Details of the Drug Combination

General Information of Drug Combination (ID: DCUR88V)

Drug Combination Name
Crizotinib Dasatinib
Indication
Disease Entry Status REF
Large cell lung carcinoma Investigative [1]
Component Drugs Crizotinib   DM4F29C Dasatinib   DMJV2EK
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: NCI-H460
Zero Interaction Potency (ZIP) Score: 22.1
Bliss Independence Score: 22.48
Loewe Additivity Score: 21.29
LHighest Single Agent (HSA) Score: 21.65

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Crizotinib
Disease Entry ICD 11 Status REF
Non-small-cell lung cancer 2C25.Y Approved [2]
Crizotinib Interacts with 4 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Proto-oncogene c-Met (MET) TTNDSF4 MET_HUMAN Modulator [5]
ALK tyrosine kinase receptor (ALK) TTPMQSO ALK_HUMAN Modulator [5]
Proto-oncogene c-Ros (ROS1) TTSZ6Y3 ROS1_HUMAN Modulator [5]
HGF/Met signaling pathway (HGF/Met pathway) TTKA5LP NOUNIPROTAC Inhibitor [10]
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Crizotinib Interacts with 3 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [11]
Organic anion transporting polypeptide 1B1 (SLCO1B1) DT3D8F0 SO1B1_HUMAN Substrate [12]
Organic anion transporting polypeptide 1B3 (SLCO1B3) DT9C1TS SO1B3_HUMAN Substrate [12]
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Crizotinib Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [13]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Metabolism [13]
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Crizotinib Interacts with 45 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Increases Expression [14]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Decreases Activity [15]
Hepatocyte growth factor receptor (MET) OT7K55MU MET_HUMAN Increases Response To Substance [8]
ALK tyrosine kinase receptor (ALK) OTV3P4V8 ALK_HUMAN Decreases Response To Substance [16]
Prominin-1 (PROM1) OTBHV8NX PROM1_HUMAN Decreases Expression [7]
CD44 antigen (CD44) OT9TTJ41 CD44_HUMAN Decreases Expression [7]
Epithelial cell adhesion molecule (EPCAM) OTHBZK5X EPCAM_HUMAN Decreases Expression [7]
Cytidine deaminase (CDA) OT3HXP6N CDD_HUMAN Decreases Expression [7]
Insulin-induced gene 1 protein (INSIG1) OTZF5X1D INSI1_HUMAN Increases Expression [17]
Acyl-CoA 6-desaturase (FADS2) OTUX531P FADS2_HUMAN Increases Expression [17]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) OTRT3F3U HMDH_HUMAN Increases Expression [17]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Activity [17]
Fatty acid synthase (FASN) OTFII9KG FAS_HUMAN Increases Expression [17]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Increases Activity [17]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1) OTCO26FV HMCS1_HUMAN Increases Expression [17]
Sterol regulatory element-binding protein 2 (SREBF2) OTBXUNPL SRBP2_HUMAN Increases Expression [17]
Potassium voltage-gated channel subfamily H member 2 (KCNH2) OTZX881H KCNH2_HUMAN Decreases Activity [17]
Acetyl-CoA carboxylase 1 (ACACA) OT5CQPZY ACACA_HUMAN Increases Phosphorylation [17]
Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C) OT6KFNMS CAC1C_HUMAN Decreases Activity [17]
Sodium channel protein type 5 subunit alpha (SCN5A) OTGYZWR6 SCN5A_HUMAN Decreases Activity [17]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [8]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Increases Expression [8]
Follitropin subunit beta (FSHB) OTGLS283 FSHB_HUMAN Decreases Secretion [18]
Lutropin subunit beta (LHB) OT5GBOVJ LSHB_HUMAN Decreases Secretion [18]
Tyrosine-protein kinase Lck (LCK) OT883FG9 LCK_HUMAN Decreases Activity [19]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [20]
Tissue factor (F3) OT3MSU3B TF_HUMAN Increases Expression [21]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Increases Phosphorylation [20]
Alanine aminotransferase 1 (GPT) OTOXOA0Q ALAT1_HUMAN Increases Secretion [22]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Phosphorylation [23]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Decreases Phosphorylation [23]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Decreases Phosphorylation [24]
Signal transducer and activator of transcription 3 (STAT3) OTAAGKYZ STAT3_HUMAN Decreases Phosphorylation [25]
Ras GTPase-activating-like protein IQGAP1 (IQGAP1) OTZRWTGA IQGA1_HUMAN Decreases Phosphorylation [26]
Small ribosomal subunit protein eS6 (RPS6) OTT4D1LN RS6_HUMAN Decreases Phosphorylation [25]
Baculoviral IAP repeat-containing protein 2 (BIRC2) OTFXFREP BIRC2_HUMAN Decreases Expression [8]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Increases Cleavage [27]
Echinoderm microtubule-associated protein-like 4 (EML4) OTJC45TA EMAL4_HUMAN Increases Mutagenesis [23]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Decreases Activity [15]
GTPase KRas (KRAS) OT78QCN8 RASK_HUMAN Decreases Response To Substance [28]
Pro-epidermal growth factor (EGF) OTANRJ0L EGF_HUMAN Decreases Response To Substance [24]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Decreases Response To Substance [28]
Mast/stem cell growth factor receptor Kit (KIT) OTHUY3VZ KIT_HUMAN Decreases Response To Substance [16]
Proheparin-binding EGF-like growth factor (HBEGF) OTLU00JS HBEGF_HUMAN Decreases Response To Substance [24]
Protransforming growth factor alpha (TGFA) OTPD1LL9 TGFA_HUMAN Decreases Response To Substance [24]
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⏷ Show the Full List of 45 DOT(s)
Indication(s) of Dasatinib
Disease Entry ICD 11 Status REF
Blast phase chronic myelogenous leukemia, BCR-ABL1 positive N.A. Approved [3]
Brain disease 8C70-8E61 Approved [3]
Central nervous system disease 8A04-8D87 Approved [3]
Chronic myelogenous leukaemia 2A20.0 Approved [4]
Chronic myeloid leukaemia 2A20 Approved [5]
Glioblastoma 2A00 Approved [3]
Leukemia N.A. Approved [3]
Lung cancer 2C25.0 Approved [3]
Non-small-cell lung cancer 2C25.Y Approved [3]
