Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMAKIDV)

Drug Name
Dydrogesterone Drug Info
Synonyms
Dehydrogesterone; Didrogesterona; Didrogesterone; Diphaston; Dufaston; Duphaston; Duvaron; Dydrogesterona; Dydrogesteronum; Gestatron; Gynorest; Hydrogesterone; Hydrogestrone; Isopregnenone; Prodel; Retrone; Terolut; Didrogesterone [DCIT]; Solvay Brand of Dydrogesterone; DELTA6-Retroprogesterone; Duphaston (TN); Dydrogesterona [INN-Spanish]; Dydrogesteronum [INN-Latin]; Gynorest (TN); Delta(6)-Retroprogesterone; Delta(sup 6)-Retroprogesterone; Retro-6-dehydroprogesterone; Dydrogesterone (JP15/USP/INN); Dydrogesterone [USAN:INN:BAN:JAN]; Pregna-4,6-diene-3,20-dione, (9-beta,10-alpha)-(9CI); (8S,9R,10S,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one; (9-beta,10-alpha)-Pregna-4,6-diene-3,20-dione; (9beta,10alpha)-pregna-4,6-diene-3,20-dione; 10alpha-Isopregnenone; 6 Dehydro 9 beta 10 alpha progesterone; 6-Dehydro-9 beta-10 alpha-progesterone; 6-Dehydro-9.beta.,10.alpha.-progesterone; 6-Dehydro-9beta,10alpha-progesterone; 6-Dehydro-retro-progesterone; 6-Dehydroretroprogesterone; 9-.beta.,10.alpha.-Pregna-4,6-diene-3,20-dione; 9-beta,10-alpha-Pregna-4,6-diene-3,20-dione; 9-beta,10alpha-Pregna-4,6-diene-3,20-dione; 9.beta.,10.alpha.-Pregna-4,6-diene-3,20-dione; 9beta,10alpha-Pregna-4,6-diene-3,20-dione; 9beta,10alpha-Pregna-4,6-diene-3,20-dione (8CI)
Indication
Disease Entry ICD 11 Status REF
Menstrual disorder GA20.3 Approved [1]
Therapeutic Class
Progesterones
Cross-matching ID
PubChem CID
9051
ChEBI ID
CHEBI:31527
CAS Number
CAS 152-62-5
TTD Drug ID
DMAKIDV
INTEDE Drug ID
DR0556

