Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFYAM1)

Drug Name
Enalaprilat Drug Info
Synonyms
Extract of ginger root; Ginger extract; Ginger root extract; Ginger, ext; LS-3194; Zingiber officinale extract; Zingiber officinale root extract; CCRIS 7641; EINECS 283-634-2; FEMA No. 2520; FEMA No. 2521; FEMA No. 2523; Ginger extract (Zingiber officinale); ginger, extract (zingiber officinale rosc.)
Indication
Disease Entry ICD 11 Status REF
Congestive heart failure BD10 Approved [1]
Hypertension BA00-BA04 Approved [2]
Malignant essential hypertension BA00 Approved [1]
Cross-matching ID
PubChem CID
6850776
CAS Number
CAS 84696-15-1
TTD Drug ID
DMFYAM1
INTEDE Drug ID
DR2736

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Angiotensin-converting enzyme (ACE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Enalapril DMNFUZR Congestive heart failure BD10 Approved [10]
Spirapril DM5XLTY Hypertension BA00-BA04 Approved [11]
Captopril DM458UM Chronic heart failure BD1Z Approved [12]
Benazepril DMH1M9B Hypertension BA00-BA04 Approved [13]
Moexipril DM26E4B Hypertension BA00-BA04 Approved [14]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [15]
Perindopril DMOPZDT Hypertension BA00-BA04 Approved [16]
Trandolapril DM4L6EU Chronic heart failure BD1Z Approved [17]
Fosinopril DM9NJ52 Chronic heart failure BD1Z Approved [18]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [19]
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Drug(s) Transported By Peptide transporter 1 (SLC15A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [20]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [21]
Ampicillin DMHWE7P Acute epiglottitis Approved [22]
Losartan DM72JXH Diabetic kidney disease GB61.Z Approved [23]
Enalapril DMNFUZR Congestive heart failure BD10 Approved [24]
Cefazolin DMPDYFR Bacteremia 1A73 Approved [25]
Ceftriaxone DMCEW64 Acute gonococcal cervicitis Approved [26]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [21]
Cefadroxil DMMC345 Bacterial infection 1A00-1C4Z Approved [23]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [23]
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Drug(s) Metabolized By Dipeptidase (pepV)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Enalapril DMNFUZR Congestive heart failure BD10 Approved [5]
Spirapril DM5XLTY Hypertension BA00-BA04 Approved [5]
Drug(s) Affected By Endothelin-1 (EDN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [27]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [29]
Methotrexate DM2TEOL Anterior urethra cancer Approved [30]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [31]
Quercetin DM3NC4M Obesity 5B81 Approved [32]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [33]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [34]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [35]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [7]
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Drug(s) Affected By B1 bradykinin receptor (BDKRB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [36]
Testosterone DM7HUNW Hot flushes GA30 Approved [37]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [37]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [38]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [39]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [40]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [41]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [42]
Beclomethasone dipropionate DM5NW1E Allergic rhinitis CA08.0 Phase 4 [43]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [44]
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Drug(s) Affected By Organic anion transporter 3 (SLC22A8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valsartan DMREUQ6 Chronic heart failure BD1Z Approved [45]
Methotrexate DM2TEOL Anterior urethra cancer Approved [46]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [47]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [48]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [49]
Cimetidine DMH61ZB Acid-reflux disorder DA22 Approved [49]
Cefdinir DMJ7A0H Bacterial infection 1A00-1C4Z Approved [50]
Cefaclor DMJXDGC Bacterial infection 1A00-1C4Z Approved [50]
Famotidine DMRL3AB Gastric ulcer DA60 Approved [51]
Tetracycline DMZA017 Acne vulgaris ED80 Approved [52]
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Drug(s) Affected By Solute carrier family 22 member 11 (SLC22A11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [53]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [53]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [54]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [53]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [53]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [55]
Mefenamic acid DMK7HFI Dysmenorrhea GA34.3 Approved [53]
Probenecid DMMFWOJ Acute gonococcal cervicitis Approved [56]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [53]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [57]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Solute carrier organic anion transporter family member 1B1 (SLCO1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Enalapril DMNFUZR Congestive heart failure BD10 Approved [9]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [58]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [59]
Repaglinide DM5SXUV Diabetic complication 5A2Y Approved [60]
Methotrexate DM2TEOL Anterior urethra cancer Approved [61]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [62]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [63]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [63]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [64]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [65]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Angiotensin-converting enzyme (ACE) TTL69WB ACE_HUMAN Inhibitor [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Peptide transporter 1 (SLC15A1) DT9G7XN S15A1_HUMAN Substrate [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Dipeptidase (pepV) Main DME DEQMBHW Q84BU9_LACLH Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
B1 bradykinin receptor (BDKRB1) OT1DHSVQ BKRB1_HUMAN Gene/Protein Processing [6]
Endothelin-1 (EDN1) OTZCACEG EDN1_HUMAN Protein Interaction/Cellular Processes [7]
Organic anion transporter 3 (SLC22A8) OT8BY933 S22A8_HUMAN Regulation of Drug Effects [8]
Solute carrier family 22 member 11 (SLC22A11) OTAJLNJZ S22AB_HUMAN Regulation of Drug Effects [8]
Solute carrier organic anion transporter family member 1B1 (SLCO1B1) OTNEN8QK SO1B1_HUMAN Regulation of Drug Effects [9]

References

1 Enalaprilat FDA Label
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5 Characterization and kinetic analysis of enzyme-substrate recognition by three recombinant lactococcal PepVs. Arch Biochem Biophys. 2006 Oct 15;454(2):137-45.