Plasma cell myeloma 2A83.1 Approved [3]
Multiple myeloma 2A83 Phase 2 [4]
Middle East Respiratory Syndrome (MERS) 1D64 Investigative [6]
Severe acute respiratory syndrome (SARS) 1D65 Investigative [6]
Dasatinib Interacts with 5 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
LCK tyrosine protein kinase (LCK) TT860QF LCK_HUMAN Inhibitor [32]
Fyn tyrosine protein kinase (FYN) TT2B9KF FYN_HUMAN Inhibitor [32]
Fusion protein Bcr-Abl (Bcr-Abl) TTS7G69 BCR_HUMAN-ABL1_HUMAN Inhibitor [32]
Proto-oncogene c-Src (SRC) TT6PKBN SRC_HUMAN Inhibitor [32]
HUMAN fusion protein Bcr-Abl (Bcr-Abl) TTE63HY BCR_HUMAN/ABL1_HUMAN Inhibitor [6]
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Dasatinib Interacts with 4 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [33]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [34]
Organic anion transporting polypeptide 1B1 (SLCO1B1) DT3D8F0 SO1B1_HUMAN Substrate [12]
Organic anion transporting polypeptide 1B3 (SLCO1B3) DT9C1TS SO1B3_HUMAN Substrate [12]
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Dasatinib Interacts with 4 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [35]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Metabolism [35]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Metabolism [35]
Dimethylaniline oxidase 3 (FMO3) DEP76YL FMO3_HUMAN Metabolism [36]
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Dasatinib Interacts with 453 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Tyrosine-protein kinase Fyn (FYN) OTLSLVZS FYN_HUMAN Affects Binding [29]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3) OTB6YLFT ENPP3_HUMAN Decreases Expression [29]
Tyrosine-protein kinase HCK (HCK) OTRL6OSI HCK_HUMAN Decreases Phosphorylation [29]
CD63 antigen (CD63) OT2UGZA9 CD63_HUMAN Decreases Expression [29]
Tyrosine-protein kinase Fgr (FGR) OTCUYU9F FGR_HUMAN Affects Binding [29]
Heat shock cognate 71 kDa protein (HSPA8) OTJI2RCI HSP7C_HUMAN Affects Binding [29]
Aminopeptidase N (ANPEP) OTP3WYFD AMPN_HUMAN Decreases Expression [29]
Tyrosine-protein kinase CSK (CSK) OTP03OD0 CSK_HUMAN Affects Binding [29]
Tyrosine-protein kinase Tec (TEC) OTU6QJAJ TEC_HUMAN Affects Binding [29]
Tyrosine-protein kinase FRK (FRK) OTEKV1SC FRK_HUMAN Affects Binding [29]
Ephrin type-A receptor 5 (EPHA5) OTAM0CVX EPHA5_HUMAN Affects Binding [29]
Ephrin type-B receptor 4 (EPHB4) OTKLPVXJ EPHB4_HUMAN Affects Binding [29]
Sialomucin core protein 24 (CD164) OTZ7FIU8 MUC24_HUMAN Decreases Expression [29]
Amidophosphoribosyltransferase (PPAT) OTXK12ZB PUR1_HUMAN Affects Binding [29]
Mitogen-activated protein kinase 14 (MAPK14) OT5TCO3O MK14_HUMAN Affects Binding [29]
Mitogen-activated protein kinase kinase kinase 20 (MAP3K20) OT0ALMEG M3K20_HUMAN Affects Binding [29]
ATP-dependent RNA helicase DDX39A (DDX39A) OT0Z6E1K DX39A_HUMAN Decreases Expression [30]
Cell division cycle 7-related protein kinase (CDC7) OT5133XY CDC7_HUMAN Decreases Expression [30]
Serine/threonine-protein kinase PLK4 (PLK4) OTV8KZDZ PLK4_HUMAN Decreases Expression [30]
Nuclear envelope integral membrane protein 1 (NEMP1) OTWN3S47 NEMP1_HUMAN Decreases Expression [30]
Kinetochore protein NDC80 homolog (NDC80) OTS7D306 NDC80_HUMAN Decreases Expression [30]
Aurora kinase A (AURKA) OTMX0HYT AURKA_HUMAN Decreases Expression [30]
DNA-directed RNA polymerase III subunit RPC7 (POLR3G) OTU3TGQ9 RPC7_HUMAN Decreases Expression [30]
Fanconi anemia group A protein (FANCA) OTPEFJD4 FANCA_HUMAN Decreases Expression [30]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [30]
Monocarboxylate transporter 7 (SLC16A6) OT7BIIZX MOT7_HUMAN Decreases Expression [30]
ATP-binding cassette sub-family C member 3 (ABCC3) OTC3IJV4 MRP3_HUMAN Increases Expression [30]
Protein sprouty homolog 2 (SPRY2) OTH0CRCZ SPY2_HUMAN Decreases Expression [30]
Protein regulator of cytokinesis 1 (PRC1) OTHD0XS0 PRC1_HUMAN Decreases Expression [30]
Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1) OT80DZMT BUB1_HUMAN Decreases Expression [30]
EGF-like repeat and discoidin I-like domain-containing protein 3 (EDIL3) OTDVVNS0 EDIL3_HUMAN Increases Expression [30]
NUAK family SNF1-like kinase 1 (NUAK1) OTLLHJJQ NUAK1_HUMAN Increases Expression [30]
Neuropilin-2 (NRP2) OTZL256E NRP2_HUMAN Increases Expression [30]
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B) OT8KME51 BUB1B_HUMAN Decreases Expression [30]
Tetraspanin-2 (TSPAN2) OTTDPQF1 TSN2_HUMAN Increases Expression [30]
Leupaxin (LPXN) OTUNV3CK LPXN_HUMAN Decreases Expression [30]
Hyaluronan mediated motility receptor (HMMR) OT4M0JTZ HMMR_HUMAN Decreases Expression [30]
DNA polymerase theta (POLQ) OTBHK0E6 DPOLQ_HUMAN Decreases Expression [30]
Cell division control protein 45 homolog (CDC45) OT6NNLOD CDC45_HUMAN Decreases Expression [30]
Glypican-4 (GPC4) OTUJ14DW GPC4_HUMAN Increases Expression [30]
Serpin B7 (SERPINB7) OTZ95LR2 SPB7_HUMAN Decreases Expression [30]
Transient receptor potential cation channel subfamily A member 1 (TRPA1) OTRDIR5M TRPA1_HUMAN Decreases Expression [30]
Ribonuclease H2 subunit A (RNASEH2A) OT8G3G7K RNH2A_HUMAN Decreases Expression [30]
Short-chain dehydrogenase/reductase 3 (DHRS3) OTSK1DTP DHRS3_HUMAN Increases Expression [30]
Dickkopf-related protein 1 (DKK1) OTRDLUSP DKK1_HUMAN Decreases Expression [30]
Centrosomal protein of 152 kDa (CEP152) OTOKZR9B CE152_HUMAN Decreases Expression [30]
Potassium channel subfamily K member 2 (KCNK2) OTWBT8MG KCNK2_HUMAN Decreases Expression [30]
Chromosome-associated kinesin KIF4A (KIF4A) OT3UWL7D KIF4A_HUMAN Decreases Expression [30]
Structural maintenance of chromosomes protein 2 (SMC2) OT5S0DV4 SMC2_HUMAN Decreases Expression [30]
Phospholipid-transporting ATPase ABCA1 (ABCA1) OT94G6BQ ABCA1_HUMAN Increases Expression [30]
Reversion-inducing cysteine-rich protein with Kazal motifs (RECK) OT9QIHEQ RECK_HUMAN Increases Expression [30]
Securin (PTTG1) OTIMYS4W PTTG1_HUMAN Decreases Expression [30]
