Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMEM2SW)

Drug Name
CYCLOPAMINE Drug Info
Synonyms
CYCLOPAMINE; 11-Deoxojervine; 4449-51-8; UNII-ZH658AJ192; CHEMBL254129; CHEBI:4021; 11-Deoxyjervine; ZH658AJ192; HSDB 3505; Jervine, 11-deoxo-; Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol, 1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-octadecahydro-3',6',10,11b-tetramethyl-, (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)- (9CI); (3beta,22S,23R)-17,23-epoxyveratraman-3-ol; Veratraman-3-ol, 17,23-epoxy-, (3beta,23beta)-; CY8; [3H]-Cyclopamine; AC1L9DRQ; DSSTox_CID_23709; DSSTox_RID_80067; SCHEMBL29153
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
442972
ChEBI ID
CHEBI:4021
CAS Number
CAS 4449-51-8
TTD Drug ID
DMEM2SW

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Smoothened homolog (SMO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PF-04449913 DMSB068 Chronic myelomonocytic leukaemia 2A40 Approved [6]
Vismodegib DM5IXKQ Basal cell carcinoma 2C32 Approved [7]
LDE225 DMM9F25 Basal cell carcinoma 2C32 Phase 2 [8]
LY2940680 DMTJWIQ Solid tumour/cancer 2A00-2F9Z Phase 1/2 [6]
BMS-833923 DM459Q7 Solid tumour/cancer 2A00-2F9Z Phase 1b [9]
LEQ-506 DM5INZP Solid tumour/cancer 2A00-2F9Z Phase 1 [10]
TAK-441 DM7DFBL Solid tumour/cancer 2A00-2F9Z Phase 1 [11]
PMID25726713-Compound-49 DM2CT4G N. A. N. A. Patented [12]
PMID25726713-Compound-51 DMF0OW4 N. A. N. A. Patented [12]
PMID25726713-Compound-48 DMSIOUA N. A. N. A. Patented [12]
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Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [13]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [14]
Gefitinib DM15F0X Colon adenocarcinoma Approved [15]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [16]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [17]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [16]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [18]
Selenium DM25CGV N. A. N. A. Approved [19]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [20]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [21]
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Drug(s) Affected By Arginase-1 (ARG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [22]
Methotrexate DM2TEOL Anterior urethra cancer Approved [23]
Quercetin DM3NC4M Obesity 5B81 Approved [24]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [25]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [26]
Testosterone DM7HUNW Hot flushes GA30 Approved [27]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [27]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Cholecalciferol DMGU74E Adult acute monocytic leukemia Approved [30]
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Drug(s) Affected By Interleukin-6 (IL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [31]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [32]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [33]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [34]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [35]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [14]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [36]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [18]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [37]
Methotrexate DM2TEOL Anterior urethra cancer Approved [31]
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Drug(s) Affected By Prostate-specific antigen (KLK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [38]
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [39]
Selenium DM25CGV N. A. N. A. Approved [40]
Quercetin DM3NC4M Obesity 5B81 Approved [41]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [42]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [43]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [44]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [45]
Testosterone DM7HUNW Hot flushes GA30 Approved [46]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [27]
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Drug(s) Affected By Zinc finger protein GLI1 (GLI1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Vismodegib DM5IXKQ Basal cell carcinoma 2C32 Approved [47]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [48]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [49]
Tofacitinib DMBS370 Rheumatoid arthritis FA20 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [51]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [52]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [53]
Arsenic DMTL2Y1 N. A. N. A. Approved [54]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [55]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [56]
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Drug(s) Affected By Androgen receptor (AR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [57]
Nilutamide DMFN07X Prostate cancer 2C82.0 Approved [57]
Hydroxyflutamide DMGIZF5 Prostate cancer 2C82.0 Approved [57]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [58]
Bicalutamide DMZMSPF Prostate cancer 2C82.0 Approved [59]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [60]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [61]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [62]
Selenium DM25CGV N. A. N. A. Approved [40]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [63]
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Drug(s) Affected By Interleukin-10 (IL10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [64]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [65]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [66]
Methotrexate DM2TEOL Anterior urethra cancer Approved [67]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [68]
Quercetin DM3NC4M Obesity 5B81 Approved [69]
Bisoprolol DM3UZ95 Hypertension BA00-BA04 Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [71]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [72]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [73]
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Drug(s) Affected By Macrophage mannose receptor 1 (MRC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [74]
Valsartan DMREUQ6 Chronic heart failure BD1Z Approved [75]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [76]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [77]
Drug(s) Affected By Nitric oxide synthase, inducible (NOS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [78]
Indomethacin DMSC4A7 Bursitis Approved [79]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [80]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [81]
