcinoma cells through an estrogen-receptor dependent pathway. Cell Motil Cytoskeleton. 2009 Jul;66(7):378-88.
• [36] Fulvestrant: pharmacologic profile versus existing endocrine agents for the treatment of breast cancer. Ann Pharmacother. 2006 Sep;40(9):1572-83.
• [37] Inactivation of the pure antiestrogen fulvestrant and other synthetic estrogen molecules by UDP-glucuronosyltransferase 1A enzymes expressed in breast tissue. Mol Pharmacol. 2006 Mar;69(3):908-20.
• [38] Analysis of estrogen agonism and antagonism of tamoxifen, raloxifene, and ICI182780 in endometrial cancer cells: a putative role for the epidermal growth factor receptor ligand amphiregulin. J Soc Gynecol Investig. 2005 Oct;12(7):e55-67.
• [39] Regulation of aryl hydrocarbon receptor function by selective estrogen receptor modulators. Mol Endocrinol. 2010 Jan;24(1):33-46.
• [40] Red clover aryl hydrocarbon receptor (AhR) and estrogen receptor (ER) agonists enhance genotoxic estrogen metabolism. Chem Res Toxicol. 2017 Nov 20;30(11):2084-2092.
• [41] Effect of ellagic acid on the expression of human telomerase reverse transcriptase (hTERT) alpha+beta+ transcript in estrogen receptor-positive MCF-7 breast cancer cells. Clin Biochem. 2009 Sep;42(13-14):1358-62. doi: 10.1016/j.clinbiochem.2009.05.017. Epub 2009 Jun 6.
• [42] Estrogen-mediated inactivation of FOXO3a by the G protein-coupled estrogen receptor GPER. BMC Cancer. 2015 Oct 15;15:702. doi: 10.1186/s12885-015-1699-6.
• [43] Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR). Toxicol Appl Pharmacol. 2005 Dec 1;209(2):123-33. doi: 10.1016/j.taap.2005.03.015.
• [44] Estrogens and human papilloma virus oncogenes regulate human ether--go-go-1 potassium channel expression. Cancer Res. 2009 Apr 15;69(8):3300-7. doi: 10.1158/0008-5472.CAN-08-2036. Epub 2009 Apr 7.
• [45] Identification of TACC1, NOV, and PTTG1 as new candidate genes associated with endocrine therapy resistance in breast cancer. J Mol Endocrinol. 2009 Feb;42(2):87-103. doi: 10.1677/JME-08-0076. Epub 2008 Nov 4.
• [46] Estradiol attenuates EGF-induced rapid uPAR mobilization and cell migration via the G-protein-coupled receptor 30 in ovarian cancer cells. Int J Gynecol Cancer. 2009 Feb;19(2):214-22. doi: 10.1111/IGC.0b013e31819bcb75.
• [47] Antiestrogens induce transforming growth factor beta-mediated immunosuppression in breast cancer. Cancer Res. 2010 Feb 15;70(4):1314-22. doi: 10.1158/0008-5472.CAN-09-3292. Epub 2010 Feb 9.
• [48] Differential effects of estrogen receptor antagonists on pituitary lactotroph proliferation and prolactin release. Mol Cell Endocrinol. 2005 Jul 15;239(1-2):27-36. doi: 10.1016/j.mce.2005.04.008.
• [49] ERE-independent ERalpha target genes differentially expressed in human breast tumors. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):53-9. doi: 10.1016/j.mce.2005.10.003. Epub 2005 Nov 17.
• [50] Cross-talk between non-genomic and genomic signalling pathways--distinct effect profiles of environmental estrogens. Toxicol Appl Pharmacol. 2010 Jun 1;245(2):160-70. doi: 10.1016/j.taap.2010.02.015. Epub 2010 Mar 4.
• [51] Resveratrol modulates the phosphoinositide 3-kinase pathway through an estrogen receptor alpha-dependent mechanism: relevance in cell proliferation. Int J Cancer. 2004 Mar 20;109(2):167-73. doi: 10.1002/ijc.11720.
• [52] Fulvestrant induces resistance by modulating GPER and CDK6 expression: implication of methyltransferases, deacetylases and the hSWI/SNF chromatin remodelling complex. Br J Cancer. 2013 Nov 12;109(10):2751-62. doi: 10.1038/bjc.2013.583. Epub 2013 Oct 29.
• [53] Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancer. Endocr Relat Cancer. 2011 Apr 28;18(3):333-45. doi: 10.1530/ERC-10-0262. Print 2011 Jun.
• [54] Effects of the environmental estrogens bisphenol A, o,p'-DDT, p-tert-octylphenol and coumestrol on apoptosis induction, cell proliferation and the expression of estrogen sensitive molecular parameters in the human breast cancer cell line MCF-7. J Steroid Biochem Mol Biol. 2002 Jan;80(1):61-70. doi: 10.1016/s0960-0760(01)00173-x.
• [55] Regulation of ERRalpha gene expression by estrogen receptor agonists and antagonists in SKBR3 breast cancer cells: differential molecular mechanisms mediated by g protein-coupled receptor GPR30/GPER-1. Mol Endocrinol. 2010 May;24(5):969-80. doi: 10.1210/me.2009-0148. Epub 2010 Mar 8.