Histone-lysine N-methyltransferase NSD2 (NSD2) OTQ6SW4R NSD2_HUMAN Decreases Expression [30]
Aldehyde dehydrogenase 1A1 (ALDH1A1) OTCUWZKB AL1A1_HUMAN Increases Expression [30]
Dihydrofolate reductase (DHFR) OT3DVIGM DYR_HUMAN Decreases Expression [30]
Complement C1r subcomponent (C1R) OTA0ZNIU C1R_HUMAN Increases Expression [30]
Urokinase-type plasminogen activator (PLAU) OTX0QGKK UROK_HUMAN Decreases Expression [30]
Alpha-2-macroglobulin (A2M) OTFTX90K A2MG_HUMAN Increases Expression [30]
Insulin-like growth factor II (IGF2) OTJ4O6MW IGF2_HUMAN Increases Expression [30]
Collagen alpha-1(III) chain (COL3A1) OTT1EMLM CO3A1_HUMAN Increases Expression [30]
Collagen alpha-1(IV) chain (COL4A1) OTL6D1YE CO4A1_HUMAN Increases Expression [30]
Alpha-crystallin B chain (CRYAB) OTY4JGYU CRYAB_HUMAN Increases Expression [30]
Interstitial collagenase (MMP1) OTI4I2V1 MMP1_HUMAN Decreases Expression [30]
Thymidine kinase, cytosolic (TK1) OTY5JFM1 KITH_HUMAN Decreases Expression [30]
Aldehyde dehydrogenase, mitochondrial (ALDH2) OTKJ9I3N ALDH2_HUMAN Increases Expression [30]
Plasminogen activator inhibitor 2 (SERPINB2) OT72QLZB PAI2_HUMAN Decreases Expression [30]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Increases Expression [30]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Decreases Expression [30]
Integrin alpha-V (ITGAV) OTAM7JTR ITAV_HUMAN Increases Expression [30]
Epoxide hydrolase 1 (EPHX1) OTBKWQER HYEP_HUMAN Increases Expression [30]
Neurofilament medium polypeptide (NEFM) OT8VCBNF NFM_HUMAN Decreases Expression [30]
Laminin subunit beta-1 (LAMB1) OT6J9LJR LAMB1_HUMAN Increases Expression [30]
Asparagine synthetase (ASNS) OT8R922G ASNS_HUMAN Increases Expression [30]
Matrix Gla protein (MGP) OTZWU3FU MGP_HUMAN Increases Expression [30]
Collagen alpha-2(IV) chain (COL4A2) OTJK1LKN CO4A2_HUMAN Increases Expression [30]
Platelet-derived growth factor receptor beta (PDGFRB) OTYSNK9Q PGFRB_HUMAN Increases Expression [30]
Complement C1s subcomponent (C1S) OTCIZU2A C1S_HUMAN Increases Expression [30]
DNA polymerase alpha catalytic subunit (POLA1) OT1WXFVY DPOLA_HUMAN Decreases Expression [30]
Histone H2A.Z (H2AZ1) OT3KJJNQ H2AZ_HUMAN Decreases Expression [30]
Myb-related protein A (MYBL1) OTBJMC2P MYBA_HUMAN Decreases Expression [30]
Myb-related protein B (MYBL2) OTZ3JX8Q MYBB_HUMAN Decreases Expression [30]
Histone H1.4 (H1-4) OTQ450A3 H14_HUMAN Decreases Expression [30]
Clusterin (CLU) OTQGG0JM CLUS_HUMAN Increases Expression [30]
DNA topoisomerase 2-alpha (TOP2A) OT6LPS08 TOP2A_HUMAN Decreases Expression [30]
Fibroblast growth factor 5 (FGF5) OTQXGHBY FGF5_HUMAN Decreases Expression [30]
Collagen alpha-1(XI) chain (COL11A1) OTB0DRMS COBA1_HUMAN Increases Expression [30]
Elastin (ELN) OTFSO7PG ELN_HUMAN Increases Expression [30]
Aggrecan core protein (ACAN) OTUOCW8K PGCA_HUMAN Increases Expression [30]
Histone H1.5 (H1-5) OTAN7RD9 H15_HUMAN Decreases Expression [30]
Stathmin (STMN1) OTDJ4RV0 STMN1_HUMAN Decreases Expression [30]
Lamin-B1 (LMNB1) OT100T3P LMNB1_HUMAN Decreases Expression [30]
Biglycan (BGN) OT3AV6IF PGS1_HUMAN Increases Expression [30]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1) OT3MPPYX ENPP1_HUMAN Decreases Expression [30]
Liver carboxylesterase 1 (CES1) OT9L0LR8 EST1_HUMAN Increases Expression [30]
Integrin alpha-6 (ITGA6) OT3FA39C ITA6_HUMAN Decreases Expression [30]
Ribonucleoside-diphosphate reductase large subunit (RRM1) OTXGQOR9 RIR1_HUMAN Decreases Expression [30]
Insulin-like growth factor-binding protein 5 (IGFBP5) OTRE5V0C IBP5_HUMAN Increases Expression [30]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Decreases Expression [30]
Pentraxin-related protein PTX3 (PTX3) OTPXHRKU PTX3_HUMAN Decreases Expression [30]
High mobility group protein B2 (HMGB2) OTGEGAOK HMGB2_HUMAN Decreases Expression [30]
Cardiac phospholamban (PLN) OTT3RRJN PPLA_HUMAN Increases Expression [30]
G0/G1 switch protein 2 (G0S2) OT8FL49L G0S2_HUMAN Decreases Expression [30]
Dipeptidyl peptidase 4 (DPP4) OT16MVL9 DPP4_HUMAN Increases Expression [30]
Leiomodin-1 (LMOD1) OTZ2MEMG LMOD1_HUMAN Increases Expression [30]
M-phase inducer phosphatase 1 (CDC25A) OTSLKKCO MPIP1_HUMAN Decreases Expression [30]
M-phase inducer phosphatase 3 (CDC25C) OTPQI71S MPIP3_HUMAN Decreases Expression [30]
Ribonucleoside-diphosphate reductase subunit M2 (RRM2) OTOB6J6R RIR2_HUMAN Decreases Expression [30]
Fibroblast growth factor 9 (FGF9) OT2SKDGM FGF9_HUMAN Increases Expression [30]
Sodium- and chloride-dependent taurine transporter (SLC6A6) OT67U7G3 SC6A6_HUMAN Increases Expression [30]
Cyclin-dependent kinases regulatory subunit 2 (CKS2) OTPTMHIV CKS2_HUMAN Decreases Expression [30]
Histone H2B type 1-B (H2BC3) OT1BLFJO H2B1B_HUMAN Decreases Expression [30]
Dual specificity protein kinase TTK (TTK) OTBY1Z5H TTK_HUMAN Decreases Expression [30]
DNA replication licensing factor MCM7 (MCM7) OT6FXC6K MCM7_HUMAN Decreases Expression [30]
Syndecan-2 (SDC2) OTEEHY1D SDC2_HUMAN Increases Expression [30]
Replication factor C subunit 4 (RFC4) OTWALD2R RFC4_HUMAN Decreases Expression [30]
Replication factor C subunit 2 (RFC2) OTJ9N6BD RFC2_HUMAN Decreases Expression [30]
Thrombospondin-2 (THBS2) OTXET551 TSP2_HUMAN Increases Expression [30]
Myosin-10 (MYH10) OTXN2WXS MYH10_HUMAN Increases Expression [30]
Myosin-11 (MYH11) OTVNVWY3 MYH11_HUMAN Increases Expression [30]
Chitinase-3-like protein 1 (CHI3L1) OT2Z7VJH CH3L1_HUMAN Increases Expression [30]
Breast cancer type 1 susceptibility protein (BRCA1) OT5BN6VH BRCA1_HUMAN Decreases Expression [30]
Flap endonuclease 1 (FEN1) OT6QGG7O FEN1_HUMAN Decreases Expression [30]
Nicotinamide N-methyltransferase (NNMT) OTFM38GU NNMT_HUMAN Increases Expression [30]
Pre-B-cell leukemia transcription factor 1 (PBX1) OTORABGO PBX1_HUMAN Increases Expression [30]
Replication factor C subunit 5 (RFC5) OTAD79RT RFC5_HUMAN Decreases Expression [30]