Methotrexate DM2TEOL Anterior urethra cancer Approved [82]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [83]
Quercetin DM3NC4M Obesity 5B81 Approved [84]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [85]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [86]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [87]
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Drug(s) Affected By T-lymphocyte activation antigen CD86 (CD86)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [88]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [65]
Kanamycin DM2DMPO Bacteremia 1A73 Approved [89]
Methotrexate DM2TEOL Anterior urethra cancer Approved [90]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [91]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [25]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [89]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [92]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [89]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [93]
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Drug(s) Affected By Neurogenic locus notch homolog protein 1 (NOTCH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [94]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [95]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [96]
Propranolol DM79NTF Angina pectoris BA40 Approved [97]
Testosterone DM7HUNW Hot flushes GA30 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [99]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [100]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [101]
Mebendazole DMO14SG Ascariasis 1F62 Approved [102]
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Drug(s) Affected By Thyroxine 5-deiodinase (DIO3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Vemurafenib DM62UG5 Melanoma 2C30 Approved [104]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [105]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ergocalciferol DMHO0AR Hypoparathyroidism 5A50 Approved [106]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [103]
Masoprocol DMMVNZ0 Prostate cancer 2C82.0 Approved [106]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [103]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [107]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [103]
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Drug(s) Affected By Protein patched homolog 1 (PTCH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [38]
Quercetin DM3NC4M Obesity 5B81 Approved [24]
Vismodegib DM5IXKQ Basal cell carcinoma 2C32 Approved [47]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [48]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [108]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [109]
Ethanol DMDRQZU Chronic pain MG30 Approved [110]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [111]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [53]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [112]
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Drug(s) Affected By Protein smoothened (SMO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [33]
Quercetin DM3NC4M Obesity 5B81 Approved [113]
Vismodegib DM5IXKQ Basal cell carcinoma 2C32 Approved [47]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [114]
Leflunomide DMR8ONJ Arthritis FA20 Approved [115]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [101]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [116]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [52]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [53]
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Drug(s) Affected By Resistin-like beta (RETNLB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Folic Acid DMEMBJC Colorectal carcinoma Approved [117]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [118]
Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [33]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [119]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [120]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [121]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [122]
Quercetin DM3NC4M Obesity 5B81 Approved [24]
Fluoxetine DM3PD2C Bipolar depression Approved [123]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [124]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [125]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [126]
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Drug(s) Affected By Insulin-like growth factor-binding protein 6 (IGFBP6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [127]
Methotrexate DM2TEOL Anterior urethra cancer Approved [82]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [128]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [85]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [129]
Testosterone DM7HUNW Hot flushes GA30 Approved [130]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [132]
Menthol DMG2KW7 Back pain ME84.Z Approved [133]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [101]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Smoothened homolog (SMO) TT8J1S3 SMO_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Androgen receptor (AR) OTUBKAZZ ANDR_HUMAN Gene/Protein Processing [2]
Arginase-1 (ARG1) OTHZITAM ARGI1_HUMAN Gene/Protein Processing [3]
G1/S-specific cyclin-E1 (CCNE1) OTLD7UID CCNE1_HUMAN Drug Response [4]
Insulin-like growth factor-binding protein 6 (IGFBP6) OTW878VI IBP6_HUMAN Drug Response [4]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Gene/Protein Processing [3]
Interleukin-10 (IL10) OTIRFRXC IL10_HUMAN Gene/Protein Processing [3]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Gene/Protein Processing [3]
Macrophage mannose receptor 1 (MRC1) OTTVCOPT MRC1_HUMAN Gene/Protein Processing [3]
Neurogenic locus notch homolog protein 1 (NOTCH1) OTI1WADQ NOTC1_HUMAN Protein Interaction/Cellular Processes [5]
Nitric oxide synthase, inducible (NOS2) OTKKIOJ1 NOS2_HUMAN Gene/Protein Processing [3]

References

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41 Quercetin inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells. Carcinogenesis. 2001 Mar;22(3):409-14. doi: 10.1093/carcin/22.3.409.
42 EPI-001 is a selective peroxisome proliferator-activated receptor-gamma modulator with inhibitory effects on androgen receptor expression and activity in prostate cancer. Oncotarget. 2015 Feb 28;6(6):3811-24.
43 Androgen receptor or estrogen receptor-beta blockade alters DHEA-, DHT-, and E(2)-induced proliferation and PSA production in human prostate cancer cells. Prostate. 2007 Aug 1;67(11):1152-62. doi: 10.1002/pros.20585.
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