• [56] Estrogen utilization of IGF-1-R and EGF-R to signal in breast cancer cells. J Steroid Biochem Mol Biol. 2010 Feb 28;118(4-5):219-30. doi: 10.1016/j.jsbmb.2009.09.018. Epub 2009 Oct 6.
• [57] Regulation of expression and activity of multidrug resistance proteins MRP2 and MDR1 by estrogenic compounds in Caco-2 cells. Role in prevention of xenobiotic-induced cytotoxicity. Toxicology. 2014 Jun 5;320:46-55. doi: 10.1016/j.tox.2014.03.007. Epub 2014 Mar 28.
• [58] Cell cycle and anti-estrogen effects synergize to regulate cell proliferation and ER target gene expression. PLoS One. 2010 Jun 8;5(6):e11011. doi: 10.1371/journal.pone.0011011.
• [59] The estrogen receptor influences microtubule-associated protein tau (MAPT) expression and the selective estrogen receptor inhibitor fulvestrant downregulates MAPT and increases the sensitivity to taxane in breast cancer cells. Breast Cancer Res. 2010;12(3):R43. doi: 10.1186/bcr2598. Epub 2010 Jun 28.
• [60] Inhibition of estrogen receptor reduces connexin 43 expression in breast cancers. Toxicol Appl Pharmacol. 2018 Jan 1;338:182-190. doi: 10.1016/j.taap.2017.11.020. Epub 2017 Nov 24.
• [61] Estrogen receptor regulates E2F1 expression to mediate tamoxifen resistance. Mol Cancer Res. 2010 Mar;8(3):343-52. doi: 10.1158/1541-7786.MCR-09-0395. Epub 2010 Mar 9.
• [62] Estrogen and pure antiestrogen fulvestrant (ICI 182 780) augment cell-matrigel adhesion of MCF-7 breast cancer cells through a novel G protein coupled estrogen receptor (GPR30)-to-calpain signaling axis. Toxicol Appl Pharmacol. 2014 Mar 1;275(2):176-81. doi: 10.1016/j.taap.2014.01.005. Epub 2014 Jan 17.
• [63] Expression and mitogenic effect of fibroblast growth factor-9 in human endometriotic implant is regulated by aberrant production of estrogen. J Clin Endocrinol Metab. 2003 Nov;88(11):5547-54. doi: 10.1210/jc.2003-030597.
• [64] Gestational bisphenol A exposure induces fatty liver development in male offspring mice through the inhibition of HNF1b and upregulation of PPAR. Cell Biol Toxicol. 2021 Feb;37(1):65-84. doi: 10.1007/s10565-020-09535-3. Epub 2020 Jul 4.
• [65] Mechanisms of estrogen receptor antagonism toward p53 and its implications in breast cancer therapeutic response and stem cell regulation. Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15081-6. doi: 10.1073/pnas.1009575107. Epub 2010 Aug 9.
• [66] Dehydroepiandrosterone Activation of G-protein-coupled Estrogen Receptor Rapidly Stimulates MicroRNA-21 Transcription in Human Hepatocellular Carcinoma Cells. J Biol Chem. 2015 Jun 19;290(25):15799-15811. doi: 10.1074/jbc.M115.641167. Epub 2015 May 11.
• [67] Methylparaben stimulates tumor initiating cells in ER+ breast cancer models. J Appl Toxicol. 2017 Apr;37(4):417-425. doi: 10.1002/jat.3374. Epub 2016 Sep 1.
• [68] The putative tumor suppressor deleted in malignant brain tumors 1 is an estrogen-regulated gene in rodent and primate endometrial epithelium. Endocrinology. 2005 Mar;146(3):1066-73. doi: 10.1210/en.2004-1304. Epub 2004 Nov 24.
• [69] FKBPL regulates estrogen receptor signaling and determines response to endocrine therapy. Cancer Res. 2010 Feb 1;70(3):1090-100. doi: 10.1158/0008-5472.CAN-09-2515. Epub 2010 Jan 26.
• [70] Anterior gradient-2 plays a critical role in breast cancer cell growth and survival by modulating cyclin D1, estrogen receptor-alpha and survivin. Breast Cancer Res. 2010;12(3):R32. doi: 10.1186/bcr2586. Epub 2010 Jun 4.
• [71] ARID1A determines luminal identity and therapeutic response in estrogen-receptor-positive breast cancer. Nat Genet. 2020 Feb;52(2):198-207. doi: 10.1038/s41588-019-0554-0. Epub 2020 Jan 13.
• [72] Artemin is estrogen regulated and mediates antiestrogen resistance in mammary carcinoma. Oncogene. 2010 Jun 3;29(22):3228-40. doi: 10.1038/onc.2010.71. Epub 2010 Mar 22.
• [73] CRK7 modifies the MAPK pathway and influences the response to endocrine therapy. Carcinogenesis. 2009 Oct;30(10):1696-701. doi: 10.1093/carcin/bgp187. Epub 2009 Aug 3.
• [74] Biologically active neutrophil chemokine pattern in tonsillitis.Clin Exp Immunol. 2004 Mar;135(3):511-8. doi: 10.1111/j.1365-2249.2003.02390.x.