Replication factor C subunit 3 (RFC3) OT1MS7AO RFC3_HUMAN Decreases Expression [30]
5-hydroxytryptamine receptor 2B (HTR2B) OTM1AD9J 5HT2B_HUMAN Increases Expression [30]
Lamina-associated polypeptide 2, isoform alpha (TMPO) OTL68EL4 LAP2A_HUMAN Decreases Expression [30]
Aldo-keto reductase family 1 member C3 (AKR1C3) OTU2SXBA AK1C3_HUMAN Increases Expression [30]
Condensin-2 complex subunit D3 (NCAPD3) OTOZY2UL CNDD3_HUMAN Decreases Expression [30]
Neutral amino acid transporter A (SLC1A4) OTVODHAE SATT_HUMAN Increases Expression [30]
Cell surface glycoprotein MUC18 (MCAM) OTT8XKGE MUC18_HUMAN Increases Expression [30]
DNA mismatch repair protein Msh2 (MSH2) OT10H1AB MSH2_HUMAN Decreases Expression [30]
Proliferation marker protein Ki-67 (MKI67) OTA8N1QI KI67_HUMAN Decreases Expression [30]
Glutathione S-transferase Mu 5 (GSTM5) OTMMBFY8 GSTM5_HUMAN Increases Expression [30]
Histone H3-like centromeric protein A (CENPA) OT0NEJ4X CENPA_HUMAN Decreases Expression [30]
Centromere protein F (CENPF) OT7AG0SW CENPF_HUMAN Decreases Expression [30]
DNA primase small subunit (PRIM1) OTWWP8Y6 PRI1_HUMAN Decreases Expression [30]
DNA primase large subunit (PRIM2) OTGT0KTF PRI2_HUMAN Decreases Expression [30]
Thrombospondin-3 (THBS3) OTDKMUBD TSP3_HUMAN Increases Expression [30]
Regulator of G-protein signaling 4 (RGS4) OTG94HHL RGS4_HUMAN Decreases Expression [30]
Selenoprotein P (SELENOP) OT02B8IR SEPP1_HUMAN Increases Expression [30]
Kinetochore-associated protein 1 (KNTC1) OTI2OOFN KNTC1_HUMAN Decreases Expression [30]
Ras association domain-containing protein 2 (RASSF2) OT2JHDO4 RASF2_HUMAN Increases Expression [30]
DNA replication ATP-dependent helicase/nuclease DNA2 (DNA2) OT4DJFFU DNA2_HUMAN Decreases Expression [30]
Breast cancer type 2 susceptibility protein (BRCA2) OTF1XSV1 BRCA2_HUMAN Decreases Expression [30]
Lumican (LUM) OTSRC874 LUM_HUMAN Increases Expression [30]
Calponin-1 (CNN1) OTVPG39Z CNN1_HUMAN Increases Expression [30]
Importin subunit alpha-1 (KPNA2) OTU7FOE6 IMA1_HUMAN Decreases Expression [30]
Stanniocalcin-1 (STC1) OTGVVXYF STC1_HUMAN Decreases Expression [30]
High mobility group protein HMGI-C (HMGA2) OTBMBHHL HMGA2_HUMAN Decreases Expression [30]
Serine/threonine-protein kinase PLK1 (PLK1) OTRZX45T PLK1_HUMAN Decreases Expression [30]
Microfibril-associated glycoprotein 4 (MFAP4) OT5W64QY MFAP4_HUMAN Increases Expression [30]
DNA polymerase epsilon subunit 2 (POLE2) OTAC9V6L DPOE2_HUMAN Decreases Expression [30]
Cyclin-dependent kinases regulatory subunit 1 (CKS1B) OTNUPLUJ CKS1_HUMAN Decreases Expression [30]
Transforming growth factor beta-2 proprotein (TGFB2) OTC0TXEP TGFB2_HUMAN Increases Expression [30]
Actin, aortic smooth muscle (ACTA2) OTEDLG8E ACTA_HUMAN Increases Expression [30]
Actin, gamma-enteric smooth muscle (ACTG2) OTRDWUO0 ACTH_HUMAN Increases Expression [30]
Actin, alpha cardiac muscle 1 (ACTC1) OTJU04B1 ACTC_HUMAN Increases Expression [30]
Protein jagged-1 (JAG1) OT3LGT6K JAG1_HUMAN Increases Expression [30]
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) OTEUYEW6 ROR1_HUMAN Increases Expression [30]
Centromere-associated protein E (CENPE) OTQ7AP04 CENPE_HUMAN Decreases Expression [30]
Kinesin-like protein KIF23 (KIF23) OTY850JC KIF23_HUMAN Decreases Expression [30]
Histone H1.1 (H1-1) OTSS815G H11_HUMAN Decreases Expression [30]
Aldehyde oxidase (AOX1) OT2FZP6H AOXA_HUMAN Decreases Expression [30]
DNA repair protein RAD51 homolog 1 (RAD51) OTNVWGC1 RAD51_HUMAN Decreases Expression [30]
Transcription factor SOX-4 (SOX4) OTSS40SS SOX4_HUMAN Increases Expression [30]
Prolow-density lipoprotein receptor-related protein 1 (LRP1) OTHTEH4G LRP1_HUMAN Increases Expression [30]
Forkhead box protein M1 (FOXM1) OT5887KR FOXM1_HUMAN Decreases Expression [30]
Lactadherin (MFGE8) OTQKE41R MFGM_HUMAN Increases Expression [30]
EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1) OTZVUOOB FBLN3_HUMAN Increases Expression [30]
Cell division cycle protein 20 homolog (CDC20) OTCOEZRV CDC20_HUMAN Decreases Expression [30]
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) OTA0UNHM ECH1_HUMAN Increases Expression [30]
MAL-like protein (MALL) OTKGZ89D MALL_HUMAN Decreases Expression [30]
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1) OTXNGZCG MD2L1_HUMAN Decreases Expression [30]
Centromere protein R (ITGB3BP) OT6Q7GR3 CENPR_HUMAN Decreases Expression [30]
Origin recognition complex subunit 1 (ORC1) OTHWU8IJ ORC1_HUMAN Decreases Expression [30]
Limbic system-associated membrane protein (LSAMP) OTYXVQX2 LSAMP_HUMAN Increases Expression [30]
Four and a half LIM domains protein 1 (FHL1) OTN535SU FHL1_HUMAN Increases Expression [30]
Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C) OT6KFNMS CAC1C_HUMAN Increases Expression [30]
DNA polymerase alpha subunit B (POLA2) OTTWQ73N DPOA2_HUMAN Decreases Expression [30]
Fibroleukin (FGL2) OT8M3H72 FGL2_HUMAN Increases Expression [30]
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (PDE3A) OTKUW1WT PDE3A_HUMAN Increases Expression [30]
Semaphorin-3A (SEMA3A) OTQJSV7W SEM3A_HUMAN Decreases Expression [30]
DNA replication licensing factor MCM6 (MCM6) OTKLIAWT MCM6_HUMAN Decreases Expression [30]
Inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) OTX7MWW1 ITPR1_HUMAN Increases Expression [30]
Maternal embryonic leucine zipper kinase (MELK) OTEY2UQA MELK_HUMAN Decreases Expression [30]
DNA replication complex GINS protein PSF1 (GINS1) OTVQZMMQ PSF1_HUMAN Decreases Expression [30]
Transmembrane glycoprotein NMB (GPNMB) OTB7KQKV GPNMB_HUMAN Increases Expression [30]
Condensin complex subunit 2 (NCAPH) OTXOS97C CND2_HUMAN Decreases Expression [30]
PCNA-associated factor (PCLAF) OTMVIOUU PAF15_HUMAN Decreases Expression [30]
Condensin complex subunit 1 (NCAPD2) OT8VGE2O CND1_HUMAN Decreases Expression [30]
Disks large-associated protein 5 (DLGAP5) OTWCN39U DLGP5_HUMAN Decreases Expression [30]
