Details of the Drug-Related molecule(s) Interaction Atlas

Cepharanthine Drug Info

CEPHARANTHINE; Cepharanthin; (+)-Cepharanthine; O-Methylcepharanoline; Cepharantin; Cepharanthine [JAN]; UNII-7592YJ0J6T; CCRIS 6539; NSC 623442; BRN 0075231; 6',12'-Dimethoxy-2,2'-dimethyl-6,7-(methylenebis(oxy))oxyacanthan; CHEBI:3546; 7592YJ0J6T; NSC623442; Cepharanthine (JAN); NSC-623442; ecaene (non-preferred name); DSSTox_RID_81253; DSSTox_CID_25957; DSSTox_GSID_45957; Oxyacanthan, 6',12'-dimethoxy-2,2'-dimethyl-6,7-(methylenebis(oxy))-; CAS-481-49-2; SR-01000779734; Cepharanthin,(S)

Cross-matching ID

PubChem CID

10206

ChEBI ID

CHEBI:3546

CAS Number

CAS 481-49-2

TTD Drug ID

DM9Y5JB

VARIDT Drug ID

DR01503

General Information of Drug (ID: DM9Y5JB)

Molecule-Related Drug Atlas

Molecule Type:

DTP

DOT

Drug Status:

Approved Drug(s)

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Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[5]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[6]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[8]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[7]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[7]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[9]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[7]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[10]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[11]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[12]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[13]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[14]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[15]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[16]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[17]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[18]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[19]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[17]
Levetiracetam	DMTGDN8	Epilepsy	8A60-8A68	Approved	[15]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[22]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[23]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[24]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[25]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[26]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[27]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[28]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[29]
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Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[30]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[31]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[32]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[33]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[34]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[35]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[34]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[36]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[37]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[38]
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Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[39]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[40]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[41]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[42]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[44]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[45]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[47]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[48]
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Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[49]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[50]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[51]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[54]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[56]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[57]
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Drug(s) Affected By Potassium voltage-gated channel subfamily H member 2 (KCNH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metoclopramide	DMFA5MY	Nausea	MD90	Approved	[58]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[59]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[60]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[61]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[61]
Disopyramide	DM5SYZP	Long QT syndrome	BC65.0	Approved	[62]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[63]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[64]
Dofetilide	DMPN1TW	Sinus rhythm disorder	BC9Y	Approved	[65]
Flecainide	DMSQDLE	Tachyarrhythmias	BC71	Approved	[61]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Gene/Protein Processing	[2]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Gene/Protein Processing	[3]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	OT2YYI1A	MCL1_HUMAN	Gene/Protein Processing	[3]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Gene/Protein Processing	[3]
Potassium voltage-gated channel subfamily H member 2 (KCNH2)	OTZX881H	KCNH2_HUMAN	Gene/Protein Processing	[4]
Serine/threonine-protein kinase mTOR (MTOR)	OTHH8KU7	MTOR_HUMAN	Gene/Protein Processing	[3]

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