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Progesterone receptor (PGR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [6]
Desogestrel DM27U4Y Contraception QA21 Approved [7]
Ulipristal DMBNI20 Contraception QA21 Approved [8]
Etonogestrel DMKA8J4 Contraception QA21 Approved [9]
Megestrol DMDH9KX Breast cancer 2C60-2C65 Approved [10]
Segesterone acetate; ethinyl estradiol DMFEGB0 Contraception QA21 Approved [11]
Norgestimate DMYP4XC Acne vulgaris ED80 Approved [9]
Medroxyprogesterone DMBGWPH Solid tumour/cancer 2A00-2F9Z Approved [2]
Ethynodiol Diacetate DMZM84R Contraception QA21 Approved [12]
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [13]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [14]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [15]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [16]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [17]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [18]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [19]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [20]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [21]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [15]
Verapamil DMA7PEW Angina pectoris BA40 Approved [22]
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Drug(s) Affected By 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (SRD5A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [23]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [24]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [25]
Testosterone DM7HUNW Hot flushes GA30 Approved [26]
Hydroxyflutamide DMGIZF5 Prostate cancer 2C82.0 Approved [27]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [28]
Dutasteride DMQ4TJK Benign prostatic hyperplasia GA90 Approved [29]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [4]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [30]
Finasteride DMWV3TZ Baldness, male pattern Approved [31]
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Drug(s) Affected By 17-beta-hydroxysteroid dehydrogenase type 2 (HSD17B2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estrone DM5T6US Acne vulgaris ED80 Approved [32]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [32]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [33]
Quercetin DM3NC4M Obesity 5B81 Approved [34]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [35]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [37]
Plicamycin DM7C8YV Hypercalcaemia 5B91.0 Approved [38]
Testosterone DM7HUNW Hot flushes GA30 Approved [39]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [40]
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Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [30]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [41]
Diazepam DM08E9O Alcohol withdrawal Approved [42]
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [43]
Desogestrel DM27U4Y Contraception QA21 Approved [43]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [41]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [41]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [44]
Quercetin DM3NC4M Obesity 5B81 Approved [45]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [46]
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Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [41]
Diazepam DM08E9O Alcohol withdrawal Approved [42]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [48]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [41]
Quercetin DM3NC4M Obesity 5B81 Approved [34]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [49]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [41]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [50]
Testosterone DM7HUNW Hot flushes GA30 Approved [51]
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Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [4]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [41]
Diazepam DM08E9O Alcohol withdrawal Approved [42]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [52]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [41]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [41]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [53]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [54]
Ethacrynic acid DM60QMR Edema MG29 Approved [52]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [41]
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Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [55]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [56]
Fructose DM43AN2 Vomiting MD90 Approved [57]
Ketoprofen DMRKXPT Bursitis Approved [57]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [58]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [59]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [60]
Gefitinib DM15F0X Colon adenocarcinoma Approved [61]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [62]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
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Drug(s) Affected By Interferon gamma (IFNG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [64]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [65]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [66]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [67]
Methotrexate DM2TEOL Anterior urethra cancer Approved [68]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [69]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [71]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [72]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [73]
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Drug(s) Affected By Interleukin-4 (IL4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [74]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [75]
Tolnaftate DM28MU7 Dermatophytosis 1F28.2 Approved [76]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [77]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [78]
Prednisone DM2HG4X Acute asthma CA23 Approved [79]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [67]
Methotrexate DM2TEOL Anterior urethra cancer Approved [68]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [69]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [80]
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Drug(s) Affected By Interleukin-6 (IL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [81]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [82]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [83]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [84]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [85]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [86]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [87]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [88]
Methotrexate DM2TEOL Anterior urethra cancer Approved [81]
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Drug(s) Affected By Progesterone-induced-blocking factor 1 (PIBF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [89]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [90]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [91]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [28]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [92]
Arsenic DMTL2Y1 N. A. N. A. Approved [93]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [94]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [91]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [95]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [96]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Progesterone receptor (PGR) TTUV8G9 PRGR_HUMAN Agonist [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
17-beta-hydroxysteroid dehydrogenase type 2 (HSD17B2) OT3K7HY5 DHB2_HUMAN Gene/Protein Processing [4]
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (SRD5A1) OTQRET2B S5A1_HUMAN Gene/Protein Processing [4]
Aldo-keto reductase family 1 member C1 (AKR1C1) OTQKR4CM AK1C1_HUMAN Gene/Protein Processing [4]
Aldo-keto reductase family 1 member C2 (AKR1C2) OTQ2XMO3 AK1C2_HUMAN Gene/Protein Processing [4]
Aldo-keto reductase family 1 member C3 (AKR1C3) OTU2SXBA AK1C3_HUMAN Gene/Protein Processing [4]
Interferon gamma (IFNG) OTXG9JM7 IFNG_HUMAN Gene/Protein Processing [5]
Interleukin-4 (IL4) OTOXBWAU IL4_HUMAN Gene/Protein Processing [5]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Gene/Protein Processing [5]
Progesterone-induced-blocking factor 1 (PIBF1) OTCBT1A1 PIBF1_HUMAN Gene/Protein Processing [5]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Gene/Protein Processing [5]

References

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65 Regulatory role of nitric oxide on monocyte-derived dendritic cell functions. J Interferon Cytokine Res. 2003 Aug;23(8):423-31. doi: 10.1089/107999003322277838.
66 Direct evidence for immunomodulatory properties of ribavirin on T-cell reactivity to hepatitis C virus. Antiviral Res. 2007 Jul;75(1):36-42. doi: 10.1016/j.antiviral.2006.11.008. Epub 2006 Dec 13.
67 Differential effects of three antibiotics on T helper cell cytokine expression. J Antimicrob Chemother. 2005 Sep;56(3):502-6. doi: 10.1093/jac/dki251. Epub 2005 Jul 8.
68 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
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