SCL-interrupting locus protein (STIL) OT9799VN STIL_HUMAN Decreases Expression [30]
Pachytene checkpoint protein 2 homolog (TRIP13) OTFM3TI9 PCH2_HUMAN Decreases Expression [30]
Myosin light chain kinase, smooth muscle (MYLK) OT78QB4A MYLK_HUMAN Increases Expression [30]
Histone-lysine N-methyltransferase EZH2 (EZH2) OTIEHTKW EZH2_HUMAN Decreases Expression [30]
Insulin-like growth factor-binding protein 7 (IGFBP7) OT1D416P IBP7_HUMAN Increases Expression [30]
Neuronal regeneration-related protein (NREP) OT2AZPKK NREP_HUMAN Increases Expression [30]
Prostacyclin synthase (PTGIS) OTT3RW6N PTGIS_HUMAN Increases Expression [30]
Cyclin-dependent kinase inhibitor 3 (CDKN3) OTBE3H07 CDKN3_HUMAN Decreases Expression [30]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Increases Expression [30]
Phosphoenolpyruvate carboxykinase , mitochondrial (PCK2) OTJ8LX4N PCKGM_HUMAN Increases Expression [30]
Tumor protein D53 (TPD52L1) OTSA6U0I TPD53_HUMAN Increases Expression [30]
Flap endonuclease GEN homolog 1 (GEN1) OT1XFQXF GEN_HUMAN Decreases Expression [30]
Mitochondrial 10-formyltetrahydrofolate dehydrogenase (ALDH1L2) OTCH86VF AL1L2_HUMAN Increases Expression [30]
Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (SVEP1) OTOBICRD SVEP1_HUMAN Increases Expression [30]
Borealin (CDCA8) OT17D55D BOREA_HUMAN Decreases Expression [30]
Protein LBH (LBH) OT87AT1X LBH_HUMAN Increases Expression [30]
Shugoshin 2 (SGO2) OTNGJDS8 SGO2_HUMAN Decreases Expression [30]
Centromere protein W (CENPW) OTZL05QN CENPW_HUMAN Decreases Expression [30]
Shugoshin 1 (SGO1) OTIP6IRN SGO1_HUMAN Decreases Expression [30]
Probable E3 ubiquitin-protein ligase HERC4 (HERC4) OTU4DSDE HERC4_HUMAN Decreases Expression [30]
Testis-expressed protein 30 (TEX30) OT87WEPQ TEX30_HUMAN Decreases Expression [30]
DEP domain-containing protein 1A (DEPDC1) OT0JWE1B DEP1A_HUMAN Decreases Expression [30]
Tensin-3 (TNS3) OTPG2D8Z TENS3_HUMAN Increases Expression [30]
Cell division cycle-associated protein 2 (CDCA2) OTX8UF9J CDCA2_HUMAN Decreases Expression [30]
Protein FAM72D (FAM72D) OTCQVOXB FA72D_HUMAN Decreases Expression [30]
Repulsive guidance molecule B (RGMB) OT2DROYU RGMB_HUMAN Decreases Expression [30]
STEAP family member 1B (STEAP1B) OTZJDFWK STEAL_HUMAN Decreases Expression [30]
Mis18-binding protein 1 (MIS18BP1) OT41T0FB M18BP_HUMAN Decreases Expression [30]
Mitochondrial fission regulator 2 (MTFR2) OTLOR68D MTFR2_HUMAN Decreases Expression [30]
Rho GTPase-activating protein 11A (ARHGAP11A) OTVQCFVP RHGBA_HUMAN Decreases Expression [30]
E3 ubiquitin-protein ligase RFWD3 (RFWD3) OTDUULBQ RFWD3_HUMAN Decreases Expression [30]
Podocan-like protein 1 (PODNL1) OTL72ES9 PONL1_HUMAN Increases Expression [30]
Protein aurora borealis (BORA) OTV2ZPKP BORA_HUMAN Decreases Expression [30]
Neutral cholesterol ester hydrolase 1 (NCEH1) OTZ66CKX NCEH1_HUMAN Decreases Expression [30]
Fidgetin-like protein 1 (FIGNL1) OTKII63K FIGL1_HUMAN Decreases Expression [30]
ATPase family AAA domain-containing protein 2 (ATAD2) OT8MCRNY ATAD2_HUMAN Decreases Expression [30]
Serine protease FAM111B (FAM111B) OT9IQ9NV F111B_HUMAN Decreases Expression [30]
Protein FAM180A (FAM180A) OTKQ7XUG F180A_HUMAN Decreases Expression [30]
Golgi-associated kinase 1B (GASK1B) OT2HPHEI GAK1B_HUMAN Increases Expression [30]
Plexin domain-containing protein 2 (PLXDC2) OTS1FUV6 PXDC2_HUMAN Increases Expression [30]
ALK and LTK ligand 1 (ALKAL1) OTZGAZ79 ALKL1_HUMAN Increases Expression [30]
Protein MMS22-like (MMS22L) OTJI0HM9 MMS22_HUMAN Decreases Expression [30]
Centrosomal protein of 128 kDa (CEP128) OT922YCJ CE128_HUMAN Decreases Expression [30]
DNA-binding protein RFX8 (RFX8) OT27SFGQ RFX8_HUMAN Decreases Expression [30]
Centromere protein U (CENPU) OTQ4TZRS CENPU_HUMAN Decreases Expression [30]
Protein MCM10 homolog (MCM10) OTV0O3JN MCM10_HUMAN Decreases Expression [30]
Treslin (TICRR) OT2HKWOC TICRR_HUMAN Decreases Expression [30]
MAM domain-containing protein 2 (MAMDC2) OT4GICNY MAMC2_HUMAN Increases Expression [30]
LisH domain-containing protein ARMC9 (ARMC9) OT0MZER2 ARMC9_HUMAN Increases Expression [30]
Rho GTPase-activating protein 22 (ARHGAP22) OTXUQEFL RHG22_HUMAN Decreases Expression [30]
Podocan (PODN) OTV3P7P5 PODN_HUMAN Increases Expression [30]
Schlafen family member 11 (SLFN11) OTJWFPMY SLN11_HUMAN Decreases Expression [30]
Amphoterin-induced protein 2 (AMIGO2) OTPAIT1O AMGO2_HUMAN Increases Expression [30]
Alpha-protein kinase 2 (ALPK2) OTWZZDQ9 ALPK2_HUMAN Increases Expression [30]
Myopalladin (MYPN) OTHTOFDU MYPN_HUMAN Decreases Expression [30]
E3 ubiquitin-protein ligase MARCHF3 (MARCHF3) OT89V4N5 MARH3_HUMAN Decreases Expression [30]
Ras GTPase-activating-like protein IQGAP3 (IQGAP3) OT4RZV2M IQGA3_HUMAN Decreases Expression [30]
Condensin-2 complex subunit G2 (NCAPG2) OTZYENKO CNDG2_HUMAN Decreases Expression [30]
GAS2-like protein 3 (GAS2L3) OTWPVI29 GA2L3_HUMAN Decreases Expression [30]
Histone H2A type 2-B (H2AC21) OTH7W2NJ H2A2B_HUMAN Decreases Expression [30]
Pleckstrin homology domain-containing family H member 2 (PLEKHH2) OT3TK3NN PKHH2_HUMAN Increases Expression [30]
Extracellular sulfatase Sulf-2 (SULF2) OTIXMUVL SULF2_HUMAN Increases Expression [30]
Extracellular sulfatase Sulf-1 (SULF1) OTJCNCO0 SULF1_HUMAN Increases Expression [30]
CD302 antigen (CD302) OTX580VU CD302_HUMAN Increases Expression [30]
Spindle and kinetochore-associated protein 3 (SKA3) OTLHEVJD SKA3_HUMAN Decreases Expression [30]
DNA damage-induced apoptosis suppressor protein (DDIAS) OTTGG2PM DDIAS_HUMAN Decreases Expression [30]
Cytoskeleton-associated protein 2-like (CKAP2L) OT4T73GG CKP2L_HUMAN Decreases Expression [30]
Fanconi anemia group M protein (FANCM) OTNJG99Z FANCM_HUMAN Decreases Expression [30]
Lung adenoma susceptibility protein 2 (C18ORF54) OT4WJKTF LAS2_HUMAN Decreases Expression [30]
Abnormal spindle-like microcephaly-associated protein (ASPM) OTKXQMNA ASPM_HUMAN Decreases Expression [30]
