Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMI2QPE)

Drug Name
Didanosine Drug Info
Synonyms
didanosine; 69655-05-6; DIDEOXYINOSINE; Videx; Videx EC; Inosine, 2',3'-dideoxy-; ddIno; Didanosina; Didanosinum; DDI; BMY-40900; UNII-K3GDH6OH08; K3GDH6OH08; Didanosinum [INN-Latin]; Didanosina [INN-Spanish]; CHEBI:490877; 9-(2,3-Dideoxy-beta-D-ribofuranosyl)-6-oxopurine; NSC 612049; 9-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,9-dihydro-6H-purin-6-one; 9-[(2R,5R)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-2-YL]-1,9-DIHYDRO-6H-PURIN-6-ONE; NCGC00159514-02; NCGC00090691-03; DRG-0016; BMY 40900; DSSTox_CID_2927
Indication
Disease Entry ICD 11 Status REF
Human immunodeficiency virus infection 1C62 Approved [1]
Therapeutic Class
Anti-HIV Agents
Cross-matching ID
PubChem CID
135398739
ChEBI ID
CHEBI:490877
CAS Number
CAS 69655-05-6
TTD Drug ID
DMI2QPE
VARIDT Drug ID
DR01175
ACDINA Drug ID
D00195

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Human immunodeficiency virus Reverse transcriptase (HIV RT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [9]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [10]
Zalcitabine DMH7MUV Human immunodeficiency virus infection 1C62 Approved [11]
Tenofovir DM1IS6U Chronic hepatitis B virus infection Approved [9]
Lamivudine DMI347A Chronic HBV infection 1E51.0Z Approved [12]
Abacavir DMMN36E Human immunodeficiency virus infection 1C62 Approved [13]
Delavirdine DM3NF5G Human immunodeficiency virus infection 1C62 Approved [12]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [12]
Rilpivirine DMJ0QOW Human immunodeficiency virus infection 1C62 Approved [14]
Etravirine DMGV8QU Human immunodeficiency virus-1 infection 1C62 Approved [15]
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Drug(s) Transported By Concentrative nucleoside transporter 2 (SLC28A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [16]
Entecavir DM7VTQO Hepatitis B virus infection 1E51.0 Approved [17]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [18]
Uridine DMQTREB Depression 6A70-6A7Z Approved [19]
Drug(s) Affected By Cytochrome P450 2E1 (CYP2E1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fomepizole DM6VOWQ Athylene glycol or methanol poisoning NE61 Approved [20]
Ademetionine DMYQDBO Hepatic fibrosis DB93.0 Approved [21]
Theophylline DMRJFN9 Bronchitis CA20 Approved [6]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [22]
Ethanol DMDRQZU Chronic pain MG30 Approved [23]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [24]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [26]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [27]
Quercetin DM3NC4M Obesity 5B81 Approved [28]
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Drug(s) Affected By Cytochrome c oxidase subunit 2 (COX2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [29]
Quercetin DM3NC4M Obesity 5B81 Approved [30]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [31]
Clarithromycin DM4M1SG Acute maxillary sinusitis Approved [32]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [32]
Menthol DMG2KW7 Back pain ME84.Z Approved [36]
Josamycin DMKJ8LB Bacterial infection 1A00-1C4Z Approved [32]
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Drug(s) Affected By Albumin (ALB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [37]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [6]
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [38]
Diazepam DM08E9O Alcohol withdrawal Approved [39]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [40]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [41]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [42]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [43]
Methotrexate DM2TEOL Anterior urethra cancer Approved [44]
Quercetin DM3NC4M Obesity 5B81 Approved [45]
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Drug(s) Affected By Antileukoproteinase (SLPI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [5]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [5]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [46]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [5]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [5]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [5]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [5]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [47]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [5]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [5]
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Drug(s) Affected By Interleukin-24 (IL24)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [48]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [5]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [49]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [5]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [5]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [50]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [5]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [52]
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Drug(s) Affected By DNA-directed RNA polymerase, mitochondrial (POLRMT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [26]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [37]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [53]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [6]
Zalcitabine DMH7MUV Human immunodeficiency virus infection 1C62 Approved [6]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [53]
INX-189 DMSTJ6Q Hepatitis C virus infection 1E51.1 Phase 2 [54]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [55]
QUERCITRIN DM1DH96 Discovery agent N.A. Investigative [56]
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Drug(s) Affected By L-serine dehydratase/L-threonine deaminase (SDS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [57]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [58]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [59]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [60]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [61]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [24]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [6]
Zalcitabine DMH7MUV Human immunodeficiency virus infection 1C62 Approved [6]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [55]
PMID28870136-Compound-48 DMPIM9L N. A. N. A. Patented [62]
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Drug(s) Affected By Equilibrative nucleoside transporter 3 (SLC29A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [63]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [64]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [65]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [61]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [26]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [66]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [67]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [68]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [8]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [8]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [69]
Methotrexate DM2TEOL Anterior urethra cancer Approved [57]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [71]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [72]
Paclitaxel DMLB81S Breast carcinoma Approved [73]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [74]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [75]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [76]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [77]
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Drug(s) Affected By Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [78]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [79]
Methotrexate DM2TEOL Anterior urethra cancer Approved [80]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [81]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [82]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [83]
Mitotane DMU1GX0 Adrenocortical carcinoma 2D11.Z Approved [84]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [85]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Human immunodeficiency virus Reverse transcriptase (HIV RT) TT84ETX POL_HV1B1 Inhibitor [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Concentrative nucleoside transporter 2 (SLC28A2) DT82KPY S28A2_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Albumin (ALB) OTVMM513 ALBU_HUMAN Protein Interaction/Cellular Processes [4]
Antileukoproteinase (SLPI) OTUNFUU8 SLPI_HUMAN Gene/Protein Processing [5]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Drug Response [6]
Cytochrome c oxidase subunit 2 (COX2) OTTMVBJJ COX2_HUMAN Gene/Protein Processing [7]
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) OTU0FC24 COX41_HUMAN Drug Response [6]
Cytochrome P450 2E1 (CYP2E1) OTHQ17JG CP2E1_HUMAN Drug Response [6]
DNA-directed RNA polymerase, mitochondrial (POLRMT) OT5Q8ZUJ RPOM_HUMAN Drug Response [6]
Equilibrative nucleoside transporter 3 (SLC29A3) OTGLX8XU S29A3_HUMAN Regulation of Drug Effects [8]
Interleukin-24 (IL24) OT4VUWH1 IL24_HUMAN Gene/Protein Processing [5]
L-serine dehydratase/L-threonine deaminase (SDS) OT5WTJ2M SDHL_HUMAN Drug Response [6]

References

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