Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMEMRW0)

Drug Name
Lipoteichoic acid Drug Info
Synonyms Oncomycin; Lipoteichoic acid (cancer); Lipoteichoic acid (cancer), Lunamed; TLR-2 modulator (subcutaneous, solid tumor), LUNAMeD; Toll like receptor-2 modulator (subcutaneous, solid tumor), LUNAMeD
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1/2 [1]
Cross-matching ID
PubChem CID
137349712
CAS Number
CAS 56411-57-5
TTD Drug ID
DMEMRW0

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Toll-like receptor 2 (TLR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cadi-05 DMPTCYB Prostate cancer 2C82.0 Phase 3 [10]
MCS-18 DMX4U0B Autoimmune diabetes 5A10 Phase 2 [11]
OPN-305 DM1IBRT Myelodysplastic syndrome 2A37 Phase 2 [12]
MALP-2S DMBZ68C Pancreatic cancer 2C10 Phase 1/2 [13]
OM-174 DM2THBX Solid tumour/cancer 2A00-2F9Z Phase 1 [14]
F-50040 DMMG6W5 Melanoma 2C30 Discontinued in Phase 1 [15]
S-(Dimethylarsenic)Cysteine DMSCHL0 Discovery agent N.A. Investigative [16]
CBLB-612 DMCFR8U Radiation syndrome NF00 Investigative [17]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [18]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [19]
Fructose DM43AN2 Vomiting MD90 Approved [20]
Ketoprofen DMRKXPT Bursitis Approved [20]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [21]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [22]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [23]
Gefitinib DM15F0X Colon adenocarcinoma Approved [24]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [25]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [26]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lactotransferrin (LTF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [27]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [28]
Capsaicin DMGMF6V Back pain ME84.Z Approved [29]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [30]
Budesonide DMJIBAW Allergic rhinitis CA08.0 Approved [31]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [32]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [33]
Arsenic DMTL2Y1 N. A. N. A. Approved [34]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [27]
Diphenylpyraline DMW4X37 Allergic rhinitis CA08.0 Approved [35]
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Drug(s) Affected By Granulocyte-macrophage colony-stimulating factor (CSF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [36]
Quercetin DM3NC4M Obesity 5B81 Approved [37]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [38]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [39]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [40]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [41]
Testosterone DM7HUNW Hot flushes GA30 Approved [42]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [43]
Acetylcholine DMDF79Z Cataract 9B10 Approved [44]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [45]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ubiquitin-like protein ISG15 (ISG15)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [46]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [48]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [46]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [49]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [50]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [51]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [52]
Testosterone enanthate DMB6871 N. A. N. A. Approved [53]
Tofacitinib DMBS370 Rheumatoid arthritis FA20 Approved [54]
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Drug(s) Affected By Interleukin-6 (IL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [46]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [55]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [56]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [57]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [58]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [59]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [26]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [60]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [61]
Methotrexate DM2TEOL Anterior urethra cancer Approved [46]
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Drug(s) Affected By Neutrophil elastase (ELANE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [62]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [63]
Glyceryl trinitrate DMF72W3 N. A. N. A. Phase 4 [64]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [65]
KOJIC ACID DMP84CS Discovery agent N.A. Investigative [66]
fMet-Leu-Phe DMQ391A N. A. N. A. Investigative [67]
paraquat DMR8O3X Discovery agent N.A. Investigative [68]
Aniline DMLCAR9 N. A. N. A. Investigative [69]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [70]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [71]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [72]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [57]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [73]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [59]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [74]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [75]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [76]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [74]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [58]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [27]
Gefitinib DM15F0X Colon adenocarcinoma Approved [77]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [26]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [78]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [79]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [80]
Methotrexate DM2TEOL Anterior urethra cancer Approved [81]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [82]
Quercetin DM3NC4M Obesity 5B81 Approved [83]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-10 (IL10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [36]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [84]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [85]
Methotrexate DM2TEOL Anterior urethra cancer Approved [86]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [88]
Bisoprolol DM3UZ95 Hypertension BA00-BA04 Approved [89]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [90]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [91]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [92]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-X-C chemokine receptor type 2 (CXCR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [93]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [94]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [95]
Prednisolone DMQ8FR2 Acute adrenal insufficiency Approved [96]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [97]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [98]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [99]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [100]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [101]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Toll-like receptor 2 (TLR2) TTY7ZHS TLR2_HUMAN Modulator [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Protein Interaction/Cellular Processes [3]
C-X-C chemokine receptor type 2 (CXCR2) OTISGW7L CXCR2_HUMAN Gene/Protein Processing [4]
Granulocyte-macrophage colony-stimulating factor (CSF2) OT1M7D28 CSF2_HUMAN Protein Interaction/Cellular Processes [3]
Interleukin-10 (IL10) OTIRFRXC IL10_HUMAN Gene/Protein Processing [5]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Gene/Protein Processing [6]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Protein Interaction/Cellular Processes [7]
Lactotransferrin (LTF) OT8JWCZ0 TRFL_HUMAN Protein Interaction/Cellular Processes [8]
Neutrophil elastase (ELANE) OTCOHLXR ELNE_HUMAN Protein Interaction/Cellular Processes [8]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Gene/Protein Processing [5]
Ubiquitin-like protein ISG15 (ISG15) OT53QQ7N ISG15_HUMAN Gene/Protein Processing [9]

