General Information of Drug (ID: DMH5MVE)

Drug Name
Sodium stibogluconate Drug Info
Synonyms Lenocta; Sodium stibogluconate (cancer); VQD-001; Sodium stibogluconate (cancer), Greenwich; Sodium stibogluconate (cancer), VioQuest
Indication
Disease Entry ICD 11 Status REF
Advanced cancer 2A00-2F9Z Approved [1]
Leishmaniasis 1F54 Approved [2]
Solid tumour/cancer 2A00-2F9Z Phase 2 [3]
Cross-matching ID
PubChem CID
16683012
TTD Drug ID
DMH5MVE

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [9]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [10]
Fructose DM43AN2 Vomiting MD90 Approved [11]
Ketoprofen DMRKXPT Bursitis Approved [11]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [12]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [13]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [14]
Gefitinib DM15F0X Colon adenocarcinoma Approved [15]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [16]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [17]
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Drug(s) Affected By Interferon gamma (IFNG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [18]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [19]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [20]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [21]
Methotrexate DM2TEOL Anterior urethra cancer Approved [22]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [23]
Quercetin DM3NC4M Obesity 5B81 Approved [24]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [25]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [26]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [27]
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Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [28]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [29]
Gefitinib DM15F0X Colon adenocarcinoma Approved [30]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [31]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [32]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [31]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [33]
Selenium DM25CGV N. A. N. A. Approved [34]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [35]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [36]
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Drug(s) Affected By Erythropoietin (EPO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [37]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [38]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [39]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [41]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [42]
Fenoterol DMIP3ZV Asthma CA23 Approved [43]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [44]
Enalapril DMNFUZR Congestive heart failure BD10 Approved [45]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [46]
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Drug(s) Affected By Interleukin-4 (IL4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [47]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [48]
Tolnaftate DM28MU7 Dermatophytosis 1F28.2 Approved [49]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [50]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [51]
Prednisone DM2HG4X Acute asthma CA23 Approved [52]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [21]
Methotrexate DM2TEOL Anterior urethra cancer Approved [22]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [23]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [53]
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Drug(s) Affected By Integrin alpha-M (ITGAM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [54]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [55]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [57]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [58]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [59]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [60]
Cholecalciferol DMGU74E Adult acute monocytic leukemia Approved [61]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [62]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [63]
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Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [64]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [65]
Gefitinib DM15F0X Colon adenocarcinoma Approved [66]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [17]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [48]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [67]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [68]
Methotrexate DM2TEOL Anterior urethra cancer Approved [22]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [69]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [28]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [71]
Methotrexate DM2TEOL Anterior urethra cancer Approved [72]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [73]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [74]
Leflunomide DMR8ONJ Arthritis FA20 Approved [75]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Clozapine DMFC71L Schizophrenia 6A20 Approved [78]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [8]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [11]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [79]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [80]
Methotrexate DM2TEOL Anterior urethra cancer Approved [81]
Quercetin DM3NC4M Obesity 5B81 Approved [82]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [84]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [85]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [86]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [87]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [88]
Quercetin DM3NC4M Obesity 5B81 Approved [89]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [90]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [91]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [87]
Lenalidomide DM6Q7U4 Adult T-cell leukemia/lymphoma Approved [92]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [92]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [93]
Ethanol DMDRQZU Chronic pain MG30 Approved [94]
Menthol DMG2KW7 Back pain ME84.Z Approved [95]
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Drug(s) Affected By Interleukin-10 (IL10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [96]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [19]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [50]
Methotrexate DM2TEOL Anterior urethra cancer Approved [97]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [98]
Quercetin DM3NC4M Obesity 5B81 Approved [99]
Bisoprolol DM3UZ95 Hypertension BA00-BA04 Approved [100]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [25]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [101]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [102]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [71]
Selenium DM25CGV N. A. N. A. Approved [103]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [73]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [104]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [105]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [41]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Sodium chloride DMM3950 Skin burns ME65.0 Approved [106]
Bortezomib DMNO38U Leukemia Approved [107]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [108]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [71]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [73]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [109]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [109]
Leflunomide DMR8ONJ Arthritis FA20 Approved [75]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [41]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [109]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [110]
Bortezomib DMNO38U Leukemia Approved [111]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [108]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Leishmania DNA topoisomerase I (Leishm TOP1) TTNJKC3 Q9NJG8_LEIDO Modulator [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
B-cell lymphoma 6 protein (BCL6) OTQAWWO1 BCL6_HUMAN Gene/Protein Processing [4]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Gene/Protein Processing [5]
Erythropoietin (EPO) OTZ90CN4 EPO_HUMAN Gene/Protein Processing [6]
Integrin alpha-M (ITGAM) OTAG6HWU ITAM_HUMAN Gene/Protein Processing [7]
Interferon gamma (IFNG) OTXG9JM7 IFNG_HUMAN Gene/Protein Processing [5]
Interferon gamma receptor 1 (IFNGR1) OTCTQBWW INGR1_HUMAN Gene/Protein Processing [8]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Gene/Protein Processing [5]
Interleukin-10 (IL10) OTIRFRXC IL10_HUMAN Gene/Protein Processing [5]
Interleukin-4 (IL4) OTOXBWAU IL4_HUMAN Gene/Protein Processing [5]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Gene/Protein Processing [5]