6 Novel mode of action of angiotensin I converting enzyme inhibitors: direct activation of bradykinin B1 receptor. J Biol Chem. 2002 May 10;277(19):16847-52. doi: 10.1074/jbc.M200355200. Epub 2002 Mar 5.
7 Different effects of angiotensin converting enzyme inhibitors on endothelin-1 and nitric oxide balance in human vascular endothelial cells: evidence of an oxidant-sensitive pathway. Mediators Inflamm. 2008;2008:305087. doi: 10.1155/2008/305087. Epub 2008 Dec 1.
8 Completing the Enalaprilat Excretion Pathway-Renal Handling by the Proximal Tubule. Pharmaceutics. 2020 Sep 30;12(10):935. doi: 10.3390/pharmaceutics12100935.
9 Effect of organic anion-transporting polypeptide 1B1 (OATP1B1) polymorphism on the single- and multiple-dose pharmacokinetics of enalapril in healthy Chinese adult men. Clin Ther. 2011 May;33(5):655-63. doi: 10.1016/j.clinthera.2011.04.018.
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11 Central angiotensin II controls alcohol consumption via its AT1 receptor. FASEB J. 2005 Sep;19(11):1474-81.
12 Using ACE inhibitors appropriately. Am Fam Physician. 2002 Aug 1;66(3):461-8.
13 Efficacy of benazepril hydrochloride to delay the progression of occult dilated cardiomyopathy in Doberman Pinschers. J Vet Intern Med. 2009 Sep-Oct;23(5):977-83.
14 Moexipril for treatment of primary biliary cirrhosis in patients with an incomplete response to ursodeoxycholic acid. Dig Dis Sci. 2010 Feb;55(2):476-83.
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16 Fixed combination perindopril-amlodipine (Coveram) in the treatment of hypertension and coronary heart disease. Rev Med Liege. 2009 Apr;64(4):223-7.
17 Selective reduction of central pulse pressure under angiotensin blockage in SHR: role of the fibronectin-alpha5beta1 integrin complex. Am J Hypertens. 2009 Jul;22(7):711-7.
18 Angiotensin-converting enzyme inhibition and novel cardiovascular risk biomarkers: results from the Trial of Angiotensin Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors (TRAIN) study. Am Heart J. 2009 Feb;157(2):334.e1-8.
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20 Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters. Drug Metab Dispos. 2006 Apr;34(4):547-55.
21 Peptide transporter substrate identification during permeability screening in drug discovery: comparison of transfected MDCK-hPepT1 cells to Caco-2 cells. Arch Pharm Res. 2007 Apr;30(4):507-18.
22 Several hPepT1-transported drugs are substrates of the Escherichia coli proton-coupled oligopeptide transporter YdgR. Res Microbiol. 2017 Jun;168(5):443-449.
23 High-affinity interaction of sartans with H+/peptide transporters. Drug Metab Dispos. 2009 Jan;37(1):143-9.
24 The intestinal H+/peptide symporter PEPT1: structure-affinity relationships. Eur J Pharm Sci. 2004 Jan;21(1):53-60.
25 Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1. J Med Chem. 2005 Jun 30;48(13):4410-9.
26 Intestinal transport of beta-lactam antibiotics: analysis of the affinity at the H+/peptide symporter (PEPT1), the uptake into Caco-2 cell monolayers and the transepithelial flux. Pharm Res. 1999 Jan;16(1):55-61.
27 ?-adrenoceptors and muscarinic receptors mediate opposing effects on endothelin-1 expression in human lung fibroblasts. Eur J Pharmacol. 2012 Sep 15;691(1-3):218-24. doi: 10.1016/j.ejphar.2012.07.002. Epub 2012 Jul 13.
28 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
29 Induction of endothelin-1 expression by oxidative stress in vascular smooth muscle cells. Cardiovasc Pathol. 2001 Nov-Dec;10(6):311-5. doi: 10.1016/s1054-8807(01)00095-3.
30 Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
31 [Effect of simvastatin on endothelin-1 expression in endothelial cell cultured hypoxically]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2008 Jan;39(1):72-5.
32 Effects of dietary polyphenols on gene expression in human vascular endothelial cells. Proc Nutr Soc. 2008 Feb;67(1):42-7.