Retinol dehydrogenase 10 (RDH10) OTL9FSGF RDH10_HUMAN Increases Expression [30]
Centromere protein L (CENPL) OT7P006B CENPL_HUMAN Decreases Expression [30]
Rho GTPase-activating protein 18 (ARHGAP18) OTYMJP6H RHG18_HUMAN Decreases Expression [30]
T-complex protein 11-like protein 2 (TCP11L2) OTTIZO7B T11L2_HUMAN Increases Expression [30]
Aminopeptidase O (AOPEP) OT0MMANL AMPO_HUMAN Increases Expression [30]
Junction-mediating and -regulatory protein (JMY) OTH5FFVK JMY_HUMAN Increases Expression [30]
Holliday junction recognition protein (HJURP) OTWMV16B HJURP_HUMAN Decreases Expression [30]
SHC SH2 domain-binding protein 1 (SHCBP1) OT3A21CM SHCBP_HUMAN Decreases Expression [30]
MAM domain-containing glycosylphosphatidylinositol anchor protein 1 (MDGA1) OTVXEF85 MDGA1_HUMAN Increases Expression [30]
(Lyso)-N-acylphosphatidylethanolamine lipase (ABHD4) OTQK3M9X ABHD4_HUMAN Increases Expression [30]
DEP domain-containing mTOR-interacting protein (DEPTOR) OTCBP1BT DPTOR_HUMAN Increases Expression [30]
Protein CIP2A (CIP2A) OTVS2GXA CIP2A_HUMAN Decreases Expression [30]
Sodium-dependent phosphate transporter 1 (SLC20A1) OTC3D894 S20A1_HUMAN Decreases Expression [30]
DEP domain-containing protein 1B (DEPDC1B) OTMVFOT1 DEP1B_HUMAN Decreases Expression [30]
Basic helix-loop-helix ARNT-like protein 2 (BMAL2) OTIBDGQC BMAL2_HUMAN Decreases Expression [30]
Centromere protein I (CENPI) OTWRIMZ3 CENPI_HUMAN Decreases Expression [30]
Serine protease HTRA1 (HTRA1) OTR8ACBF HTRA1_HUMAN Increases Expression [30]
Hyaluronan synthase 2 (HAS2) OTTD3PAL HYAS2_HUMAN Decreases Expression [30]
Neogenin (NEO1) OTGJ1997 NEO1_HUMAN Increases Expression [30]
Histone H2B type 1-H (H2BC9) OTQ9XX72 H2B1H_HUMAN Decreases Expression [30]
F-box only protein 32 (FBXO32) OTUE978R FBX32_HUMAN Increases Expression [30]
Tumor protein p53-inducible nuclear protein 1 (TP53INP1) OT2363Z9 T53I1_HUMAN Increases Expression [30]
Transcription factor E2F7 (E2F7) OTWW358N E2F7_HUMAN Decreases Expression [30]
Spindle and kinetochore-associated protein 1 (SKA1) OTDYJ12A SKA1_HUMAN Decreases Expression [30]
Mdm2-binding protein (MTBP) OTWLCW9C MTBP_HUMAN Decreases Expression [30]
Sororin (CDCA5) OTZLCQ5U CDCA5_HUMAN Decreases Expression [30]
Aurora kinase B (AURKB) OTIY4VHU AURKB_HUMAN Decreases Expression [30]
Serine/threonine-protein kinase greatwall (MASTL) OTQ7YKK5 GWL_HUMAN Decreases Expression [30]
Centromere protein N (CENPN) OTRO7XPD CENPN_HUMAN Decreases Expression [30]
Proline-rich protein 11 (PRR11) OT2JJ08Z PRR11_HUMAN Decreases Expression [30]
Lymphokine-activated killer T-cell-originated protein kinase (PBK) OT5Z27TW TOPK_HUMAN Decreases Expression [30]
Leucine-rich repeat protein 1 (LRR1) OTSWDXVY LLR1_HUMAN Decreases Expression [30]
Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 (PCMTD1) OT5TS6P7 PCMD1_HUMAN Increases Expression [30]
Discoidin, CUB and LCCL domain-containing protein 2 (DCBLD2) OTB71I02 DCBD2_HUMAN Decreases Expression [30]
Kinesin-like protein KIF20B (KIF20B) OTS68AHH KI20B_HUMAN Decreases Expression [30]
ATPase family AAA domain-containing protein 5 (ATAD5) OTI8ABKF ATAD5_HUMAN Decreases Expression [30]
Hemicentin-1 (HMCN1) OTLZAS0P HMCN1_HUMAN Increases Expression [30]
Hyaluronan and proteoglycan link protein 3 (HAPLN3) OTB853Z1 HPLN3_HUMAN Increases Expression [30]
Proheparin-binding EGF-like growth factor (HBEGF) OTLU00JS HBEGF_HUMAN Decreases Expression [30]
Cell division cycle-associated protein 3 (CDCA3) OTUI8QK3 CDCA3_HUMAN Decreases Expression [30]
Kinesin-like protein KIF2C (KIF2C) OTJ8G3NP KIF2C_HUMAN Decreases Expression [30]
Cell division control protein 6 homolog (CDC6) OTX93FE7 CDC6_HUMAN Decreases Expression [30]
Endothelial PAS domain-containing protein 1 (EPAS1) OTRE3O8U EPAS1_HUMAN Increases Expression [30]
Histone H2B type 1-M (H2BC14) OTSDZZZY H2B1M_HUMAN Decreases Expression [30]
Condensin complex subunit 3 (NCAPG) OT1AI9EO CND3_HUMAN Decreases Expression [30]
Mitochondrial genome maintenance exonuclease 1 (MGME1) OTC5LPXX MGME1_HUMAN Decreases Expression [30]
Synaptotagmin-15 (SYT15) OT7Q088G SYT15_HUMAN Increases Expression [30]
Hephaestin (HEPH) OTZ2F15Z HEPH_HUMAN Increases Expression [30]
DNA replication complex GINS protein SLD5 (GINS4) OTCVOO3S SLD5_HUMAN Decreases Expression [30]
Centromere protein K (CENPK) OTKPUF8K CENPK_HUMAN Decreases Expression [30]
Protein PIMREG (PIMREG) OTKC8T3E PIMRE_HUMAN Decreases Expression [30]
Nucleoporin NDC1 (NDC1) OTF2GQC1 NDC1_HUMAN Decreases Expression [30]
Centromere protein O (CENPO) OTXAH83Y CENPO_HUMAN Decreases Expression [30]
Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1) OTJGE772 CHAC1_HUMAN Increases Expression [30]
TIMELESS-interacting protein (TIPIN) OT9PZHXV TIPIN_HUMAN Decreases Expression [30]
Kinesin-like protein KIFC1 (KIFC1) OTNQDS00 KIFC1_HUMAN Decreases Expression [30]
Meiotic nuclear division protein 1 homolog (MND1) OTS87F3H MND1_HUMAN Decreases Expression [30]
Nucleolar and spindle-associated protein 1 (NUSAP1) OT85HIJ5 NUSAP_HUMAN Decreases Expression [30]
Fanconi anemia group D2 protein (FANCD2) OTVEB5LF FACD2_HUMAN Decreases Expression [30]
Transmembrane 6 superfamily member 1 (TM6SF1) OTQR4I2N TM6S1_HUMAN Increases Expression [30]
Cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2) OTVSFHTL CRLD2_HUMAN Increases Expression [30]
Rac GTPase-activating protein 1 (RACGAP1) OTQE8IEH RGAP1_HUMAN Decreases Expression [30]
Centromere protein H (CENPH) OTPOO9LK CENPH_HUMAN Decreases Expression [30]
Kinetochore-associated protein DSN1 homolog (DSN1) OTHROI0H DSN1_HUMAN Decreases Expression [30]
Uncharacterized protein C1orf198 (C1ORF198) OTK3L4G7 CA198_HUMAN Increases Expression [30]
Golgi-associated plant pathogenesis-related protein 1 (GLIPR2) OTFTH6ZY GAPR1_HUMAN Increases Expression [30]
Very long chain fatty acid elongase 6 (ELOVL6) OTB26UJJ ELOV6_HUMAN Decreases Expression [30]