References

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28 Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
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63 Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
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66 Toxicogenomics of kojic acid on gene expression profiling of a375 human malignant melanoma cells. Biol Pharm Bull. 2006 Apr;29(4):655-69.
67 2-(2-Fluorobenzamido)benzoate ethyl ester (EFB-1) inhibits superoxide production by human neutrophils and attenuates hemorrhagic shock-induced organ dysfunction in rats. Free Radic Biol Med. 2011 Jun 15;50(12):1737-48. doi: 10.1016/j.freeradbiomed.2011.03.026. Epub 2011 Mar 30.
68 CD34+ derived macrophage and dendritic cells display differential responses to paraquat. Toxicol In Vitro. 2021 Sep;75:105198. doi: 10.1016/j.tiv.2021.105198. Epub 2021 Jun 9.
69 Similarities between human and rat leukocyte elastase and cathepsin G. Eur J Biochem. 1984 Oct 1;144(1):1-9. doi: 10.1111/j.1432-1033.1984.tb08423.x.
70 Monomeric and oligomeric flavanols maintain the endogenous glucocorticoid response in human macrophages in pro-oxidant conditions in vitro. Chem Biol Interact. 2018 Aug 1;291:237-244.
71 Nicotine up-regulates IL-8 expression in human gingival epithelial cells following stimulation with IL-1 or P. gingivalis lipopolysaccharide via nicotinic acetylcholine receptor signalling. Arch Oral Biol. 2012 May;57(5):483-90. doi: 10.1016/j.archoralbio.2011.10.007. Epub 2011 Nov 25.
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73 Nitrogen mustard prevents transport of Fra-1 into the nucleus to promote c-Fos- and FosB-dependent IL-8 induction in injured mouse epidermis. Toxicol Lett. 2020 Feb 1;319:256-263. doi: 10.1016/j.toxlet.2019.10.006. Epub 2019 Oct 19.
74 An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
75 Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food Chem Toxicol. 2018 Feb;112:76-85.
76 Nitric oxide synthase inhibitors attenuate ozone-induced airway inflammation in guinea pigs. Possible role of interleukin-8. Am J Respir Crit Care Med. 2000 Jan;161(1):249-56. doi: 10.1164/ajrccm.161.1.9804096.
77 Crosstalk between alveolar macrophages and alveolar epithelial cells/fibroblasts contributes to the pulmonary toxicity of gefitinib. Toxicol Lett. 2021 Mar 1;338:1-9. doi: 10.1016/j.toxlet.2020.11.011. Epub 2020 Nov 25.
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