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29 ERE-independent ERalpha target genes differentially expressed in human breast tumors. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):53-9. doi: 10.1016/j.mce.2005.10.003. Epub 2005 Nov 17.
30 Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction. J Toxicol Sci. 2020;45(11):673-680. doi: 10.2131/jts.45.673.
31 An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
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33 (9)-Tetrahydrocannabinol Suppresses Monocyte-Mediated Astrocyte Production of Monocyte Chemoattractant Protein 1 and Interleukin-6 in a Toll-Like Receptor 7-Stimulated Human Coculture. J Pharmacol Exp Ther. 2019 Oct;371(1):191-201. doi: 10.1124/jpet.119.260661. Epub 2019 Aug 5.
34 Changes in gene expression profiles in response to selenium supplementation among individuals with arsenic-induced pre-malignant skin lesions. Toxicol Lett. 2007 Mar 8;169(2):162-76. doi: 10.1016/j.toxlet.2007.01.006. Epub 2007 Jan 19.
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39 Normal erythropoietin response in chronic hepatitis C patients with ribavirin-induced anaemia. Antivir Ther. 2003 Feb;8(1):57-63.
40 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
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43 Fenoterol but not dobutamine increases erythropoietin production in humans. Clin Pharmacol Ther. 1997 Jun;61(6):669-76. doi: 10.1016/S0009-9236(97)90102-8.
44 Vitamin A supplementation in children with poor vitamin A and iron status increases erythropoietin and hemoglobin concentrations without changing total body iron. Am J Clin Nutr. 2006 Sep;84(3):580-6. doi: 10.1093/ajcn/84.3.580.
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48 Cannabidiol selectively modulates interleukin (IL)-1 and IL-6 production in toll-like receptor activated human peripheral blood monocytes. Toxicology. 2021 Dec;464:153016. doi: 10.1016/j.tox.2021.153016. Epub 2021 Nov 2.
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52 Immune responses in autoimmune hepatitis: effect of prednisone and azathioprine treatment: case report. Int J Med Sci. 2009 Jun 30;6(4):177-83. doi: 10.7150/ijms.6.177.
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55 Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
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58 Comparative study of the effects of ziram and disulfiram on human monocyte-derived macrophage functions and polarization: involvement of zinc. Cell Biol Toxicol. 2021 Jun;37(3):379-400. doi: 10.1007/s10565-020-09540-6. Epub 2020 Jul 25.
59 Integrin expression on monocytes and lymphocytes in unstable angina short term effects of atorvastatin. Rom J Intern Med. 2007;45(2):193-9.
60 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
61 Targeting iron homeostasis induces cellular differentiation and synergizes with differentiating agents in acute myeloid leukemia. J Exp Med. 2010 Apr 12;207(4):731-50. doi: 10.1084/jem.20091488. Epub 2010 Apr 5.
62 MEK/ERK dependent activation of STAT1 mediates dasatinib-induced differentiation of acute myeloid leukemia. PLoS One. 2013 Jun 25;8(6):e66915. doi: 10.1371/journal.pone.0066915. Print 2013.
63 [Analysis of in vitro anti-leukemia effect of 5-aza-2'-deoxycitydine]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2008 Apr;33(4):344-52.
64 Some HIV antiretrovirals increase oxidative stress and alter chemokine, cytokine or adiponectin production in human adipocytes and macrophages. Antivir Ther. 2007;12(4):489-500.
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