Anthrax toxin receptor 1 (ANTXR1) OT5W1GPC ANTR1_HUMAN Increases Expression [30]
Gremlin-2 (GREM2) OTE91EWT GREM2_HUMAN Increases Expression [30]
Metal transporter CNNM2 (CNNM2) OTZHO8WU CNNM2_HUMAN Increases Expression [30]
Protein ECT2 (ECT2) OTQDUCT6 ECT2_HUMAN Decreases Expression [30]
Claspin (CLSPN) OTZZXNDK CLSPN_HUMAN Decreases Expression [30]
Mineralization regulator ANKH (ANKH) OTCN25R5 ANKH_HUMAN Increases Expression [30]
Ribonucleoprotein PTB-binding 2 (RAVER2) OT0MDL7K RAVR2_HUMAN Increases Expression [30]
Neurexin-3-beta (NRXN3) OTJ0I7HJ NRX3B_HUMAN Increases Expression [30]
Solute carrier family 40 member 1 (SLC40A1) OT8RV2VY S40A1_HUMAN Increases Expression [30]
Anillin (ANLN) OTXJY54C ANLN_HUMAN Decreases Expression [30]
Phospholipid scramblase 4 (PLSCR4) OT2AMYLY PLS4_HUMAN Increases Expression [30]
Lymphoid-specific helicase (HELLS) OTVVV668 HELLS_HUMAN Decreases Expression [30]
FIGNL1-interacting regulator of recombination and mitosis (FIRRM) OTALLHT1 FIRRM_HUMAN Decreases Expression [30]
Protein diaphanous homolog 3 (DIAPH3) OTPOT23F DIAP3_HUMAN Decreases Expression [30]
Structural maintenance of chromosomes protein 4 (SMC4) OTEJE6AG SMC4_HUMAN Decreases Expression [30]
Protein DEPP1 (DEPP1) OTB36PHJ DEPP1_HUMAN Increases Expression [30]
Tyrosyl-DNA phosphodiesterase 1 (TDP1) OTYINMBR TYDP1_HUMAN Decreases Expression [30]
Fanconi anemia group I protein (FANCI) OTW8E3SC FANCI_HUMAN Decreases Expression [30]
Histone chaperone ASF1B (ASF1B) OTKXX12I ASF1B_HUMAN Decreases Expression [30]
PCNA-interacting partner (PARPBP) OTPZDGW7 PARI_HUMAN Decreases Expression [30]
DNA damage-inducible transcript 4 protein (DDIT4) OTHY8SY4 DDIT4_HUMAN Increases Expression [30]
Dapper homolog 1 (DACT1) OT19Z704 DACT1_HUMAN Increases Expression [30]
Protein Mis18-alpha (MIS18A) OTD80K5X MS18A_HUMAN Decreases Expression [30]
Denticleless protein homolog (DTL) OTC29RYE DTL_HUMAN Decreases Expression [30]
Programmed cell death 1 ligand 1 (CD274) OTJ0VFDL PD1L1_HUMAN Decreases Expression [30]
LIM and cysteine-rich domains protein 1 (LMCD1) OT3AWE8O LMCD1_HUMAN Increases Expression [30]
Calcium-binding and coiled-coil domain-containing protein 1 (CALCOCO1) OT1PAIN0 CACO1_HUMAN Increases Expression [30]
Homologous-pairing protein 2 homolog (PSMC3IP) OT9UB5UO HOP2_HUMAN Decreases Expression [30]
Fibulin-5 (FBLN5) OTLVNZ8U FBLN5_HUMAN Increases Expression [30]
DNA dC->dU-editing enzyme APOBEC-3B (APOBEC3B) OTHLNI51 ABC3B_HUMAN Decreases Expression [30]
STEAP1 protein (STEAP1) OTJMW5R9 STEA1_HUMAN Decreases Expression [30]
Carboxypeptidase A4 (CPA4) OT66MP0F CBPA4_HUMAN Decreases Expression [30]
DNA helicase MCM8 (MCM8) OTC93H3S MCM8_HUMAN Decreases Expression [30]
F-box only protein 5 (FBXO5) OTTR957W FBX5_HUMAN Decreases Expression [30]
Angiopoietin-related protein 2 (ANGPTL2) OTB6JG41 ANGL2_HUMAN Increases Expression [30]
Integrin alpha-11 (ITGA11) OTBWSRA1 ITA11_HUMAN Increases Expression [30]
Protein HEG homolog 1 (HEG1) OT3CUXA7 HEG1_HUMAN Increases Expression [30]
Targeting protein for Xklp2 (TPX2) OTWLJYH0 TPX2_HUMAN Decreases Expression [30]
Synaptopodin-2 (SYNPO2) OTC3U0YH SYNP2_HUMAN Increases Expression [30]
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) OT953SV2 ATS5_HUMAN Increases Expression [30]
Protein timeless homolog (TIMELESS) OTD8DCBJ TIM_HUMAN Decreases Expression [30]
LIM and calponin homology domains-containing protein 1 (LIMCH1) OTYPC4XA LIMC1_HUMAN Increases Expression [30]
Exonuclease 1 (EXO1) OTI87RS5 EXO1_HUMAN Decreases Expression [30]
Protein phosphatase 1 regulatory subunit 3C (PPP1R3C) OTEU05TX PPR3C_HUMAN Increases Expression [30]
Transcription factor 19 (TCF19) OT7NKLF9 TCF19_HUMAN Decreases Expression [30]
DNA replication complex GINS protein PSF2 (GINS2) OT974IYI PSF2_HUMAN Decreases Expression [30]
Serine/threonine-protein kinase 38-like (STK38L) OTI00JVW ST38L_HUMAN Increases Expression [30]
Small kinetochore-associated protein (KNSTRN) OTYA7UXS SKAP_HUMAN Decreases Expression [30]
Origin recognition complex subunit 6 (ORC6) OTKQN3KP ORC6_HUMAN Decreases Expression [30]
Phosphoserine aminotransferase (PSAT1) OTVV1YV9 SERC_HUMAN Increases Expression [30]
Carboxypeptidase Q (CPQ) OTTNZNLD CBPQ_HUMAN Increases Expression [30]
Transforming acidic coiled-coil-containing protein 3 (TACC3) OTRNEZTA TACC3_HUMAN Decreases Expression [30]
Inositol 1,4,5-triphosphate receptor associated 1 (IRAG1) OTMRW5U5 IRAG1_HUMAN Increases Expression [30]
Adenylate kinase isoenzyme 5 (AK5) OTTGXLOT KAD5_HUMAN Decreases Expression [30]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Decreases Activity [37]
Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS) OTFBFPV4 ADAS_HUMAN Increases Expression [38]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Decreases Expression [38]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [38]
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) OT5BZ1J9 P85A_HUMAN Decreases Phosphorylation [38]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Decreases Phosphorylation [38]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Decreases Expression [38]
cAMP-regulated phosphoprotein 19 (ARPP19) OTZS3IT6 ARP19_HUMAN Increases Expression [38]
Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) OTPGHZB9 IFIT3_HUMAN Increases Expression [39]
Apoptosis-inducing factor 1, mitochondrial (AIFM1) OTKPWB7Q AIFM1_HUMAN Affects Localization [40]
Tyrosine-protein kinase ABL1 (ABL1) OT09YVXH ABL1_HUMAN Decreases Activity [41]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [39]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Decreases Activity [42]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Decreases Expression [43]
Interferon gamma (IFNG) OTXG9JM7 IFNG_HUMAN Decreases Expression [43]
C-X-C motif chemokine 10 (CXCL10) OTTLQ6S0 CXL10_HUMAN Increases Expression [39]
Granulocyte-macrophage colony-stimulating factor (CSF2) OT1M7D28 CSF2_HUMAN Decreases Expression [43]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Decreases Activity [44]
