Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMI0GDH)

Drug Name

Oxybuprocaine Drug Info

Synonyms

Benoxil; Benoxinate; Butoxyaminobenzoyldiethylaminoethanol; Butoxyprocaine; Conjucain; Dorsacain; Novescine; Novesinol; Oxibuprocaina; Oxibuprocainum; Oxibuprokain; Oxybucaine; Oxybuprocainum; Oxyriprocaine; Prescaina; Benoxinate hydrochloride; Monofree oxybuprocaine; Oxybuprocaine HCL; Oxybuprocaine hydrochloride; S 749;Monofree oxybuprocaine (TN); Novesin (TN); Novesine (TN); Oxibuprocaina [INN-Spanish]; Oxybuprocaine (INN); Oxybuprocaine [INN:BAN]; Oxybuprocainum [INN-Latin]; Diethylaminoethyl-4-amino-3-butoxybenzoate; BENZOIC ACID, 4-AMINO-3-BUTOXY-, 2-(DIETHYLAMINO)ETHYL ESTER; Benzoic acid, 4-amino-3-butoxy-, 2-(diethylamino)ethyl ester (7CI,8CI,9CI); 2-(Diethylamino)ethyl 4-amino-3-butoxybenzoate; 2-(diethylamino)ethyl 4-amino-3-n-butoxybenzoate; 2-Diethylaminoethyl 4-amino-3-butoxybenzoate; 3-Butoxy-4-aminobenzoic acid 2-(diethylamino)ethyl ester; 3-Butoxy-4-aminobenzoic acid 2-diethylaminoethyl ester; 4-Amino-3-butoxy-2-(diethylamino)ethyl ester benzoic acid; 4-Amino-3-butoxy-benzoic acid 2-diethylamino-ethyl ester; 4-Amino-3-butoxybenzoic acid 2-(diethylamino)ethyl ester; 4-Amino-3-butoxybenzoicacid 2-diethylaminoethyl ester; 4-Amino-3-n-butoxy-benzoesaeure-diaethylaminoaethylester; 4-Amino-3-n-butoxy-benzoesaeure-diaethylaminoaethylester [German]

Indication

Disease Entry	ICD 11	Status	REF
Anaesthesia	9A78.6	Approved	[1]

Therapeutic Class

Anesthetics

Cross-matching ID

PubChem CID: 4633
ChEBI ID: CHEBI:309594
CAS Number: CAS 99-43-4
TTD Drug ID: DMI0GDH

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting Sodium channel unspecific (NaC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[6]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[7]
Zonisamide	DM0DTF7	Alcohol dependence	6C40.2	Approved	[8]
Eslicarbazepine	DMZREFQ	Seizure disorder	8A6Z	Approved	[9]
LIDOFLAZINE	DMV23GL	Angina pectoris	BA40	Approved	[10]
LOMERIZINE	DME0TC8	Migraine	8A80	Approved	[11]
Levobupivacaine	DM783CH	Anaesthesia	9A78.6	Approved	[12]
Tetrodotoxin	DMWMPRG	Bacterial infection	1A00-1C4Z	Approved	[13]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[14]
Rufinamide	DMWE60C	Epilepsy	8A60-8A68	Approved	[15]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[4]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[4]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[16]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[17]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[18]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[4]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[4]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[4]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[19]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[20]
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Drug(s) Affected By Apoptosis-inducing factor 1, mitochondrial (AIFM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[21]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[22]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[23]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[24]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[26]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[27]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[28]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[29]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
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Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[33]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[34]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[35]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[36]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[37]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[38]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[39]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[40]
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Drug(s) Affected By Caspase-2 (CASP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[41]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[42]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[43]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[46]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[28]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[47]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[48]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[49]
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Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[49]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[50]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[51]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[41]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[52]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[23]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[54]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[55]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[56]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[57]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[40]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[51]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[58]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[59]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[52]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[60]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[61]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[62]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[63]
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Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[64]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[65]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[23]
Selenium	DM25CGV	N. A.	N. A.	Approved	[66]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[67]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[68]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[69]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[72]
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Drug(s) Affected By Potassium voltage-gated channel subfamily H member 2 (KCNH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metoclopramide	DMFA5MY	Nausea	MD90	Approved	[73]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[74]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[75]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[76]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[76]
Disopyramide	DM5SYZP	Long QT syndrome	BC65.0	Approved	[77]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[78]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[79]
Dofetilide	DMPN1TW	Sinus rhythm disorder	BC9Y	Approved	[80]
Flecainide	DMSQDLE	Tachyarrhythmias	BC71	Approved	[76]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Sodium channel unspecific (NaC)	TTRK8B9	NOUNIPROTAC	Blocker	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[3]
Apoptosis-inducing factor 1, mitochondrial (AIFM1)	OTKPWB7Q	AIFM1_HUMAN	Gene/Protein Processing	[3]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Gene/Protein Processing	[3]
Caspase-2 (CASP2)	OTUDYSPP	CASP2_HUMAN	Gene/Protein Processing	[3]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Gene/Protein Processing	[3]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Gene/Protein Processing	[3]
Nuclear receptor subfamily 1 group I member 2 (NR1I2)	OTC5U0N5	NR1I2_HUMAN	Gene/Protein Processing	[4]
Potassium voltage-gated channel subfamily H member 2 (KCNH2)	OTZX881H	KCNH2_HUMAN	Gene/Protein Processing	[5]

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