33 Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
34 Nucleoside reverse transcriptase inhibitors induce a mitophagy-associated endothelial cytotoxicity that is reversed by coenzyme Q10 cotreatment. Toxicol Sci. 2013 Aug;134(2):323-34. doi: 10.1093/toxsci/kft105. Epub 2013 May 2.
35 Cardiac toxicity of high-dose cyclophosphamide in patients with multiple myeloma undergoing autologous hematopoietic stem cell transplantation. Int J Hematol. 2007 Jun;85(5):408-14. doi: 10.1532/IJH97.E0620.
36 Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
37 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
38 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
39 Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
40 Progesterone regulation of implantation-related genes: new insights into the role of oestrogen. Cell Mol Life Sci. 2007 Apr;64(7-8):1009-32.
41 Dose- and time-dependent effects of phenobarbital on gene expression profiling in human hepatoma HepaRG cells. Toxicol Appl Pharmacol. 2009 Feb 1;234(3):345-60.
42 Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
43 Comparison of kinin B(1) and B(2) receptor expression in neutrophils of asthmatic and non-asthmatic subjects. Int Immunopharmacol. 2007 Dec 20;7(14):1862-8. doi: 10.1016/j.intimp.2007.07.012. Epub 2007 Aug 6.
44 Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. Oncotarget. 2014 May 15;5(9):2355-71.
45 Uric acid accumulation in the kidney triggers mast cell degranulation and aggravates renal oxidative stress. Toxicology. 2023 Jan 1;483:153387. doi: 10.1016/j.tox.2022.153387. Epub 2022 Dec 1.
46 P-gp, MRP2 and OAT1/OAT3 mediate the drug-drug interaction between resveratrol and methotrexate. Toxicol Appl Pharmacol. 2016 Sep 1;306:27-35. doi: 10.1016/j.taap.2016.06.030. Epub 2016 Jul 1.
47 Intracellular concentrations determine the cytotoxicity of adefovir, cidofovir and tenofovir. Toxicol In Vitro. 2015 Feb;29(1):251-8. doi: 10.1016/j.tiv.2014.10.019.
48 Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol. 2001 May;59(5):1277-86.
49 A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters. J Pharmacol Exp Ther. 2005 Oct;315(1):337-45.
50 Human organic anion transporter hOAT3 is a potent transporter of cephalosporin antibiotics, in comparison with hOAT1. Biochem Pharmacol. 2005 Oct 1;70(7):1104-13.
51 Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A). Eur J Pharmacol. 2004 Oct 25;503(1-3):25-30.
52 Human organic anion transporters mediate the transport of tetracycline. Jpn J Pharmacol. 2002 Jan;88(1):69-76.
53 Interactions of human organic anion transporters and human organic cation transporters with nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther. 2002 Nov;303(2):534-9.
54 Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
55 Vitamin D3 transactivates the zinc and manganese transporter SLC30A10 via the Vitamin D receptor. J Steroid Biochem Mol Biol. 2016 Oct;163:77-87.
56 Neonicotinoid pesticides poorly interact with human drug transporters. J Biochem Mol Toxicol. 2019 Oct;33(10):e22379. doi: 10.1002/jbt.22379. Epub 2019 Jul 31.
57 Multiple drug transporters mediate the placental transport of sulpiride. Arch Toxicol. 2017 Dec;91(12):3873-3884. doi: 10.1007/s00204-017-2008-8. Epub 2017 Jun 9.
58 Differential interaction of 3-hydroxy-3-methylglutaryl-coa reductase inhibitors with ABCB1, ABCC2, and OATP1B1. Drug Metab Dispos. 2005 Apr;33(4):537-46.
59 Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures. Arch Toxicol. 2018 Jun;92(6):1939-1952.
60 Polymorphic organic anion transporting polypeptide 1B1 is a major determinant of repaglinide pharmacokinetics. Clin Pharmacol Ther. 2005 Jun;77(6):468-78. doi: 10.1016/j.clpt.2005.01.018.
61 SLC19A1, SLC46A1 and SLCO1B1 polymorphisms as predictors of methotrexate-related toxicity in Portuguese rheumatoid arthritis patients. Toxicol Sci. 2014 Nov;142(1):196-209. doi: 10.1093/toxsci/kfu162. Epub 2014 Aug 14.
62 SLCO1B1 variants and statin-induced myopathy--a genomewide study. N Engl J Med. 2008 Aug 21;359(8):789-99.
63 Transport of fluorescent chenodeoxycholic acid via the human organic anion transporters OATP1B1 and OATP1B3. J Lipid Res. 2006 Jun;47(6):1196-202.
64 Transcellular movement of hydroxyurea is mediated by specific solute carrier transporters. Exp Hematol. 2011 Apr;39(4):446-56.
65 Severe toxicities after irinotecan-based chemotherapy in a patient with lung cancer: a homozygote for the SLCO1B1*15 allele. Ther Drug Monit. 2007 Oct;29(5):666-8. doi: 10.1097/FTD.0b013e3181357364.