Interleukin-5 (IL5) OTAFPSCO IL5_HUMAN Decreases Expression [43]
Cathepsin B (CTSB) OTP9G5QB CATB_HUMAN Decreases Expression [45]
Tyrosine-protein kinase Lyn (LYN) OTP686K2 LYN_HUMAN Decreases Activity [31]
Hepatocyte growth factor receptor (MET) OT7K55MU MET_HUMAN Decreases Phosphorylation [46]
Growth-regulated alpha protein (CXCL1) OT3WCTZV GROA_HUMAN Decreases Expression [43]
High mobility group protein B1 (HMGB1) OT4B7CPF HMGB1_HUMAN Increases Expression [47]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Decreases Activity [45]
C-C motif chemokine 3 (CCL3) OTW2H3ND CCL3_HUMAN Decreases Expression [43]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [48]
Mast/stem cell growth factor receptor Kit (KIT) OTHUY3VZ KIT_HUMAN Decreases Phosphorylation [49]
Integrin alpha-M (ITGAM) OTAG6HWU ITAM_HUMAN Increases Expression [39]
Breakpoint cluster region protein (BCR) OTCN76C1 BCR_HUMAN Decreases Activity [41]
C-C motif chemokine 4 (CCL4) OT6B8P25 CCL4_HUMAN Decreases Expression [43]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Decreases Activity [45]
C-C motif chemokine 5 (CCL5) OTSCA5CK CCL5_HUMAN Decreases Expression [43]
Interleukin-1 receptor type 1 (IL1R1) OTTU8959 IL1R1_HUMAN Decreases Expression [43]
Platelet-derived growth factor receptor alpha (PDGFRA) OTDJXUCN PGFRA_HUMAN Decreases Phosphorylation [50]
C-C motif chemokine 1 (CCL1) OT23NON8 CCL1_HUMAN Decreases Expression [43]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Decreases Expression [51]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Phosphorylation [31]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Decreases Phosphorylation [31]
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38) OTG0TTX7 CD38_HUMAN Decreases Expression [43]
G1/S-specific cyclin-D3 (CCND3) OTNKPQ22 CCND3_HUMAN Decreases Expression [51]
Receptor-type tyrosine-protein kinase FLT3 (FLT3) OTMSRYMK FLT3_HUMAN Decreases Phosphorylation [49]
Signal transducer and activator of transcription 3 (STAT3) OTAAGKYZ STAT3_HUMAN Decreases Phosphorylation [52]
Serine/threonine-protein kinase mTOR (MTOR) OTHH8KU7 MTOR_HUMAN Decreases Phosphorylation [48]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Activity [41]
Tyrosine-protein kinase ABL2 (ABL2) OTS8F4GD ABL2_HUMAN Affects Binding [53]
Crk-like protein (CRKL) OTOYSD1R CRKL_HUMAN Decreases Phosphorylation [54]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Increases Expression [51]
Stromal cell-derived factor 1 (CXCL12) OT2QX5LL SDF1_HUMAN Decreases Expression [43]
Paxillin (PXN) OTVMMUOF PAXI_HUMAN Decreases Phosphorylation [52]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Increases Cleavage [31]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Increases Activity [55]
Interleukin-2 (IL2) OTGI4NSA IL2_HUMAN Decreases Expression [43]
Small ribosomal subunit protein eS6 (RPS6) OTT4D1LN RS6_HUMAN Decreases Phosphorylation [43]
Mothers against decapentaplegic homolog 3 (SMAD3) OTNA96MR SMAD3_HUMAN Decreases Phosphorylation [42]
Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1) OT4Y9NQI MP2K1_HUMAN Increases Phosphorylation [39]
Focal adhesion kinase 1 (PTK2) OT3Q1JDY FAK1_HUMAN Decreases Phosphorylation [51]
Early activation antigen CD69 (CD69) OTGJHSVP CD69_HUMAN Decreases Expression [43]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [31]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Decreases Expression [31]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Increases Activity [55]
Pre-mRNA 3'-end-processing factor FIP1 (FIP1L1) OTF91GTL FIP1_HUMAN Decreases Phosphorylation [50]
Bile acid receptor (NR1H4) OTWZLPTB NR1H4_HUMAN Decreases Phosphorylation [56]
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1) OTYRXD2T PMYT1_HUMAN Decreases Activity [57]
Transcription factor SOX-17 (SOX17) OT9H4WWE SOX17_HUMAN Decreases Localization [58]
Diablo IAP-binding mitochondrial protein (DIABLO) OTHJ9MCZ DBLOH_HUMAN Affects Localization [40]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Increases Response To Substance [51]
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (NSDHL) OTK3EJFD NSDHL_HUMAN Decreases Response To Substance [59]
Methylsterol monooxygenase 1 (MSMO1) OTKV62RZ MSMO1_HUMAN Decreases Response To Substance [59]
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⏷ Show the Full List of 453 DOT(s)

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Diffuse Intrinsic Pontine Glioma DC6G7W1 N. A. Phase 1 [60]
Advanced Cancers DCMIGX4 N. A. Phase 1 [61]
Adenocarcinoma DC7CM9K DU-145 Investigative [1]
Adenocarcinoma DC8GWRW A549 Investigative [1]
Adenocarcinoma DC74W5D HT29 Investigative [1]
Astrocytoma DCCILNB U251 Investigative [1]
Chronic myelogenous leukemia DCEHK4S K-562 Investigative [1]
Clear cell renal cell carcinoma DC84GSH TK-10 Investigative [1]
Clear cell renal cell carcinoma DCRUZA9 CAKI-1 Investigative [1]
Glioma DC43WUP SF-268 Investigative [1]
Lung adenocarcinoma DC7ZT0X MDA-MB-231 Investigative [1]
Lung adenocarcinoma DCMZ3OV EKVX Investigative [1]
Lung adenocarcinoma DCWFOK7 HOP-62 Investigative [1]
Lung adenocarcinoma DCYXX70 NCI-H522 Investigative [1]
Minimally invasive lung adenocarcinoma DC8TRHK NCI-H322M Investigative [1]
Mixed endometrioid and clear cell carcinoma DCJ4FZG IGROV1 Investigative [1]
Non-small cell lung carcinoma DCY4KUE HOP-92 Investigative [1]
Ovarian serous cystadenocarcinoma DCV3QWN SK-OV-3 Investigative [1]
Papillary renal cell carcinoma DC3H4CV ACHN Investigative [1]
Pleural epithelioid mesothelioma DCP4R8G NCI-H226 Investigative [1]
Prostate carcinoma DCDG694 PC-3 Investigative [1]
Invasive ductal carcinoma DCN96HJ T-47D Investigative [62]
------------------------------------------------------------------------------------
⏷ Show the Full List of 22 DrugCom(s)

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